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A Clinical Database of Breast Cancer Patients Reveals Distinctive Clinico-pathological Characteristics: a Study From Central China

  • Wang, Lin-Wei;Yang, Gui-Fang;Chen, Jia-Mei;Yang, Fang;Yuan, Jing-Ping;Sun, Sheng-Rong;Chen, Chuang;Hu, Ming-Bai;Li, Yan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.4
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    • pp.1621-1626
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    • 2014
  • Background: Breast cancer is the most common malignant tumor in females worldwide. Many differences exist in clinico-pathological characteristics of breast cancer patients between China and Western countries. This study aimed to analyze clinico-pathological characteristics of breast cancer from central China. Methods: Clinico-pathological information on breast cancer from three hospitals in central China was collected and analyzed. Results: From 1994 to 2012, 2,525 patients with a median age 50 years were included in this study. The 45-49-year age group and invasive ductal carcinoma not otherwise specified accounted for the highest proportions (19.1%, 480/2,525 and 81.0%, 1,982/2,446). Stages 0-I, II and III accounted for 28.0% (682/2,441), 48.4% (1,180/2,441), and 23.7% (578/2,441), respectively. Distribution of N stage showed that N0 accounted for 53.2% (1,344/2,525), and proportion of N0 rose from 51.1% (157/307) in 30-39-year age group to 64.3% (110/171) in ${\geq}$ 70-year age group, with an average increase of 2.1% in each age group. Modified radical mastectomy, radical mastectomy, breast-conserving surgery and simple mastectomy were performed for 71.8% (1,812/2,525), 18.0% (454/2,525), 5.2% (131/2,525) and 2.6% (66/2,525), respectively. Proportions of breast-conserving surgery in age ${\leq}$ 44-year group (68/132, 51.5%) and simple mastectomy in age ${\geq}$ 60-year group (57/89, 64.0%) were higher than in the other age groups. Breast cancers positive for estrogen receptor accounted for 53.0% (1,107/ 2,112). The comparisons among this study and other reports showed higher proportion of younger patients, lower proportion of breast-conserving surgery and positive estrogen receptor patients in China than western countries. Conclusions: Clinico-pathological characteristics in this study demonstrated clear differences between the center of China than Western countries. Additional classification systems should be developed to guide grading of early breast cancer more accurately, especially for N0 patients. Invasive ductal carcinoma is a focus for intensive research.

Association of 8 Loci on Chromosome 8q24 with Prostate Carcinoma Risk in Northern Chinese Men

  • Zhao, Cheng-Xiao;Liu, Ming;Wang, Jian-Ye;Xu, Yong;Wei, Dong;Yang, Kuo;Yang, Ze
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6733-6738
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    • 2013
  • Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (PCa). As PCa risk SNPs may also influence disease outcome, we studied here eight 8q24 risk alleles, and evaluated their role in PCa clinical covariates in northern Chinese men. Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=289) and from age-matched normal controls (n=288). Eight 8q24 SNPs were genotyped by polymerase chain reaction-high- resolution melting analysis in 577 subjects. We examined the prevalence distribution of 8q24 risk alleles and analyzed the associations between the risk allele and PCa and clinical covariates to infer their impact on aggressive PCa. Three of the eight SNPs were associated with PCa risk in northern Chinese men, including rs16901966 (OR 1.31, 95% CI 1.01-1.70, p=0.042), rs1447295 (OR 1.47, 95% CI 1.09-1.98, p=0.011) and rs10090154 (OR 1.55, 95% CI 1.14-2.12, p=0.005). Haplotype analysis based association with the risk alleles revealed significant differences between cases and controls (OR 1.43, 95%CI 0.99-2.06, p=0.049). The risk alleles rs16901966, rs1447295 and rs10090154 were associated with age at diagnosis and tumor stage as compared with controls, while rs16901966 was associated with aggressive PCa (OR 1.43, 95% CI 1.01-2.03, p=0.042). The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates. The three SNPs at 8q24 could be PCa susceptible genetic markers in northern Chinese men.

Directions and Current Issues on the Policy of Prevention and Management for Hypertension and Diabetes, and Development of Chronic Disease Prevention and Management Model in Korea (우리나라 고혈압·당뇨병 예방관리사업 정책 동향과 분석 그리고 한국형 만성질환 예방관리 모형)

  • Lee, Moo-Sik;Lee, Kyeong-Soo;Lee, Jung-Jeung;Hwang, Tae-Yoon;Lee, Jin-Yong;Yoo, Weon-Seob;Kim, Keon-Yeop;Kim, Sang-Kyu;Kim, Jong-Yeon;Park, Ki-Soo;Hwang, Bo-Young
    • Journal of agricultural medicine and community health
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    • v.45 no.1
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    • pp.13-40
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    • 2020
  • Objectives: The purpose of this manuscript was to propose the policy and perspectives of prevention and management for hypertension and diabetes in Korea. Methods: Authors reviewed the chronic disease prevention and management projects and models were executed in Korea until now, and analyzed and evaluated their performances. Results: In the circumstances of Korea, the following several requisites should be improved ; Specific Korean strategy for development and pursuing of national level policy agenda for chronic disease management must be established. There are a need to establish several means of supplementing the weaknesses of the current chronic disease management policies and programs. Firstly, development and distribution of contents of guidelines on the systematic project execution regime (regarding systematization of local community, subjects and contents of the projects) with guarantee for the quality of chronic disease prevention and management are necessary. Secondly, there is a need for development of information system that can lead the chronic disease management programs currently being implemented. Thirdly, there is urgent need to develop resources such as cultivation of manpower and facilities for provision of education and consultation for the patients and holders of risk factors of chronic disease. Fourthly, there is a need for means of securing management system and financial resources for operation of policies and programs. Conclusions: The results can be able to use as a road map, models, and direction and strategies of policies for chronic disease prevention and management of Korea.

Application of IHS Transform Method for Understanding of Groundwater Resources Distribution in the Haenam area (해남지역 지하수 부존 분포 파악을 위한 IHS 변환 적용)

  • 김승태;이기원;유인걸;송무영
    • Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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    • 2003.04a
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    • pp.51-55
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    • 2003
  • 본 연구는 조사대상지역인 전라남도 해남군 전역에 대해 현장조사된 지질 및 지하수 양수량 자료등과 같은 수리정보를 종합적으로 분석하고 이를 Landsat 영상자료과의 영상융합 과정을 통해 지하수 부존가능성에 대한 수리 지질 지표정보로 추출함으로서 지하수 특성정보를 위성영상정보와 연계하여 효과적으로 도시하고자 하였다. 현장조사시 획득된 자료는 해남지역을 11개 소유역으로 구분한 후 각 구역에 대한 2000여개 관점에서 측정된 양수량과 안정지하수위를 이용하여 산출한 비용출량 자료(groundwater specific capacity)와 각 소 유역 (unit watershed)에 대한 선구조 분석자료, 지질별 분포, 정밀고도자료를 추출하여 산출한 고도, 경사도 분포, 수계패턴과 수계밀도로서 이를 통합적으로 분석하여 해남지역에 대한 지하수 특성을 파악하고자 하였다. 위성영상자료의 처리과정은 Landsat 5 TM 영상자료는 '86. 12. 11 및 '98. 12. 28에 촬영된 WRS(World Reference System) Row-Path116-36로서, 1986년 영상은 12년 차이의 해남의 변화지역을 탐지하기 위한 영상자료로서 활용하였으며 98년 영상을 주요 분석 자료로 이용하였으며 지표 이용정보 추출은 크게 수역추출, 식생분포추출, 지표분류도, 변화탐지영역추출로 구분된다. 본 연구방법은 크게 위성영상분석을 통해 추출된 정보와 지표조사를 통해 획득된 선구조 및 지하수 정보를 Data fusion 방식으로 이용되고 있는 IHS 변환 기법을 통해 본 역에 대한 지하수 정보 및 간척지 등에 의한 지표 개발에 따른 지하수 부존 가능성을 탐색하기 위한 현황을 효과적인 자료로 표현하고자 하였다.및 스페클 잡영 제거 정도에 있어 다른 필터들과 큰 차이가 없지만 경계선보존지수는 다른 필터들에 비하여 가장 우수함을 확인할 수 있었다.rbon 탐식효율을 조사한 결과 B, D 및 E 분획에서 유의적인 효과를 나타내었다. 이상의 결과를 종합해볼 때, ${\beta}$-glucan은 고용량일 때 직접적으로 또는 $IFN-{\gamma}$ 존재시에는 저용량에서도 복강 큰 포식세로를 활성화시킬 뿐 아니라, 탐식효율도 높임으로써 면역기능을 증진 시키는 것으로 나타났고, 그 효과는 crude ${\beta}$-glucan의 추출조건에 따라 달라지는 것을 알 수 있었다.eveloped. Design concepts and control methods of a new crane will be introduced in this paper.and momentum balance was applied to the fluid field of bundle. while the movement of′ individual material was taken into account. The constitutive model relating the surface force and the deformation of bundle was introduced by considering a representative prodedure that stands for the bundle movement. Then a fundamental equations system could be simplified considering a steady state of the process. On th

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GCP Data Acquisition using Image Chip (영상 CHIP을 이용한 지상기준점 정보취득)

  • 손홍규;이재원;허민;김기홍;이준명
    • Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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    • 2003.04a
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    • pp.349-353
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    • 2003
  • 최근 관심이 증대되고 있는 국토모니터링과 관련하여 기존의 SPOT, IRS, KOMPSAT, LANDSAT 등의 중ㆍ저해상도 위성영상과 IKONOS 등의 고해상도 위성영상을 이용하여 국토의 변화를 탐지하고자 하는 시도가 활발히 진행되고 있다. 이 때 영상의 기하보정은 필수적인 과정이며 영상의 기하보정시 기준점을 취득하는 과정에 많은 시간과 작업비용이 소요된다. 현재 기준점 취득은 수치지도 등을 통해 기존의 지상기준점을 이용하는 방법과 GPS를 이용한 현지 측량방법이 활용되고 있는데 동일지역에 대해 매번 사업 때마다 수행되고 있는 실정이다. 따라서 이러한 과정을 보다 효율적으로 수행하기 위한 하나의 방안으로 본 연구에서는 image chip을 이용하여 GCP를 취득하고 이를 데이터베이스로 구축하여 기존의 작업을 자동화, 체계화하고자 하였다. 이를 통하여 중복측량 방지와 데이터의 균질성을 기할 수 있었다. Image Chip의 영상 정합을 위해서는 상관계수법과 최소제곱정합법을 이용하여 부영상소 단위까지 정합결과를 얻을 수 있었으며 위성의 header 정보로부터의 영상의 표정각과 입사각에 대한 정보를 이용하여 축척과 회전요소를 고려함으로써 영상 정합시 보다 정확한 기준점 정보를 취득할 수 있었다. 또한, 이종 센서간 영상정합 가능성에 대해서 연구한 결과 KOMPSAT과 SPOT간에는 신뢰할 만한 수준의 정합 결과를 얻을 수 있었으나 고해상도 영상의 경우에는 항공사진과 IKONOS의 영상 정합시 센서의 방사학적 특성의 차이로 신뢰할 안한 결과를 얻을 수 없었다. 영상 정합시 정확도에 영향을 미치는 인자들에 관한 실험 결과 센서의 파장, 계절, Chip 영상의 크기 등이 큰 영향을 미쳤으며 영상정합을 위해 영상 GCP를 데이터베이스에서 검색할 때 이에 대한 고려가 우선적으로 이루어져야 할 것으로 사료된다.n of hub-and-spoke system, integration of logistics bases, introduction of (automatic) parking building, diversification of transportation mode, and etc. At the same time, we constructed three practically executable scenarios based on those ideas. The first is "Center Hub" scenario, the second is "Metropolitan Hub" scenario. The third and last scenario is "Regional Consolidation of Warehouses (distribution centers)".f worldly desire' and 'cordiality' that one could be deserved his diligency becoming a part of the harmonious idealistic living place. Fourthly, on the character of story teller. Originally he is a incomer of "Gang-Ho" from real world. so that reason, he is showing dualism not to deny the loyalty oath to his king, while he intends to satisfy with the life in "Gang- Ho" separating himself from real world. As a gentry, at that time, the loyalty oath is inevitable one and that is found from wr

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Performance of a Hybrid DS/SFH Spread Spectrum System over Nakagami Fading Channel in the Presence of Multiple Tone Jamming (다중 톤 방해신호가 존재하는 나카가미 페이딩 전송로에서 DS/SFH 복합 확산대역 시스템의 성능분석)

  • Byun, Woo-Sub;Sung, Koeng-Mo
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.36S no.8
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    • pp.8-16
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    • 1999
  • In this paper, the performance of a hybrid DS/SFH-SS(direct-sequence/slow-frequency-hopped spread-spectrum) system with coherent BPSK modulation over Nakagami fading channel in the presence of multiple tone jamming is analyzed. Because the Nakagami m-distribution can describe not only Rayleigh fading but also more general fluctuations involving a specular component by adjusting the value of the fading index m. It is known that for m=1 corresponds to Rayleigh fading, for $1/2{\le}m{\le}1$ corresponds to the worst case fading condition, for m>1 corresponds to Rician fading, and for $m{\to}{\infty}$ corresponds to the nonfading condition. The bit error probability is derived over Nakagami model and numerical evaluations are presented for some combinations of system parameters. The results show that as m increases, the bit error probability is better. Also, at a low JSR(jamming-to-signal power ratio), a pure DS-SS system can achieve lower bit error probability than a hybrid DS/SFH-SS system. But at a high JSR, a hybrid DS/SFH-SS system is shown to be superior to a pure DS-SS system. Therefore, it is demonstrated that without increasing the total system bandwidth, the performance of a hybrid DS/SFH-SS is superior to that of a pure DS-SS system in the presence of multiple tone jamming.

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A Study of the Actual Condition for Inducing Container Cargos to Gunsan Port (군산항 컨테이너화물 유치를 위한 실태조사연구)

  • Song, Yong-Zong;Park, Hyoung-Chang;Kim, Myoung-Ryong
    • Journal of Korea Port Economic Association
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    • v.23 no.4
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    • pp.71-90
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    • 2007
  • To induce container cargos to Gunsan port, we should struggle on securing the quantity of goods transported from the competitive Jeonbuk and Chungcheong areas by reducing transportation expenses by land, and make an activating plan for the international exchange between Gunsan port and nearby ports in China. As a result, if the plan to induce container cargos to Gunsan port is activated, the regular liners will stop at Gusan port. So the new sea route will be opened so that consignors can ship cargos in the proper time. The consignors will use Gunsan port frequently because of the reduction of distribution expenses. To do so, for the first, many incentives should be implemented to attract container cargos. In addition, various facilities should be fully equipped and improved. This paper is to improve the problems for which consignors, the shipping lines and forwarders may feel uncomfortable when they use Gunsan port. According to the research on the actual condition, the biggest problem in Gunsan port is the depth of water. The management, relation system, infrastructure and information system of Gunsan port are also insufficient. Therefore, this paper will make an alternative plan to improve these problems and help the container cargos induce to Gunsan port.

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Estimation of BDI Volatility: Leverage GARCH Models (BDI의 변동성 추정: 레버리지 GARCH 모형을 중심으로)

  • Mo, Soo-Won;Lee, Kwang-Bae
    • Journal of Korea Port Economic Association
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    • v.30 no.3
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    • pp.1-14
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    • 2014
  • This paper aims at measuring how new information is incorporated into volatility estimates. Various GARCH models are compared and estimated with daily BDI(Baltic Dry Index) data. While most researchers agree that volatility is predictable, they differ on how this volatility predictability should be modelled. This study, hence, introduces the asymmetric or leverage volatility models, in which good news and bad news have different predictability for future. We provide the systematic comparison of volatility models focusing on the asymmetric effect of news on volatility. Specifically, three diagnostic tests are provided: the sign bias test, the negative size bias test, and the positive size bias test. From the Ljung-Box test statistic for twelfth-order serial correlation for the level we do not find any significant serial correlation in the unpredictable BDI. The coefficients of skewness and kurtosis both indicate that the unpredictable BDI has a distribution which is skewed to the left and significantly flat tailed. Furthermore, the Ljung-Box test statistic for twelfth-order serial correlations in the squares strongly suggests the presence of time-varying volatility. The sign bias test, the negative size bias test, and the positive size bias test strongly indicate that large positive(negative) BDI shocks cause more volatility than small ones. This paper, also, shows that three leverage models have problems in capturing the correct impact of news on volatility and that negative shocks do not cause higher volatility than positive shocks. Specifically, the GARCH model successfully reveals the shape of the news impact curve and is a useful approach to modeling conditional heteroscedasticity of daily BDI.

The Dynamic Group Authentication for P2P based Mobile Commerce (P2P 기반의 모바일 상거래를 위한 동적 그룹 인증)

  • Yun, Sunghyun
    • Journal of Digital Convergence
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    • v.12 no.2
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    • pp.335-341
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    • 2014
  • To play the networked video contents in a client's mobile device in real time, the contents should be delivered to it by the contents server with streaming technology. Generally, in a server-client based commerce model, the server is in charge of both the authentication of the paid customer and distribution of the contents. The drawback of it is that if the customers' requests go on growing rapidly, the service quality would be degraded results from the problems of overloaded server or restricted network bandwidth. On the contrary, in P2P based networks, more and more the demand for service increasing, the service quality is upgraded since a customer can act as a server. But, in the P2P based network, there are too many servers to manage, it's possible to distribute illegal contents because the P2P protocol cannot control distributed servers. Thus, it's not suitable for commercial purposes. In this paper, the dymanic group authentication scheme is proposed which is suited to P2P based applications. The proposed scheme consists of group based key generation, key update, signature generation and verification protocols. It can control the seeder's state whether the seeder is joining or leaving the network, and it can be applied to hybrid P2P based commerce model where sales transactions are covered by the index server and the contents are distributed by the P2P protocol.

Potential for Application of Microhistological Analysis in Diet Plants of Korean Water Deer($Hydropotes$ $inermis$) (한국에 서식하는 고라니($Hydropotes$ $inermis$) 먹이식물의 미세조직분석법 적용 가능성 연구)

  • Kim, Eui-Kyeong;Park, Yung-Chul;Kim, Won-Myeong;Kim, Jong-Kuk
    • Korean Journal of Environment and Ecology
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    • v.26 no.2
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    • pp.192-199
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    • 2012
  • This study was to evaluate the application of microhistological analysis to collect information on food materials of korean water deer from september to October 2006. For microhistological analysis we extracted type-materials of 4 plant species ($Ipomoea$ $batatas$, $Rubus$ $coreanus$, $Glycine$ $max$, and $Pueraria$ $thunbergiana$) from fecal pellets of korean water deer ($Hydropotes$ $inermis$) and then made preparations of the fecal materials for microscopic analysis. The fecal preparations were compared with reference preparation under the microscope. In microscopic analysis of fecal preparations, we could identify the four plant species by the followings: tip shape and morphology of trichomes, epidermal cell, morphological composition and shape of stomatal apparatus, arrangement of long-cell, and distribution of crystals in cells. According to the comparisons of the preparations, the morphology of trichome, epidermal cell and stomata are similar between both preparations of the fecal pellets and the references, respectively. This methodology will contribute to understanding feeding behavior and behavioural ecology by climate change of other hervibores as well as korean water deers.