• 한국언론정보학보
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• 제59권
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• pp.180-210
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• 2012

이 연구의 목적은 우리나라에서 이루어진 2000년대 10년간의 사과문 분석을 통하여 우리나라 사람들이 어떤 위기 커뮤니케이션 전략을 사용하고 있는지 실제적인 상황 진단을 내려 보는 것이다. 이를 위해 기존 문헌에서 사용된 사과전략의 유형과 우리나라 사과문에서 독 특하게 발견된 사과 유형을 탐색하여 분석에 이용하였다. 또한 조직별, 위기 유형별, 위기진행시기별로 각각 다르게 나타나는 위기 커뮤니케이션 전략을 세부적으로 알아보았다. 분석 결과 위기 커뮤니케이션 전략 중 사과 전략과 수정행위 전략이 가장 많이 사용되고 있었으며, 입지 강화와 동정심유발 전략이 그 뒤를 이었다. 조직별, 위기 유형별, 위기 진행시기별로도 선호되는 위기 커뮤니케이션 전략에 차이가 있었는데, 정부나 공적기관의 경우, 위기의 책임성이 내부에 있는 경우 및 통제력이 있다고 여겨지는 인문사회위기인 경우 정당화 전략을 선호하는 경향이 나타났다. 이와 같은 결과는 우리나라의 문화적 특징인 정, 체면 의식과 관련되어 있는 것으로 보인다. 즉 광범위한 의미에서 간접적 수정행위 전략, 초월 전략 등은 일종의 체면유지 전략으로 이해될 수 있으며, 입지강화나 동정심 유발은 인정에 호소하는 전략이라고 해석할 수 있다. 향후 연구에서는 이러한 우리나라의 문화적 특징을 반영한 새로운 위기 커뮤니케이션 유형화와 함께 그것의 효과를 입증하는 실증연구가 이루어져야 할 것으로 보인다.

• 문화기술의 융합
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• 제9권4호
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• pp.431-436
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• 2023

영화 <애프터썬> (2022)은 스코틀랜드 출신감독 샬롯 웰즈의 장편 데뷔작으로 그해 국제적인 예술영화 씬에서 가장 큰 주목을 받은 영화 중의 하나이다. 영화의 전체구조는 이제는 성인이 된 소피가 11살 때 엄마와 이혼한 뒤 떨어져 지내던 30살의 '젊은 아빠' 캘럼(Calum)과 튀르키에로 떠났던 어떤 여름휴가를 돌아보는 것이다. 그것은 사실 기억의 재구성이라 할 만한 것으로서, <애프터썬>은 기억된 내용의 서술뿐만 아니라, 기억의 재구성 과정의 드러냄을 통해서 영화를 사후작용의 기억작업의 과정으로 만든다. <애프터썬>은 이 과정에서 영화는 인덱스적 예술이라는 레프 마노비치의 말을 증명한다. 홈 비디오와 영화적 디제시스를 오가며 <애프터썬>은 홈 비디오에 새겨진 인덱스적 기호로서의 흔적과 현재적인 시간들을, 그리고 두 시간의 대화를 통하여 새로운 상상의 시간성을 풀어놓는다. 영화는 혼란스러운 시간 속에 있던 무의지적 기억을 현재로 재촉하면서, 미디어와 미디어, 과거와 현재 사이의 대화 속에서 흔적과 강렬한 몸짓의 기호를 통해 의미화작용을 한다. 우리는 이야기가 정지되는 시간, 몸짓이 함축하는 것을 통해 의미를 사유하게 된다.

• Journal of Korean Neurosurgical Society
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• 제38권5호
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• pp.366-374
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• 2005

Objective : Nitric oxide[NO] is implicated in a wide range of biological processes in tumors and is produced in glioma. To investigate the role of NO and its interaction with the tumoricidal effects of anticancer drugs, we study the antitumor activities of NO donors, with or without anticancer drugs, in human glioma cell lines. Methods : U87MG and U373MG cells were treated with the NO donors sodium nitroprusside[SNP] and S-nitroso-N-acetylpenicillamine[SNAP], alone or in combination with the anticancer drugs 1,3-bis[2-chloroethyl]-1-nitrosourea[BCNU] and cisplatin. Cell viability, cell proliferation, DNA fragmentation, nitrite level, and the expression of Bcl-2 and Bax were determined. Results : NO was markedly increased after treatment with SNP or SNAP; however, the addition of the anticancer drugs did not significantly affect NO production NO donors or anticancer drugs reduced glioma cell viability and, in combination, acted synergistically to further decrease cell viability in a dose- and time-dependent manner. Cell proliferation was inhibited and apoptosis were enhanced by combined treatment. Bax expression was increased by combined treatment, whereas Bcl-2 expression was reduced. The antitumor cytotoxicity of NO donors and anticancer drugs differed according to cell type. Conclusion : BCNU or cisplatin can inhibit cell viability and proliferation of glioma cells and can induce apoptosis. These effects are further enhanced by the addition of a NO donor which modulates the antitumor cytotoxicity of chemotherapy depending on cell type. Further biological, chemical, and toxicological studies of NO are required to clarify its mechanism of action in glioma.

• 보건교육건강증진학회지
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• 제24권3호
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• pp.73-86
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• 2007

Objective: The purposes of this study are to understand the characteristics of the participants in a community walking campaign and to analyze the factors related to their participation based on the Transtheoretical Model (TTM). Methods: The study composed of the description of participant characteristics and comparison of them with non-participant characteristics in a walking campaign in K province. The data were collected through a survey of 2,590 participants and 258 non-participants from the same community. The survey instrument included questions about stages of walking and exercise, knowledge and attitude toward walking, and environmental condition for walking. Results: A majority of the walking campaign participants were in the action(24.8%) and maintenance(43.6%) stages of walking and exercise behavior. The non-participant group was split between maintenance(51.6%) and precontemplation (30.6%) stages. Among the participants, effective campaign promotion channels differed by age group while motivation for participation and participation patterns were associated with both age and gender. Favorable physical environment was a significant factor of participating in walking campaign(OR=1.396, CI=1.149-1.696). Although the campaign participants scored higher than the non-participants in most attitude toward walking questions, differences in knowledge scores between two groups were less significant. Conclusion: In conclusion, further social marketing to increase the awareness and to increase the concern of population in the community is needed based on the survey result. Transtheoretical model seems appropriate to apply to the evaluation and the planning the program of the behavior change in the community. Also, more organized and sustainable support in need to maintain the good habit of walking for the participants in walking campaign.

• Archives of Pharmacal Research
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• 제21권2호
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• pp.198-206
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• 1998

Fourty eight derivatives of 2-(1-oxyalkyl)-1,4-dioxy-9,10-anthraquinone were synthesized, and their antitumor activity was evaluated. On the whole, 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones (DHAQ=1,4-dihydroxy-9,10-anthraquinone) showed stronger cytotoxic activity against L1210 cells than 2-(l-hydroxyalkyl)-1,4-dimethoxy-9,10-anthraquinones(DMAQ =1,4-dimethoxy-9,10-anthraquinone), implying that free hydroxy groups at C-1 and C-4 of the anthraquinone structure are necessary for the cytotoxic activity. The bioactivity of 2-(lhydroxyalkyl)-DHAQ derivatives differed according to the size of alkyl group at C-1;while the elongation of alkyl group over 7 carbon atoms failed to enhance the bioactivity, the derivatives possessing alkyl moiety of 1-6 carbon atoms showed an increase in the cytotoxicity and the antitumor activity in Sarcoma-180; 2-hydroxymethyl-DHAQ ($ED_{50}$, $15\mu\textrm{g}$/ml; T/C, 125%), 2-(1 -hydroxyethyl)-DHAQ($1.9{\mu}g/ml;139.2%)$;, 2-(1-hydroxypropyl)-DHAQ ($7.2{\mu}g$/ml; 135.1%), 2-(1-hydroxybutyl)-DHAQ ($10.2{\mu}g/ml; 125.3%)$, 2-(1-hydroxypentyl)-DHAQ ($23.7{\mu}g/ml; 110.1%$). and 2-(1-hydroxyhexyl)-DHAQ ($58{\mu}g/ml;108%$). Next, 2-(1-Hydroxyalkyl)-DHAQ derivatives were acetylated to produce 2-(1-acetoxyalkyl)-DHAQ analogues. Although the acetylation somewhat enhanced the cytotoxicity, but not the antitumor action. In addition, the presence of phenyl group at $C-1^{l}$ enhanced the cytotoxicity and the T/C value, compared to alkyl groups of same size; 2-(1-hydroxy-1-phenyl)-DHAQ ($ED_{50}$, $5.6{\mu}g$, T/C, 137%).

• Journal of Plant Biology
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• 제20권2호
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• pp.91-101
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• 1977

Using barley seeds (Hordeum sativum Jess, var.), the influences of gibberellic acid (GA) and indole-3-acetic acid(IAA) on the amylase synthesis and that of the nucleic acid metabolism were investigated. 1. With the deembrynized barley seeds, the increase of amylase treated with a $10^{-5}M$ of GA and the decrease of amylase treated with $10^{-5}M$IAA were matched by a proportionate increase and decrease in the amount of RNA. The influence of the hormones on the RNA synthesis has appeared immediately after the treatment but on the amylase synthesis it has appeared 8 hours later. But no influence on the DNA synthesis was observed on both hormones. 2. The amylase from deembryonized barley seeds treated with GA and IAA have been fractionated by gel filteration on Sephadex G-100. The amylase components showed four fractions on both enzymes treated with GA and IAA. Fraction I(FI) was differed from fraction Ⅵ(FIV) in Km value and the effects of temperature, pH and metal ions. On the basis of their emzymatic properties, it was considered that the FI was $\beta$-amylase and FIV was $\alpha$-amylase. The influences of GA and IAA on each fractions appeared to be similar but on the amylase units per souble protein, IAA inhibited the production of amylase FIV while it promoted that of amylase FI. 3. An experiment was conducted to determine whether IAA inhibits GA-promoted amylase synthesis competitively or non-competitively. Using a Lineweaver-Burk plot, it was clear that IAA was acting in a non-competitive fashion. From this, IAA was probably not competing with GA at the same site, but it was acting at some other site which resutled in partial blocking of the action of GA on the amylase synthesis.

• The Korean Journal of Physiology and Pharmacology
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• 제7권3호
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• pp.125-130
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• 2003

The aim of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine the effect of chlorhexidine digluconate on differential rotational mobility of different positions of the number of membrane bilayer phospholipid carbon atoms. The six membrane components differed with respect to 2, 3, 6, 9, 12, and 16-(9-anthroyloxy)stearic acid (2-AS, 3-AS, 6-AS, 9-AS, 12-AS and 16-AP) probes, indicating different membrane fluidity. Chlorhexidine digluconate increased the rate of rotational mobility of hydrocarbon interior of the cultured Porphyromonas gingivalis outer membranes (OPG) in a dose-dependent manner, but decreased the mobility of surface region (membrane interface) of the OPG. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.

• 대한영양사협회학술지
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• 제24권1호
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• pp.1-18
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• 2018

Sustainable practices of school foodservices are gaining more attentions. The study aimed to investigate dietitians' performance levels of sustainable practices in school foodservice settings in Gyeonggi Provinces. Using a survey method was used, and data were collected from 358 participants (response rate 59.7%) to be analyzed using the SPSS program. The evaluation tool for sustainable practices of school foodservices consisted of four sections and 34 criteria with 100 points. Employment status of the respondents was as follows: nutrition teachers 40.9%, dietitians (permanent) 45.1%, and temporary position dietitians 13.2%. Dietitians' performance for sustainable practices marked 65.67 points out of 100 (performance rate 66%) and were in the following order by section: sustainable foodservice management criteria (69%), support activities (69%), planning and evaluation (68%), and outcome management (52%). Regarding sub-sections, criteria that acquired higher performance rates were labelling of food origin (99%), use of seasonal vegetables and fruits (98%), food waste management by contract dealer (98%), and planning for reducing of food waste and solid waste (91%). Meanwhile, criteria that showed the lowest scores were installing water conservation devices on equipment (19%), operating food donation programs for communities (21%), use of sensor lights for electricity conservation (24%), planning for annual energy conservation (40%), and implementation of education programs for foodservice workers on sustainable activities (42%). Performance scores differed according to school levels and working experience of dietitians, indicating that dietitians at elementary school foodservices or with work experience of 15 to 20 years showed higher performance than those at high schools or with less than 5 years of work experience (P<0.001, P<0.05). Based on the results, action plans for improvement were suggested.

• Human Ecology Research
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• 제56권5호
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• pp.417-424
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• 2018

The use stage of a textile product impacts sustainability more significantly than other stages of the product's life cycle due to repeated washing and drying. This study determines efficient washing conditions, with high detergency, to reduce energy consumption from excessive washing and improve the washing process sustainability. Detergency was measured at various washing temperatures ($20^{\circ}C$, $40^{\circ}C$, and $60^{\circ}C$) and time (10 min, 20 min, and 30 min) using standardized soiled fabrics, i.e., 100% cotton, polyester/cotton (65%/35%), and 100% polyester woven fabric soiled with pigment/sebum, carbon black/mineral oil, soot/mineral oil, cocoa, blood, and red wine. Detergency at the washing condition of $20^{\circ}C$ and 30 min was higher than that at $40^{\circ}C$ and 10 min. In addition, detergency at the condition of $40^{\circ}C$ and 30 min was also higher than that at $60^{\circ}C$ and 10 minutes. This may be because a reduced washing effect at low washing temperatures was complemented by increased mechanical action over a long time. Further, washing temperature and time, with the same detergency, differed based on the type of fiber and soil. Also, the influence of a detergent on the detergency depends on the type of soil. The results suggest that energy and detergent have been consumed more than necessary in actual laundry. According to each type of fiber and soil, washing conditions designed to reduce the energy consumption of the washing process while maintaining the same detergency, were determined.

• Archives of Pharmacal Research
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• 제22권3호
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• pp.249-254
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• 1999

Enzymatic conversion of brain glycosylphosphatidylinositol-linked alkaline phosphatase (GPI-AP), amphiphilic, was examined. When GPI-AP was incubated with glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a negligible conversion of GPI-AP to hydrophilic form was observed. The inclusion of monoacylglycerols enhanced the enzymatic conversion, although the action of monoacylglycerols differed greatly according to the size of acyl group; the enzymatic conversion was enhanced considerably in the presence of monoacylglycerols possessing acyl group of longer chain length ($C_{10-}C_{18}$), which monoacylglycerols with acyl moiety of shorter length ($C_{4-}C_{8}$) did fail to augment the enzymatic conversion. Noteworthy, monooleoylglycerol was much more effective than the other monoacylglycerols in promoting the enzymatic conversion, indicating a beneficial role of the unsaturation in acyl chain. Meanwhile, ionic amphiphiles such as monohexadecyllysophosphatidylcholoine and palmitoyl-carnitine decreased the enzymatic conversion of GPI-AP in a concentration-dependent manner, with monohexadecyllysophosphatidylcholine and palmitoyl-carnitine deceased the enzymatic conversion of GPI-AP in a concentration-dependent manner, with monohexadecyllysophosphatidylcholoine being more inhibitory than palmitoylcarnitine. Separately when GPI-AP was exposed to various oxidants prior to the incubation with GPI-PLD, a remarkable decrease of the enzymatic conversion was observed with hypochlorite and peroynitrite generators, but not $H_{2}O_{2}$. In further study, hypochlorite was found to inactivate GPI-PLD at low concentrations ($3~100{\mu}M$). From these results, it is suggested that the enzymatic conversion of GPI-AP by GPI-PLD may be regulated in vivo system.