• Korean Journal of Oriental Medicine
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• v.17 no.3
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• pp.77-85
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• 2011

Objectives : The purpose of this study was to develop a simulator which can analyze the anti-inflammatory effects of medical herbs based on e-cell concerning p38 MAPK signal pathway. Methods : We collected data concerning medical herbs with anti-inflammatory effects and the active compounds to provide as a fundamental databse and to validate the newly developed algorithm. At this time, we used the target database as pubmed and gathered the data by data mining tool, pathway studio. Also we have developed the web-based search system for confirming database related to anti-inflammation. We researched the mechanism of actions of proteins in p38 MAPK signal pathway when active compound has been inserted into the network. We reduced total network into TAK-MKK3-p38 and made the two types of mathematical model about active compounds' interaction. Results & Conclusion : We constructed the database which have 69 cases of medical herbs, 71 cases of active compounds, about 8,000 cases of URL(Uniform Resource Locator) related to papers and reports. We designed the ordinary differential equations for response of TAK, MKK3, p38 in e-cell's cytosol and nucleus. We used this formular as measure whether an active compound of medicinal plants which is inputted by an user would have an anti-inflammation effects. We developed the visualization program which could show the change of concentration over time.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.49 no.1
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• pp.19-30
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• 2012

For digital data compression, the quantization is the main part of the lossy source coding. In order to improve the performance of quantization, the vector quantizer(VQ) can be employed. The encoding complexity, however, exponentially increases as the vector dimension or bit rate gets large. Much research has been conducted to alleviate such problems of VQ. Especially for high bit rates, a constrained VQ, which is called the sample-adaptive product quantizer(SAPQ), has been proposed for reducing the hugh encoding complexity of regular VQs. SAPQ has very similar structure as to the product VQ(PQ). However, the quantizer performance can be better than the PQ case. Further, the encoding complexity and the memory requirement for the codebooks are lower than the regular full-search VQ case. Among SAPQs, 1-SAPQ has a simple quantizer structure, where each product codebook is symmetric with respect to the diagonal line in the underlying vector space. It is known that 1-SAPQ shows a good performance for i.i.d. sources. In this paper, a study on designing 1-SAPQ for the first-order Markov process. For an efficient design of 1-SAPQ, an algorithm for the initial codebook is proposed, and through the numerical analysis it is shown that 1-SAPQ shows better quantizer distortion than the VQ case, of which encoding complexity is similar to that of 1-SAPQ, and shows distortions, which are close to that of the DPCM(differential pulse coded modulation) scheme with the Lloyd-Max quantizer.

• Journal of Korean Tunnelling and Underground Space Association
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• v.15 no.3
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• pp.357-373
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• 2013

In this paper, a back analysis program for analyzing the behavior of tunnel-ground system and evaluating the material properties and tunnel design parameters was developed. This program was designed to be able to implement the back analysis of underground structure by combination of using FLAC and optimized algorithm as direct method. In particular, Rosenbrock method which is able to do direct search without obtaining differential coefficient was adopted for the back analysis algorithm among optimization methods. This back analysis program was applied to the site to evaluate the design parameters. The back analysis was carried out using field measurement results from 5 sites. In the course of back analysis, nonlinear regression analysis was carried out to identify the optimum function of the measured ground displacement. Exponential function and fractional function were used for the regression analysis and total displacement calculated by optimum function was used as the back analysis input data. As a result, displacement recalculated through the back analysis using measured displacement of the structure showed 4.5% of error factor comparing to the measured data. Hence, the program developed in this study proved to be effectively applicable to tunnel analysis.

• The KIPS Transactions:PartB
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• v.12B no.6 s.102
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• pp.671-678
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• 2005

In this paper, we suggest an algorithm that allows us to extract the important obbject from motion pictures and then replace the background with arbitrary images. The suggested technique can be used not only for protecting privacy and reducing the size of data to be transferred by removing the background of each frame, but also for replacing the background with user-selected image in video communication systems including mobile phones. Because of the relatively large size of image data, digital image processing usually takes much of the resources like memory and CPU. This can cause trouble especially for mobile video phones which typically have restricted resources. In our experiments, we could reduce the requirements of time and memory for processing the images by restricting the search area to the vicinity of major object's contour found in the previous frame based on the fact that the movement of major object is not wide or rapid in general. Specifically, we detected edges and used the edge image of the initial frame to locate candidate-object areas. Then, on the located areas, we computed the difference image between adjacent frames and used it to determine and trace the major object that might be moving. And then we computed the contour of the major object and used it to separate major object from the background. We could successfully separate major object from the background and replate the background with arbitrary images.