• Journal of rehabilitation welfare engineering & assistive technology
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• v.10 no.4
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• pp.267-272
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• 2016

In the era of ultra high speed information communication technology represented by Smart phone and Tablet PC, the disable and the aged people came to be in a position of so-called 'relatively weak people' in the field of information communication due to inconvenience of use and difference in information acquisition and processing ability. Thus, a survey was conducted on Smart phone accessibility items based on previous studies of the disabled with crippled disorder, brain lesions, myelopathy and muscular disabilities having more inconvenience relatively in their use of smart phone due to upper limb dysfunctions. Especially, people with upper limb dysfunctions with relatively weak grip had big inconvenience in the conditions of uses requiring actions such as grabbing and rotating the devices, and due to the characteristics of touch screen input method of Smart phone, they had big inconvenience due to a lack of a guidance for keyboard in input. As a result of questionnaires by the type of disability, it turned out that severe myelopathy causes the most inconvenience in using smart phone.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.48 no.4
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• pp.232-236
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• 2022

A ranula is a pseudocyst that originates from the sublingual gland after trauma. Acute cases of ranulas that progress rapidly and cause respiratory distress are rare. Holoprosencephaly is a complex brain malformation caused by incomplete cleavage of the prosencephalon. Children with holoprosencephaly may experience upper airway obstruction due to the associated dentoalveolar malformations and oromotor dysfunctions. We present the case of an eight-year-old female patient with holoprosencephaly and a plunging ranula that manifested as an acute course due to difficult airway management. She required gastrostomy for oromotor dysfunctions related to feeding and swallowing and difficulty managing oral secretions. The sublingual gland and ranula were removed under general anesthesia. Postoperatively, urgent reintubation and close monitoring in the intensive care unit were required due to upper airway obstruction. We successfully managed the patient with close cooperation of a pediatrician and an anesthetist, and no recurrence was observed at the one-year follow-up. A ranula can be caused by trauma to the floor of the mouth in association with lingually inclined mandibular teeth, a type of dentoalveolar compensation seen in maxillary hypoplasia associated with holoprosencephaly. Careful consideration is needed in such cases since airway management can be difficult due to postoperative swelling and oromotor dysfunctions.

• International Journal of Oral Biology
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• v.49 no.3
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• pp.61-68
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• 2024

Coronavirus disease 2019 (COVID-19) is a highly contagious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease is characterized by a wide spectrum of symptoms, ranging from mild to severe, including fatal outcomes. This study aims to review gustatory and salivary secretion dysfunctions and determine their potential pathogenic mechanisms. Gustatory impairment and salivary dysfunction are prevalent among patients with acute COVID-19 and those recovering from the disease. The mouth serves as a critical entry route for SARS-CoV-2. The cells within the oral epithelium, taste buds, and minor and major salivary glands express key entry factors for SARS-CoV-2, including angiotensin-converting enzyme 2, transmembrane serine protease 2, and furin. The co-occurrence of gustatory and salivary secretion dysfunctions possibly has pathogenetic association with the following factors: the expression of SARS-CoV-2 cellular entry receptors in the taste buds and salivary glands and SARS-CoV-2-induced zinc deficiency, which is crucial for normal taste perception and saliva secretion. Furthermore, the cytokine storm triggered by COVID-19 contributes to secondary damage affecting gustatory and salivary functions.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.1 no.1
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• pp.37-48
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• 1995

The correlation between mobility abnormalities and positional findings(pelvic asymmetry) is essential for complete pelvic girdle evaluation. For mobility tests, there are four tests include : 1. Standing forward bending test. 2. Seated forward bending test. 3. Posterior anterior sacral pressures. 4. Kinetic test. To determine specific pelvic dysfunction, positional findings should bo assessed with bony landmarks. According to the assessment findings, the suggested order of treatment is as follows. 1. Pubic malalignment. 2. Sacroiliac dysfunction. 3. Iliosacral dysfunction. Many of the pelvic dysfunctions will respond to the simplified approach as shown in this paper but some dysfunctions will require more specific treatment.

• Journal of Korean Physical Therapy Science
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• v.2 no.1
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• pp.431-443
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• 1995

The correlation between mobility abnormalities and positional findings(pelvic asymmetry) is essential for complete pelvic girdle evaluation. For mobility tests, there are four tests include : 1. Standing forward bending test. 2. Seated forward bending test. 3. Posterior anterior sacral pressures. 4. Kinetic test. To determine specific pelvic dysfunction, positional findings should bo assessed with bony land-marks. According to the assessment findings, the suggested order of treatment is as follows. 1. Pubic malalignment 2. Sacroiliac dysfunction. 3. Iliosacral dysfunction. Many of the pelvic dysfunctions will respond to the simplified approach as shown in this paper but some dysfunctions will require more specific treatment.

• BMB Reports
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• v.50 no.6
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• pp.299-307
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• 2017

Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial quality control and homeostasis. Mitochondrial dysfunctions and defective mitophagy in neurodegenerative diseases, cancer, and metabolic diseases indicate a close link between human disease and mitophagy. Furthermore, recent studies showing the involvement of mitophagy in differentiation and development, suggest that mitophagy may play a more active role in controlling cellular functions. A better understanding of mitophagy will provide insights about human disease and offer novel chance for treatment. This review mainly focuses on the recent implications for mitophagy in human diseases and normal physiology.

• Korean Journal of Pharmacognosy
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• v.43 no.2
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• pp.184-191
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• 2012

The aim of this study was to explore the potent phosphodiesterase type 5 (PDE %) inhibitor from various herbal medicines for erectile dysfunctions. In this study, 61 herbal medicines, which were extracted with ethanol, have been investigated with PDE 5 assay using enzyme inhibitory activity on 22 species of herbal medicines. Of these, 5 species of herbal medicines, Cnidium monieri, Cuscuta chinensis, Epimedium koreanum, Morinda officinalis, and Tribulus terrestris were exhibited stronger inhibitory effect against phosphodiesterase 5 (PDE 5) among 61 species; Cnidium monieri ($IC_{50}=33.7{\mu}g/ml$), Cuscuta chinensis ($IC_{50}=65.7{\mu}g/ml$), Epimedium koreanum ($IC_{50}=90.3{\mu}g/ml$), Morinda officinalis ($IC_{50}=48.7{\mu}g/ml$) and Tribulus terrestris ($IC_{50}=32.5{\mu}g/ml$).

• Journal of Ginseng Research
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• v.33 no.4
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• pp.260-267
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• 2009

Recent studies have shown that Panax ginseng has a variety of beneficial effects on the cardiovascular system. Homocysteine (Hcy), which is derived from methionine, has been closely associated with the increased risk of cardiovascular diseases. In the present study, whether the in-vivo long-term co-administration of ginseng total saponins (GTS), active ingredients of Panax ginseng, with L-methionine (Met) inhibits methionine-induced hyperhomocysteine (HHcy) and H-Hcy-induced cardiovascular dysfunctions was investigated, and it was found that the plasma Hcy level, which was measured after 30 and 60 days, in the GTS+Met co-administration group was more significantly reduced than in the Metalone-treatment group. The left-ventricle (LV) wall thickness of the heart was likewise examined in each treatment group, and it was found that the co-administration of GTS with Met significantly reduced the Met-induced LV wall thickness. The results of the study indicate that the in-vivo long-term co-administration of GTS with Met not only inhibited H-Hcy induced by long-term Met-alone administration but also attenuated the H-Hcy-induced cardiovascular dysfunctions in rats.

• Journal of Pharmacopuncture
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• v.12 no.2
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• pp.107-112
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• 2009

Mountain cultivated wild ginseng(MCWG) pharmacopuncture, which is known to have anti-cancer and anti-oxidation actions, was administered for clinical usage and changes in manifestations were observed on three patients suffering from pain attributed from liver dysfunctions. In two cases of hepatitis due to poisoning by drugs and one case of liver cirrhosis, long-term administration of MCWG pharmacopuncture yielded significant changes in AST and ALT, which are important indices for liver functions. Improved liver functions after the administration of MCWG pharmacopuncture suggest a need for investigation on future usage of MCWG pharmacopuncture on liver dysfunctions, hepatitis, liver cirrhosis, or liver cancer. Further studies on treating aforementioned disorders by MCWG pharmacopuncture are needed immediately.

• Journal of Acupuncture Research
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• v.36 no.2
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• pp.113-117
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• 2019

Parkinson's disease (PD) is a neurodegenerative disease, where treatment with medication may lead to gastrointestinal (GI) symptoms. The objective of this case study was to investigate the effectiveness of Korean medicine (KM) in treating PD with drug-induced GI dysfunction. A 70-year-old female participant was diagnosed with PD in 2010 and drug-induced gastritis in 2016. Her major symptoms were related to GI, PD, and overall feeling of weakness. She was treated with KM including pharmacopuncture, acupuncture, moxibustion, and herbal medicines, in combination with Western medicines during 46 days of in-patient care. This study showed an improvement in symptoms and scores on the GI symptom scale, Unified Parkinson's disease rating scale, Hoehn and Yahr staging, Berg balance scale, PD quality of life, and stress index at discharge. This case demonstrated that the symptoms of drug-induced GI dysfunctions in PD was improved by treatment with KM.