• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7211-7217
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• 2015

Background: The aims of this study were to evaluate the diagnostic and prognostic roles of serum osteopontin (OPN) and single nucleotide polymorphisms (SNPs) in the OPN promoter in patients with hepatitis B-related hepatocellular carcinoma (HCC). Materials and Methods: Four groups were studied, which included 157 patients with HCC, 73 with liver cirrhosis (LC) and 97 with chronic hepatitis (CH), along with 80 healthy subjects. Serum OPN and alpha-fetoprotein (AFP) levels were measured. The SNPs -66 T/G, -156 G/${\Delta}G$ and -433 C/T within the OPN promoter were determined by direct sequencing. Results: Serum OPN levels were significantly higher in patients with HCC than in the other groups. Area under receiver operating characteristics curves in distinguishing HCC from chronic liver disease (CLD; CH and LC) were 0.782 (95% CI; 0.729-0.834) for OPN and 0.888 (95% CI; 0.850-0.927) for AFP. Using the optimal cut-off value (70 ng/mL), OPN had sensitivity and specificity of 72% and 71%, respectively. Serum OPN was superior to AFP in detecting early-stage HCC (68% vs. 46%). A combination of both markers yielded an improved sensitivity for detecting early HCC to 82%. A high OPN level was significantly correlated with advanced BCLC stage and was an independent prognostic factor for HCC. The SNPs -156 and -443 were associated with susceptibility to HCC, but were not related to overall survival. Conclusions: Serum OPN is a useful diagnostic and prognostic marker for HCC. The combined use of serum OPN and AFP improved the diagnosis of early HCC. Genetic variation in the OPN promoter is associated with the risk, but not the prognosis of HCC.

• 건축역사연구
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• 제15권1호
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• pp.7-27
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• 2006

This study aims to identify and analyze the factors that influenced the construction of London Eye which was led by private groups, including characteristics in progress, differentiated value in design, the combination of technology and design, and construction costs. The results of this study were the followings. 1) London Eye provides a new construction method for a landmark in the downtown in that the architects became the clients of the project which might have been hoarded, procuring the construction costs and completing it by themselves. 2) London Eye presents a space utilization method where undeveloped spaces in the downtown are used in three-dimensions by erecting a structure on the river with a minimum land. 3) The process of design, production and erection is propelled the realization of technical intention design with one system and from at the initial stage, the participation of the engineer where the designer is equal with you must accompany. 4) London Eye is endowed with strong shape by a circle in design concept, which is the simplest geometrical figure, and it provides organic relationship between the past and the present by utilizing historical elements in various ways. 5) The construction was completed through four phases including idea phase, promotion phase, turn-key contract phase, and design-build phase. The most critical factor to the success is derived from the direct contact with Involved companies from the production phase. 6) In a project facing many challenges in terms of technology, the design-build method proves to be a more effective method than turn-key contract in that it may more allocate risks and enable coherent implementation of the core concept in design. The organization for the design-build method was composed of three phases including general affairs, responsible contracting by sector, and cooperative system by sector. Since that was a new concept structure, high-level contractors who hadn't had existing cooperative relationships with one another formed new cooperative relationship, while collaborating companies who had long cooperated led the responsible contracting and sub-cooperative system, which resulted in reduction of risks and time. 7) The major factors to change design were the design characteristics, derived from a technically great combination, and the opening time. 8) A new erection method was applied to London Eye, a structure that overcame the limitation in land and period, and the process of installation demonstrated that it is an important value for the construction of a landmark in the city. 9) In spite of many visitors and tremendous operational income, the factors that London Eye fails to free itself from debts include the construction costs expended double than expected, and interest burden to the investments, which occurred in the course of procuring the costs. Absolute limit in time increased the construction costs, resulting in being a great obstacle in the course of operation.

• 한국지반신소재학회논문집
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• 제18권4호
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• pp.75-85
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• 2019

차량하중에 의해 옹벽에 전달되는 수평토압은 등가상재하중높이로 표현하며, 표준트럭의 축하중 크기와 위치에 따라 그 영향이 달라진다. 한계상태설계법은 2015년부터 국내 도로교 설계에 적용되어 왔다. 하지만 우리나라 실정을 고려한 토압하중계수(등가상재하중높이)가 제시되어 있지 않아 설계에 적용하는데 어려움이 있다. 본 연구에서는 국내 표준트럭의 축하중 크기 및 위치를 반영한 등가상재하중높이를 산정하였다. 3차원 수치해석 방법으로 등가상재하중높이를 산정하였으며, AASHTO 기준치와 차별화된 등가상재하중 높이를 제시하였다. 우리나라 표준트럭의 축하중은 미국과 달리 축하중이 집중되는 구조를 가지고 있어 옹벽의 높이가 낮은 경우 등가상재하중높이가 AASHTO에서 제안한 값보다 다소 크게 평가 되었다. 따라서 우리나라 교통하중으로부터 도출된 등가상재하중높이는 옹벽 구조물의 장기 안정성을 확보하는 측면에서 AASHTO 기준치보다 보수적으로 제시하는 것이 합리적일 것이다.

• 한국지반신소재학회논문집
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• 제15권3호
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• pp.27-37
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• 2016

국내 GCP공법은 많은 선행연구가 진행되었으나, 설계자의 경험에 의해 의존하여 설계되고 있는 실정이므로 파괴사례가 종종 보고되고 있다. 이에 따라 명확한 파괴 원인규명 및 파괴예방대책 수립이 어려운 실정이다. 따라서 본 연구에서는 GCP공법의 합리적인 설계법의 제안을 위한 기초단계로써, GCP에 사용되는 최적배합비를 대형직접전단시험을 통해 결정하고, 내부마찰각의 변화에 따른 응력분담비의 변화 및 지반의 수직/수평 침하거동을 수치해석을 통하여 분석하였다. 직접전단 실험결과 쇄석과 모래의 최적배합비는 70:30으로 평가되었다. 수치해석결과 내부마찰각이 증가할수록 응력분담비가 증가하나 일정한 값으로 수렴하고 침하량이 감소하며, 최적배합비로 시공할 경우 측방유동 및 히빙현상의 감소를 유도할 것으로 판단된다.

• 한국전자파학회논문지
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• 제16권7호
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• pp.671-680
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• 2005

CQPSK(Compatible QPSK) 디지털 변조 기술을 이용하는 초협대역 단말기용 송신기에 가장 핵심적인 부품들 중의 하나인 카테지안 궤환 루프(CFL: Cartesian Feedback Loop) 선형화 칩을 $0.35{\mu}m$ CMOS 기술을 이용하여 설계 및 제작하였다. 직접 변환 방식 및 CFL칩을 이용하여 요구되는 부품 수를 줄임에 의하여 송신기의 저비용 및 소형화가 가능하고, 이를 통하여 송신 전력 효율 및 선형성을 향상시켰다. 또한 CMOS기술을 통하여 저전력 구동이 가능하도록 하였다. 송신 성능 시험 결과 PEP 37 dBm(5 W)의 출력 전력에서 CFL 칩을 구동하여 -25 dBc의 상호 변조 왜곡(@ 3 kHz주파수 오프셋) 개선을 통하여 FCC 47 CFR 90.210 E에 정의된 방사 마스크 규격을 만족함을 확인하였다. 또한 상기 언급된 송신 특성 개선에 가장 영 향을 미치는 성분들인 DC-offset 성분, 궤환 루프에서 발생하는 왜곡 성분을 보상하기 위한 루프 이득 및 위상 값들을 조정할 수 있도록 컴퓨터와의 외부 인터페이스를 구현하여 소프트웨어적으로 이러한 값들을 제어할 수 있도록 프로그램화 하였다.

• Clinical and Experimental Reproductive Medicine
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• 제19권2호
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• pp.169-174
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• 1992

Previous studies have indicated that immunological factor is responsible for the infertility. We have detected sperm antibodies in ZIFT patients which grouped as fertilization failure (A; n=18) and low fertilization rate (${\leq}50%$)(B; n=20). Patients, however, had normal oocytes and sperms. We collected serum from wives and semen from husbands and donors (fertile sperm), if it was needed. We examined class, binding patterns and amounts of antisperm antibodies(ASA) by direct and indirect immunobead binding assay. In group A, 11 husbands were ASA positive showing 62.2% and 61.1% binding with IgA and IgG, respectively, and two wives were ASA positive showing 70.0% and 71.0% binding with IgA and IgG, respectively. Binding sites were mainly at the head of sperms (84%). In group B, 8 husbands were ASA positive showing 37.5% and 40.0% binding with IgA and IgG, respectively, and two wives were ASA positive showing 41.3% and 42.0% binding with IgA and IgG, respectively. Binding sites were also mainly at the head of sperms (78%). For the treatment of ZIFT patients who had fertilization failure at the first trial, we used albumin fractionation method and dilution method with 30% fetal cord serum (FCS) to reduce the titer of ASA. We used partial zona dissection (P.Z.D.) method for wives who have antisperm antibodies in their serum. According to represented method, we could inhance the fertilization rate to 60.0% by albumin fractionation and 20.0% by P.Z.D., respectively. We concluded that the use of micromanipulation like P.Z.D. or the other sperm processing methods is required to increase a chance of fertilization. This result suggested that it should be a prerequisite to test antisperm antibodies prior to entering assisted reproductive technologies (ART) programs.

• Journal of Preventive Medicine and Public Health
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• 제38권3호
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• pp.359-365
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• 2005

Objectives : An abrupt economic decline may widen the socioeconomic differences in health between the advantaged and disadvantaged in a society. The aim of this study was to examine whether the South Korean economic crisis of 1997-98 affected the socioeconomic inequality from all-causes and from cause-specific mortality between 1995 and 2001. Methods : Population denominators were obtained from the registration population data, with the number of death (numerators) calculated from raw death certificate data. The indicator used to assess the geographic socioeconomic position was the per capita regional tax revenue. Administrative districts (Si-Gun-Gu) were ranked according to this socioeconomic measure, and divided into equal population size quintiles on the basis of this ranking. The sex- and 5-year age-specific numbers of the population and deaths were used to compute the sex- and age-adjusted mortality rates (via direct standardization method), standardized mortality ratios (via indirect standardization methods) and relative indices of inequality (RII) (via Poisson regression). Results : Geographic inequalities from all-causes of mortality, as measured by RII, did not increase as a result of the economic crisis (from 1998-2001). This was true for both sexes and all age groups. However, the cause-specific analyses showed that socioeconomic inequalities in mortalities from external causes were affected by South Korean economic crisis. For males, the RIIs for mortalities from transport accidents and intentional self-harm increased between 1995 and 2001. For females, the RII for mortality from intentional self-harm increased during the same period. Conclusions : The South Korean economic crisis widened the geographic inequality in mortalities from major external causes. This increased inequality requires social discourse and counter policies with respect to the rising health inequalities in the South Korean society.

• 한국광학회지
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• 제7권3호
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• pp.213-218
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• 1996

액정셀에서 액정분자의 선경사각과 액정층의 두께를 함께 결정하며 측정범위와 정밀도를 높이는 개선된 결정회전법을 고안하고 그 타당성을 실험으로 확인하였다. 이 방법은 종래의 입사각에 따른 편광투과율의 변화를 재는 대신, 직교하는 두 선편광이 액정셀을 지나올 때의 위상차를 재고 그 결과를 바탕으로 액정층의 두께와 선경사각을 결정한다. 아울러 굴절율이 유리기판과 비슷한 액체가 채원진 액체통에 액정셀을 넣고 실험하여 유리판 표면에서의 빛의 반사를 줄이고 액정층에서의 굴절각의 범위를 늘려서 측정의 정밀도를 높였다. 이 방법을 쓰면 액정층의 두께가 10.mu.m보다 적거나 선경사각이 10.deg. 이상인 액정셀에 대해서도 선경사각과 액정층의 두께를 동시에 잴 수 있다.

• 한국결정성장학회지
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• 제21권6호
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• pp.225-229
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• 2011

현재 결정질 태양전지에서 웨이퍼 가공은 대부분 슬러리 분사 방식의 다중 와이어를 이용한 방법이 사용되고 있다. 이와 같은 슬러리 분사 방식의 웨이퍼 가공은 가공속도가 낮아 생산성이 떨어지는 단점이 있을 뿐만 아니라 금속 재질의 와이어와 실리콘 블록의 직접적인 마찰에 의하여 웨이퍼 표면의 금속 불순물에 의한 오염이 발생되는 단점이 있다. 뿐만 아니라 와이어와 실리콘 블록간의 직접적인 마찰로 인하여 와이어가 빨리 마모되며, 이로 인하여 일회성의 와이어를 사용하게 되면서 제조원가는 상승하게 된다. 반면에 다이아몬드 입자가 코팅된 와이어를 이용하여 실리콘 웨이퍼를 가공하게 되면, 가공속도가 기존 슬러리 분사방식보다 빠르며, 공정진행에 따른 와이어의 마모율이 적어 와이어의 재사용에 의한 제조원가 절감이 가능하다. 따라서 이와 같은 다이아몬드 입자가 코팅된 와이어를 이용하여 가공하는 기술은 슬러리 분사방식에 비하여 더 효율적이라 할 수 있다. 본 연구에서는 슬러리 분사방식으로 가공된 웨이퍼와 다이아몬드 코팅된 와이어로 가공된 웨이퍼의 표면특성에 대하여 분석하고 셀 공정에 영향을 미치는 것에 대하여 설명하고자 한다. 또한, 다이아몬드 와이어로 가공된 웨이퍼를 활용하기 위한 셀 공정의 개선방향에 대하여 제안하고자 한다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권1호
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• pp.1-16
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• 2004

The use of artificial nerve conduit containing viable Schwann cells is one of the most promising strategies to repair the peripheral nerve injury. To fabricate an effective nerve conduit whose microstructure and internal environment are more favorable in the nerve regeneration than existing ones, a new three-dimensional Schwann cell culture technique using $Matrigel^{(R)}$. and dorsal root ganglion (DRG) was developed. Nerve conduit of three-dimensionally arranged Schwann cells was fabricated using direct seeding of freshly harvested DRG into a $Matrigel^{(R)}$ filled silicone tube (I.D. 1.98 mm, 14 mm length) and in vitro rafting culture for 2 weeks. The nerve regeneration efficacy of three-dimensionally cultured Schwann cell conduit (3D conduit group, n=6) was assessed using SD rat sciatic nerve defect of 10 mm, and compared with that of silicone conduit filled with $Matrigel^{(R)}$ and Schwann cells prepared from the conventional plain culture method (2D conduit group, n=6). After 12 weeks, sciatic function was evaluated with sciatic function index (SFI) and gait analysis, and histomorphology of nerve conduit and the innervated tissues of sciatic nerve were examined using image analyzer and electromicroscopic methods. The SFI and ankle stance angle (ASA) in the functional evaluation were $-60.1{\pm}13.9$, $37.9^{\circ}{\pm}5.4^{\circ}$ in 3D conduit group (n=5) and $-87.0{\pm}12.9$, $32.2^{\circ}{\pm}4.8^{\circ}$ in 2D conduit group (n=4), respectively. And the myelinated axon was $44.91%{\pm}0.13%$ in 3D conduit group and $13.05%{\pm}1.95%$ in 2D conduit group to the sham group. In the TEM study, 3D conduit group showed more abundant myelinated nerve fibers with well organized and thickened extracellular collagen than 2D conduit group, and gastrocnemius muscle and biceps femoris tendon in 3D conduit group were less atrophied and showed decreased fibrosis with less fatty infiltration than 2D conduit group. In conclusion, new three-dimensional Schwann cell culture technique was established, and nerve conduit fabricated using this technique showed much improved nerve regeneration capacity than the silicone tube filled with $Matrigel^{(R)}$ and Schwann cells prepared from the conventional plain culture method.