• Journal of Korean Tunnelling and Underground Space Association
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• v.22 no.5
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• pp.591-610
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• 2020

Concrete with activated carbon and titanium dioxide (TiO₂) has been used to reduce the particulate matter (PM) in underground structures (e.g., tunnels) due to the high performance of nitrogen oxides (NOx) abatement. Damage (e.g. crack, spalling, or detachment) can be caused by the environmental and ageing effects on the surface of the particulate matter reduction concrete, installed on the tunnel lining. Therefore, it is important to evaluate the existence of spalling on the concrete surface for maintaining performance of NOx reduction. In this study, a basic research was performed for feasibility of spalling evaluation using electrical resistivity characteristics. Given the test results, the electrical resistivity was decreased as the ratios of activated carbon (0~15%) and TiO₂ (0~25%) were increased for specimens. Under a dry condition, electrical resistivity of cement specimens, mixed with activated carbon and TiO₂, was decreased up to 2.3 times, compared with the normal cement specimen. In addition, under saturation conditions (degree of saturation: 85~98%), electrical resistivity of cement specimens with activated carbon, was decreased up to 3.5 times, compared with the normal cement specimen. Regardless of the condition (dry or saturated), the difference of electrical resistivity values shows the range of 2.3~2.8 times between the mixing specimen (with activated carbon (15%) and TiO₂ (25%)) and the normal cement specimen. This study can help to provide basic knowledge for spalling evaluation using the electrical resistivity on the surface of the particulate matter reduction concrete in tunnels.

• The korean journal of orthodontics
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• v.27 no.1
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• pp.1-20
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• 1997

Skeletal Class III malocclusions are growth-related discrepancies, and the problems are more severe until growth is complete. Causes of skeletal Class III malocclusion are classified into mandibular overgrowth, maxillary deficiency, and combination of the two. Face mask has been recommended for treatment of Class III malocclusion with maxillary deficiency in the early time of growth. Numerous experiments were performed and clinical studies have been reported on face mask ; nevertheless, studies on profile changes and stability after treatment of face mask are considered to be somewhat insufficient. The author selected 50 patients who can be checked for follow-up. They had been diagnosed as skeletal Class III malocclusion with maxillary deficiency and then treated with face mask ; the sample group was divided according to sex, treatment beginning age, palatal suture opening (intraoral appliance). For each group, changing pattern of facial profile and stability of treatment observed, and comparison with 20 Korean normal children(Angle's Class I). The following results were obtained. 1. skeletal, dental, and soft tissue measurements indicated more changes in the amounts of maxillary forward movement during face mask treatment. 2. R.P.E. group showed more significant maxillofacial changes and La-Li group showed more dental changes. 3. Growth changes of maxilla induced in the treatment group during wearing face mask were much more than those of normal group. 4. Growth changes of maxilla in the treatment group after treatment of face mask were less than those of normal group. From the obtained aata, it can be concluded that there was a stimulative effect on forward growth of maxilla during the use of face mask ; however, on removal of face mask, the stimulative effect was eliminated and undergrowth tendency of maxilla resumed.

• Reproductive and Developmental Biology
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• v.30 no.3
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• pp.213-218
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• 2006

This study was conducted to investigate the effect of abnormal ovarian cycle postpartum on subsequent reproductive performance of Holstein cows. The cows were considered to have resumed ovarian cyclicity on the day of ovulation if followed by regular ovarian cycles. Total 58.8 percentage of the cows(l14/194) had normal resumption of ovarian cyclicity(resumption within 40 days after calving), and 41.2%(80/194) had delayed resumption(resumption did not occur until >40 days after calving). Delayed resumption Type I(one or more ovarian cycles with luteal phase >20 days, i.e. prolonged luteal phase; 17.5%) and delayed resumption Type II(first ovulation did net occur until $\geq$40 days after calving, i.e. anovulation 22.7%) were the most common types of delayed resumptions. When compared with cows with a normal ovarian cycle, the cows of delayed resumption Type I had a lower 100 days AI submission conception and pregnancy rates(84.2% vs 40.0%; p<0.01, 24.0% vs 21.4% and 20.2% vs 11.1%, respectively), and longer intervals to first AI and to conception($64.7{\pm}2.79$ days vs $105.7{\pm}7.48$ days and $105.1{\pm}7.16$ days vs $133.7{\pm}11.17$ days, respectively; p<0.01). Similarly, when compared with cows with normal ovarian cycles, the cows of delayed resumption Type II had lower 100 days conception and pregnancy rates(24.0% vs 20.0% and 20.2% vs 16.3%, respectively), and longer intervals to first AI and to conception($64.7{\pm}2.79$ days vs $72.6{\pm}4.45$ days and $105.1{\pm}7.16$ days vs $120.8{\pm}12.33$ days, respectively). In conclusion, abnormal ovarian cycles postpartum adversely affected reproductive performance, including AI submission rate, pregnancy rate, interval to first AI, and calving to conception interval in Holstein cows.

• The Journal of Internal Korean Medicine
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• v.29 no.4
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• pp.1083-1099
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• 2008

Objective : We aimed to identify the effects of Bogimakseong-bang(BGMSB) treatment on cBSA-induced MN in a mouse model. Methods : We divided 20 mice into 4 groups. The normal group (NR) had no treatment. We used cBSA to induced MN to the other 3 groups. One group (CT) was treated with cBSA (7mg/kg i.p) only. The second (BG-250) was treated with cBSA (7mg/kg i.p) and BGMSB extract (250mg/kg, p.o). The third group (BG-500) was treated with cBSA(7mg/kg i.p) and BGMSB extract (500mg/kg, p.o). After cBSA and BGMSB extract treatment for 4 weeks, proteinuria, serum albumin, total cholesterol, serum creatinine, BUN, total nucleated spleen cell number and total infiltrated kidney cell number of all groups were measured. CD3e+/CD19+ and CD4+/CD8 cells ratio of peripheral blood, kidney and spleen of all groups were analyzed. $IL-1{\beta}$ and $TNF-{\alpha}$, IL-6, IgG, IgM, and $IFN-{\gamma}$ levels of all groups were gauged. Histological analysis of kidney tissue and immunohistochemical staining (CD4 CD8) of kidneys were observed. Results : Proteinuria significantly decreased and serum albumin increased in groups treated with cBSA and BGMSB extract compared with the control. Total cholesterol decreased but not significantly. CD3e+/CD19cells ratio of peripheral blood decreased. CD3e+/CD19+ and CD4+/CD8 cells percentage of kidney and spleen showed no significant change. Level of $IL-1{\beta}$, $TNF-{\alpha}$ and IL-6 significantly decreased. and $IFN-{\gamma}$ increased but has not significantly. Concentration of IgG and IgM significantly decreased compared with control. Thickness of GBM decreased on histological analysis of kidney. Deposition of CD4 and CD8 decreased on immunohistochemical staining of kidney. Conclusions : According to the above result, BGMSB had a significant effect for treating MN which is cBSA-induced.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.2
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• pp.248-256
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• 2003

Two experiments were conducted to determine the effects of expander processing and enzyme supplementation of wheat-based diets on growth performance and nutrient digestibility in finishing pigs. For Exp. 1, 60 finishing pigs (average initial BW of 49.5 kg) were fed meal, standard pellets and expanded pellets in a 70 d growth assay. From 49.5 to 79.0 kg, 79.0 to 111.8 kg, and overall (49.5 to 111.8 kg), ADG and ADFI were not affected by pelleting or standard vs expander conditioning (p>0.22). However, from 49.5 to 79.0 kg, pigs fed pellets have greater gain/feed than pigs fed mash (p<0.04), and pigs fed expanded pellets tended to have greater (p<0.10) gain/feed than pigs fed standard pellets. Overall (i.e. from 49.5 to 111.8 kg), gain/feed (p<0.02) and apparent fecal digestibilities of DM (p<0.001) and N (p<0.02) were improved by pelleting the diets. Also, expander processing further improved gain/feed (p<0.06) and digestibility of DM (p<0.04) compared to standard steam conditioning. Scores for keratinization (p<0.002) and ulceration (p<0.003) of the stomach were increased by pelleting, but the mean scores for the various treatments ranged only from 0.05 to 1.08 (i.e., low to mild keratosis and ulceration). For Exp. 2, 80 pigs (average initial BW of 54.1 kg) were fed mash and pellets (standard or expander) without and with xylanase. The enzyme was added to supply 4,000 units of xylanase activity/kg of diet. Adding xylanase to the mash diet improved gain/feed from 90.7 to 115.9 kg (p<0.04) of the growth assay and digestibility of DM (p<0.05) on d 39. However, in pelleted diets, adding the enzyme did not improve growth performance or digestibility of nutrients. Pelleting tended to increase scores for ulceration (p<0.06), and enzyme supplementation decreased stomach keratinization scores for pigs fed the standard pellets (p<0.01). However, as in Exp. 1, the mean scores for all treatment groups were quiet low (i.e., ranging from normal to mild). In conclusion, pelleting improved efficiency of growth, but additional benefits from expander conditioning were observed only in Exp. 1. Finally, xylanase tended to improve growth performance and nutrient digestibility, only in pigs fed mash diets but not in pigs fed pellets.

• IMMUNE NETWORK
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• v.1 no.2
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• pp.104-108
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• 2001

Aging is a senescence and defined as a normal physiologic and structural alterations in almost all organ systems with age. As Leonard Hayflick, one of the first gerontologists to propose a theory of biologic aging, indicated that a theory of aging or longevity satisfies the changes of above conditions to be universal, progressive, intrinsic and deleterious. Although a number of theories have been proposed, it is now clear that cell aging (cell senescence) is multifactorial. No single mechanism can account for the many varied manifestations of biological aging. Many theories have been proposed in attempt to understand and explain the process of aging. Aging is effected in individual by genetic factors, diet, social conditions, and the occurrence of age-related diseases as diabetes, hypertension, and arthritis. It involves an endogenous molecular program of cellular senescence as well as continuous exposure throughout life to adverse exogenous influences, leading to progressive infringement on the cell's survivability so called wear and tear. So we could say the basic mechanism of aging depends on the irreversible and universal processes at cellular and molecular level. The immediate cause of these changes is probably an interference in the function of cell's macromolecules-DNA, RNA, and cell proteins-and in the flow of information between these macromolecules. The crucial questions, unanswered at present, concerns what causes these changes in truth. Common theories of aging are able to classify as followings for the easy comprehension. 1. Biological, 1) molecular theories - a. error theory, b. programmed aging theory, c. somatic mutation theory, d. transcription theory, e. run-out-of program theory, 2) cellular theories - a. wear and tear theory, b. cross-link theory, c. clinker theory, d. free radical theory, e. waste product theory, 3) system level theory-a. immunologic/autoimmune theory, 4) others - a. telomere theory, b. rate of living theory, c. stress theory, etc. Prevention of aging is theoretically depending on the cause or theory of aging. However no single theory is available and no definite method of delaying the aging process is possible by this moment. The most popular action is anti-oxidant therapy using vitamin E and C, melatonin and DHEA, etc. Another proposal for the reverse of life-span is TCP-17 and IL-16 administration from the mouse bone marrow B cell line study for the immunoglobulin VDJ rearrangement with RAG-1 and RAG-2. Recently conclusional suggestion for the extending of maximum life-span thought to be the calory restriction.

• The korean journal of orthodontics
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• v.26 no.4
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• pp.349-358
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• 1996

To extract or not to extract permanent teeth for the correction of malocclusion has been a great debate in the history of orthodontics, and there is a variety of analytic methods and criteria to aid in the diagnosis. Extraction formulas that has been presented are many analytic methods that depend on arch length discrepancy, dental prominence, and skeletal pattern of the each patients. Of these analysis, the most important diagnostic factor is patient's skeletal pattern. Because the behavior of the dentition is closely dependent upon the skeletal pattern of each patient, dentition must be arranged within that person's skeletal frame. EI(Extraction Index) is composed of CF, interincisal angle, and lip position. CF is made of ODI and APDI that differentiate vertical and horizontal component of the skeletal pattern. So, EI not only represents patient's skeletal pattern, but also takes facial appearance into consideration. This study was undertaken to investigate EI and related cephalometric variables on the cephalogram of Korean adolescents which consisted of 153 persons with normal occlusion, harmonious skeleton and pleasing face. The following conclusions were obtained. 1. The mean value of the ODI is $73.5^{\circ}$, APDI $82.5^{\circ}$, CF $156.3^{\circ}$ 2. The mean value of the interincisal angle is $123.6^{\circ}$ 3. The mean distance of upper lip to E-line is 0.0mm, lower lip to E-line is 1.4mm. 4. The mean value of the EI is $153.8^{\circ}$.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.15 no.4
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• pp.239-252
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• 1993

This study was done to analyze phonetic dysfunction and the effect of orthognathic surgery to phonation in the patients of mandibular prognathism. 20 persons were chosen as normal group and 20 patients of mandibular prognathism as abnormal for this study. 5 vowel sounds-'ㅏ(a)', 'ㅔ(e)', 'ㅣ(i)', 'ㅗ(o)', 'ㅜ(u)' and 14 consonant sounds-'ㄱ(g)', "ㄴ(n), 'ㄷ(d)', 'ㄹ(l)', 'ㅁ(m)', 'ㅂ(b)', 'ㅅ(s)', 'ㅇ(ng)', 'ㅈ(j)', 'ㅊ(ch)', 'ㅋ(k)', 'ㅌ(t)', 'ㅍ(p)', 'ㅎ(h)', were checked. We recorded these sounds in the period of preopration, postop. 12 months, postop. 24 months. A Formant ratio and a length of consonant time were studied with discriminant analysis. As a result of the study, the following conclusion were gained. 1. As a result of the analysis on vowel dysfunction patiensts of mandibular prognathism, more than 80% of men patients showed the dysfunction in prelingual sound 'ㅔ(e)' and 'ㅣ(i)'. More than 70% of women patients showed the dysfunction in all vowel. 2. One year later from the orthognathic surgery, men patients showed a marked improvement in 'ㅏ(a)'. The next were 'ㅗ(o)', 'ㅜ(u)' and 'ㅣ(i)'. Women patients showed a marked improvement in 'ㅜ(u)'. 3. Two year later from the orthognathic surgery, men patients showed a marked improvement in prelingual sound 'ㅔ(e)' and postlingual sound 'ㅗ(o)'. Women patients showed a marked improvement in 'ㅏ(a)'. More than 20% of patients showed the phonetic improvement compared with the condition of the postop. 12 months. 4. As a result of the analysis on consonant dysfunction patient of mandibular prognathism. more than 80% of men patients showed the dysfunction in lingual sound 'ㅅ(s)'. Most women patients showed the dysfunction in labial sound 'ㅁ(m)' and lingual sound 'ㄴ(n)'. More than 50% of patients showed the dysfunction in labial sound and lingual sound. 5. One year later from the orthognathic surgery. men patients showed a complete improvement in hard palatal sound 'ㅈ(j)'. The next were labial sound 'ㅂ(b)', lingual sound 'ㅅ(s)', soft palatal sound 'ㄱ(g)' and 'ㅋ(k)'. Women patients showed a marked improvement in soft palatal sound 'ㅇ(ng)' and 'ㄱ(g)'. 6. Two year later from the orthognathic surgery, all patients showed remarkable improvement in consonant sounds. except for labial sound 'ㅁ(m)', 'ㅍ(p)' and lingual sound 'ㄴ(n)'. The improvement ratio was increased as the time was going on compared with the condition of postop 12 months.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1611-1620
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• 2008

This clinical research was conducted to test patients with Atopic Dermatitis by external application with Hwangryeonhaedok-Tang in cosmetics. We gave scores to 31 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Semyung University Jecheon Oriental Medical Hospital from May 15th, 2008 to June 26th. Fifteen patients were treated with the ointment that contain Hwangryeonhaedok-Tang (experimental group) and sixteen patients were treated with normal ointment that doesn't have Hwangryeonhaedok-Tang (control group) for 4 weeks. We observed change of total IgE, eosinophil count, Skin Temperature, Transepidermal Water Loss(TEWL), Skin Hydration and Skin pH. Also Clinical Index of Atopic Dermatitis(SCORAD Index) and global assesment of efficacy were used to evaluate the effects of Hwangryeonhaedok-Tang. Statistical analysis was performed by using frequency analysis and descriptive analysis. Statistical significance was achieved if the probability was less than 5%(p<0.05). After 4 weeks of external application treatment, SCORAD Index in experimental group was significant statistically decreased compared with control group. After 4 weeks of external application treatment, total IgE of both groups were decreased and eosinophil count in control group was decreased but experimental group was unstatistically decreased. Unstatistically, both groups didn't showed significant effect on Skin Temperature. Transepidermal Water Loss(TEWL) in both groups were increased but experimental group was significant decreased compared with control group. Skin Hydration in experimental group was significant statistically increased compared with control group. Statistically, both groups didn't showed significant effect on Skin pH. Only experimental group showed little increase. After 4 weeks of external application treatment, experimental group showed significant effect on global assesment of efficacy. Considering the above results, we can speculate that cosmetics with Hwangryeonhaedok-Tang has some therapeutical effects in mitigating the symptoms of Atopic Dermatitis.

• Applied Biological Chemistry
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• v.50 no.4
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• pp.287-294
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• 2007

Effect of combined use of anti-microbial materials, such as ethanol, mustard and chitosan, on the quality of low salted kochujang was investigated during fermentation at $20^{\circ}C$ for 12 weeks. Viable cells of yeast increased remarkably during fermentation, but increasing ratio was significantly low in ethanol-mustard added kochujang. Activity of ${\beta}-amylase$ was high in anti-microbial material added kochujang, whereas ${\alpha}-amylase$ and protease activities were low in those groups. Water activity decreased during fermentation with being low in the control kochujang prepared with normal-salt without anti-microbial materials. Hunter L-, a- and b-values of kochujang increased during fermentation, and the degree of increase in total color difference $({\Delta}E)$ was low in ethanol added kochujang. Titratable acidity of kochujang was decreased in anti-microbial materials added group at late aging period, and oxidation-reduction potential was low in the control kochujang. Total sugar and reducing sugar contents of kochujang were high in ethanol-mustard added kochujang. Ethanol contents of kochujang increased at late aging period, with high values in ethanol-chitosan added kochujang. Amino nitrogen content increased during middle of fermentation, and ammonia nitrogen content of kochujang decreased in ethanol-mustard-chitosan added group during fermentation. After 12 weeks fermentation, sensory results showed that ethanol or ethanol-mustard added kochujang were the highest in color and flavor with the highest overall acceptability.