DOI QR코드

DOI QR Code

Disease risk prediction system using correlated health indexes

  • Kim, Yoonjung (Laboratory of Computational Biology & Bioinformatics, Institute of Public Health and Environment, Graduate School of Public Health, Seoul National University) ;
  • Son, Hyeon Seok (SNU Bioinformatics Institute, Interdisciplinary Graduate Program in Bioinformatics, College of Natural Science, Seoul National University) ;
  • Kim, Hayeon (Department of Biomedical Laboratory Science, Kyungdong University)
  • Received : 2018.08.31
  • Accepted : 2018.09.11
  • Published : 2018.12.31

Abstract

With developments in science and technology and improvement in living standards, human life expectancy is steadily increasing worldwide. For effective healthcare, it is necessary to check health conditions according to individuals' behavior and acquire prior knowledge on possible diseases. In this study, we classified the diseases that are major causes of death in Korea by referring to data provided by the Korea National Health and Nutrition Examination Survey. We selected indexes that could be used as indicators of major diseases and created the LCBB-SC. In the LCBB-SC, the data are systematically subdivided into related fields to provide integrated data related to each disease and to provide an infrastructure that can be used by researchers. In addition, by developing a web interface allowing for self-symptom assessments, this resource will be beneficial to people who want to check their own health condition using a list of diseases that might be caused by their behaviors.

Keywords

OTNBCL_2018_v7n4_1_f0001.png 이미지

Figure 1. Workflow of the research

OTNBCL_2018_v7n4_1_f0002.png 이미지

Figure 2. The Lab of Computer Biology and Bioinformatics - Symptom Checker (LCBB-SC)

Table 1. System development environment

OTNBCL_2018_v7n4_1_t0001.png 이미지

Table 2. Type and number of data used for system construction

OTNBCL_2018_v7n4_1_t0002.png 이미지

Table 3. Multiple layer perceptron result for chronic disease (10-folds)

OTNBCL_2018_v7n4_1_t0003.png 이미지

References

  1. M. Fortin, G. Bravo, C. Hudon, A. Vanasse and L. Lapointe. Prevalence of multimorbidity among adults seen in family practice. The Annals of Family Medicine. Vol. 3, No. 3, pp. 223-228, May 2005. https://doi.org/10.1370/afm.272
  2. C. Vogeli, A. Shields, T.A. Lee, T.B. Gibson, W.D. Marder, K.B. Weiss and D. Blumenthal. Multiple chronic conditions: prevalence, health consequences, and implications for quality, care management, and costs. Journal of general internal medicine. Vol. 22 No. 3, pp. 391-395, Dec 2007. https://doi.org/10.1007/s11606-007-0322-1
  3. I.H. Witten, E. Frank, M.A. Hall and C.J Pal. Data Mining: Practical machine learning tools and techniques. Morgan Kaufmann. Oct 1, 2016.
  4. J.R. Quinlan. Induction of decision trees. Machine learning. Vol. 1, No. 1, pp. 91-106, Mar 1986.
  5. G.A Colditz, R. Bonita, M. J. Stampfer, W. C. Willett, B. Rosner, F.E. Speizer and C.H. Hennekens. Cigarette smoking and risk of stroke in middle-aged women. New England Journal of Medicine. Vol. 318, No. 15, pp. 937-941, Apr 1988. https://doi.org/10.1056/NEJM198804143181501
  6. M. Higa and Z. Davanipour. Smoking and stroke. Neuroepidemiology. Vol. 10, No. 4, pp. 211-222, 1991. https://doi.org/10.1159/000110272
  7. R. Shinton and G. Beevers. Meta-analysis of relation between cigarette smoking and stroke. Bmj. Vol. 298, No. 6676, pp. 789-794, Mar 1989. https://doi.org/10.1136/bmj.298.6676.789
  8. P.A. Wolf, R.B. D'Agostino, W.B. Kannel, R. Bonita and A.J. Belanger. Cigarette smoking as a risk factor for stroke: The Framingham Study. Jama. Vol. 259, No. 7, pp. 1025-1029, Feb 1988. https://doi.org/10.1001/jama.1988.03720070025028
  9. G.J. Hankey. Smoking and risk of stroke. Journal of cardiovascular risk. Vol. 6, No. 4, pp. 207-211, Aug 1999. https://doi.org/10.1177/204748739900600403
  10. W.H. Chow, C.A. Swanson, J. Lissowska, F.D. Groves and L.H. Sobin, A. Nasierowska-Guttmejer, J. Radziszewski, J. Regula, A.W. Hsing, S. Jagannatha and W. Zatonski. Risk of stomach cancer in relation to consumption of cigarettes, alcohol, tea and coffee in Warsaw, Poland. International journal of cancer. Vol. 81, No. 6, pp. 871-876, Jun 1999. https://doi.org/10.1002/(SICI)1097-0215(19990611)81:6<871::AID-IJC6>3.0.CO;2-#
  11. P. Boffetta and M. Hashibe. Alcohol and cancer. The lancet oncology. Vol. 7, No. 2, pp. 149-156, Feb 2006. https://doi.org/10.1016/S1470-2045(06)70577-0
  12. K. Ma, Z. Baloch, T.T. He and X. Xia. Alcohol consumption and gastric cancer risk: A meta-analysis. Medical science monitor: international medical journal of experimental and clinical research. Vol. 28, pp. 238, 2017.