• BMB Reports
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• v.34 no.5
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• pp.484-488
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• 2001

STATs are proteins with a dual function: signal transducers in the cytoplasm and transcriptional activators in the nucleus. Among the six known major STATs (STAT1-6), STAT3 has been implicated in the widest range of signaling pathways that regulate cell growth and differentiation. As a part of our on-going investigation on the pleiotropic functions of STAT proteins, we examined the role of STAT3 as a molecular adaptor that links diverse cell growth signaling pathways. We observed that STAT3 can be specifically activated by multiple cytokines, such as IL-3, in transformed fibroblasts and IL-4 or IFN-$\gamma$ in primary immune cells, respectively. The selective activation of STAT3 in H-ras-transformed NIH3T3 cells is associated with an increased expression of phosphoserioe STAT3 in these cells, compared to the parental cells. Notably phosphoresine-STAT3 interacts with oncogenic ras, shown by immunoprecipitation and Western blots. The results suggest the role of STAT3 in rasinduced cellular transformation as a molecular adaptor linking the Jak/STAT and Ras/MAPK pathways. In primary immune cells, IL-4 and IFN-$\gamma$ each induced (in addition to the characteristic STAT6 and STAT1 homodimers) the formation of STAT3-containing complexes that bind to GAS probes, which correspond to the $Fe{\varepsilon}$ Rll and $Fe{\gamma}$ RI promoter sequences, respectively. Since IL-4 and IFN-$\gamma$ are known to counter-regulate the expression of these genes, the ability of STAT3 to form heterodimeric complexes with STAT6 or STAT1 implies its role in the fine-tuned control of genes that are regulated by IL-4 and IFN-$\gamma$.

• Cartoon and Animation Studies
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• s.45
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• pp.75-99
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• 2016

Unlike the other media, the animation has its unique aesthetic characteristics. First, one of the media characteristics of the animation is creativity images of the hand drawn animation by shooting of frame by frame. Next the animation image which is created through metamorphosis obtain new space-time by unique motility. This paper treats of two parts of space and time in animation. One is the metamorphosis image of animation and the other is the motility. To concrete this, this paper analyzed Georges Schwizgebel's Works. They are very interesting that the structural characteristics of the animation. Especially, , < La course ${\grave{a}}$ $l^{\prime}ab{\hat{i}}me$ > directed by Georges Schwizgebel are a good text for analyzing space-time of animation in that it combines various metamorphosis and motility with his expressions. The images of his works are continuously maintained transformational stream by his main expressions of metamorphosis and motility etc. This study focuses on analyzing the way of metamorphosis and motility function to make meaning in this texts. His works consist with metamorphosis and motility, and various moving images to let audience feel the characteristics of space and time in animation. We can experience numerous dual structures like space and time, freeze-frame and motility, rhythm and repetition, two dimension and three dimension, dissolution and reconstitution, abstract shape and concrete form etc from these cases. One of the main apparat is the emphasis of metamorphosis and motility by independent space of animation.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.6
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• pp.515-523
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• 2000

Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts following ischemia and reperfusion. Additional control rat hearts were perfused with $75{\times}10^6$ PMNs, with $75{\times}10^6$ platelets, or with $75{\times}10^6\;PMNs+75{\times}10^6$ platelets over a five minute perfusion followed by a 75 min observation period. No significant reduction in coronary flow (CF), left ventricular developed pressure (LVDP), or the first derivative of LVDP (dP/dt max) was observed at the end of the observation period in any non-ischemic group. Similarly, global ischemia (I) for 20 min followed by 45 minutes of reperfusion (R) produced no sustained effects on the final recovery of any of these parameters in any group of hearts perfused in the absence of blood cells. However, I/R hearts perfused with either PMNs or platelets alone exhibited decreases in these variables of $5{\sim}10%$ (p＜0.05 from control). Furthermore, I/R hearts perfused with both PMNs and platelets exhibited decreases of 50 to 60% in all measurements of cardiac function (p＜0.01). These dual cell perfused I/R hearts also exhibited marked increases in cardiac myeloperoxidase (MPO) activity indicating a significant PMN infiltration, and enhanced P-selectin expression on the coronary microvascular endothelium. All cardiaodynamic effects as well as PMN accumulation and P-selectin expression were markedly attenuated by a recombinant soluble PSGL-1 which inhibits selectin mediated cell adhesion. These results provide evidence that platelets and PMNs act synergistically in provoking post-reperfusion cardiac dysfunction, and that this may be largely due to cell to cell interactions mediated by P-selectin. These results also demonstrate that a recombinant soluble PSGL-1 reduces myocardial reperfusion injury by platelet and PMNs interaction.

• Journal of radiological science and technology
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• v.39 no.3
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• pp.429-434
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• 2016

This study was performed in order to identify the relation between bone nineral density and life styles of some of Korean colleage students. A total of 121 college students were assessed through bone mineral density test on femoral neck and lumbar spine using dual energy X-ray absorptiometry(DEXA). The survey about their lifestyles with a self-rating questionnaire, was conducted from September 2014 to November 2014. SPSS 18.0 Program was used for those research data analyses such as the frequency analysis, the cross analysis. The percentage of the osteoporisis, osteopenia and normal groups were 0.0%, 24.8% and 75.2%. BMI, Regular menstrual cycle, Walking and Regular exercise in adolescence were positively related with T-score. But Using time of electronic devices was negative related with T-score. It can be concluded that desirable life style in time of college students and adolescence is important for their bone health. The necessity of preparing guideline for preventing bone disease in old age connected with the school curriculum should be recognized to the public and educational authorities.

• Archives of design research
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• v.11
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• pp.22-29
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• 1995

I have to find standpoint of sight moulding of Chi I Sung Hwa(seven stars picture) analysis of graphic systems of a symbol sight native to our nation. And I will comprehend emotion of folkways by simple and graphic lines and colors in mathematical Grid of which ancestor had expressed in gauge moulding consciousness. This papers aim is to make a contribution to lead by on part of communication design. About structural analysis of pictorial graphic side. I) Mathematical thought of the Orient and space constitution are first basically the Orient expressed number notion of mathematics of unlimitedness and notion of zero so called space and empty second can analigize a diagonal expansion method by development of symmetry notion to basic the dual principle of the negative and positive by degrees development expressed space division method by direction notion. 2) About the proportion analysis it based the golden section globularity and in modern layout it takes vision center of position, after appointing the brow of sacred image of Chil Sung Hwa as center point of proportion and applied to the point proportion and so analigized the posibility of established. Rule in union of each elements and rule of forms about picture image. 3) Mathematical structure analysis to search a unified principle at the balanced arrangement and rule of forms it analigized the standard the rule of forms. it analigized the standard the rule of forms to body module of basic movement of protagonist and follower above basic forms of grid that is the basis of design system.

• Journal of Internet Computing and Services
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• v.17 no.3
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• pp.75-85
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• 2016

Changes in the distribution and sharing information using the Internet is changing the most part in our daily life, Utilizing the Internet of our lives to the rapid development of IT technology, are living in the off-line (off-line) and online (on-line) a mix of life, We expect now online life specific gravity is further increased. However, do not systematically implement the education of Internet ethics awareness deficiencies of objective indicators to assess the current knowledge level of the Internet ethics is the actual situation. Therefore, in this paper, it provides a development process in order to establish a common standard for the evaluation of Internet ethics index. Development procedure of Internet ethics index in order to establish a common standard, "evaluation item (draft) derivation", "Creating a questionnaire", "the calculation of the analysis and item-by-item weight of the questionnaire", and a common reference determination of the stage having. Was also a questionnaire that target 46 people to calculate the weight of the common reference. Internet ethics index evaluation model through the establishment of the common standards developed in this paper, municipal road Office of Education, related organizations, high school, such as small, medium, can be utilized as an indicator to measure the Internet ethics education level.

• Applied Chemistry for Engineering
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• v.23 no.1
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• pp.112-118
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• 2012

In this study, physical properties of synthesized DE7-OSA82-AO and DEP52-OSA82-AOQ82 zwitterionic surfactants were measured such as critical micelle concentration, surface tension, interfacial tension, contact angle and viscosity. Phase behavior study was also performed. The dual function characteristics of a zwitterionic surfactant were investigated by determining an isoelectric point, which was attained using zeta potential measurements and QCM (quartz crystal microbalance) experiments. The isoelectric point of DE7-OSA82-AO surfactant determined by the zeta potential measurement and QCM experiment was about 7.2 and 7.4, respectively. On the other hand, the isoelectric point of DEP52-OSA82-AOQ82 surfactant determined by the zeta potential measurement and QCM experiment was about 10.9 and 11.0, respectively. The frictional property measured using an automated mildness tester showed that DE7-OSA82-AO surfactant can provide a good softening effect at an acidic or neutral condition. On the other hand, DEP52-OSA82-AOQ82 was found to provide a good softening effect to a fabric surface at a pH below its isoelectric point of 11.

• Journal of Energy Engineering
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• v.24 no.4
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• pp.192-199
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• 2015

Under the economic banner of "self-reliance," North Korea has focused on hydro and thermal power as its main energy supply sources. However, in the face of extreme energy penury caused by machinery and material supply instability in the wake of the collapse of the former communist block as well as equipment aging and deterioration due to floods and other disasters, North Korea and international aid organizations are increasingly turning their attention toward energy source diversification. In particular, renewable energy is recognized as the best strategic energy source for North Korea and it is a decentralized energy option that is suitable in light of North Korea's power distribution networks and its pursuit of self-reliance. Biogas can contribute to improving the human rights situation of North Koreans in conjunction with an increase in food production. For this reason, renewable energy is the most promising option for an energy source that is likely to secure humanitarian aid from international organizations such as the Food and Agricultural Organization (FAO) and the World Food Programme (WFP). However, the implementation of such humanitarian aid has been hampered by rising concerns about the diversion of provided energy materials for military purposes and the disguised introduction of dual use items strategic materials as well as UN Security Council resolutions and sanctions of the international community against North Korea's military provocation, including nuclear tests and missile launches. This paper explores the possibility of solving this dilemma and proceeding with the humanitarian aid to North Korea by evaluating the potential for sanction and the risk of diversion of the possible products for biogas-related aid on the basis of the list of UN-sanctioned items.

• Journal of Biomedical Engineering Research
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• v.20 no.2
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• pp.173-182
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• 1999

Contrast-enhanced CT has an important role in assessing liver lesions, the optimal protocol to get most effective result is not clear. The mein goal when deciding injention protocol is to optimize lesion detectability with rapid scanning when lesion to liver contrast is maximum. For this purpose, we developed a physiological model of the contrast medium enhancement based on the compartment modeling and pharmacokinetics. Blood supply to liver is achieved in two paths. This dual supply characteristic distinguishes the CT enhancement of liver from that of the other organs. The first path is by hepatic artery and to second, by portal vein. However, it is assumed that only gepatic artery can supply blood to hepatocellular carcinoma(HCC) compartment, thus, the difference of contrast enhancement is resulted between normal liver tissue and hepatic tumor. By solving differential equations for each compartment simultaneously using the computer program Matlab, CT contrast-enhancement curves were simulated. The simulated enhancement curves for aortic, hepatic, portal vein, and HCC compartments were compared with the mean enhancement curves from 24 patients exposed to the same protocols as the simulation. These enhancement curves showed a good agreement. Furthermore, we simulated lesion-to-liver curves for various injection protocols, and the effects were analyzed. The variables to be considered in the injection protocol were injection rate, dose, and concentration of contrast material. These data may help to optimize scanning protocols for better diagnosis.

• Korea journal of population studies
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• v.21 no.2
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• pp.37-57
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• 1998

In recent, Korea introduced the local self-government system. And the local government tried to establish and implement plans for women. Those plans were established on the basis of not the particular environments of regional societies but similar policies of central government. Despite of geographical migrations, we can find differences of population structure and economic status among regions. As the result, most of regional policies for women were ineffective. This paper examines population structure and economic status of women by regions and recommends the long and medium direction for local policies for women. For analysis, it utilizes the 2% sample data-set of National Statistical Office's '1995 Population and Housing Census' in Korea. The findings of this paper are summarized as following; Firstly, the dependency rate of Chungchong-do, Cholla-do, Kyongsangnam-do will reach about 45% in 2000. Therefore, as soon as possible, those local government should establish the labor policies to enhance the economically active participation rate of the elderly persons and welfare policy for them. Secondly, the level of women's economic participation. Thus, local governments should set up labor market policies for women according to regional situations. For examples, in Kyonggi-do, Seoul, Daejeon, Daeku which unemployment rate of the highly educated women are relatively high, those local governments should seek the measures to tackle unemployment problem of them. Thirdly, due to the differences regional economic structure, women's employment structures differed also by region. Hence, local governments should formulate suitable plans to consider the working status of regional women's workers.