• Mycobiology
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• 제43권2호
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• pp.150-156
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• 2015

2',4'-Dihydroxychalcone (2',4'-DHC) was identified from a heat shock protein 90 (Hsp90)-targeting library as a compound with Hsp90 inhibitory and antifungal effects. In the presence of 2',4'-DHC ($8{\mu}g/mL$), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked. The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC. The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced. The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin. Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90. These results suggest that 2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.159.1-159.1
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• 2003

Human Topoisomerase I (topo I) helps the control of DNA supercoiling in cells by assisting breaking and religation of DNA strand. It is essential for cellular metabolism and survival, hence, a good target for a novel class of anticancer drugs. As topo I inhibitor binds to the DNA-topo I complex, the religation of DNA strand is suppressed which results in the death of the target cell. Seven compounds of H-Imidazo［4, 5-g］phthalazing-4, 9-dione derivatives with $IC_50$ in the range of 0.001 and 6.27 $\mu$M in 5 different cancer cells and four compounds of 7-chloro-6-quinazoline-5, 8-dione derivatives with positive and negative topo I inhibition activities were studied. (omitted)

• 로봇학회논문지
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• 제18권3호
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• pp.233-240
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• 2023

In this paper, we proposed a hybrid type robot that simultaneously surveillance and reconnaissance on the ground and in the air. It was possible to expand the surveillance and reconnaissance range by expanding the surveillance and reconnaissance area of the ground robot and quickly moving to the hidden area through the drone. First, ground robots go to mission areas through drones and perform surveillance and reconnaissance missions for urban warfare or mountainous areas. Second, drones move ground robots quickly. It transmits surveillance and reconnaissance images of ground robots to the control system and performs reconnaissance missions at the same time. Finally, in order to secure the interoperability of these hybrid robots, basic performance and environmental performance were verified. The evaluation method was tested and verified based on the KS standards.

• The Plant Pathology Journal
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• 제33권6호
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• pp.529-542
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• 2017

Control of plant diseases is largely dependent on use of agrochemicals. However, there are widening gaps between our knowledge on plant diseases gained from genetic/mechanistic studies and rapid translation of the knowledge into target-oriented development of effective agrochemicals. Here we propose that the time is ripe for computer-aided drug discovery/design (CADD) in molecular plant pathology. CADD has played a pivotal role in development of medically important molecules over the last three decades. Now, explosive increase in information on genome sequences and three dimensional structures of biological molecules, in combination with advances in computational and informational technologies, opens up exciting possibilities for application of CADD in discovery and development of agrochemicals. In this review, we outline two categories of the drug discovery strategies: structure- and ligand-based CADD, and relevant computational approaches that are being employed in modern drug discovery. In order to help readers to dive into CADD, we explain concepts of homology modelling, molecular docking, virtual screening, and de novo ligand design in structure-based CADD, and pharmacophore modelling, ligand-based virtual screening, quantitative structure activity relationship modelling and de novo ligand design for ligand-based CADD. We also provide the important resources available to carry out CADD. Finally, we present a case study showing how CADD approach can be implemented in reality for identification of potent chemical compounds against the important plant pathogens, Pseudomonas syringae and Colletotrichum gloeosporioides.

• Reproductive and Developmental Biology
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• 제33권1호
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• pp.1-5
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• 2009

To search a new pig pheromonal odorant, the $N^1$-allyl-$N^2$-(tetrahydrofuran-Z-ylmethyl)oxalamide molecule predicted by ligand based approach and molecular docking method was synthesized by nucleophilic addition-elimination reaction ($Ad_{NU-E}$) between N-allyloxalamic acid ethylester and tetrahydrofurlmethylamine. According to the evaluation results for efficiency of pig estrus control, the synthesized pig pheromonal $N^1$-allyl-$N^2$-(tetrahydrofuran-2-ylmethyl)oxalamide molecule advanced the estrus by 11.3 days (p<0.05) compared with the non-pheromone group. And from these results, it is predicted that the synthesized pig pheromonal compound will be able to increase the reproduction efficiency of pig.

• Journal of Advanced Marine Engineering and Technology
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• 제33권6호
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• pp.880-885
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• 2009

The ships have a lot of electric machinery needed to supply electricity from the moment of launching coming out of dry dock to docking at jetty. Thus, the ships always have to use alternator and electric machinery that has low efficiency under the low load. Many government service ships like the MMU training ship have been spending lots of time at jetty rather than sailing at sea. These ships are operated under the condition of low load due to the operation of basic machinery at jetty and electric machineries are driven with the status of low efficiency. This paper would suggest the energy saving method for these ships. The investigation describes that shore connection is a great asset to these ships and that the flow rate control by adjusting revolution with the adoption of inverter is better than flow rate control by using throttle valve to save energy. The result is based on the investigation of cooling pump at MMU training ship.

• 한국해양공학회지
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• 제21권2호
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• pp.67-74
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• 2007

Maritime and Ocean Engineering Research Institute (MOERI), a branch of KORDI, has designed and manufactured a model of an autonomous underwater vehicle (AUV) named ISiMI (Integrated Submergible for Intelligent Mission Implementation). ISiMI is an AUV platform to satisfy the various needs of experimental test required for development of challenging technologies newly investigated in the field of underwater robot; control and navigational algorithms and software architectures. The main design goal of ISiMI AUV is downsizing which will reduce substantially the operating cost compared to other vehicles previously developed in KORDI such as VORAM or DUSAUV. As a result of design and manufacturing process, ISiMI is implemented to be 1.2 m in length, 0.17 m in diameter and weigh 20 kg in air. A series of tank test is conducted to verify the basic functions of ISiMI in the Ocean Engineering Basin of MOERI, which includes manual control with R/F link, auto depth, auto heading control and a final approach control for underwater docking. This paper describes the implementation of ISiMI system and the experimental results to verify the function of ISiMI as a test-bed AUV platform.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2006년 창립20주년기념 정기학술대회 및 국제워크샵
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• pp.347-350
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• 2006

Maritime and Ocean Engineering Research Institute (MOERI), a branch of KORDI, has designed and manufactured a model of an autonomous underwater vehicle (AUV) named ISiMI(Integrated Submergible for Intelligent Mission Implementation). ISiMI is an AUV platform to satisfy the various needs of experimental test required for development of challenging technologies newly investigated in the field of underwater robot; control and navigational algorithms and software architectures. The main design goal of ISiMI AUV is downsizing which will reduce substantially the operating cost compared to other vehicles previously developed in KORDI such as VORAM or DUSAUV. As a result of design and manufacturing process, ISiMI is implemented to be 1.2m in length, 0.17m in diameter and weigh 20 kg in air. A series of tank test is conducted to verify the basic functions of ISiMI in the Ocean Engineering Basin of MOERI, which includes manual control with R/F link, auto depth, auto heading control and a final approach control for underwater docking. This paper describes the implementation of ISiMI system and the experimental results to verify the function of ISiMi as a test-bed AUV platform.

• ETRI Journal
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• 제39권2호
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• pp.222-233
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• 2017

Debugging in distributed environments, such as wireless sensor networks (WSNs), which consist of sensor nodes with limited resources, is an iterative and occasionally laborious process for programmers. In sensor networks, it is not easy to find unintended bugs that arise during development and deployment, and that are due to a lack of visibility into the nodes and a dearth of effective debugging tools. Most sensor network debugging tools are not provided with effective facilities such as real-time tracing, remote debugging, or a GUI environment. In this paper, we present a hybrid debugging framework (HDF) that works on WSNs. This framework supports query-based monitoring and real-time tracing on sensor nodes. The monitoring supports commands to manage/control the deployed nodes, and provides new debug commands. To do so, we devised a debugging device called a Docking Debug-Box (D2-Box), and two program agents. In addition, we provide a scalable node monitor to enable all deployed nodes for viewing. To transmit and collect their data or information reliably, all nodes are connected using a scalable node monitor applied through the Internet. Therefore, the suggested framework in theory does not increase the network traffic for debugging on WSNs, and the traffic complexity is nearly O(1).

• Advances in aircraft and spacecraft science
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• 제7권3호
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• pp.271-290
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• 2020

The paper describes the analysis of deployment strategies and trajectories design suitable for executing the inspection of an operative spacecraft in orbit through re-usable CubeSats. Similar missions have been though indeed, and one mission recently flew from the International Space Station. However, it is important to underline that the inspection of an operative spacecraft in orbit features some peculiar characteristics which have not been demonstrated by any mission flown to date. The most critical aspects of the CubeSat inspection mission stem from safety issues and technology availability in the following areas: trajectory design and motion control of the inspector relative to the target, communications architecture, deployment and retrieval of the inspector, and observation needs. The objectives of the present study are 1) the identification of requirements applicable to the deployment of a nanosatellite from the mother-craft, which is also the subject of the inspection, and 2) the identification of solutions for the trajectories to be flown along the mission phases. The mission for the in-situ observation of Space Rider is proposed as reference case, but the conclusions are applicable to other targets such as the ISS, and they might also be useful for missions targeted at debris inspection.