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A feasibility study evaluating the relationship between dose and focal liver reaction in stereotactic ablative radiotherapy for liver cancer based on intensity change of Gd-EOB-DTPA-enhanced magnetic resonance images

  • Jung, Sang Hoon;Yu, Jeong Il;Park, Hee Chul;Lim, Do Hoon;Han, Youngyih
    • Radiation Oncology Journal
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    • v.34 no.1
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    • pp.64-75
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    • 2016
  • Purpose: In order to evaluate the relationship between the dose to the liver parenchyma and focal liver reaction (FLR) after stereotactic ablative body radiotherapy (SABR), we suggest a novel method using a three-dimensional dose distribution and change in signal intensity of gadoxetate disodium-gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) hepatobiliary phase images. Materials and Methods: In our method, change of the signal intensity between the pretreatment and follow-up hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was calculated and then threshold dose (TD) for developing FLR was obtained from correlation of dose with the change of the signal intensity. For validation of the method, TDs for six patients, who had been treated for liver cancer with SABR with 45-60 Gy in 3 fractions, were calculated using the method, and we evaluated concordance between volume enclosed by isodose of TD by the method and volume identified as FLR by a physician. Results: The dose to normal liver was correlated with change in signal intensity between pretreatment and follow-up MRI with a median $R^2$ of 0.935 (range, 0.748 to 0.985). The median TD by the method was 23.5 Gy (range, 18.3 to 39.4 Gy). The median value of concordance was 84.5% (range, 44.7% to 95.9%). Conclusion: Our method is capable of providing a quantitative evaluation of the relationship between dose and intensity changes on follow-up MRI, as well as determining individual TD for developing FLR. We expect our method to provide better information about the individual relationship between dose and FLR in radiotherapy for liver cancer.

Assessment of Selective Withdrawal Facility in the Imha Reservoir Using CE-QUAL-W2 Model (CE-QUAL-W2 모델을 이용한 임하호 선택배제시설의 효과분석)

  • Lee, Sanguk;Kim, Jeongkon;Noh, Joonwoo;Ko, Ick Hwan
    • Journal of Korean Society on Water Environment
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    • v.23 no.2
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    • pp.228-235
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    • 2007
  • For efficient turbid water withdrawal in the Imha reservoir, a selective withdrawal facility was recently installed and operated during summer season of year 2006. In this research, CE-QUAL-W2 model was utilized to assess the efficiency of the selective withdrawal facility, in comparison with the original surface withdrawal, on turbid water management. Model calibration was carried out using data observed at four automatic monitoring stations in the reservoir. It was found that the model appropriately simulated, with the RMSE less than 5.2 NTU, the observed vertical and horizontal distributions of water temperature and turbidity as well as the location of maximum turbid water at each monitoring station. The analysis results showed that selective withdrawal is more effective in removing high turbid water than surface withdrawal as selective withdrawal contributed to reducing $35Mm^3$ of high turbidity water (> 100 NTU) in the reservoir by increasing outflows of high turbid water. Therefore, effective management of turbid water in the reservoir can be achieved by changing locations of intake depending on turbid water distribution conditions. The results of this study will provide some basic information for establishing better operation strategies to cope with turbid water problems.

Analysis of Hydrodynamic Separators for Combined Sewer Overflows and Stromwater Runoff Control (합류식 하수관거 월류수 및 우수관거 유출수의 수리동력학적 오염부하저감장치의 분석)

  • Lee, Soo Young;Oh, Ji Hyun;Ryu, Seong Ho;Kwon, Bong Ki;Chung, Tai Hak
    • Journal of Korean Society of Water and Wastewater
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    • v.19 no.2
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    • pp.117-124
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    • 2005
  • Appropriate removal of pollutants from combined sewer overflows(CSOs) and stormwater runoff is of primary concern to watershed managers trying to meet water quality standards even under a wet weather condition. Harmful substances associated with particles besides TSS and BOD are subjected to removal prior to discharge into the natural waters. Effectiveness of five major hydrodynamic separation technologies, Vortechs, Downstream Defender including Storm King for CSOs control, CDS, Stormceptor, and IHS, were evaluated in this study. There is not sufficient information for accurate evaluation of the removal efficiency for the pollutants from the stormwater runoff and CSOs. Based upon limited engineering data, however, all technologies were found to be effective in separation of heavy particles and floating solids. Technologies utilizing screens seem to have advantage in the treatment capacity than the other technologies relied fully on hydrodynamic behavior. The IHS system seems to have a strong potential in application for control of CSOs because of unique hydrodynamic behavior as well as a flexibility in opening size of the screens. Size of the particulate matter in the CSOs and stormwater runoff is found to be the most important parameter in selection of the type of the hydrodynamic separators. There exists an upper limit in the solids removal efficiency of a hydrodynamic separator, which is strongly dependent upon the particle size distribution of the CSOs and stormwater runoff.

Chewing Lice of Swan Geese (Anser cygnoides): New Host-Parasite Associations

  • Choi, Chang-Yong;Takekawa, John Y.;Prosser, Diann J.;Smith, Lacy M.;Ely, Craig R.;Fox, Anthony D.;Cao, Lei;Wang, Xin;Batbayar, Nyambayar;Natsagdorj, Tseveenmayadag;Xiao, Xiangming
    • Parasites, Hosts and Diseases
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    • v.54 no.5
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    • pp.685-691
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    • 2016
  • Chewing lice (Phthiraptera) that parasitize the globally threatened swan goose Anser cygnoides have been long recognized since the early 19th century, but those records were probably biased towards sampling of captive or domestic geese due to the small population size and limited distribution of its wild hosts. To better understand the lice species parasitizing swan geese that are endemic to East Asia, we collected chewing lice from 14 wild geese caught at 3 lakes in northeastern Mongolia. The lice were morphologically identified as 16 Trinoton anserinum (Fabricius, 1805), 11 Ornithobius domesticus Arnold, 2005, and 1 Anaticola anseris (Linnaeus, 1758). These species are known from other geese and swans, but all of them were new to the swan goose. This result also indicates no overlap in lice species between older records and our findings from wild birds. Thus, ectoparasites collected from domestic or captive animals may provide biased information on the occurrence, prevalence, host selection, and host-ectoparasite interactions from those on wild hosts.

Effects of Hospital-based Home Care Demonstration Project on Physical and Emotional Problems and Cost - effectiveness of Patients having Arthritis (병원중심 가정간호 사업의 평가 연구 -외래 관절염 환자를 대상으로 -)

  • Lim, Nan-Young;Kim, Seong-Yoon;Lee, Eun-Ok;Lee, In-Sook
    • Journal of muscle and joint health
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    • v.3 no.1
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    • pp.4-22
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    • 1996
  • Purposes of this study were to identify a hospital-based home care model and to improve the physical, emotional and economical effectiveness of arthritic patients through medical and nursing team approach. The design in nonequivalent control group pretest-posttest design with matched samples in terms of age, sex and disease severity. Fifty two patients in each group were assigned in Seoul, Kyunggi, Kangwon and Kwangju. Before and after 6-month period of home care, level of pain, duration of morning stiffness, Richie Index, ADL, self efficacy, depression, cost expenditure were measured. Nine patients were excluded from the control group in the period of study because of denial of participation. Contents of home care provided to the experimental group include mainly distribution of prescribed drugs, 'assessment of patients' condition and side-reactions of drug. All of the information related to the home care patient were reported to the physician. On the bases of these data, the physician prescribe the specific drugs to each patient. Each patient visited the physician every 2 or 3 month for laboratory test. Patients assigned to the control group visited the outpatient clinic once a month as usual. Null hypotheses were selected because physicians concerned about the ineffective change of patients' conditions due to indirect communication with patients through nurses. Level of pain, Richie index, ADL, self-efficacy, depression, duration of morning stiffness and direct medical cost were the home care provided to them. If a family member accompany in a home care group can save 10,676 Won/month in Seoul, 34,000 Won/month in other districts. Other in-direct cost for transportation and meal can also be saved. In conclusion, those patients with low level of ADL, high level of pain and Richie index, living in the remote area definitely need the home care.

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Method Discrimination for Product Traceability and Identification of Korean Native Chicken using Microsatellite DNA (초위성체를 이용한 한국 재래닭의 원산지 추적 및 개체 식별 방법에 관한 연구)

  • Park, Mi-Hyun;Oh, Jae-Don;Jeon, Gwang-Joo;Kong, Hong-Sik;Sang, Byong-Don;Choi, Chull-Hwan;Yeon, Sung-Hum;Cho, Byong-Wok;Lee, Hak-Kyu
    • Korean Journal of Organic Agriculture
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    • v.12 no.4
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    • pp.451-461
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    • 2004
  • In an animals, identification system has been widely used by ear tag with dummy code and blood typing for parernity. Also, genotyping methods were using for useful mean of individual identification for live animals. In the case of genotyping estimation of gene in population of korean native chicken. In this study, we tested for development of genetic markers used it possible to determination of individual identification system. The candidate genetic markers were used already bow 10 of microstalite DNA sequence information in chromosome No. 1 and 14. Result of analysis for genotyping, the number of alleles of those microstatelites DNA was shown minimal 3 to 12 and the heterozygote expression frequency range was shown from 0.617 to 0.862. In our result, effective number of allele for each microsatellites DNA was shown 3~7, and the accuracy of individual identification was shown nearly 100%, when used with 6 genetic marker. This study was about genotyping method for identification used specific genetic marker form microsatellite DNA in the brand marketing of korean native chicken. Our results suggest that genotyping method used specific genetic marker from microsatellite DNA might be very useful for determination of individual identification.

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Kerogen Facies of the Cretaceous Black Shales from the Angola Basin (DSDP Site 530), South Atlantic (앙골라분지 백악기 흑색셰일의 유기물상)

  • 박영수
    • 한국해양학회지
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    • v.22 no.2
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    • pp.87-104
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    • 1987
  • The middle Cretaceous stratigraphec section of Deep Sea Drilling Project (DSDP) Site 530 in the Angola Basin is characterized by cyclic interbeds of organic-carbon-rich black shales and organic-carbon-poor red and green claystones, namely the black shale sequence. A number of samples from the black shale sequence were analyzed for the typesand distribution of insoluble sedimentary organic matter(kerogen) in order to give more information on the depositional conditions of the black shales in the Angola Basin. The dominant type of kerogen in the black shale sequence at Site 530 is amorphous organic matter mainly of marine planktonic algal origin. It probably consists of remains of some unfossiliqed dinoflagellates. The cyclic preservation of organic-carbon-rich black shales in the Angola Basin during the mid-Cretaceous could be explained by the low dissolved-oxygen concentration in the warm, saline deep and bottom waters combined with the sluggish circulation within the highly restricted basin, and the periodic high productivity in the surface waters.

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A Study on Improvement of Face Recognition Rate with Transformation of Various Facial Poses and Expressions (얼굴의 다양한 포즈 및 표정의 변환에 따른 얼굴 인식률 향상에 관한 연구)

  • Choi Jae-Young;Whangbo Taeg-Keun;Kim Nak-Bin
    • Journal of Internet Computing and Services
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    • v.5 no.6
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    • pp.79-91
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    • 2004
  • Various facial pose detection and recognition has been a difficult problem. The problem is due to the fact that the distribution of various poses in a feature space is mere dispersed and more complicated than that of frontal faces, This thesis proposes a robust pose-expression-invariant face recognition method in order to overcome insufficiency of the existing face recognition system. First, we apply the TSL color model for detecting facial region and estimate the direction of face using facial features. The estimated pose vector is decomposed into X-V-Z axes, Second, the input face is mapped by deformable template using this vectors and 3D CANDIDE face model. Final. the mapped face is transformed to frontal face which appropriates for face recognition by the estimated pose vector. Through the experiments, we come to validate the application of face detection model and the method for estimating facial poses, Moreover, the tests show that recognition rate is greatly boosted through the normalization of the poses and expressions.

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The Modified Block Matching Algorithm for a Hand Tracking of an HCI system (HCI 시스템의 손 추적을 위한 수정 블록 정합 알고리즘)

  • Kim Jin-Ok
    • Journal of Internet Computing and Services
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    • v.4 no.4
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    • pp.9-14
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    • 2003
  • A GUI (graphical user interface) has been a dominant platform for HCI (human computer interaction). A GUI - based interaction has made computers simpler and easier to use. The GUI - based interaction, however, does not easily support the range of interaction necessary to meet users' needs that are natural. intuitive, and adaptive. In this paper, the modified BMA (block matching algorithm) is proposed to track a hand in a sequence of an image and to recognize it in each video frame in order to replace a mouse with a pointing device for a virtual reality. The HCI system with 30 frames per second is realized in this paper. The modified BMA is proposed to estimate a position of the hand and segmentation with an orientation of motion and a color distribution of the hand region for real - time processing. The experimental result shows that the modified BMA with the YCbCr (luminance Y, component blue, component red) color coordinate guarantees the real - time processing and the recognition rate. The hand tracking by the modified BMA can be applied to a virtual reclity or a game or an HCI system for the disable.

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An Explorative Study on the Features of Activity Trackers as IoT based Wearable Devices (사물인터넷 기반 웨어러블 디바이스인 활동량측정기의 특성에 대한 탐색연구)

  • Hong, Suk-Ki
    • Journal of Internet Computing and Services
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    • v.16 no.5
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    • pp.93-98
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    • 2015
  • IoT (Internet of Things) is recently burgeoning as business applications as well as ICT itself. Among the business applications of IoT, wearable devices are recognized as a leading area of customer devices. This research first identifies customer needs of activity trackers (fitness trackers), as one of representative wearable devices, and mapping the identified needs with the well-known marketing model of marketing mix (4 P's: Product, Price, Promotion, and Place). Survey was applied to university students for identifying current and potential needs for activity trackers. The needs were classified by 4 P's, and according to the results, different from other IT devices, activity trackers has more potential needs. Moreover, reliable distribution channels, offline and company owned shops were preferred, rather than online shopping mall by third parties. The results would provide some valuable implications to not only designers of activity trackers but also business management.