• International journal of advanced smart convergence
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• 제7권4호
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• pp.1-9
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• 2018

With developments in science and technology and improvement in living standards, human life expectancy is steadily increasing worldwide. For effective healthcare, it is necessary to check health conditions according to individuals' behavior and acquire prior knowledge on possible diseases. In this study, we classified the diseases that are major causes of death in Korea by referring to data provided by the Korea National Health and Nutrition Examination Survey. We selected indexes that could be used as indicators of major diseases and created the LCBB-SC. In the LCBB-SC, the data are systematically subdivided into related fields to provide integrated data related to each disease and to provide an infrastructure that can be used by researchers. In addition, by developing a web interface allowing for self-symptom assessments, this resource will be beneficial to people who want to check their own health condition using a list of diseases that might be caused by their behaviors.

• 대한수의학회지
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• 제59권2호
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• pp.97-100
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• 2019

It is important to select the correct disinfectants and to use them appropriately in order to prevent the initial spread of highly infectious livestock disease, such as foot-and-mouth disease or highly pathogenic avian influenza. This study describes a smartphone application developed to enable livestock workers to observe information related to disinfectants for the prevention of livestock disease in the domestic market, regardless of time and location, through a Linux-based Android mobile platform. This application (Konkuk-Disinfectant Information Database) provides information on disinfectant names, components, license and use; it was designed to enable the user to share disinfectant information through social media.

• Radiation Oncology Journal
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• 제36권4호
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• pp.276-284
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• 2018

Purpose: Traditionally, three-dimensional conformal radiation therapy (3D-CRT) is used for neoadjuvant chemoradiation in locally advanced rectal cancer. Intensity-modulated radiation therapy (IMRT) was later developed for more conformal dose distribution, with the potential for reduced toxicity across many disease sites. We sought to use the National Cancer Database (NCDB) to examine trends and predictors for IMRT use in rectal cancer. Materials and Methods: We queried the NCDB from 2004 to 2015 for patients with rectal adenocarcinoma treated with neoadjuvant concurrent chemoradiation to standard doses followed by surgical resection. Odds ratios were used to determine predictors of IMRT use. Univariable and multivariable Cox regressions were used to determine potential predictors of overall survival (OS). Propensity matching was used to account for any indication bias. Results: Among 21,490 eligible patients, 3,131 were treated with IMRT. IMRT use increased from 1% in 2004 to 22% in 2014. Predictors for IMRT use included increased N stage, higher comorbidity score, more recent year, treatment at an academic facility, increased income, and higher educational level. On propensity-adjusted, multivariable analysis, male gender, increased distance to facility, higher comorbidity score, IMRT technique, government insurance, African-American race, and non-metro location were predictive of worse OS. Of note, the complete response rate at time of surgery was 28% with non-IMRT and 21% with IMRT. Conclusion: IMRT use has steadily increased in the treatment of rectal cancer, but still remains only a fraction of overall treatment technique, more often reserved for higher disease burden.

• 디지털콘텐츠학회 논문지
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• 제10권2호
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• pp.327-332
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• 2009

본 논문에서는 애견 질병에 대한 전문적인 지식이 부족한 일반인들을 대상으로 자신의 애견 건강 상태를 파악할 수 있는 진단 시스템을 제안한다. 제안된 진단 시스템은 105가지 질병과 각 질병의 증상을 데이터베이스에 구축하여 입력된 증상을 통해서 애견의 질병을 도출한다. 신경망의 자율 학습 방법인 ART2 알고리즘을 적용하여 질병을 클러스터링하고 그 결과 값인 클러스터의 출력값과 연결강도를 데이터베이스에 저장한 후 질병의 증상과 관련된 질의 결과를 입력 벡터로 제시하여 학습된 질병 정보와 비교하여 애견의 건강 상태를 진단한다. 애견의 건강 상태를 진단하는데 있어서 질병과 증상의 정확한 정보는 매우 중요하다. 따라서 본 논문에서는 질병과 증상의 정보를 데이터베이스로 구축하고 질병과 증상 정보를 효율적으로 관리할 수 있도록 하였다. 제안된 진단 시스템을 구현하여 수의학 전문의가 분석한 결과, 본 논문에서 제안한 시스템이 애견 질병의 보조 진단 시스템으로서의 가능성을 확인하였다.

• 한국콘텐츠학회논문지
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• 제9권9호
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• pp.90-96
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• 2009

본 연구의 목표는 당뇨 및 심혈관계 질환자의 상태를 주기적 지속적으로 관리하기 위하여 당뇨 심혈관 관련 질병 DB를 구축하고, 기존 OCS, PACS, EMR, ERP등의 환자 DB를 통합 연계하는 지능형 통합 인터페이스 환경을 통해 환자가 원하는 최적의 서비스를 최적의 타이밍에 제공할 수 있는 개인 맞춤형 의료정보 융합시스템을 설계하는 것이다. 이를 위해 당뇨 및 심혈관 질환에 대한 지능형 DB를 구축하고, OCS, EMR, PACS 등 기존의 타 시스템과의 유연한 연계처리를 통한 데이터 통합 환경을 제공한다. 또한, 개인 맞춤형 의료정보 응합 시스템의 QoS와 신뢰성, 확장성 등을 고려하여 H/W설계, S/W설계와 데이터호환 방법을 설계한다.

• 대한한의학방제학회지
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• 제29권1호
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• pp.19-31
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• 2021

Objectives : The root of Salvia miltiorrhiza, known as 'Dansam (DS, 丹參)', is used for and treating cardiovascular diseases based on its efficacy of promoting blood circulation and breaking through a blood stasis. In this study, we would like to see if DS could be effectively used for stroke from the perspective of network pharmacology. Methods : The analysis was conducted using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database to derive the main active compounds of DS and identify the mechanism of each compound acting on the human body. The networks between compounds, target protein and disease were expressed through Cytoscape. Protein-protein interaction (PPI) analysis was performed using STRING database. Results : Fifty two active compounds of DS were identified by screening the ingredients of DS through TCMSP. Based on the networks of these compounds with target protein and disease, it can be said that DS might be effective for preventing and treating stroke. PPI result showed that adrenergic receptor has many interactions among proteins, indicating its significance in stroke pathway. Conclusion : In this study, we derived target proteins and target diseases of DS that could be used in study of stroke. However, since it is uncertain if these targets can be controlled by DS extracts or not, we would like to confirm the results with further animal experiments.

• The Plant Pathology Journal
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• 제21권2호
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• pp.111-118
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• 2005

Weather data for disease forecasts are usually derived from automated weather stations (AWS) that may be dispersed across a region in an irregular pattern. We have developed an alternative method to simulate local scale, high-resolution weather and plant disease in a grid pattern. The system incorporates a simplified mesoscale boundary layer model, LAWSS, for estimating local conditions such as air temperature and relative humidity. It also integrates special models for estimating of surface wetness duration and disease forecasts, such as the grapevine downy mildew forecast model, DMCast. The system can recreate weather forecasts utilizing the NCEP/NCAR reanalysis database, which contains over 57 years of archived and corrected global upper air conditions. The highest horizontal resolution of 0.150 km was achieved by running 5-step nested child grids inside coarse mother grids. Over the Finger Lakes and Chautauqua Lake regions of New York State, the system simulated three growing seasons for estimating the risk of grape downy mildew with 1 km resolution. Outputs were represented as regional maps or as site-specific graphs. The highest resolutions were achieved over North America, but the system is functional for any global location. The system is expected to be a powerful tool for site selection and reanalysis of historical plant disease epidemics.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
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• pp.508-510
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• 2001

Adopting the method of user weighting fuzzy mathematics, the author accomplished the subject title “Study on Expert System of Chicken\`s Common Diseases Diagnostics”, which could properly diagnose 30 kinds of chicken\`s common diseases and the accordance rate reached 80% verified through 244 disease cases. On the basis of the accomplishment, the multimedia technology was adopted further more to establish a system, which integrated with the input, display, query, and processing of sound, picture and text etc., combined with the previous chicken disease diagnostic expert system, make the output information of computer more rich and comprehensive, and the accordance rate of disease diagnosis could be improved. The system consists of database, knowledge base, graphics and picture base. This system is easy to operate and interface of which is vivid and intuitive. It could output diagnostic result and prescribe rapidly, so that, such a system is not only adapted to large, medium chicken farm but also to grass-roots veterinary station for developing health care and disease diagnosing. It is sure that the system could have side prospect of application.

• Genomics & Informatics
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• 제5권4호
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• pp.152-160
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• 2007

Most common diseases are caused by multiple genetic and environmental factors. Among the genetic factors, single nucleotide polymorphisms (SNPs) are common DNA sequence variations in individuals and can serve as important genetic markers. Recently, investigations of gene-based and whole genome-based SNPs have been applied to association studies for marker discovery. However, SNPs are so population-specific that the association needs to be verified. Fifty-five genes and 384 SNPs were selected based on association with disease. Genotypes of 337 SNPs in candidate genes were determined using Illumina Sentrix Array Matrix (SAM) chips by an allele-specific extension method in 364 unrelated Korean individuals. Allelic frequencies of SNPs were compared with those of other populations obtained from the International HapMap database. Minor allele frequencies, linkage disequilibrium blocks, tagSNPs, and haplotypes of functional candidate SNPs in 55 genetic disease-associated genes were provided. Our data may provide useful information for the selection of genetic markers for gene-based genetic disease-association studies of the Korean population.

• 식물병연구
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• 제24권2호
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• pp.138-144
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• 2018

In December 2016, stem rot symptoms were observed on Persian buttercup (Ranunculus asiaticus) plants in Chilgok, Gyeongbuk, Korea. In the early stage of the disease, several black spots appeared on the stem of infected plants. As the disease progressed, the infected stem cleaved and wilted. The causal agent was isolated from a lesion and incubated on Reasoner's 2A (R2A) agar at $25^{\circ}C$. Total genomic DNA was extracted for phylogenetic analysis. Based on the 16S rRNA gene analysis, the isolated strain was found to belong to the genus Pseudomonas. To identify the isolated bacterial strain at the species level, the nucleotide sequences of the gyrase B (gyrB) and RNA polymerase D (rpoD) genes were obtained and compared with the sequences in the GenBank database. As the result, the causal agent of the stem rot disease was identified as Pseudomonas marginalis. To determine the pathogenicity of the isolated bacterial strain, it was inoculated into the stem of healthy R. asiaticus plant, the inoculated plant showed a lesion with the same characteristics as the naturally infected plant. Based on these results, this is the first report of bacterial stem rot on R. asiaticus caused by P. marginalis in Korea.