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Changes in Steroid Receptor Number of and Bioactivity of Gonadotropin in the Follicular Fluid of Porcine Ovafian Atretic Follicles I. Bioavailable Testosterone (돼지의 폐쇄여포내 스테로이드 수용체의 변화와 여포액내 생식소자극 호르몬의 활성도 변화 1. 활성적 Testosterone의 농도)

  • 윤용달;이창주;전은현;이주영
    • The Korean Journal of Zoology
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    • v.32 no.3
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    • pp.281-289
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    • 1989
  • The present study was disigned to determine the concentration of bioavailable steroid hormones in the atretic follicular fluid (FF). The concentradons of progesterone (P), testosterone (T), estradiol (E), androstenedione (A), and 5-$\alpha$ dihydrotestosterone (DIlT) were determined by the established methods of luminescent immunoassay (LIA) or radioimmunoassay (RIA). Concentrations of T, A and Diff in human FF from smail (< 6 mm). medium (8-15 mm), and large (> 15 mm) atretic follicles were significandy higher than those of normal ones (p < 0.01). However, the levels of T, A and DHT in smail atretic foflicle were significandy lower than those found in normal one. The concentrations of P in atretic FF from porcine small (< 3 mm), medium (4-6 mm), and large (> 7 mm) follicles were not different from that of normal ones. However, the concentration of E in atretic forncles of each group was significantly lower than that of normal group (p < 0.001 in each group). On the other hand, the percentages of bioavailable T (BI) in human FF were significandy (p <0.001) higher than those in normal groups. The BT in normal or atretic FF was more than 90 % of total T. The present result demonstrates that the bioavailable androgen, but not E levels in atretic follicles is higher than that of normal one, and that the atretic mechanism might be dependent on the ovarian forncle size in the developmental stage and on the animal model system. Moreover, the present study suggests that the steroids found in the FF are the bioavailable forms and the concentration of BT in FF could be used as one of the valuable criteria classifying the ovarian atretic follicle.

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A SYSTEM OF NONLINEAR VARIATIONAL INCLUSIONS IN REAL BANACH SPACES

  • Bai, Chuan-Zhi;Fang, Jin-Xuan
    • Bulletin of the Korean Mathematical Society
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    • v.40 no.3
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    • pp.385-397
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    • 2003
  • In this paper, we introduce and study a system of nonlinear implicit variational inclusions (SNIVI) in real Banach spaces: determine elements $x^{*},\;y^{*},\;z^{*}\;\in\;E$ such that ${\theta}\;{\in}\;{\alpha}T(y^{*})\;+\;g(x^{*})\;-\;g(y^{*})\;+\;A(g(x^{*}))\;\;\;for\;{\alpha}\;>\;0,\;{\theta}\;{\in}\;{\beta}T(z^{*})\;+\;g(y^{*})\;-\;g(z^{*})\;+\;A(g(y^{*}))\;\;\;for\;{\beta}\;>\;0,\;{\theta}\;{\in}\;{\gamma}T(x^{*})\;+\;g(z^{*})\;-\;g(x^{*})\;+\;A(g(z^{*}))\;\;\;for\;{\gamma}\;>\;0,$ where T, g : $E\;{\rightarrow}\;E,\;{\theta}$ is zero element in Banach space E, and A : $E\;{\rightarrow}\;{2^E}$ be m-accretive mapping. By using resolvent operator technique for n-secretive mapping in real Banach spaces, we construct some new iterative algorithms for solving this system of nonlinear implicit variational inclusions. The convergence of iterative algorithms be proved in q-uniformly smooth Banach spaces and in real Banach spaces, respectively.

Pretreatment of normal responders in fresh in vitro fertilization cycles: A comparison of transdermal estradiol and oral contraceptive pills

  • Pereira, Nigel;Petrini, Allison C.;Zhou, Zhen N.;Lekovich, Jovana P.;Kligman, Isaac;Rosenwaks, Zev
    • Clinical and Experimental Reproductive Medicine
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    • v.43 no.4
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    • pp.228-232
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    • 2016
  • Objective: The aim of this study was to investigate the impact of pretreatment with transdermal estradiol ($E_2$) compared to oral contraceptive pills (OCPs) on controlled ovarian stimulation (COS) response in normal responders undergoing fresh in vitro fertilization (IVF)-embryo transfer (ET) cycles. Methods: A retrospective cohort study was performed of normal responders undergoing fresh IVF-ET cycles who received pretreatment with transdermal $E_2$ versus OCPs prior to fresh IVF-ET. The total days of ovarian stimulation, total dosage of gonadotropins, total number of oocytes, and mature oocytes retrieved were noted. Pregnancy outcomes after ET were also recorded. Results: A total of 2,092 patients met the inclusion criteria: 1,057 and 1,035 patients in the transdermal $E_2$ and OCP groups, respectively. Patients in the OCP group had a longer duration of COS ($10.7{\pm}1.63days$, p< 0.01) than the $E_2$ group ($9.92{\pm}1.94days$). Patients in the OCP group also required higher cumulative doses of gonadotropins ($2,657.3{\pm}1,187.9IU$) than those in the $E_2$ group ($2,550.1{\pm}1,270.2IU$, p= 0.002). No statistically significant differences were found in the total and mature oocytes retrieved or in the rates of biochemical pregnancy, clinical pregnancy, spontaneous miscarriage, and live birth between the groups. Conclusion: Our findings suggest that compared to OCPs, pretreatment with transdermal $E_2$ is associated with a shorter duration of ovarian stimulation and lower gonadotropin utilization, without compromising the oocyte yield or pregnancy outcomes in normal-responder patients undergoing fresh IVF.

Investigation of Photoelectrochemical Water Splitting for Mn-Doped In2O3 Film

  • Sun, Xianke;Fu, Xinhe;You, Tingting;Zhang, Qiannan;Xu, Liuyang;Zhou, Xiaodong;Yuan, Honglei;Liu, Kuili
    • Electronic Materials Letters
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    • v.14 no.6
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    • pp.733-738
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    • 2018
  • Undoped and Mn-doped $In_2O_3$ films were prepared by radiofrequency magnetron sputtering technique. The effects of Mn doping on the structural and optical properties of as-prepared films were investigated using X-ray diffraction, X-ray photoelectron spectroscopy and ultraviolet-visible spectroscopy. Mn doping can enhance the intensity of (222) peak in Mn-doped $In_2O_3$ thin film, indicating Mn dopant promotes preferred orientation of crystal growth along (222) plane. XPS analyses revealed that the doped Mn ions exist at + 2 oxidation states, substituting for the $In^{3+}$ sites in the $In_2O_3$ lattice. UV-Vis measurements show that the optical band gap $E_g$ decreases from 3.33 to 2.87 eV with Mn doping in $In_2O_3$, implying an increasing sp-d exchange interaction in the film. Our work demonstrates a practical means to manipulate the band gap energy of $In_2O_3$ thin film via Mn impurity doping, and significantly improves the photoelectrochemical activity.

The Normal Stress of TiO2 Electrorheological Fluid and Its Model Prediction (이산화티타늄 전기유변 유체의 수직 응력과 정전기 분극 모델에 의한 전산모사)

  • Young Dae Kim
    • Korean Chemical Engineering Research
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    • v.62 no.3
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    • pp.269-273
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    • 2024
  • The normal stress of TiO2 ER fluid under an electric field showed negative values due to the electrostatic attraction force in the normal direction between particles and the absolute value increased dramatically with electric field strengths. The normal yield stress exhibited E2 dependence similar to the dynamic yield stress, indicating that normal stress can be utilized for evaluating the ER effect. Numerical simulation demonstrated good qualitative agreement with the experimental data and suggested that the decrease in the absolute value of normal stress with increasing shear rates was attributed to the rearrangement of particle configurations under shear.

The Characteristic Analysis of E.M.F. Induced by Moving Normal Spot in a Cylindrical Superconducting Foil

  • Kim, Ho-Min;Bae, Joon-Han;Yoon, Yong-Soo;Chu, Yong;Ko, Tae-Kuk;Han, Tae-Su
    • Progress in Superconductivity
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    • v.1 no.2
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    • pp.99-104
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    • 2000
  • The e.m.f. induced by a normal spot moving in a superconducting foil has been investigated by using the simulation and the experiment of a simple superconducting Power Supply. The induced e.m.f. has been derived theoretically from the magnetic field distribution within the spot. It is the sum of a DC component induced constantly by the Faraday's law during the spot's movement and a pulse component induced periodically by the flux conservation law at every electrical degrees 2$\pi$ radians. The DC component of the output voltage appears slightly nonlinear to the rotating speed, having values greater than the linear approximation values. The theoretical interpretation has been verified through experiment.

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The static thrust and normal force calculation of a Hybrid type LPM as a servo actuator (서보 액튜레이터용 Hybrid형 LPM의 정추력 및 수직력 계산)

  • Cho, Yun-Hyou;Koo, Dae-Hyon;Lee, Jae-Bong
    • Proceedings of the KIEE Conference
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    • 1994.07a
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    • pp.43-45
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    • 1994
  • This paper proposes the new method to calculate the static thrust and normal force of a hybrid type double-sided linear pulse motor by the coenergy which considered the magnetic nonlinealities. In the process of the computation, the nonlinear characteristics of the magnetic material were interpolated by the cubic spline method. And, to investigate the characteristics of the hybrid type DLPM, the static thrust and the normal force is shown as a function of displacement, input current and air airgap length. Also the simulation values are compared with the experimental ones obtained from a hybrid type DLPM.

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The Experimental study of B.E.P.(Biological Energy Projector) on the swimming Time of Mice and on the Recovery of Muscular Fatigue of Rats (B.E.P.가 생쥐의 수영능(水泳能)과 수영부하(水泳負荷)로 야기(惹起)된 흰쥐의 피로회복(疲勞恢復)에 미치는 실험적(實驗的) 연구(硏究))

  • Lee, Cheol-Wan
    • Journal of Haehwa Medicine
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    • v.4 no.1
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    • pp.357-371
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    • 1995
  • We have completed a study to measure the contents of glucose, BUN, creatinine. LDH, and T-protein with respect to a fatigued condition in the bloods of rats which a constant swimming is loaded and to measure the maximun swimming time of mice The test has been carried out as a part of the basic study on the efficacy of B. E. P. (Biological Energy Projector) for emitting a light energy having a specific wavelength out of far-infrared rays. As a result. We have reached the following conclusions: 1. At testing of mice's maximun swimming time, all of B.E.P.(2. 4. 8. 24hrs) treated group have been increased in comparison with the control group, but only 24hrs-B.E.P. treated group significantly increased during 4 weeks. 2. The contents of glucose, BUN. creatinine, LDH, and T-protein measured immediately after the swimming of mice have been distinctly changed but not been significantly changed at their increase and decrease in comparison with the control group. 3. At 3rd day out of the swimming loading, the contents of glucose in the blood serum of the white rat have been distinctly increased in comparison with the control group. And 24hrs-B.E.P treated group surpassed 8hrs-B.E.P. treated group. 4. At 1st and 3rd day, the contents of creatinine in the blood serum of the white rat have been distinctly increased at B.E.P. (8, 24hrs) treated groups in comparison with the control group and have been recovered to the condition of the normal group. 5. After three days, the contents of BUN in the blood serum of the white rat have been significantly decreased in B.E.P.(8, 24hrs) treated groups at 3rd day in comparison with the control group and have been recovered to the condition of the normal group. 6. The contents of LDH in the blood serum of the white rat have been decreased in B.E.P.(8, 24hrs) treated groups at 3rd day in comparison with the control group, in particular 24hrs-B.E.P. treated group has been decreased distinctly than the normal group. 7. The contents of T-protein in the blood serum of the white rat have been distinctly increased in B.E.P. (8, 24hrs) treated groups at 3rd day in comparison with the control and normal group. As the above results, it has been proved that the execise of mice and the fatigue metabolism of rats were influenced by the light energy emitted the B.E.P., and it has been also proved that the external stimulation could be used as a preferable stimulative factor for the biological metabolism. If the clinical training and study are positively achieved, the B.E.P. would be used as curative means and preventive measures for helping human body.

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Red AGNs becoming normal AGNs

  • Kim, Dohyeong;Im, Myungshin;Glikman, E.;Woo, Jong-Hak;Urrutia, T.
    • The Bulletin of The Korean Astronomical Society
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    • v.39 no.2
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    • pp.57.2-57.2
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    • 2014
  • Red active galactic nuclei (AGNs) are supposed to be transitional objects becoming normal AGNs in the galaxy evolution scenario. So far, ~200 red AGNs have been found by very red color in optical through NIR wavelength (e.g., r'-K >5 and J-K>1.3; Urrutia et al. 2009). Here, we compare nuclear activities of the red AGNs to those of normal AGNs to verify the evolutionary phase of the red AGNs. In order to study the nuclear activities of the red AGNs, we use broad emission lines of $P{\beta}$ ($1.28{\mu}m$) of which flux is less suppressed by a factor of 100 than the $H{\beta}$ line in the case of the red AGNs with a color excess of E(B-V)=2 mag. We use 16 red AGNs discovered in previous red AGN surveys by using SDSS, 2MASS, and FIRST (Glikman et al. 2007; Urrutia et al. 2009) at z ~0.7 for which $P{\beta}$ lines are redshifted to the sky window at ${\sim}2.2{\mu}m$. The mean Eddington ratio of the 16 red AGNs is 0.562, and that of the normal AGNs is 0.320, which indicates the red AGNs include more active black hole (BH) than the normal AGNs. To test how significantly the nuclear activities of the red AGNs and the normal AGNs are different, we perform a two-dimensional Kolmogorov-Smirnov test (K-S test) on their Eddington ratio distributions. The K-S test shows the maximum deviation between the cumulative distributions, D, is 0.48, and the probability of null hypothesis, p, is even less than 0.001. This result is consistent with a picture of that the red AGNs are in intermediate phase between the stage of merger-driven starburst galaxy and the normal AGN.

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Normal Interpolation on AX = Y in CSL-algebra AlgL

  • Jo, Young Soo;Kang, Joo Ho
    • Kyungpook Mathematical Journal
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    • v.45 no.2
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    • pp.293-299
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    • 2005
  • Let ${\cal{L}}$ be a commutative subspace lattice on a Hilbert space ${\cal{H}}$ and X and Y be operators on ${\cal{H}}$. Let $${\cal{M}}_X=\{{\sum}{\limits_{i=1}^n}E_{i}Xf_{i}:n{\in}{\mathbb{N}},f_{i}{\in}{\cal{H}}\;and\;E_{i}{\in}{\cal{L}}\}$$ and $${\cal{M}}_Y=\{{\sum}{\limits_{i=1}^n}E_{i}Yf_{i}:n{\in}{\mathbb{N}},f_{i}{\in}{\cal{H}}\;and\;E_{i}{\in}{\cal{L}}\}.$$ Then the following are equivalent. (i) There is an operator A in $Alg{\cal{L}}$ such that AX = Y, Ag = 0 for all g in ${\overline{{\cal{M}}_X}}^{\bot},A^*A=AA^*$ and every E in ${\cal{L}}$ reduces A. (ii) ${\sup}\;\{K(E, f)\;:\;n\;{\in}\;{\mathbb{N}},f_i\;{\in}\;{\cal{H}}\;and\;E_i\;{\in}\;{\cal{L}}\}\;<\;\infty,\;{\overline{{\cal{M}}_Y}}\;{\subset}\;{\overline{{\cal{M}}_X}}$and there is an operator T acting on ${\cal{H}}$ such that ${\langle}EX\;f,Tg{\rangle}={\langle}EY\;f,Xg{\rangle}$ and ${\langle}ET\;f,Tg{\rangle}={\langle}EY\;f,Yg{\rangle}$ for all f, g in ${\cal{H}}$ and E in ${\cal{L}}$, where $K(E,\;f)\;=\;{\parallel}{\sum{\array}{n\\i=1}}\;E_{i}Y\;f_{i}{\parallel}/{\parallel}{\sum{\array}{n\\i=1}}\;E_{i}Xf_{i}{\parallel}$.

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