• 사회복지연구
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• 제39호
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• pp.395-423
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• 2008

본 연구는 자발적으로 마약류 의존 치료재활 서비스를 이용하고 있는 한국 성인남녀를 대상으로 그들의 서비스 이용에 영향을 미치는 개인적 특성을 분석하는데 그 목적이 있으며, 이론적 틀로 건강서비스 이용행태 분석에 널리 사용되는 Andersen의 '건강서비스이용 행동모형'을 활용하였다. 연구참여자 모집의 어려움으로 유의표집을 통해 조사된 80명의 자료를 분석에 활용하였으며, 분석방법으로 위계적 회귀분석을 사용하였다. 분석 결과, '학력(선행요인)'이 높을수록 현재 이용하는 치료재활 서비스 수가 많으며, '동료의존자의 지지(자원요인)'가 클수록 현재 이용하는 치료재활 서비스 수도 많고 향후 지속적으로 서비스를 이용할 의사도 높은 것으로 나타났다. 또한 의존자들이 느끼는 '인지된 욕구(욕구요인)'가 클수록 입원 입소 경향이 높은 것으로 분석되었다. 엔더슨모형에 의하면 우리나라 마약류 의존자 치료재활 서비스 이용에 영향을 미치는 요인은 매우 제한적이며, 또한 서비스 이용의 형평성도 낮은 것을 알 수 있다.

• Archives of Pharmacal Research
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• 제4권2호
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• pp.99-107
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• 1981

To investigate the protein binding characteristics of ibuprofenlysine, the effects of drub conentration, pH, ionic strength and protein concentration on the binding of drug to protein concentration on the binding of drug to protein were studied by fluorescence probe method. The conformational change of protein was investigated by circular dichroism (CD) measurement. As the concentration of drug increases, the association constant decreases. These may be due to complex formation of the probe and drug, or the interaction of the protein-probe complex and drug. The association constant for ibuprofenlysine increased with increasing protein concentration. These finding suggest a sharing of one ibuprofenlysine molecule by more than one protein molecule in the binding. The binding between ibuprofenlysine and protein was dependent on pH and ionic strength. It seems that both hydrophobic binding and some electrostatic forces are involved in the binding of ibuprofenlysing to protein.

• 대한불안의학회:학술대회논문집
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• 대한불안의학회 2005년도 춘계학술대회
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• pp.88-103
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• 2005

o Rational Use of BZ - relative safe, widely useful o Hidden side effects/disastrous effects in vulnerable patients o Review tolerance, dependency, withdrawal symptoms o Consider Drug interaction o Periodic Evaluation of Risk/Benefit of BZ o Advice to patients planning a pregnancy

• 보건교육건강증진학회지
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• 제21권3호
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• pp.67-86
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• 2004

This study attempted to investigate the factors influencing alcohol drinking habit of college students in Korea. To find how many students are alcohol dependents and what factors are related to problem drinking habit, the current study estimated problem drinkers and analyzed the relationship of problem drinking and various factors. In 2000, 736 students reported the questionnaires. Estimated rates of problem drinkers standardized by age were 0.7% of male and 0.5% of female students by NAST, amounting 9,300 college students. Age of initiation of alcohol drinking, alcohol or drug use problems of parents or mends, psychological factors, emotional factors, and two of MMPI scales were significantly different between moderate drinkers and alcohol dependents. The moderate and problem drinkers were significantly different in Mf and Pa average scores. However, economic factors were not significantly different between the moderate drinkers and alcohol dependents. Based on the results, this study suggested that further multivariate studies with large sample need be conducted to investigate the relationship between alcohol dependency and its factors.

• 한국방사선학회논문지
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• 제12권6호
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• pp.769-776
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• 2018

국제전기기술위원회의 문서 IEC 60601-1의 3판 규격과 IEC 60601-2-45의 개별 규격에서는 진단용 X선 장치에서 X선 피폭 선량 정보를 표시하고 그 정확성을 명시할 것을 권고하고 있다. 하지만 임상에서 사용하는 부착형 공기커마 면적선량계는 교정에 어려움이 있다. 이에 본 연구에서는 임상에 적용 가능한 RQR 표준 선질을 이용하여 공기커마 면적선량계의 에너지 의존성과 정확도를 평가하였고 임상에서 간접 교정을 시행할 수 있도록 방법론을 마련하고자 하였다. RQR5의 표준 선질에서 시행한 시험에서 부착형 공기커마 면적선량계는 -7.5%의 오차를 나타냈고, RQR8의 표준 선질에서는 -10.3%의 오차를 나타냈으며 시험한 모든 RQR 선질에 대해 평균 절대오차는 $8.30%{\pm}2.85%$를 나타내 IEC 60580과 AAPM TG 190의 조건을 만족하였다. 본 연구에서 도출한 공기커마 면적선량계의 교정 방법은 임상에서 사용하는 공기커마 면적 선량계의 간접 교정법으로 사용할 수 있을 것으로 기대한다.

• 보건행정학회지
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• 제6권2호
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• pp.149-189
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• 1996

The aims of this study were to find out present situation of self-medication, and to explicate the factors affecting self-medication propensity. To explicate empirically the factors affecting self-medication propensity, a model containing five groups of determining factors such as attitudinal, behavioral, knowled해, and need of health care factors, and demographic factors were developed. Data were collected from 647 residents in Pusan and Kyungnam using the self-administered questionnaire. The major reslts obtained were as follows: First, self-medication was 32% of all utilization of pharmacy. The drugs used for self-medication most commonly were analgesics(16.2%), followed by antacids and stomachics(14.2%), dermatologic preparations(13.1%), tonics and drinks (12.6%). Second, the sources from which people obtained drug information at self-medication were label of the container(50.8%), pharmacist(32.4%), self-decision or lay person(16.8%). The experience of side effect was 10.6% of all self-medication and how people cope with was withdrawal(59.0%), consultation by pharmacist or doctor(35.9%). Third, the results of ANOVA showed a statistically significant relationship between self-medication propensity and 3 demograpic factors, such as sex(p<0.10), age(p<0.10) and job(p<0.05). Forth, the results of multiple regression analysis showed a statistically significant positive relationship betwee self-medication propensity and satisfaction of previous self-medication, knowledge of drug, drug dependency, the frequency of doctor visiting, confidence in drug advertisement, tendency toward self-treatment of the family, and job. And it showed negative relationship between self-medication propensity and confidence in the medical profession, and health behavior. The model explained 29.5% of the variance in self-medication(p<0.001).

• 대한간호학회지
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• 제23권3호
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• pp.487-503
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• 1993

This study was designed to investigate the situation of adolescent drug use in Seoul, and to com-pare this with the 1991 survey in order to better understand the present situation. The subject for this study were 1000 students in High School and Middle School. The data were collected during the period from september 1, 1992 to December 30, 1992. The guestionnaire developed by Kim So Ya Ja (1991) to survey adolescent drug use was used. The data was analyzed using descriptive statistics, 1-test and ANOVA with the SPSS program. The results of this study can be summarized as follows 1. Prevalence of Substance use : Antihistamines were used by 0.3% of adolescent, Sedatives 0.6%, Stimulants 8.1%, Hallucinogens 0.9%, Inhalants 3.2%, Narcotics 1.7%, and Analgetics 154.3%. 2. Trend in substance use compared to the 1991 surbey : Alcohol use increased from 52.8% to 63.7% and narcotics from 0.6% to 1.7%, while Smeking, Analgetics, Antihistamines, Sedatives, and Inhalants showed a decrease. 3. Smoking and Alcohol use : Twenty five percent of school adolescent had experienced cigarette smoking and 63.7% of school adolescent had experienced alcohol use. 4. Motives for drug use : The highest was avoidence of sleep at 49.4% and the next highest was adventure seeking at 27.7%. As to feeling after drug use, 34.3％ felt apathy, 22.8% had feelings of sleepiness and unconsciousness. 5. Places were dreg were purchased : The most frequent was the drug store (78.3%) and 84.4% of the respondents answered that drug purchase was easy and 86.7% that drug use was mainly at home. 6. Related Variables : There was a statistically significent high score for drug and alcohol use by adolescents whose fathers used drugs. (PC.05) In conclusion, adolescents in Seoul showed in decrease in the tendency to use drugs compared to the 1991 survey, however drugs which are habit-forming and lead to dependency are still being abused. Therefore, counter-plans and preventive stratiges are important.

• 경영과정보연구
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• 제32권2호
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• pp.359-379
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• 2013

본 연구에서는 십 수년간 조직의 경영진과 CIO의 가장 큰 관심사 중 하나인 IT-비즈니스 연계에 실무적 관점에서 영향을 주는 요인에 대해 분석하였다. 기업이 시장경쟁력을 갖추기 위해서는 끊임없이 혁신해야 하고 혁신도구로 IT활용이 일반화되어 대두된 IT혁신, 업무의 IT활용이 늘어남에 따른 IT의존성, 그리고 업무와 IT의 복잡성이 증대되어 이를 해결하기 위한 EA활용은 IT-비즈니스 연계에 영향을 미칠 것이라는 가설을 제시하였고 이를 검증하기 위해 관련 전문가 120명으로 부터 설문을 수집하여 PLS(Partial Least Square)를 통해 유의성을 조사하였다. 본 연구를 통한 시사점은 첫째 IT혁신을 효율화하기 위해서는 기술적, 업무적인 사전검토와 사후활용에 대한 고려가 필요하고 두 번째 IT의존성이 높아지면 IT구축시에 보다 명확한 요구사항 정의가 가능해지며 세 번째 EA활용이 IT-비즈니스 연계에 유의성을 입증한 만큼 EA를 보다 적극적으로 활용하기 위한 시스템 적용이 활성화 될 것으로 기대한다.

• Environmental Analysis Health and Toxicology
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• 제21권4호
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• pp.349-355
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• 2006

Dextromethorphan hydrobromide (DXM) has been widely used as a nonopioid antitussive drug with low toxicity and low potential for drug dependency. DXM is a psychotropic drug since 2003 in our country. This study was performed to investigate the immunotoxicity induced by abuse of DXM. Mice were orally exposed to DXM dissolved in saline as concentration of 30, 60, and 120 mg/kg b.w. before (day-2) or after (day+2) immunization (OVA-antigen, day 0). Thereafter, we measured the increased rate of body weight, relative weight of organ (thymus, spleen, liver, kidney) and OVA-specific IgM level in sera. In addition, mouse splenocytes were exposed to various concentration of DXM $(0.001{\sim}100{\mu}M)$ and cultured with B cell mitogen (LPS) and splenocytes proliferations (SP) were measured by MTT-assay. Thymus-weight were slightly changed on day 9 after administration of DXM, but body-, spleen-, liver-, and kidney-weight were not different between control group and DXM-treated group. SP to LPS were significantly decreased at high concentration $(100{\mu}M)$ when compared with controls. When DXM was administered before or after immunization with OVA-antigen, OVA-specific IgM levels were significantly lowered in a dose-dependent manner. These results indicate that DXM nay depress the primary humoral immune response to the initial antigenic challenge.

• Archives of Pharmacal Research
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• 제18권3호
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• pp.141-145
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• 1995

Omeprazole, a proton pump inhibitor, was given intravenously (iv), orally (po), intraperitoneally (ip), hepatoportalvenously (pv), and intrarectally (ir) to rats at a dose of 72mg/kg in order to investigate the bioavailability of the drug, The extent of bioavailabilities of omeprazole administered through pv, ip, po, and ir routes were 88.5, 79.4, 40,8, and 38.7%, respectively. Pharmacokinetic analysis in this study and literatures (Regardh et al., 1985 : Watanabe et al., 1994) implied significant dose-dependency in hepatic first-pass metabolism, clearance and distribution, and acidic degradation in gastric fluid. The high bioavailability from the pv administration (88.5%) means that only 11.5% of dose was extracted by the first-pass metabolism through the liver at this dose (72 mg/kg). The low bioavailability from the oral administration (40.8%) in spite of minor hepatic first-pass extraction indicates low transport of the drug from GI lumen to portal vein. From the literature (Pilbrant and Cederberg, 1985), acidic degradation in gastric fluid was considered to be the major cause of the low transport. Thus, enteric coating of oral preparations would enhance the oral bioavailability substantially. The bioavailability of the drug from the rectal route, in which acidic degradation and hepatic first-pass metabolism may not occur, was low (38.7%) but comparable to that from the oral route (40.8 %) indicating poor transport across the rectal membrane. In this case, addition of an appropriate absorption enhancer would improve the bioavailability. Rectal route seems to be an possible alternative to the conventional oral route for omeprazole administration.