Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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A Clinical Database of Breast Cancer Patients Reveals Distinctive Clinico-pathological Characteristics: a Study From Central China

  • Wang, Lin-Wei (Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center) ;
  • Yang, Gui-Fang (Department of Pathology, Zhongnan Hospital of Wuhan University) ;
  • Chen, Jia-Mei (Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center) ;
  • Yang, Fang (Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center) ;
  • Yuan, Jing-Ping (Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center) ;
  • Sun, Sheng-Rong (Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University) ;
  • Chen, Chuang (Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University) ;
  • Hu, Ming-Bai (Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center) ;
  • Li, Yan (Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center)
  • Published : 2014.02.28
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Abstract

Background: Breast cancer is the most common malignant tumor in females worldwide. Many differences exist in clinico-pathological characteristics of breast cancer patients between China and Western countries. This study aimed to analyze clinico-pathological characteristics of breast cancer from central China. Methods: Clinico-pathological information on breast cancer from three hospitals in central China was collected and analyzed. Results: From 1994 to 2012, 2,525 patients with a median age 50 years were included in this study. The 45-49-year age group and invasive ductal carcinoma not otherwise specified accounted for the highest proportions (19.1%, 480/2,525 and 81.0%, 1,982/2,446). Stages 0-I, II and III accounted for 28.0% (682/2,441), 48.4% (1,180/2,441), and 23.7% (578/2,441), respectively. Distribution of N stage showed that N0 accounted for 53.2% (1,344/2,525), and proportion of N0 rose from 51.1% (157/307) in 30-39-year age group to 64.3% (110/171) in ${\geq}$ 70-year age group, with an average increase of 2.1% in each age group. Modified radical mastectomy, radical mastectomy, breast-conserving surgery and simple mastectomy were performed for 71.8% (1,812/2,525), 18.0% (454/2,525), 5.2% (131/2,525) and 2.6% (66/2,525), respectively. Proportions of breast-conserving surgery in age ${\leq}$ 44-year group (68/132, 51.5%) and simple mastectomy in age ${\geq}$ 60-year group (57/89, 64.0%) were higher than in the other age groups. Breast cancers positive for estrogen receptor accounted for 53.0% (1,107/ 2,112). The comparisons among this study and other reports showed higher proportion of younger patients, lower proportion of breast-conserving surgery and positive estrogen receptor patients in China than western countries. Conclusions: Clinico-pathological characteristics in this study demonstrated clear differences between the center of China than Western countries. Additional classification systems should be developed to guide grading of early breast cancer more accurately, especially for N0 patients. Invasive ductal carcinoma is a focus for intensive research.

Keywords

References

  1. Abrams JS, Phillips PH, Friedman MA (1995). Meeting highlights: a reappraisal of research results for the local treatment of early stage breast cancer. J Natl Cancer Inst, 87, 1837-45. https://doi.org/10.1093/jnci/87.24.1837
  2. Afsharfard A, Mozaffar M, Orang E, Tahmasbpour E (2013). Trends in epidemiology, clinical and histopathological characteristics of breast cancer in Iran: results of a 17 year study. Asian Pac J Cancer Prev, 14, 6905-11. https://doi.org/10.7314/APJCP.2013.14.11.6905
  3. Al-Hashimi MM, Wang XJ (2014). Breast cancer in Iraq, incidence trends from 2000-2009. Asian Pac J Cancer Prev, 15, 281-6. https://doi.org/10.7314/APJCP.2014.15.1.281
  4. Anderson WF, Pfeiffer RM, Dores GM, Sherman ME (2006). Comparison of age distribution patterns for different histopathologic types of breast carcinoma. Cancer Epidemiol Biomarkers Prev, 15, 1899-905. https://doi.org/10.1158/1055-9965.EPI-06-0191
  5. Bao PP, Shu XO, Gao YT, et al (2011). Association of hormonerelated characteristics and breast cancer risk by estrogen receptor/progesterone receptor status in the Shanghai breast cancer study. Am J Epidemiol, 174, 661-71. https://doi.org/10.1093/aje/kwr145
  6. Bigaard J, Stahlberg C, Jensen MB, Ewertz M, Kroman N (2012). Breast cancer incidence by estrogen receptor status in Denmark from 1996 to 2007. Breast Cancer Res Treat, 136, 559-64. https://doi.org/10.1007/s10549-012-2269-0
  7. Brouckaert O, Schoneveld A, Truyers C, et al (2013). Breast cancer phenotype, nodal status and palpability may be useful in the detection of overdiagnosed screening-detected breast cancers. Ann Oncol, 24, 1847-52. https://doi.org/10.1093/annonc/mdt179
  8. Cronin KA, Ravdin PM, Edwards BK (2009). Sustained lower rates of breast cancer in the United States. Breast Cancer Res Treat, 117, 223-4. https://doi.org/10.1007/s10549-008-0226-8
  9. Desantis C, Ma J, Bryan L, Jemal A (2013). Breast cancer statistics, 2013. CA Cancer J Clin, 64, 52-62.
  10. Edge SB, Byrd DR, Compton CC, Et A (2010). AJCC Cancer Staging Manual (ed 7). New York.
  11. Fan L, Zheng Y, Yu KD, et al (2009). Breast cancer in a transitional society over 18 years: trends and present status in Shanghai, China. Breast Cancer Res Treat, 117, 409-16. https://doi.org/10.1007/s10549-008-0303-z
  12. Forouzanfar MH, Foreman KJ, Delossantos AM, et al (2011). Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet, 378, 1461-84. https://doi.org/10.1016/S0140-6736(11)61351-2
  13. Fritz P, Klenk S, Goletz S, et al (2010). Clinical impacts of histological subtyping primary breast cancer. Anticancer Res, 30, 5137-44.
  14. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  15. Ko BS, Noh WC, Kang SS, et al (2012). Changing patterns in the clinical characteristics of korean breast cancer from 1996- 2010 using an online nationwide breast cancer database. J Breast Cancer, 15, 393-400. https://doi.org/10.4048/jbc.2012.15.4.393
  16. Kumar P, Mukherjee M, Johnson JP, et al (2012). Cooperativity of Rb, Brca1, and p53 in malignant breast cancer evolution. PLoS Genet, 8, e1003027. https://doi.org/10.1371/journal.pgen.1003027
  17. Kwong A, Mang OW, Wong CH, et al (2011). Breast cancer in Hong Kong, Southern China: the first population-based analysis of epidemiological characteristics, stage-specific, cancer-specific, and disease-free survival in breast cancer patients: 1997-2001. Ann Surg Oncol, 18, 3072-8. https://doi.org/10.1245/s10434-011-1960-4
  18. Lakhani SR, Ellis IO, Schnitt SJ, Et A (2012). WHO classification of tumours of the breast. World Health Organization classification of tumours, 4th ed. Lyon: IARC Press.
  19. Leong SP, Shen ZZ, Liu TJ, et al (2010). Is breast cancer the same disease in Asian and Western countries? World J Surg, 34, 2308-24. https://doi.org/10.1007/s00268-010-0683-1
  20. Newman LA (2004). Locoregional control of breast cancer: surgical technique does matter. Ann Surg Oncol, 11, 11-3. https://doi.org/10.1007/BF02524339
  21. Pan L, Han LL, Tao LX, et al (2013). Clinical risk factor analysis for breast cancer: 568,000 subjects undergoing breast cancer screening in Beijing, 2009. Asian Pac J Cancer Prev, 14, 5325-9. https://doi.org/10.7314/APJCP.2013.14.9.5325
  22. Piscitelli P, Barba M, Crespi M, et al (2012). The burden of breast cancer in Italy: mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge records. J Exp Clin Cancer Res, 31, 96. https://doi.org/10.1186/1756-9966-31-96
  23. Shin HR, Joubert C, Boniol M, et al (2010). Recent trends and patterns in breast cancer incidence among Eastern and Southeastern Asian women. Cancer Causes Control, 21, 1777-85. https://doi.org/10.1007/s10552-010-9604-8
  24. Turashvili G, McKinney SE, Goktepe O, et al (2011). P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer. Mod Pathol, 24, 64-81. https://doi.org/10.1038/modpathol.2010.189
  25. Wang LW, Qu AP, Yuan JP, et al (2013). Computer-based image studies on tumor nests mathematical features of breast cancer and their clinical prognostic value. PLoS One, 8, e82314. https://doi.org/10.1371/journal.pone.0082314
  26. Wei R, Lau SS, Cheung PS (2010). Breast carcinoma in Chinese women: does age affect treatment choice and outcome? Asian J Surg, 33, 97-102. https://doi.org/10.1016/S1015-9584(10)60017-6
  27. Yu KD, Di GH, Wu J, et al (2007). Development and trends of surgical modalities for breast cancer in China: a review of 16-year data. Ann Surg Oncol, 14, 2502-9. https://doi.org/10.1245/s10434-007-9436-2
  28. Zarbo RJ, Hammond ME (2003). Conference summary, Strategic Science symposium. Her-2/neu testing of breast cancer patients in clinical practice. Arch Pathol Lab Med, 127, 549-53.
  29. Zhang B, Song Q, Zhang B, et al (2013). A 10-year (1999 - 2008) retrospective multi-center study of breast cancer surgical management in various geographic areas of China. Breast, 22, 676-81. https://doi.org/10.1016/j.breast.2013.01.004
  30. Zhang L, Jiang M, Zhou Y, et al (2012). Survey on breast cancer patients in China toward breast-conserving surgery. Psychooncology, 21, 488-95. https://doi.org/10.1002/pon.1922
  31. Zheng S, Bai JQ, Li J, et al (2012). The pathologic characteristics of breast cancer in China and its shift during 1999-2008: a national-wide multicenter cross-sectional image over 10 years. Int J Cancer, 131, 2622-31. https://doi.org/10.1002/ijc.27513

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