• Journal of Yeungnam Medical Science
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• 제36권2호
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• pp.85-91
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• 2019

The incidence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is increasing worldwide, but the diagnosis is difficult. Most patients are asymptomatic or complain of nonspecific gastrointestinal symptoms. As the endoscopic features of gastric MALT lymphoma are variable and nonspecific, the possibility of this condition may be overlooked during esophagogastroduodenoscopy, and it remain undiagnosed. Therefore, this condition needs to be considered when an abnormal mucosa is observed during this procedure. Biopsy performed during endoscopy is the primary diagnostic test, but false negative results are possible; large numbers of samples should be collected from both normal and abnormal mucosae. Endoscopic ultrasonography is useful to assess the depth of invasion and to predict the treatment response. After treatment, follow-up tests are required every 3 months until complete remission is achieved, and annually thereafter. Early diagnosis of gastric MALT lymphoma is difficult, and its diagnosis and follow-up require wide experience and competent endoscopic technique.

• Journal of Ceramic Processing Research
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• 제13권spc1호
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• pp.154-157
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• 2012

We present the simultaneous growth of single-walled carbon nanotubes and graphene with the optimal conditions of the synthesizing parameters. The dense and vertically aligned SWNTs having the length of over 100 ㎛ was grown by 2 nm-thick Fe catalytic layer. From 650 ℃, the vertically well-grown SWNTs were obtained by increasing the temperature. The severallayered graphene was synthesized with the gas mixing ratio of 15 : 1(H2 : C2H2) at 650 ℃ and higher temperatures. With these optimal conditions, the vertically well-grown SWNTs and the several-layered graphene were synthesized simultaneously. The presence of SWNTs and the layer of graphene were verified by field emission scanning electron microscopy and high resolution transmission electron microscopy. From the result of this simultaneous synthesizing approach, the possibility of one step growth process of CNTs and grapheme could be verified.

• Tuberculosis and Respiratory Diseases
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• 제86권3호
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• pp.176-182
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• 2023

Since the introduction of low-dose computed tomography (CT) screening for patients at high risk of lung cancer, the detection rate of suspicious lung cancer has increased. In addition, there have been many advances in therapeutics targeting oncogenic drivers in non-small cell lung cancer. Therefore, accurate pathological diagnosis of lung cancer, including molecular diagnosis, is increasingly important. This review examines the problems in the pathological diagnosis of suspected lung cancer. For successful pathological diagnosis of lung cancer, clinicians should determine the appropriate modality of the diagnostic procedure, considering individual patient characteristics, CT findings, and the possibility of complications. Furthermore, clinicians should make efforts to obtain a sufficient amount of tissue sample using non- or less-invasive procedures for pathological diagnosis and biomarker analysis.

• Journal of Acupuncture Research
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• 제19권1호
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• pp.101-110
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• 2002

Background and Purpose : Most diagnostic method for lumbago were invasive and complex. So we need to simplify and objectify diagnostic method for lumbago. Some study with EAV which is one of Physiological Signal Measuring Instruments, report significantly result as objective diagnostic method for other clinical symptom. By using EAV, we have obtained some physiological signal data from meridian-acupoints of 31 lumbago cases. Objective and Methods : This study researched into the clinical statistics for 31 case who ware in lumbago, and they ware treated with oriental medical care at the Dong-shin university oriental hospital during 6 month from June 1 2001 to November 10 2001. The data were analyzed and interpreted to compare with traditional differentiation of symptom-complexes, then further evaluated as the Five Evolutive Phases to make them differentiated. The EAV valus of Five Evolutive Phases were identified with the sequence of wood(木), fire(火), earth(土)steel(金), water(水). Results and Conclusion : These values of physiological signal were identical with standard differentiation of symptom-complexes of lumbago which is the main cause of deficiency of Qi and blood of the kidney and bladder. Among Five Evolutive Phases, Earth and wood values were increased, steel, fire and water were decreased significantly. This data imply the possibility of somewhat generalization from measuring instruments.

• 한국멀티미디어학회논문지
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• 제15권5호
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• pp.595-605
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• 2012

사시 진단을 위해 임상에서는 다양한 사시각 측정 방법들이 개발되어 이용되어 왔다. 그러나 기존 방법들은 대부분 육안 검사에 의해 이루어지므로 사용자의 주관적인 판단이 개입할 가능성이 크며 협조적인 대상에 대해서만 측정이 용이하다는 단점이 있다. 따라서 보다 이를 보완할 수 있는 객관적이고 신뢰성 있는 사시각 측정 방법의 개발이 필요하다. 본 논문에서는 임상 측정 방법의 문제점들을 보완할 수 있는 컴퓨터 기반의 새로운 자동 사시각 측정 소프트웨어의 개발을 소개한다. 먼저 간단하게 촬영된 환자의 전안부 영상을 획득하고 구형 RGB 모델을 이용하여 전처리를 수행하였다. 이후 새롭게 개발된 3차원 안구모델과 수학적인 측정 알고리즘을 이용하여 사시각 측정이 자동적으로 이루어지도록 하였다. 유효성 평가를 위해 10명의 환자 데이터를 대상으로 두 명의 검사자가 임상 측정 방법 중의 하나인 크림스키 테스트 방법을 통해 측정한 결과와 개발 소프트웨어를 이용하여 측정한 결과를 비교하였다. 그 결과, 두 명의 검사자의 상관계수는 각각 0.955, 0.969로 나타났으며, 두 검사자 간의 상관계수는 0.968로 나타나 객관성과 재현성이 매우 높음을 확인하였다. 향후 기존 사시진단 검사 방법들의 보조 수단이나 새로운 대안으로써 폭넓게 활용될 수 있을 것으로 기대한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제18권2호
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• pp.130-137
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• 2007

Objectives: Studies investigating problematic internet use have increased rapidly and have been focused on its causes, psychopathology, prevalence, characteristics and so on. However, there are few studies concerning the correlation between problematic internet use and youth health risk behavior. Therefore, the purpose of this study was to examine the relationship between problematic internet use and youth health risk behavior. Methods: A community sample of 632 high school students in grades 10 and 11 was collected for the survey. The sample was assessed using the Youth Risk Behavior Surveillance System(YRBSS) and Young's Diagnostic Questionnaire of Internet Addiction(YDQ). The subjects were classified into two groups: normal and problematic internet use, and the problematic internet use group was further divided into at-risk use and addiction groups. Results: There were 56 subjects(8.9%) in the internet addiction group and 56 subjects(8.9%) in the at-risk internet use group. The other 507 subjects were classified as normal. The subjects in the internet addiction group kissed more frequently and ate less fruit than those in the normal group. They also showed a relatively higher tendency to watch TV, ride in a car driven by a drunk driver and to carry a weapon than those in the normal group. There were no differences in health risk behaviors between the subjects in the internet addiction group and those in the at-risk internet use group, except for the possibility of riding in a car driven by a drunk driver. Conclusion: Unlike the normal group, there was very little difference in health risk behavior between the internet addiction group and the at-risk internet use group, which indicates that the addiction group and the at-risk internet use groups are homogenous. It is important to focus on the behavior of individuals in the at-risk group, and preventive measures should be taken in order to reduce the possibility of at-risk adolescents becoming addicted.

• 대한화학회지
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• 제47권4호
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• pp.339-344
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• 2003

Paraquat는 가장 효과적이고 널리 사용되는 제초제이지만 인간에게 매우 유독한 물질이다. 중독환자에 있어 뇨중 농도는 가장 중요한 인자중의 하나로 알려져 있으나 일반 검사실에서 이를 위한 정량검사는 거의 시행되지 않고 있다. 본 연구에서는 sodium dithionite를 이용하여 뇨중의 paraquat의 농도를 측정하는 새로운 방법의 진단 시험지를 개발하였다. 이 이차유도성 방식을 사용하여 paraquat의 농도를 측정한 결과 $0.5{\%}$ borate 완충용액(pH 8.0), 유도체 0.25 M $Na_2S_2O_4,\0.1~0.8{\%}$ PolyVinyl Pyrrolidone(PVP) 안정제, $1{\%}$ decanol의 구성비로 만들어진 진단시험지의 반응 색상이 안정하며 표준 비색표에 의한 육안적인 감별은 물론 화학 자동분석기에서의 응용성이 좋았다.

• 대한임상검사과학회지
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• 제44권1호
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• pp.7-16
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• 2012

The Korean GDP per capita doubled during the last 10 years. As the GDP increases, Korean health behaviors such as, eating, drinking, smoking, and exercise habits changed as well. Compared to the remarkably advanced diagnostic technologies and therapeutics during the last decade, the leading causes of death in Korea scarcely changed. Among the leading causes of death, cerebrovascular disease, heart disease, diabetes, liver disease and hypertension are closely related to health behaviors. Using the database of medical check-up between 2001 and 2010, the authors performed a longitudinal study for the prevalence rates and the trends of major chronic adult diseases among the 2,721 workers along with their health behavior. Among the diagnostic test items, fasting blood sugar, cholesterol and BMI levels showed steady increase and these three test items all showed linear trends (p<0.001). The average blood sugar and cholesterol levels were near worrying levels. Moreover, the average BMI of males was found to be at the overweight level, intimating the possibility reaching thee Obese Class I level soon if there are no aggressive counter measures. Fasting blood sugar and cholesterol levels were higher in a drinking group as compared to a non-drinking group, and the BMI levels were also higher in the drinking group and the smoking group as compared to the non-drinking and the non-smoking group (p<0.001). Finally, the authors believe that the fasting blood sugar, cholesterol and BMI levels should be designated as target monitoring test items in the medical check-up for Korean employees.

• Radiation Oncology Journal
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• 제37권4호
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• pp.302-308
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• 2019

The abscopal effect is a term that has been used to describe the phenomenon in which localized radiation therapy treatment of a tumor lesion triggers a spontaneous regression of metastatic lesion(s) at a non-irradiated distant site(s). Radiation therapy induced abscopal effects are believed to be mediated by activation and stimulation of the immune system. However, due to the brain's distinctive immune microenvironment, extracranial abscopal responses following cranial radiation therapy have rarely been reported. In this report, we describe the case of 42-year-old female patient with metastatic melanoma who experienced an abscopal response following her cranial radiation therapy for her brain metastasis. The patient initially presented with a stage III melanoma of the right upper skin of her back. Approximately 5 years after her diagnosis, the patient developed a large metastatic lesion in her upper right pectoral region of her chest wall and axilla. Since the patient's tumor was positive for BRAF and MEK, targeted therapy with dabrafenib and trametinib was initiated. However, the patient experienced central nervous system (CNS) symptoms of headache and disequilibrium and developed brain metastases prior to the start of targeted therapy. The patient received radiation therapy to a dose of 30 Gy delivered in 15 fractions to her brain lesions while the patient was on dabrafenib and trametinib therapy. The patient's CNS metastases improved significantly within weeks of her therapy. The patient's non-irradiated large extracranial chest mass and axilla mass also shrank substantially demonstrating the abscopal effect during her CNS radiation therapy. Following radiation therapy of her residual chest lesions, the patient was disease free clinically and her CNS lesions had regressed. However, when the radiation therapy ended and the patient continued her targeted therapy alone, recurrence outside of her previously treated fields was noted. The disease recurrence could be due to the possibility of developing BRAF resistance clones to the BRAF targeted therapy. The patient died eventually due to wide spread systemic disease recurrence despite targeted therapy.

• 한국정보통신학회논문지
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• 제20권4호
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• pp.763-768
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• 2016

IT기술 동향 정보는 정부/공공 정책과 산업계의 R&D의 투자 의사결정에 직접적인 영향을 미치는 중요한 정보이다. 이러한 특성으로 인해 기술 동향 정보는 공공 데이터 개방에 필수적인 정보이기 때문에 해당 기술을 담당하는 정부 부처와 공공기관별로 지속적으로 생산 및 제공하고 있다. 본 논문에서는 다양한 기관에서 제공되는 기술 동향정보를 통합하여 하나의 성숙도 수준으로 진단할 수 있는 방법과 가능성을 실험을 통해 확인하였다. 또한 기술 성숙도 진단을 위한 데이터 수집과 처리 저장, 최적화된 서비스 방법을 제안한다. 이를 위해 종합적인 시스템 구성 방법과 ITFIND 서비스에 수집된 데이터를 활용하여 종합적인 성숙도 수준 진단이 가능한지를 판단하고 보정을 통해 더 정확한 수준 진단을 진행할 수 있을 것으로 사료된다.