• Korean Journal of Biological Psychiatry
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• v.4 no.2
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• pp.155-161
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• 1997

Serotonin has been implicated in the etiology of many disease states and may be particularly important mental illness, such as depression, anxiety, schizophrenia, sleep disorders, suicide, eating disorders, obsessive compulsive disorders, migraine and others. Many currently used treatments of these disorders are thought to act by modulating serotonergic function. The identification of many serotonin subtypes, most of which have been shown to have functional activity and differential distribution, has stimulated considerable effort into synthesizing selective ligands(drugs) to help understand their significance. This should understand the role of serotonin in mental disorders and these new drugs can be studied alone and in combination with other treatments in order to clarify the parameters of drug use for the clinical effect.

• 대한상한금궤의학회지
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• v.11 no.1
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• pp.153-167
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• 2019

Objective : To explore the meaning of Eumyangyeokchahunobok-byung (陰陽易差後勞復病) through two cases and finding the relationship with the DSM-5 sleep-wake disorder. Methods : Following a disease pattern identification diagnostic system based on Shanghanlun provisions (DPIDS), we analyzed cases with chronic fatigue and diplopia caused after sleep disorders. The patients were treated with the Soshiho-tang and Yijoong-tang. Results : The two herbal medicines showed remarkable improvement in the patients. The sleep disorders and the secondary pathologies were rapidly relieved within a month. Conclusions : The patterns of sleep disorders of the two patients were found to be very similar to the circadian rhythm sleep-wake disorders, as described in DSM-5. Although the etymology of the Chinese characters has not been clearly known yet, it was possible to present the original hypotheses on 更and 了due to clinical inference.

• Journal of Korean Academy of Nursing
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• v.34 no.3
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• pp.576-585
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• 2004

Purpose: The purpose of this study was to identify the relationship between eating disorders, physical symptoms, depression and health locus of control. Method: The research design was a descriptive study done by using a constructive self-report questionnaire. A total of 464 elementary school girls were measured. The instrument was a constructive questionnaire that consisted 136 items. The subjects were divided into 4 groups according to the Body Mass Index (BMI). Data analysis was done by SPSS/WIN Programs using frequency, percentage, mean, SD, ANOVA, Pearson correlation coefficient, and stepwise multiple regression. Result: The score of eating disorders differed significantly by BMI : the score was highest in the group of obese students(F=4.208, P=.015). Stepwise multiple regression analysis revealed that the most powerful predictor of eating disorders was BMI. Conclusion: These results indicate that Korean elementary school girls need more education and counseling on diet. Also, we should take systematic efforts to reestablish the social standard of beauty to promote normal growth development.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.21 no.3
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• pp.133-140
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• 2010

Tic disorders, including Tourette syndrome, are known as neurobiologic disorders and as such, much emphasis has been placed on isolating genetic determinants. Although previous reports involving studies of discordance among monozygotic twins have shown the importance of genetic predisposition, they have also supported a role for environmental factors in the development of tic disorders. Therefore, it is important to consider that both genetic and environmental factors contribute to their clinical expression. The goal of this article was to review recent reports regarding the role of environmental factors in development and progression of tics. Specific environmental factors associated either with a more severe course of illness or improved outcomes were discussed. Given that accumulating evidence had suggested the usefulness of behavior therapies in the suppression of tic disorders, particular emphasis was placed on the impact of several contextual factors.

• Korean Journal of Biological Psychiatry
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• v.15 no.4
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• pp.243-253
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• 2008

In the post-genomic era, the mechanisms controlling activation of genes are thought to be more important. Gene-environment interactions are crucial in both development and treatment of psychiatric disorders as they are complex genetic disorders. Epigenetics is defined as a change of gene expression that occurs without a change of DNA sequence and can be heritable by certain mechanisms. Epigenetic changes play essential roles in control of gene activation. DNA methylation, chromatin remodeling and RNAi act as key mechanisms for epigenetic modifications of genes. Here, we review the basic mechanisms of epigenetics and discuss their potential involvement of human diseases, including psychiatric disorders.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.8
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• pp.3257-3269
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• 2020

Articulation disorders are characterized by an inability to achieve clear pronunciation due to misuse of the articulators. In this paper, a method of detecting such disorders by comparing to the standard pronunciations is proposed. This method defines the standard pronunciations from the speeches of normal children by clustering them with three features which are the Linear Predictive Cepstral Coefficient (LPCC), the Mel-Frequency Cepstral Coefficient (MFCC), and the Relative Spectral Analysis Perceptual Linear Prediction (RASTA-PLP). By calculating the distance between the centroid of the standard pronunciation and the inputted pronunciation, disordered speech whose features locates outside the cluster is detected. 89 children (58 of normal children and 31 of children with disorders) were recruited. 35 U-TAP test words were selected and each word's standard pronunciation is made from normal children and compared to each pronunciation of children with disorders. In the experiments, the pronunciations with disorders were successfully distinguished from the standard pronunciations.

• Anxiety and mood
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• v.5 no.1
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• pp.42-47
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• 2009

Recently, Eye Movement Desensitization and Reprocessing (EMDR) was given the status of an approved form of psychotherapy for the treatment of post-traumatic stress disorder. However, its effectiveness in the treatment of other anxiety disorders such as phobia is yet to be determined given that controlled studies have provided mixed results. This report summarizes the case of a child with a specific phobia (i.e. nighttime fear) which was successfully treated with two sessions of EMDR. This result suggests the further and thorough evaluation of this technique for use in childhood phobic disorders.

• Korean Journal of Biological Psychiatry
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• v.17 no.3
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• pp.119-126
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• 2010

Synaptic adhesion molecules mediate synapse formation, maturation and maintenance. These proteins are localized at synaptic sites in neuronal axons and dendrites. These proteins function as a bridge of synaptic cleft via interaction with another synaptic adhesion molecules in the opposite side. They can interact with scaffold proteins via intracellular domain and recruit many synaptic proteins, signaling proteins and synaptic vesicles. Scaffold proteins function as a platform in dendritic spines or axonal terminals. Recently, many genetic studies have revealed that synaptic adhesion molecules and scaffold proteins are important in neurodevelopmental disorders, psychotic disorders, mood disorders and anxiety disorders. In this review, fundamental mechanisms of synapse formation and maturation related with synaptic adhesion molecules and scaffold proteins are introduced and their psychiatric implications addressed.

• Sleep Medicine and Psychophysiology
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• v.18 no.2
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• pp.72-75
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• 2011

Sleep disorders such as insomnia, obstructive sleep apnea (OSA), and restless legs syndrome (RLS) are very common disorders and may cause significant burden in terms of individual as well as societal aspects. Sleep insufficiency from such sleep disorders may cause deleterious effects on daily work life and may be associated with other major medical or psychiatric disorders including cardiovascular disease, diabetes mellitus, depression, and anxiety disorder. Various motor or occupational accident may result from the sleep problems. In addition, recent researches provide the method to evaluate the lost productivity time in terms of absenteeism and presenteeism. Moreover, several studies on cost-effectiveness of treatment of sleep disorders show that it is cost-effective.

• Speech Sciences
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• v.13 no.4
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• pp.157-173
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• 2006

Speech-language therapist's experiences of their clinical practice offer greater insight to develop the assessment model for resonance disorders appropriate to the clinical setting. In order to investigate their experiences of resonance disorders qualitatively, a semi-structured interview questionnaire was developed on the basis of the review of the literatures about the assessment procedures. From the interviews with 4 speech therapists analysed by using a qualitative, constant-comparative method, 3 main themes were derived: (1) the currently accepted definitions and characteristics of the resonance disorders, (2) the status quo of the assessment procedures, and (3) the needs for the improvement of the assessment procedures. In addition, 15 sub-themes were emerged from the 3 main themes. All themes mentioned by the therapists provide the directions for the development of comprehensive and valid assessment model for the resonance disorders in Korea.