• 대한상한금궤의학회지
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• 제12권1호
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• pp.183-198
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• 2020

Objective: The purpose of this study was to report improvement in patients with autism spectrum disorder (ASD) treated with herbal medication described in Shanghanlun. Methods: The patient was diagnosed with Lesser Yin disease based on the 315^th provision of Shanghanlun, and Baektonggajeodamjup-tang was used for treatment. The result was evaluated using the Korean-Childhood Autism Rating Scale (K-CARS). Results: The K-CARS score decreased from 32 to 15 after 7 months of treatment. Conclusions: Lesser Yin disease 315^th provision of Shanghanlun may be a provision describing ASD; in addition, Baektonggajeodamjup-tang may be an effective treatment for ASD.

• 대한상한금궤의학회지
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• 제12권1호
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• pp.91-99
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• 2020

Objective: The aim of this study was to evaluate the effects of Gyejigamchoyonggolmoryeo-tang on facial flush. Methods: Facial flushwas evaluated using photographs and questionnaires. The (VAS) and investigator's global assessment were used to measure the improvement in facial flush symptoms. Results: The visual findings were. The VAS score decreased from 10 to 0 after administration of Gyejigamchoyonggolmoryeo-tang for 40 days. In addition, accompanying symptoms such as neck pain, palpitation, and insomnia were improved. These results indicated that Gyejigamchoyonggolmoryeo-tang was effective for emotional facial flush. Conclusions: This study shows the effective treatment of facial flush using Gyejigamchoyonggolmoryeo-tang based on the provisions of the Shanghanlun disease pattern identification diagnostic system.

• 대한상한금궤의학회지
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• 제12권1호
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• pp.161-169
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• 2020

Objective: This case report describes the improvements of a patient with recurrent cystitis who was treated using an herbal medication according to the Shanghanlun disease pattern identification diagnostic system (DPIDS). Methods: 'DPIDS'and 'Interpretation based on Etymological chinese characters,'the patient was diagnosed with Shaoyin-bing, provision number 315, and administered Baektong-tang herb medication for 30 days. The changes in the symptoms of recurrent cystitis were estimated using the Interstitial Cystitis Symptom Index and Problem Index-Korean version (ICSI/ICPI-K) and Visual Analogue Scale (VAS). Results : The ICSI/ICPI-K score changed from 33 to 0 and VAS score changed from 7 to 0. Conclusions: The main causes of the disease were 微 and 利,and the symptoms of recurrent cystitis

• 대한상한금궤의학회지
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• 제12권1호
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• pp.149-159
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• 2020

Objective: This study aimed to report the improvements of with nummular eczema treated using Osuyu-tang based on Shanghanlun provisions. Methods: According to the disease pattern identification diagnostic system based on the the patient was diagnosed with lesser-yin disease. The patient was treated with Osuyu-tang for 60 days. The severity of the patients' pruritus decreased, and changes in symptoms were assessed using visual analogue scale score and vIGA-AD^TM Results: The patients' symptoms improved, pruritus decreased, and abrasion healed. Conclusions: The results suggest that the words on the 309th provision of Shanghanlun are a direct cause of nummular eczema.

• 대한상한금궤의학회지
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• 제12권1호
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• pp.113-125
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• 2020

Objective: This study aimed to report the improvement of patients with hyperhidrosis treated using Gyejigajagyak-tang based on the Shanghanlun provisions. Methods: Two patients were diagnosed with Greater-yin disease based on the 279^th provision of Shanghanlun, and Gyejigajagyak-tang was used to treat hyperhidrosis. The result was evaluated using the Hyperhidrosis Disease Severity Scale and Visual Analogue Scale. Results: An analysis of results of the two cases showed that the patients' conditions had improved. The amount of sweat produced was decreased in both cases. Conclusions: These results suggest that the medicines defined in Shanghanlun are clinically effective when Shanghanlun is properly interpreted, considering the origins of the Chinese characters in the text, and the Shanghanlun disease pattern identification diagnostic system is applied.

• 대한상한금궤의학회지
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• 제13권1호
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• pp.189-196
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• 2021

Objective : This study aimed to report the improvement of a patient with chronic rhinitis treated with herbal medication using the disease pattern identification diagnostic system (DPIDS) based on the Shanghanlun provisions. Methods : According to the Shanghanlun DPIDS and an etymological interpretation of Chinese characters, the patient was diagnosed with Reverting yin disease (provision 352) and took Dangguisayeokgaosuyusaengang-tang herbal medication for 50 days. The change in symptoms of chronic rhinitis were estimated using the Total Nasal Symptom Score (TNSS), the Rhinitis Control Assessment Test (RCAT), and a visual analog scale (VAS). Results : The TNSS score decreased from 8 to 3, the RCAT score decreased from 14 to 24, and the VAS decreased from 10 to 2. Conclusions : The main causes of the disease were 厥 and 內. This is the first case report of describing the treatment of chronic rhinitis with Dangguisayeokgaosuyusaengang-tang.

• 대한한의학원전학회지
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• 제36권4호
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• pp.41-54
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• 2023

Objectives : To examine Korean Medical treatment of abnormal uterine bleeding in classical texts, along with their clinical applicability. Methods : The Benglou chapters in the Donguibogam, Fuqingzhunuke, Xuezhenglun were examined in terms of diagnostic pattern and treatment. Benglou chapters of other medical texts were referenced as well. Basic Korean Medical knowledge of abnormal uterine bleeding and its clinical application were studied. Results : As abnormal uterine bleeding is generally caused by internal damage or deficiency from excessive labor, sexual activity, food, emotional stress, specific causes for each individual should be considered when approaching each case. Conclusions : Korean Medical treatment allows for a tailored approach to each pathology according to age and duration of illness, and has strength in dealing with various situations such as emergency situations, excessive bleeding, blood stagnation. As such, application of Korean Medicine in abnormal uterine bleeding is highly appropriate.

• Tuberculosis and Respiratory Diseases
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• 제47권5호
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• pp.586-597
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• 1999

연구배경: 객담 도말 및 배양 검사나 방사선학적 검사 등의 기존의 결핵 진단 방법은 낮은 민감도와 진단까지 소요되는 기간이 길다는 단점이 있어서 결핵의 조기 진단 및 치료에 제한점이 있었다. 최근에 혈청학적 진단 방법의 하나로 개발된 immunochromatographic assay 기구들이 소개되고, 외국에서 비교적 높은 진단율를 보여, 결핵 유병율이 높은 국내에서 그 유용성을 평가하고, 질병 양상에 따른 차이점을 조사하여, 기존의 결핵 진단 방법들의 문제점을 해결할 수 있는지 알아보고자하였다. 연구방법: 환자군을 폐결핵 환자군(36명), 폐외결핵 환자군(3명) 및 두 가지 모두 이환된 군(22명)으로 나누었으며, 대조군은 과거 결핵 병력이 있는 비활동성 결핵환자(17명), 결핵이외의 폐질환자(16명) 및 폐질환이 없는 심장 환자(14명)를 대상으로 38kDa 항체를 포함한 ICT tuberculosis 또는 BioSign$^{TM}$TB를 이용하여 혈청화적 검사를 시행하였다. 결 과: ICT tuberculosis를 사용한 경우, 환자군 56명 및 대조군 47명에 대하여 64.3%의 민감도 및 91.5%의 특이도를 나타내었으며, 폐결핵만 있는 환자군에서 76.5%의 민감도를 보여, 폐외 결핵만 있는 환자군(33.3%)나 두 가지 모두 이환된 군(47.4%)에 비하여 더 높은 민감도를 나타내었다(p=0.039). BioSign$^{TM}$TB를 이용한 경우, 환자군 43명 및 대조군 43 명에 대하여 74.4%의 민감도 및 95.3%의 특이도를 보였으며, 폐질환이 없는 환자군에서는 100%의 특이도를 나타내었다. 환자군중에서 초발환자 및 과거 폐결핵 병력이 있는 환자군 사이에는 민감도에 차이가 없었으며, 공동성 폐결핵 환자와 비공동성 폐결핵 환자사이에 검사상 민감도 차이는 통계적으로 유의하지 않았다(73.3% vs. 69.6%, p>0.05). 결 론: 혈청학적 방법의 하나인 immunochromatographic assay 기구는 높은 특이도와 양성 예측도를 보여 임상적 유용성이 기대되나, 상대적으로 낮은 민감도와 음성 예측도를 고려할 때, 단독 사용보다는 기존 방법과의 상보적 사용이 결핵진단에 더 도움이 될 것으로 생각된다.

• 대한핵의학회지
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• 제30권1호
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• pp.145-151
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• 1996

철분이 축적하는데는 Tf나 Tf수용체에 의해 중재되는 경로와 비의존적인 경로가 둘 다 보고되어 왔다. 종양영상에 많이 사용되고 있는 Ga-67은 철분 유사 물질로 이러한 철분의 섭취 경로와 같은 경로에 의해 섭취되는지는 확실하지 않지만 Ga도 Tf의존성과 비의존성 섭취 경로가 보고되었으며 부분적으로는 철분과 같은 섭취경로를 공유할 수도 있다. 또한 종양의 변형정도에 따라 방사성 금속의 섭취기전이 다를 수도 있다. 변형세포로서 MMSV/3T3 세포와 비변형세포로서 BALB/3T3 세포를 Tf이 존재할때와 존재하지 않을 때에서 1uM의 Ga-67-citrate 혹은 Fe-59-chloride 와 함께 $37^{\circ}C$에서 15분간 배양하였다. 그 후 단일층의 세포를 HBSS로 3번, PBS로 1번 씻은 후 1% SDS로 용해시킨 후 감마카운터로 방사능을 측정한 후 단백질양을 측정하여 pmole metal/mg cellular protein으로 표시하였다. Fe-59와 Ga-67의 섭취양상은 71결합형과 이온형 둘다에서 크기의 차이는 있지만 비슷한 양상을 보였다. 즉 두 방사성 금속은 Tf 결합형과 이온형으로 세포로 들어간다. Tf과 함께 존재할 때는 철분이나 Ga 섭취가 변형세포에서 비변형세포에 비해 약 3배 이상 높았으나 Tf이 없이 이온형으로 존재할 때는 이와는 반대로 비변형세포에 의한 섭취가 변형세포에 비해 약4배 더 많았다. Ga-67이나 Fe-59의 섭취의 효율성은 Tf결합형인 Ga-Tf, Fe-Tf 형태가 이온형에 비해 약 10-15배 더 컸다. 그러나 섭취는 효율성의 크기는 Ga-67(3배)에 비해 Fe-59(10배)가 더 컸다. Ga-67의 섭취는 Tf의존성과 Tf비의존성 기전이 같이 존재하며 변형세포와 비변형세포는 서로 반대로 작용하였다. 즉 변형세포의 섭취는 Tf의존성 기전에 의하고, 비변형세포의 섭취는 Tf 비의존성 기전에 의해 주로 일어나며 종양조직에 의한 Ga-67의 섭취 기전은 부분적으로는 Fe-59와 같은 섭취기전을 공유할 수 있다고 생각되었다.

• 한국한의학연구원논문집
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• 제18권2호
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• pp.139-149
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• 2012

Objectives : This is the study to understand of the pulse wave factor according to BMI and period of sterility on female, and to confirm the relationship of pulse wave factor among left and right inch, bar and cubit. Methods : The Questions and measurement of the pulse wave were operated with subjects(76 sterile females using on public health center). The measurement of the pulse wave was operated in 6 part of left and right inch, bar and cubit. The pulse wave was prior measured in part of left bar (i.e. interior pulsation part of radial process styloides in left hand), and next was measured in part of left inch and bar. And the pulse wave was operated samely in part of right inch, bar and cubit. Results : The results were as follows. The pulse energy of 6 part of left and right inch, bar and cubit was showed statistical significance and decreased in order of left inch, right inch, left cubit, right cubit, left inch, right bar. The left and right inch and cubit were showed numerical value of normal range, but left and right bar were showed lower pulse eneregy than normal range. Also left and right cubit were showed lower than left and right inch, and higher than left and right bar. In BMI, The pulse energy of left and right inch, cubit and the average of right hand was not showed statistical significance in the range of low-weight, normal, over-weight and obesity. But in the left and right bar and the average of left hand, the pulse energy of over-weight and obesity group were showed significantly higher than low-weight group. And the pulse wave factor was divided the pattern of h1 showing high numerical value in inch (Ap, As, Aw) and the pattern of Wm showing high numerical value in bar and cubit (RAI, Ad) Conclusions : The low pulse energy of bar was significant observation on the setting of oriental medical diagnostic index on sterilitas. Also, in the numerical value pattern of diverse pulse wave factor, it was divided the pattern of high numerical value in inch and the pattern of high numerical value in bar and cubit. On this, we think that the studies need in the future.