• Journal of Advanced Navigation Technology
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• v.13 no.3
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• pp.419-425
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• 2009

The amount of incoming e-mails is increasing rapidly due to the wide usage of Internet. Therefore, it is more required to classify incoming e-mails efficiently and accurately. Currently, the e-mail classification techniques are focused on two way classification to filter spam mails from normal ones based mainly on Bayesian and Rule. The clustering method has been used for the multi-way classification of e-mails. But it has a disadvantage of low accuracy of classification and no category labels. The classification methods have a disadvantage of training and setting of category labels by user. In this paper, we propose a novel multi-way e-mail hierarchy classification method that uses PCA for automatic category generation and dynamic category hierarchy for high accuracy of classification. It classifies a huge amount of incoming e-mails automatically, efficiently, and accurately.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.3
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• pp.502-509
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• 2001

In this paper, when stress waves are propagated along the reinforced direction of the composite, the characteristic equation of Rayleigh wave is derived. The relationships between velocities of stress waves and Rayleigh wave are studied for anisotropic ratios(E(sub)11/E(sub)12 or E(sub)22/E(sub)11). The increments of anisotropic ratios is made by using known material properties and being constant of basic properties. When the anisotropic ratios are increased, Rayleigh wave velocities to the shear wave velocities are almost equal to 1 with any anisotropic ratios. Rayleigh wave velocities to the longitudinal wave velocities and Shear wave velocities ratio to the longitudinal wave velocities are almost identical each other, they are between 0.12 and 0.21. When the anisotropic ration is very high, that is, E(sub)11/E(sub)22=46.88, Rayleigh wave velocities and the shear wave velocities are almost constant with Poissons ratio, longitudinal wave velocities are very slowly increased with the increments of Poissons ratios. When E(sub)11(elastic modulus of the reinforced direction)and ν(sub)12 are constant, Rayleigh wave velocities and the shear wave velocities are steeply decreased with the increments of anisotropic ratios and the velocities of longitudinal wave are almost constant with them. When E(sub)22(elastic modulus of the normal direction to the fiber) and ν(sub)12 are constant, Rayeigh wave velocities is slowly increased with the increments of anisotropic ratios, the shear wave velocities are almost constant with them, the longitudinal wave velocities are steeply increased with them.

• Steel and Composite Structures
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• v.20 no.5
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• pp.1155-1171
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• 2016

Post-tensioned (PT) steel moment resisting frames (MRFs) with semi-rigid connections (SRC) can be used to control the hysteretic energy demands and to reduce the maximum inter-story drift (${\gamma}$). In this study the seismic behavior of steel MRFs with PT connections is estimated by incremental nonlinear dynamic analysis in terms of dissipated hysteretic energy ($E_H$) demands. For this aim, five PT steel MRFs are subjected to 30 long duration earthquake ground motions recorded on soft soil sites. To assess the energy dissipated in the frames with PT connections, a new expression is proposed for the hysteretic behavior of semi-rigid connections validated by experimental tests. The performance was estimated not only for the global $E_H$ demands in the steel frames; but also for, the distribution and demands of hysteretic energy in beams, columns and connections considering several levels of deformation. The results show that $E_H$ varies with ${\gamma}$, and that most of $E_H$ is dissipated by the connections. It is observed in all the cases a log-normal distribution of $E_H$ through the building height. The largest demand of $E_H$ occurs between 0.25 and 0.5 of the height. Finally, an equation is proposed to calculate the distribution of $E_H$ in terms of the normalized height of the stories (h/H) and the inter-story drift.

• Journal of Periodontal and Implant Science
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• v.32 no.3
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• pp.603-614
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• 2002

Human gingival fibroblasts have proven to useful as a species specific cell culture system in various system on periodontal disease and regeneration. However, their use is limited, since they are hard to obtain and lifespan is short due to replicative senescence. To overcome these disadvantages, we transfected primary human gingival fibroblasts by the E6 and E7 genes of the Human papilloma virus(HPV) 16. The full length of HPV 16 E6 and E7 was cloned from the pBR322 into BamHl and Sal I of a pBabe vector including hygromycin B resistance. Before pBabeE6/E7 plasmid transfection, peak 8 GFP including G418 resistance was transfected into primary GF to check the transfection efficency. PBabe E6/E7 plasmid was transfected using Lipofectamine plus following manufacter's instruction into primary normal human gingival fibroblasts in 60mm dishes with FBS free DMEM. After 2 days of transfection, the cells were treated with hygromycin for 2 weeks until the transfected control cells died. The resulting hygromycin resistant colonies were pooled, and clonned, and sucessful　transfection was established for immortalized gingival fibroblast cell lines. Immoralized GF cells showed stellate shape, that is similar to that of orange grains, and more rapid growth and higher proliferation than that of primary gingival fibroblasts. This cell lines overcame crisis and could be cultured over 30 subcultured, could be use for three dimentional culture, epithelial-mesenchymal interaction study.

• Journal of Preventive Medicine and Public Health
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• v.42 no.4
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• pp.261-266
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• 2009

Objectives : The aim of this study is to examine the cognitive function change related to aging, the incidence of cognitive impairment, and the association between apolipoprotein E polymorphism and cognitive impairment through a follow-up of the elderly with normal cognitive ability at baseline. Methods : Two hundred and fifteen subjects aged 65 and over were surveyed in February, 1998 (baseline survey), and their cognitive function was assessed again in 2003 1st follow-up) and the once again in 2006 (2nd follow-up). Ninety one subjects completed all surveys up through the 2nd follow-up and their cognitive function scores using MMSE-K (Korean Version of the Mini-Mental State Examination) and the distribution of apolipoprotein E allele were analyzed. Results : The cognitive function scores decreased with aging and the difference between baseline and the 2nd follow-up scores of the study increased with the age group. The incidence rate of cognitive impairment through an 8-year follow-up was 38.5% and higher in older age groups. Age was the only significant factor for incidence of cognitive impairment, but there was no significant association between apolipoprotein E genotype and incidence of cognitive impairment. Conclusions : The cognition of the elderly decreased with aging and the association of apolipoprotein E genotype with incidence of cognitive impairment was not significant in this study. To confirm the association between apolipoprotein E polymorphism and incidence of cognitive impairment further studies will be needed.

• International Journal of Oral Biology
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• v.31 no.2
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• pp.27-32
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• 2006

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline mutations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast cancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma(SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign epithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.1 s.32
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• pp.16-26
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• 2007

Background &Objectives : Rhinitis is an inflammation of nasal mucosa and the major symtoms are watery rhinorrhea, sneezing, itchy nose, and nasal obstruction. Rhinitis is classified into allergic rhinitis and nonallergic rhinitis. Allergic rhinitis is an immune reaction by allergen, and vasomotor rhinitis which is nonallergic and noninfectious is hypersensitive reaction. The incidence of allergic rhinitis has increased and the rate of vasomotor rhinitis is high. However there have been no studies about vasomotor rhinitis compared with allergic rhinitis. And there have been no studies so far performed on the effect of Tongkwansan. Therefore this study is aimed to find out the effects of Tongkwansan on allergic rhinitis and vasomotor rhinitis. Materials and Methods : Fifteen BALC/c mouses were divided into three groups : normal group, control group and sample group. To induce the allergic rhinitis in control group and sample group, mouses were sensitized intrapertioneally 0.1% ovalbumin solution three times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1 % ovalbumin solution 3 times at intervals of 2 days. After that time, mouses in the sample group were oral administration treated by Tongkwansan for 28 days. We observed changes in the segment of IL-4, IL-5, $IFN-{\gamma}$, Total IgE, and ovalvumin specific IgE in blood. We used the statistical methods of ANOVA test(p<0.05). Results : There were no significant changes statistically in $IFN-{\gamma}$, IL-4, and IL-5 in blood(p<0.05). There were also no significant changes statistically in Total IgE, OVA-specific IgE in blood(p<0.05). Conclusion : According to above results, it is supposed that Tongkwansan has no significant effects on allergic rhinitis. But it is supposed that Tongkwansan has significant effects on vasomotor rhinitis which is nonallergic and noninfectious

• Journal of Digital Convergence
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• v.17 no.8
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• pp.141-148
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• 2019

Based on the theory of information ecology, this paper conducts a quantitative analysis on the research literature of e-commerce ecosystem in China, and clarifies the research hotspots and development trends, so as to provide reference for subsequent studies. With the key words related literatures collected by CNKI as the data source, and the software CiteSpaceIV is used to draw a visual knowledge map, the distribution of e-commerce ecosystem research papers in China is statistically analyzed by econometric analysis method, and literature research is summarized and evaluated. The research results show that previous studies mainly focus on the concept of e-commerce ecosystem, and there are relatively few research results on the construction and evolution mechanism of e-commerce ecosystem, so the depth and breadth of research should be expanded. Applying the concept of e-commerce ecosystem to solve the problems in cross-border e-commerce will be the future research trend.

• Journal of Korea Society of Industrial Information Systems
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• v.29 no.3
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• pp.23-40
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• 2024

Hardware attacks involve physical reverse engineering efforts to steal sensitive information, such as encryption keys and circuit designs. Encryption and obfuscation are representative countermeasures, but they are nullified if adversaries manage to find the key. To address this issue, we propose e-Cryptex, which utilizes a Physically Unclonable Function (PUF) as an anti-tampering shield. PUF acts as a random number generator and relies on unique physical variants that cannot be replicated or restored to enhance anti-tampering mechanisms. e-Cryptex uses PUF as a shield to protect the system's structure and generate the key. Tampering with the shield will result in the destruction of the key. This paper demonstrates that e-Cryptex meets PUF security requirements and is effective in detecting of tampering attempts that pierce or completely destroy the shield. Each board consistently generates the same key under normal conditions, while also showing key uniqueness across different boards.

• Korean Journal of Veterinary Research
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• v.35 no.4
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• pp.699-712
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• 1995

The present study, to evaluate the effect of vitamin E on the oxidative stress in STZ-treated rat and BB rat, was investigated the biochemical enzyme activity in the serum, and malondialdehyde and carbonyl group in the RBC membrane, liver and microsomal fraction after vitamin E and/ or insulin treatment. Results obtained through the experiments were summarized as follows; 1. Effect of vitamin E and/or insulin treatment in STZ-treated rat 1) Lipid peroxidation level in RBC membrane, liver and microsomal fraction was significantly decreased in vi. tamin E and/or insulin treatment group, and especially more significantly decreased in vitamin E with insulin treated group. 2) Protein oxidation level in RBC membrane, liver and microsomal fraction was significantly decreased in vitamin E and/or insulin treatment group. And it was especially more significantly decreased in RBC membrane and liver of vitamin E with insulin treated group. 3) In the enzyme activity in the serum, the activity of AST and ALT was not altered in all experimental group. The increased ALP activity in STZ-treated group was significantly decreased in insulin treated group and vitamin E with insulin treated group. 4) Decreased level of albumin and creatinine after STZ treatment was significantly increased in vitamin E and/or insulin treated group. 5) Level of glucose, cholesterol and triacylglycerol in serum: Glucose level was not significantly different in vitamin E treated group compared to STZ control group. But it was significantly different in the insulin treated group and vitamin E with insulin treated group compared to STZ control group. The cholesterol content in the serum was significantly increased in STZ control group compared to normal control group. And except low dose vitamin E treatment group, it was significantly decreased in vitamin E and/or insulin treated group compared to STZ control group. The triacylglycerol content in the serum was significantly decreased in STZ control group and increased in high dose vitamin E treated group and vitamin E with insulin treated group. But it was not significantly different in low dose vitamin E treated group and insulin treated group compared to STZ control group. 2. Effect of vitamin E and/or insulin treatment in BB rat 1) Lipid peroxidation level in liver was decreased by vitamin E with insulin treatment compared to insulin treatment. But it was not different in microsomal fractions. 2) Protein oxidation level in liver and microsomal fraction was decreased by vitamin E with insulin treatment compared to insulin treatment only in microsomal fractions. These results suggest that the combination treatment of vitamin E and insulin could prevent the oxidative change of lipid and protein of the RBC membrane, liver and microsomal fraction in STZ-treated rats and BB rats.