• The Korea Journal of Herbology
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• 제29권5호
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• pp.23-30
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• 2014

Objectives : Dodam-tang has been reported to have a control effect against the hyperlipidemia and thrombosis. Based upon these previous reports, this study investigates the effects of Dodam-tang on the cerebral ischemic damage of the hyperlipidemic rats. Methods : Hyperlipidemia was induced by the beef tallow 30% diet for 14 days on Sprague-Dawley rats. Ischemic damage was induced by the middle cerebral artery occlusion (MCAO) for 2 hours with the intraluminal thread method. Then water extract of Dodam-tang was administered daily for 5 days. The effect of Dodam-tang was evaluated with the serum lipids, infarct volume and edema percentage, and immunohistochemical expressions of iNOS, MMP-9, and GFAP in the brain tissue. Results : The obtained results were as follows; Dodam-tang reduced significantly the infarct size in a TTC-stained 5th brain section of the hyperlipidemic MCAO rats. Dodam-tang suppressed the infarct volume of the hyperlipidemic MCAO rats, but not significant statistically. Dodam-tang suppressed the edema percentage of the hyperlipidemic MCAO rats significantly in the brain tissue. Dodam-tang suppressed significantly the iNOS expression in the cerebral penumbra and caudate putamen of the hyperlipidemic MCAO rats. Dodam-tang suppressed significantly the MMP-9 expression in the cerebral penumbra of the hyperlipidemic MCAO rats. Dodam-tang suppressed significantly the GFAP-expressed atrocytes in the cerebral penumbra of the hyperlipidemic MCAO rats. Conclusions : These results suggest that Dodam-tang suppresses the brain edema formation through the suppression of the iNOS, MMP-9 and GFAP, but the neuroprotective effect against the cerebral infarct are not distinct.

• Journal of Physiology & Pathology in Korean Medicine
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• 제22권2호
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• pp.438-445
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• 2008

Dodam formula (Dodam) has been used for neurodegenerative disease in Oriental medicine. Dodam is capable of protecting diverse kinds of cells from damage caused by a variety of toxic stimuli. In the present study, we investigated the underlying protective mechanism of Dodam on rotenone-induced cytotoxicity in rat neuroblastoma Neuro-2A cells. Treatment with Neuro-2A cells with rotenone caused the loss of cell viability, and condensation and fragmentation of nuclei, which was associated with the elevation of ROS level, and lipid peroxidation, the increase in Bax/Bcl-2 ratio. Rotenone induced mitochondrial dysfunction characterized by mitochondrial membrane potential loss and cytochrome-c release. These phenotypes induced by rotenone were reversed by pretreatment with Dodam. Our results suggested that major features of rotenone-induced neurotoxicity are partially mediated by mitochondrial dysfunction and oxidative stress, and that Dodam markedly protects Neuro-2A cells from oxidative injury. These data indicated that Dodam might provide a useful therapeutic strategy in treatment of the neurodegenerative diseases caused by oxidative injuries.

• Geotechnical Engineering
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• 제22권7호
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• pp.28-39
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• 2006

• 기술발표회
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• 통권2006호
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• pp.311-319
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• 2006

Artesian Pressure exists in Hwa Jeon Project Site of Nakdong Delta Area. Maxium value of the pressure ranges between 06 tonf/m2 and 1 3 tonf/m2 in the design site. This paper presents a design case study considering the Artesian Pressure to calculate the consolidation settlement of the deep marine clay.

• Proceedings of the Korean Geotechical Society Conference
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• 한국지반공학회 2005년도 지반공학 공동 학술발표회
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• pp.601-612
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• 2005

In mountainous area, Two parallel tunnels have been usually recognized as a road tunnel which has benefits in aspects of cost and stability. However, Design and construction of 2-Arch road tunnel are growing recently due to environmental destruction, compensation of land and difficulty of route separation. As studies are mainly undergoing on only guaranteeing stability and developing a waterproofing-drainage system to avoid water leakage through comprehension for characteristics of 2-arch tunnel behaviors, there is a tendency to evaluate quantity of support by empirical method with a tunnel which has a complicated cross-section and lack of construction ability. In this study, therefore, we made a plan of tunnel cross-section which had shown good construction ability and developed the waterproofing-drainage system which is able to solve the water leakage problem fundamentally by analyzing precedented 2-arch tunnels and investigating their sites in and out of nation. We also determined fixed quantity of support by a large-scale model test and numerical analysis. We want to contribute to 2-arch tunnel design hereafter introducing design procedure and method applied here.

• Journal of the Korean Institute of Educational Facilities
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• 제26권3호
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• pp.8-12
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• 2019

• Proceedings of the Korean Geotechical Society Conference
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• 한국지반공학회 2005년도 지반공학 공동 학술발표회
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• pp.174-187
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• 2005

Recently, because of environment, cost, supply and demand factors, though applying sea-sand as horizontal drains is getting difficult that usage of Gravel has been growing in large size of construction sites, Study on engineering properties and behavior characteristics of Gravel stratum is not thoroughgoing enough. We have applied Gravel Mat as the horizontal drains in O O construction site. We also conducted several field tests such as Material property test, Geosynthetics damage test with Repeated load, Discharge capacity test performed by inflow of upper soil and In-situ PBD Penetration test to review the application of Gravel Mat. Test results show that Gravel Mat is not only advantageous in Trafficability and Water drainage by Consolidation due to its great Internal friction angle and Permeability, but also easy to penetrate with Mandrel and has great discharge capacity and guarantee of the stability against geosynthetics damage at the same time. With these benefits Gravel Mat shows great application in fields.

• The Journal of Internal Korean Medicine
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• 제44권3호
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• pp.439-454
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• 2023

Objectives: As Korea transitions into an aging society, the incidence of cerebrovascular disease is expected to increase. Herbal medicine is commonly used in Oriental medicine to treat cerebrovascular disease. However, there is insufficient clinical evidence to actively support the safety of herbal medicine in clinical practice. Therefore, the aim of this study was to determine the toxicity and safety of four herbal medicines (Cheongsimyeonja-tang, Dodam-tang, Hyeolbuchukso-tang, and Boshiniknai-tang) in patients with cerebrovascular disease. Methods: This study used electronic medical records to analyze patients admitted to an oriental medicine hospital from April 1, 2017, to December 31, 2020. Liver and renal function values at the time of admission and discharge were compared. Results: A total of 25 patients were included in this study. We found no significant differences in various variables, such as complete blood count, liver-renal function test, and urine, before and after the administration of the four herbal medicines. Additionally, no significant adverse events related to herbal medicine were observed. Conclusions: This study confirmed the safety of the four herbal medicines in patients with cerebrovascular disease who were hospitalized in a single Oriental medicine hospital.

• Proceedings of the Korean Geotechical Society Conference
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• 한국지반공학회 2009년도 춘계 학술발표회
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• pp.419-433
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• 2009

Pressure grouting is a common technique in geotechnical engineering to increase the stiffness and strength of the ground mass and to fill boreholes or void space in a tunnel lining and so on. Recently, the pressure grouting has been applied to a soil-nailing system which is widely used to improve slope stability. The soil-nailing design has been empirically performed in most geotechnical applications because the interaction between pressurized grouting paste and the adjacent ground mass is complicated and difficult to analyze. The purpose of this study is to analyze the increase of pullout resistance induced by pressurized grouting with the aid of performing laboratory model tests and field tests. In this paper, two main causes of pullout resistance increases induced by pressurized grouting were verified: the increase of residual stress; and the increase of coefficient of pullout friction. From the laboratory tests, it was found that residual stress in borehole increases by pressurized grouting and dilatancy angle could be estimated by cavity expansion theory using the measured wall displacements. From the field test results, the pullout resistance of soil-nailing with pressurized grouting was found to be 10% larger than that of soil-nailing with gravitational grouting, mainly caused by mean normal stress increase and dilatancy effect. So, the pullout resistance could be estimated by considering these two effects. The radial displacement increases with dilatancy angle increase and the dilatancy angle decreases with injection pressure increase. The measured pullout resistance obtained from field tests is in good agreement with the estimated one from the cavity expansion theory.

• Journal of the Korean Geosynthetics Society
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• 제6권1호
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• pp.33-38
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• 2007

PVD (Prefabricated Vertical drain) consists of filter and core. An effective PVD has two basic filtration functions ; first to retain soil particle ; and second, to allow water to pass from the soil into the PVD core without clogging or blinding. Clogging which reduces the permeability of the geotextile filter jacket is caused by fine particles penetrating into the geotextile filter jacket in relatively low permeability soil conditions. As clogging performance increases gradually, excess pore water flow from soil is resisted and finally consolidation delays. Current soil-geotextile filter system criteria are generally based on relationships between a representative pore size of the geotextile and particle size of the soil. In Korea, PVD geotextile filter system criteria have been applied by only testing AOS (Apparent Opening Size) of filters without evaluating the filtration and clogging performance on soil-geotexile filter systems. Therefore, the filtration tests on soil-geotexile filter systems were conducted in order to evaluate the filtration and clogging performance with 3 kinds of geotextile filters. On these tests, we have applied geotextile filter system criteria on PVD in ${\bigcirc}{\bigcirc}$ sites.