• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.28 no.1
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• pp.1-21
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• 2024

This review comprehensively explores the evolution, theoretical underpinnings, variations, and applications of diffusion models. Originating as a generative framework, diffusion models have rapidly ascended to the forefront of machine learning research, owing to their exceptional capability, stability, and versatility. We dissect the core principles driving diffusion processes, elucidating their mathematical foundations and the mechanisms by which they iteratively refine noise into structured data. We highlight pivotal advancements and the integration of auxiliary techniques that have significantly enhanced their efficiency and stability. Variants such as bridges that broaden the applicability of diffusion models to wider domains are introduced. We put special emphasis on the ability of diffusion models as a crucial foundation model, with modalities ranging from image, 3D assets, and video. The role of diffusion models as a general foundation model leads to its versatility in many of the downstream tasks such as solving inverse problems and image editing. Through this review, we aim to provide a thorough and accessible compendium for both newcomers and seasoned researchers in the field.

• Anatomy and Cell Biology
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• v.57 no.2
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• pp.155-162
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• 2024

Cerebral ischemia is the important cause of worldwide disability and mortality, that is one of the obstruction of blood vessels supplying to the brain. In early stage, glutamate excitotoxicity and high level of intracellular calcium (Ca²⁺) are the major processes which can promote many downstream signaling involving in neuronal death and brain tissue damaging. Moreover, autophagy, the reusing of damaged cell organelles, is affected in early ischemia. Under ischemic conditions, autophagy plays an important role to maintain energy of the brain and its function. In the other hand, over intracellular Ca²⁺ accumulation triggers excessive autophagic process and lysosomal degradation leading to autophagic process impairment which finally induce neuronal death. This article reviews the association between intracellular Ca²⁺ and autophagic process in acute stage of ischemic stroke.

• Journal of environmental and Sanitary engineering
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• v.19 no.3 s.53
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• pp.1-12
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• 2004

This study was conducted to evaluate the variation characteristics of influent and effluent quality from sewage treatment facilities using activated sludge processes and to assess the impact caused by discharge of treated sewage on the receiving water Monthly data of five water quality items (BOD, COD, SS, T-N, T-P) were used to understand the water quality at three sewage treatment plants in Seoul for five years from 1999 to 2003. Concentration differences of water quality parameters were observed between upstream and downstream site at the sewage treatment plant outfall to investigate the impact of discharge in Tan stream and Han river basin. 1. Due to the effect of continuous improvement in sewer system, the concentrations of influent went on increasing generally. 2. Effluent concentrations of BOD, COD and SS showed the trend of a little decreasing, but the trend of increasing in T-N and T-P. 3. In Tan stream basin, the impact of sewage treatment plant discharge was not observed directly, because concentration of discharge was lower than stream water's. But discharges from sewage treatment plants affected water quality at downstream site in Han river, concentration of T-P especially.

• Journal of the Korean Society of Marine Environment & Safety
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• v.14 no.4
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• pp.333-338
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• 2008

The coastal zone is a delicate and dynamic area in which the majority of a water kinetic energy is dissipated. These processes are subsequent to the transport of the beach materials. In comparison to emerged breakwaters, submerged structures permit the passage of some wave energy and in turn allow for circulation along the shoreline zone. This research aims to examine the beach erosion prevention capability of submerged structure by laboratory model. The flow characteristics behind a submerged obstacle with bottom gap were experimentally investigated at Re = $1.2{\times}10^4$ using the two-frame PIV(CACTUS 2000) system. Streamline curvature field behind the obstacle has been obtained by using the data of time-averaged mean velocity information. And the large eddy structure in the separated shear layer seems to have signification influence on the development of the separated shear layer. As bottom gap size increases, the recirculation occurring behind the obstacle moves toward downstream and its strength is weakened.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.10
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• pp.5156-5161
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• 2013

In distributed spatial data stream processing, processed tuples of downstream nodes are replicated to the upstream node in order to increase the utilization of distributed nodes and to recover the whole system for the case of system failure. However, while the data input rate increases and multiple downstream nodes share the operation result of the upstream node, the data which stores to output queues as a backup can be lost since the deletion operation delay may be occurred by the delay of the tuple processing of upstream node. In this paper, the adaptive upstream backup scheme based on operation throughput in distributed spatial data stream system is proposed. This method can cut down the average load rate of nodes by efficient spatial operation migration as it processes spatial temporal data stream, and it can minimize the data loss by fluid change of backup mode. The experiments show the proposed approach can prevent data loss and can decrease, on average, 20% of CPU utilization by node monitoring.

• Journal of Korean Society on Water Environment
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• v.25 no.1
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• pp.48-57
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• 2009

A two-dimensional (2D), laterally-averaged hydrodynamic and water quality model, CE-QUAL-W2 was applied to evaluate the performance on simulating the effect of flushing from Daecheong Reservoir on the downstream water quality variations during the flushing events held on November, 2003 and March, 2008. The hydraulic and water quality simulation results were compared with field measurement data, as well as a one-dimensional (1D), unsteady model (KORIV1) that revealed limited capability in the previous study due to missing the resuspension process of river bottom sediments. The results showed that although the 2D model made satisfactory performance in reproducing the temporal variations of dissolved matters including phosphate, ammonia and nitrate, it revealed poor performance in simulating the increase of biological oxygen demand and suspended sediment (SS) concentrations during the passage of the flushing flow. The reason of the error was that the resuspension process of the 2D model is only the function of shear stress induced by wind. In reality, however, as shown by significant correlation between bottom shear stress ($\tau$) and observed SS concentration, the resuspension process can be significantly influenced by current velocity in the riverine system, especially during flushing event. The results indicate that the resuspension of river bottom materials should be incorporated into the water quality modeling processes if $\tau$ is greater than a critical shear stress (${\tau}_c$) for better simulation of flushing effect.

• Biomedical Science Letters
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• v.13 no.3
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• pp.239-244
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• 2007

Hoxc8 is one of the homeotic developmental control genes regulating the expression of many downstream target genes, through which animal body pattern is established during embryonic development. In previous proteomics analysis, proliferating cell nuclear antigen (PCNA) which is also known as cyclin, has been implied to be regulated by Hoxc8 in F9 murine embryonic teratocarcinoma cell. When the 5' upstream region of PCNA was analyzed, it turned out to contain 20 Hox core binding sites (ATTA) in about 1.17 kbp (kilo base pairs) region ($-520{\sim}-1690$). In order to test whether this region is responsible for Hoxc8 regulation, the upstream 2.3 kbp fragment of PCNA was amplified through PCR and then cloned into the pGL3 basic vector containing a luciferase gene as a reporter. When the luciferase activity was measured in the presence of effector plasmid (pcDNA : c8) expressing murine Hoxc8, the PCNA promoter driven reporter activity was reduced. To confirm whether this reduction is due to the Hoxc8 protein, the siRNA against Hoxc8 (5'-GUA UCA GAC CUU GGA ACU A-3' and 5'-UAG UUC CAA GGU CUG AUA C-3') was prepared. Interestingly enough, siRNA treatment up regulated the luciferase activity which was down regulated by Hoxc8, indicating that Hoxc8 indeed regulates the expression of PCNA, in particular, down regulation in NIN3T3 cells. These results altogether indicate that Hoxc8 might orchestrate the pattern formation by regulating PCNA which is one of the important proteins involved in several processes such as DNA replication and methylation, chromatin remodeling, cell cycle regulation, differentiation, as well as programmed cell death.

• Journal of Korea Water Resources Association
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• v.46 no.1
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• pp.25-34
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• 2013

In this study, the development processes of multiple bars in the channels with erodible banks were investigated by double Fourier analysis. The initially straight channels in the experiment flume were widened with eroding the side banks, and the multiple bars were generated and grew due to stalling of the sediment on the bed. The bars migrated downstream and the size of the bars increased with time. The flow was separated around the bars, and the bed and banks near the bars were scoured due to the impinged secondary flow. The morphologic changes were accelerated by the bank erosion, which affected the fluctuations of sediment discharge downstream. The double Fourier analysis of the bed waves showed that 1-1 mode (alternate bar) was dominant at the initial stage of the channel development. As time increased, 2-3 mode (central or multiple bars) was dominant due to the increased width to depth ratio. Moreover, the number of bars in a cross section of the channel were increased due to the non linearity of alternate bars. The width to depth ratio was increased by the bank erosion, which affected the bar migration and the bar wavelength. However, the dimensionless tractive force was decreased by it.

• Molecules and Cells
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• v.43 no.6
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• pp.517-529
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• 2020

Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.

• Journal of Korean Society of Environmental Engineers
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• v.22 no.1
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• pp.149-157
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• 2000

This paper presents the first results of dissolved arsenic in the Kangnung Namdae stream. The distribution of As concentrations measured in 28 August (high water flow) and in 21 November 1997 (low water flow) differs from those of other metals measured during the same period; The concentrations of Doam-dam are lower than those of Obong-dam and accumulation in the downstream in the period of low water flow is not pronounced. The As concentration in the downstream under the low water flow is lower than under high water flow, reciprocally to other metals. Freshwater concentrations are comparable with those measured in pristine river and lower than the world average and the diffrence of concentrations measured during two period is minute. Therefore, the As concentrations in the Namdae stream are background level and the source of As contamination does not exist. In the mixing zone between the freshwater and Donghae seawater, As behave conservatively, indicating the absence of any significant removal or mobilization processes. A first estimation of total dissolved As input from Namdae stream to Donghae coastal sea shows 65.12 kg/yr.