• 한국응용과학기술학회지
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• 제27권2호
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• pp.99-106
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• 2010

We have investigated the rheological behaviours of emulsions containing polymers. The polymers used in this study were polyacrylamide and carboxy vinyl polymer. The emulsion with polyacrylamide shows better prior preference than that with carboxy vinyl polymer on the skin texture. In the toxicity test, such as, LLNA cell toxicity, skin organ culture and human patch test, polyacrylamide was the appropriate materials for the cosmetics. The viscosity of polyacrylamide shows maximum value in neutral pH and good stability against temperature. The decreasing effect of viscosity against salt was not good enough but showed a better result than that of carboxy vinyl polymer. Two times the amount of polyacrylamide should be used for the formation of a similar viscosity of carboxy vinyl polymer. Yield value of polyacrylamide was low and the effect for the stabilizing emulsions was also low.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2002년도 춘계학술대회 논문집
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• pp.107-113
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• 2002

We examined the psychophysiological effects of navigation in a virtual reality (VR). Subjects were exposed to the VR, and required to detect specific objects. Ten electrophysiological signals were recorded before, during, and after navigation in the VR. Six questionnaires on the VR experience were acquired from 45 healthy subjects. There were significant changes between the VR period and the pre-VR control period in several psychophysiological measurements. During the VR period, eye blink, skin conductance level, and alpha frequency of EEG were decreased but gamma wave were increased. Physiological changes associated with cybersickness included increased heart rate, eye blink, skin conductance response, and gamma wave and decreased photoplethysmogram and skin temperature. These results suggest an attentional change during VR navigation and activation of the autonomic nervous system for cybersickness. These findings would enhance our understanding for the psychophysiological changes during VR navigation and cybersickness.

• 대한의생명과학회지
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• 제28권4호
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• pp.276-283
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• 2022

Saccharina japonica (SJ), a brown algae, exerts various pharmacological effects, including anti-oxidant, immunemodulating and anti-cancer properties. This study aimed to determine the pharmacological mechanism of SJ on atopic dermatitis in vivo and in vitro. We investigated the pharmacological effects of SJ on 2, 4-dinitrochlrobenzene (DNCB)- induced atopic dermatitis clinical symptoms in mice. Additionally, we evaluated the effects of SJ on the inflammatory cytokine production and nuclear factor-κB (NF-κB) activation in HaCaT cells. The findings of this study demonstrated that SJ reduced the clinical symptoms of atopic dermatitis, such as skin dryness, erythema and eczematous, and serum histamine and IgE level in DNCB-induced atopic dermatitis model. Additionally, SJ inhibited the NF-κB activation in atopic dermatitis-like skin lesion and HaCaT cells. Collectively, this result suggests that SJ could be used as a therapeutic agent for skin inflammation, including atopic dermatitis.

• 한국자원식물학회지
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• 제36권6호
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• pp.556-561
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• 2023

Oldenlandia diffusa (OD), a member of the Rubiaceae family, has been used for treating inflammatory and infectious diseases. However, the anti-atopic effects of OD are not completely understood yet. Thus, the aim of the present study was to elucidate beneficial effects of OD on atopic dermatitis (AD) in vivo. We examined the pharmacological effects of OD on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced AD-like skin lesions in mice. Additionally, we evaluated regulatory effects of OD on the expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in DNCB-induced AD-like skin lesions. Results showed that OD inhibited the scratching behavior and AD symptoms. It also decreased serum levels of IgE and histamine in mice. Moreover, OD significantly ameliorated the expression of IL-6 and TNF-α in AD-like skin lesion. These finding suggest experimental evidence of that OD's potential for treating AD.

• 한방안이비인후피부과학회지
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• 제25권1호
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• pp.22-32
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• 2012

Objectives : In this study, Samhwangsaejaegami extract was tested to prove its anti-atopic dermatitis effect on NC/Nga mice. Methods : In order to evaluate the external use effects of Samhwangsaejae extract on anti-atopic dermatitis, the expression of filaggrin, serine palmitoyltransferase(SPT), and COX-2 were analyzed. In vivo study, clinical skin severity score, IgE, IL-4, IL-5 and IL-6 level were analyzed through NC/Nga atopic mice model after 12 weeks external treatment. Results : In vitro study results showed the reduction in the expression of filaggrin, SPT, and COX-2. In vivo study results demonstrated the significant reduction in clinical skin severity score, IgE, IL-4, IL-5, IL-6 expression level. Conclusions : These results showed Samhwangsaejaegami extract can be a promising candidate for anti-atopic dermatitis treatment.

• Imaging Science in Dentistry
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• 제30권1호
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• pp.11-15
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• 2000

Purpose: The primary objective of this study was to estimate the radiation absorbed doses in certain critical organs in the head and neck region with an Orthopos plus, a Panelipse, and a Panex-E machines. The second objective was to compare the absorbed doses between 5 inch by 12 inch and 6 inch by 12 inch image field for the Orthopos plus. Materials and Methods: Rando phantom and LiF TLD chips were used for dosimetry. The absorbed doses were measured at the thyroid gland, the submandibular gland, the parotid gland, the mouth floor, the maxillary sinus, the brain, the mandibular body, the mandibular ramus, the 2nd cervical spine and the skin over TMJ area. Results: The highest absorbed dose value was recorded at the mandibular ramus for the Orthopos plus with narrow image field. Higher absorbed dose values were recorded at the parotid gland, the mouth floor, the submandibular gland, and the 2nd cervical spine. The doses in the parotid gland were 597 μGy and 529 μGy with Orthopos plus, 638 μGy with Panelipse, and 1094μGy with Panex-E. Corresponding figures for the mandibular ramus were 2363 Gy and 1220 μGy, 248 μGy, and 118 μGy. The absorbed doses to the thyroid gland, the maxillary sinus, the brain, and the skin over TMJ were very low. Conclusion: Higher exposure values were recorded for the Orthopos plus than Panelipse and Panex-E. There was no significant differences of the absorbed doses according to the image field size.

• Biomolecules & Therapeutics
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• 제22권6호
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• pp.477-490
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• 2014

Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.

• Fisheries and Aquatic Sciences
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• 제27권7호
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• pp.468-473
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• 2024

The tyrosinase inhibition effects of 23 marine-derived seaweeds harvested in Korea were screened to determine their potential as skin-whitening agents. Of the 23 species initially screened, the total phenolic (TP) content of brown, green, and red seaweeds were 7.62-280.11, 5.24-62.37, and 0.63-28.76 phloroglucinol equivalents (PGE) mg/g, respectively. Brown seaweed extracts exhibited much stronger inhibitory activities than green and red seaweed extracts. Among the brown seaweeds, Ecklonia cava had the highest TP content (280.11 PGE mg/g) and the strongest tyrosinase inhibitory effect with a half maximal inhibitory concentration (IC₅₀) value of 4.38 ㎍/mL. The kinetics of tyrosinase inhibition, analyzed by Lineweaver-Burk plots, found E. cava extract to be a non-competitive inhibitor. This study's results indicated that E. cava's inhibition of tyrosinase may have potential applications in the cosmetic industry.

• 대한화장품학회지
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• 제30권1호
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• pp.63-71
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• 2004

태양광선과 산소는 피부세포에 자유라디칼(free radical)과 활성산소종(Reactive oxygen species, ROS)을 생성시켜 DNA의 손상과 세포막 지질의 과산화를 유발한다. 또한 콜라겐과 같은 세포 외 기질을 파괴하는데 관여하는 효소(matrix metallo-proteinhse, MMPs)의 발현에 영향을 주어, 결합조직을 손상시키며, 피부 염증을 유발시켜 조직을 파괴하고 노화를 가속화시킨다. 본 연구는 자외선과 SLS에 의한 피부손상에 대한 향나무추물물의 피부 보호 효과에 대한 것이다. 실험 결과 프리라디칼 및 슈퍼옥사이드 라디칼 소거 효과가 우수하게 나타났으며, 피부 콜라겐과 같은 메트릭스를 분해하는 효소인 MMP-1의 활성 및 발현 저해 효과는 섬유아세포에서 UVA 조사에 의한 실험에서 우수하게 나타났으며, 피부세포 배양액에 대해 zymography를 실시하여 활성이 감소됨을 확인하였다. 피부 각질형성세포에서 자외선에 의해 유도된 염증관련 사이토카인인 인터루킨 6의 발현량 실험에서도 무처리군에 비해 향나무추출물이 인터루킨 6를 30% 정도 저해효과가 나타났으며, 염증반응 중 cyclooxygenase (COX)에 의한 경로에서 생성되는 프로스타글란딘 E$_2$의 생성량도 감소시켰다. 사람 피부에서 SLS (0.5%)첩포로 유발된 자극성 피부염의 항염증 효과 평가 시 SLS에 의해 유발되는 자극정도가 피검자의 피부상태에 따라 다양하게 나타났으며, 향나무추출물 함유 에멀젼 제품 도포 실험에서는 피부 홍반 완화 효과와 피부장벽 회복 효과가 우수하게 나타났다. 따라서 향나무추출물은 자외선 조사 및 SLS에 의한 피부손상에 대한 보호 효과를 가진 화장품에서 우수한 소재로 적용될 수 있다. 녹두추출물을 화장품에 사용하였을 경우 우수한 항자극 효과를 보임을 확인하였다.완화시키는데 기여하였다. 이러한 결과를 종합하여 한국에서 삼림쇠퇴를 유발할 수 있는 스트레스요인들의 잠재적 상호작용을 모식화하였다. 나아가 그것을 완화할 수 있는 복원방안을 토양개량과 식생복원의 측면에서 제시하였다. mg/l)치 농도가 높을지라도 이것이 낮은 cinnamic acid와 protocatechuic acid에서 현저한 억제현상을 보였다. 서양등골나물 임상의 토양보다 서양등골나물이 분포하지 않는 토양의 중금속 함량이 전반적으로 높았다. 특히 Al, Fe 및 Mn의 함량이 높았으며 이들 중금속은 total phenolic compound 함량이 높은 잎에 대부분이 축적되었다." separating himself from the real world. Thirdly, The nature of "Gang-Ho" is 'absence of worldly desire' and 'cordiality' that one could be deserved his diligency becoming a part of the harmonious idealistic living place. Fourthly, on the character of story teller. Originally he is a incomer of "Gang-Ho" from real world. so that reason, he is showing dualism not to deny the loyalty oath to his king, while he intends to satisfy with the life in "Gang- Ho" separating himself from real world. As

• 한국식품영양과학회지
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• 제44권1호
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• pp.1-6
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• 2015

본 연구는 DNCB(2,4-dinitrochlorobenzene) 도포를 통해 아토피 피부염을 유발시킨 BALB/c mice에 참치심장 에탄올 추출물(THEE)을 2주 동안 지속적으로 처리하여 THEE의 아토피 피부염 완화 효과에 대해 연구하였다. 이를 위해 Th1 및 Th2 cytokines의 분비량, 비장 세포 증식능, 혈청중 총 IgE 함량, 육안 평가 및 skin clinical severity score를 실시하였다. 그 결과 THEE를 지속적으로 도포함으로써 혈청 내 총 IgE의 분비량이 현저히 감소함을 나타내었다. Th1 세포로부터 생성되는 $IFN-{\gamma}$ cytokine은 증가하고 염증매개성 cytokine인 $TNF-{\alpha}$의 분비량은 감소함을 확인하였다. 또한 Th2 cytokine에 속하는 IL-4, IL-5, IL-13 분비량은 감소하였으며 항염증성 cytokine인 IL-10의 분비량이 증가함을 보여 항아토피 효과를 나타내었다. 육안 평가를 통해서 THEE를 2주간 지속적으로 도포 처리하였을 때 그 증상이 눈에 띄게 완화되는 것을 확인할 수 있었으며, skin clinical severity score에서도 DNCB 단독 처리군과 비교시 유의적으로 그 값이 감소하였다. 이상의 결과들로부터 THEE는 Th1과 Th2 cytokine의 생성 및 활성을 조절하고 IgE의 과다 발현을 억제함으로써 아토피 피부염의 개선에 뛰어난 효능을 가지고 있는 것으로 사료된다.