• Advances in Traditional Medicine
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• 제8권1호
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• pp.39-46
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• 2008

In the Indian traditional medicine, Lippia nodiflora (Verbenaceae) whole plant is claimed to possess powerful diuretic activity. However, the diuretic potential of this plant is not yet investigated. The aim of this study was to evaluate the diuretic potential of methanol extract of Lippia nodiflora (MELN) in rats. Control (0.9% saline solution, 25 ml/kg, b.w) or urea (1 g/kg b.w) or frusemide (5 mg/kg b.w) and different concentrations of MELN (200 and 400 mg/kg b.w) were intraperitoneally administered (n = 6 per each treatment group) to hydrated rats and their urine output was monitored over a period of 5 h and 24 h after drug administration. The diuretic responses with its electrolyte excretion potency of the extract were highly remarkable in comparison with control animals. The extract at doses of 200 and 400 mg/kg shows a significant increase in volume of urine with increase in $Na^{+}$, $Ca^{2+}$ and $Cl^{-}$ excretion accompanied by the excretion of $K^{+}$ in dose dependent manner. This study suggests that the active component(s) in MELN had similar diuretic effect to that of frusemide. These results validate the traditional use of Lippia nodiflora as a diuretic agent.

• Advances in Traditional Medicine
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• 제7권2호
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• pp.197-204
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• 2007

The present study focused on the establishment of micropropagation protocol for the high value Pluchea (P.) indica (L.) Less., genotype, an important medicinal plant and evaluation of the diuretic activity of the leaf extract of the tissue cultured plant. Leaf explants, nodal segments and shoot tips were cultured in MS medium supplemented with auxin and cytokinin and their combinations. With the objective of inducing callus giving rise to new adult plants, naphthalene acetic acid was found to be most effective for (80%) for callus induction. The methanolic extract of leaves of the micropropagated P. indica was investigated for its diuretic activity in Wistar albino rats. Urinary excretion parameters were studied for evaluation of diuretic activity using Frusemide (20 mg/kg, p.o.) as standard. The extract showed significant diuretic activity at the doses of 100, 200 and 300 mg/kg. p.o. An oral acute toxicity study for the extract was carried out and the $LD_{50}$ value was found to be 2,825 mg/kg body weight.

• Advances in Traditional Medicine
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• 제9권4호
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• pp.320-325
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• 2009

The pharmacological interest coupled with traditional uses (antidiarrhoeal, antiseptic, analgesic etc) prompted us to test for anti-inflammatory, antinociceptive and diuretic activitities of Trema (T.) orientalis Linn. The crude methanolic leaves extract of T. orientalis was investigated for its possible anti-inflammatory activities using carrageenin induced rat paw edema model and cotton pellet implantation method in mice. Then the extract analyzed for its antinociceptive activities by acetic acid induced writhing model in mice. The extract possessed significant anti-inflammatory activity in both models at the doses of 200 and 400 mg/kg body weight of mice. Moreover, the extract showed significantly reduced the number of acetic acid-induced abdominal constriction in mice of 200 and 400 mg/kg body weight. The extract also showed positive diuretic activity in albino mice.

• Natural Product Sciences
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• 제9권3호
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• pp.180-182
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• 2003

In the present study the whole plant of Ammania baccifera Linn was extracted with petroleum ether, chloroform, ethyl acetate and ethanol. The extracts were vacuum dried to yield the respective petroleum ether (PEE), chloroform (CE), ethyl acetate (EAE) and ethanol extracts (EE). PEE, CE, EAE and EE were evaluated for their antipyretic and diuretic activity at 200 mg/kg dose level. Significant antipyretic activity was associated with PEE, CE, EAE and EE. CE was found to exhibit higher antipyretic activity as paracetamol at 100 mg/kg dose level. Significant diuretic activity was exhibited by EAE, EE and PEE. The present study supports the claims of Ammania baccifera mentioned in the Indian system of medicine.

• Natural Product Sciences
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• 제8권3호
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• pp.97-99
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• 2002

In the present study, Pisonia grandis leaves were extracted with chloroform and methanol. The extracts were vacuum dried to yield the respective chloroform (CE) and methanol extract (ME). CE and ME were evaluated for analgesic, anti-inflammatory (acute and chronic) and diuretic activity at 2 dose levels (250 and 500 mg/kg). Significant analgesic and anti-inflammatory activities were associated with CE and ME. CE at the dose level of 500 mg/kg was found to exhibit equivalent chronic anti-inflammatory activity as diclofenac at 50 mg/kg dose level. Significant diuretic activity was exhibited by ME. Graded dose response for all the activities were observed for the extracts.

• Advances in Traditional Medicine
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• 제5권1호
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• pp.37-42
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• 2005

The crude methanolic extract of the leaves of Amoora cucullata Roxb. was investigated for its possible anti-inflammatory activity using carrageenin induced rat paw edema model and cotton pellet implantation method in rat. The extract was also studied for its antinociceptive activity using acetic acid induced writhing model in mice. At the doses of 200 and 400 mg/kg body weight, the extract showed significant anti-inflammatory activity in both models. At the same doses, the extract also significantly reduced the number of acetic acid-induced abdominal constriction (writhing) in mice. The crude extract also showed significant diuretic activity in albino mice.

• Natural Product Sciences
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• 제13권3호
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• pp.180-185
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• 2007

Dichrostachys cinerea (Linn.) is commonly known as Vadatalla and used as phytotherapeutic agent. Tender shoots of the plant bruised and applied to the eyes in case of ophthalmia. The root is astringent and used in rheumatism, urinary calculi and renal troubles. The effect of the Ethanolic and aqueous extract of the root of D. cinerea were studied for its anti-urolithiatic and diuretic activity at 200 mg/kg dose level in male Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Supplementation with aqueous and ethanolic extract of the plant significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. Compared to ethanolic extract, aqueous extract exhibited significant anti-urolithiatic activity. Both the extracts showed significant diuretic activity. The results of our present study supports folklore claim of D. cinerea.

• Natural Product Sciences
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• 제9권2호
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• pp.102-104
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• 2003

Aqueous and ethanolic extract of leaves of Canthium parviflorum were evaluated for wound healing and diuretic activities. Extract in the form of ointment is applied topically on excision wound in rats showed significant healing process as evidenced by increased rate of wound contraction as compared to control. The aqueous extract of 10% w/w ointment exhibited equivalent wound healing activity as Nitrofurazone oinment. Significant diuretic activity was exhibited by extracts. Graded dose response for both activities were observed for the extracts.

• 생약학회지
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• 제15권1호
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• pp.6-14
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• 1984

Pharmacological studies have been carried out with the methanol extract of the whole plant of Pseudostellaria palibiniana Ohwi (Caryophyllaceae). The results showed that it had stimulation effect on heart, hypotensive actions depending on extract contents, stimulation effect on respiration, contraction on excised intestines, enhancement of tension on excised uterus, antineoplastic activity on Ehrlich carcinoma, liver protective activity against $CCl_4$ intoxication, writhing and diuretic activities.

• 한국약용작물학회지
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• 제8권3호
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• pp.189-193
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• 2000

민간 약으로 사용되는 쇠비름의 물 추출물에 대하여 실험한 결과 간 효소 활성의 경우 $CCl_4$에 의하여 손상된 간에 대하여 간 질환 치료제인 silymarin 과 비교하여 s-GPT 치는 59.4%, s-GOT 치는 55.8% 의 개선효과가 있었으며, 이뇨활성의 경우는 최대일 때 이뇨제인 furosemide의 43.7%에 해당하는 이뇨 효과를 나타냈고, carrageenan에 의한 부종에 대하여는 항염제인 indomethacin의 61.8% 에 해당하는 부종억제 효과를 보여 쇠비름 전제(前劑)의 간질환 개선, 이뇨 및 항부종의 약용가치는 충분하다고 사료된다.