• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1977년도 제11차 학술대회연제 순서 및 초록
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• pp.3.3-3
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• 1977

1976년 1월부터 동년 12월까지 본병원 당뇨병진료실을 방문하여 당뇨병으로 진단된 환자 중 청력검사를 시행한 43례(남자 25례, 여자 18례)와 그중 청각장애자 8례를 대상으로 임상적 소견 및 그 상호관계를 관찰하여 다음과 같은 결론을 얻었다. 1) 당뇨병환자 43례 중 청각장애자는 8례이며, 청력형은 고음급추형 및 고음점경향이 대부분이다. 2) 중연속 및 고연령층에 청각장애자의 출현빈도가 높다. 3) 이식기간과는 무관하나, 혈당치 및 혈청총 cholesterol치와는 어느 정도 상관관계가 있다. 4) 강막증, 고혈압증 및 신경증 등 합병증을 동반한 례에 청각장애자가 많다. 5) 당뇨병환자의 청각장애의 성립요인은 단일한 것이 아니고 여러가지 요소가 관여하는 것으로 생각된다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제16권2호
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• pp.152-156
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• 1994

Rhinocerebral mucormycosis is an acute fulminant opportunistic fungal infection in debilitated patients with underlying pathologic conditions, which are diabetic ketoacidosis, immunosuppressed disease. We experienced a case of rhinocerebral mucormycosis. The patient was 41 year-old female, who had diabetes for five years and suffered from left facial swelling and pain, left ophthalmoplegia and facial skin necrosis. Total maxillectomy was done combined with systemic Amphotericin B therapy, Biopsy proved mucormycosis but she expired.

• International Journal of Oral Biology
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• 제42권2호
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• pp.39-45
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• 2017

Metformin (1,1-dimethylbiguanide hydrochloride), derived from French lilac (Galega officinalis), is a first-line anti-diabetic drug prescribed for patients with type 2 diabetes. However, the role of metformin in odontoblastic cell differentiation is still unclear. This study therefore undertook to examine the effect of metformin on regulating odontoblast differentiation in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. As compared to controls, metformin significantly accelerated the mineralization, significantly increased and accelerated the expressions of ALP and Col I mRNAs, and significantly increased the accelerated expressions of DSPP and DMP-1 mRNAs, during differentiation of MDPC-23 cells. There was no alteration in cell proliferation of MDPC-23 cells, on exposure to metformin. These results suggest that the effect of metformin on MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells, facilitates the odontoblast differentiation and mineralization, without altering the cell proliferation.

• Imaging Science in Dentistry
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• 제46권1호
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• pp.53-56
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• 2016

$M{\ddot{o}}nckeberg$ sclerosis is a disease of unknown etiology, characterized by dystrophic calcification within the arterial tunica media of the lower extremities leading to reduced arterial compliance. Medial calcinosis does not obstruct the lumina of the arteries, and therefore does not lead to symptoms or signs of limb or organ ischemia. $M{\ddot{o}}nckeberg$ sclerosis most commonly occurs in aged and diabetic individuals and in patients on dialysis. $M{\ddot{o}}nckeberg$ arteriosclerosis is frequently observed in the visceral arteries, and it can occur in the head and neck region as well. This report describes a remarkable case of $M{\ddot{o}}nckeberg$ arteriosclerosis in the head and neck region as detected on dental imaging studies. To the best of our knowledge, this is the first case that has been reported in which this condition presented in the facial vasculature. The aim of this report was to define the radiographic characteristics of $M{\ddot{o}}nckeberg$ arteriosclerosis in an effort to assist health care providers in diagnosing and managing this condition.

• 한국한의학연구원논문집
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• 제4권1호통권4호
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• pp.129-138
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• 1998

Angiogenesis, the formation of new blood vessels, is considered to be involved in many pathological symptoms such as diabetic retinopathy, arthritis, inflammation and solid tumour. In particular, it is thought that angiogenesis is critical for development and growth of solid tumour. Recent study shows that there is a highly significant association of microvessel density with overall survival and relapse-free survival in patients with breast tumour In this study, the inhibition effect of angiogenesis of traditional herbs used for the treatment of cancer was examined. It was found out that the extract of Agaricus blazei by boiling water is a possible inhibitor of angiogenesis. It inhibited normal developmental angiogenesis In the chorioallantoic membrane of chick embryos and also inhibited capillary-like tube formation by endotherial cells on matrigel in vitro. These results suggest that Agaricus blazei can be a potent angiogenesis inhibitor.

• 대한한의진단학회지
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• 제17권3호
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• pp.241-252
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• 2013

Objectives The purpose of this study was to investigate the effects of walking exercise on diabetes mellitus indicator and vascular compliance of type 2 diabetes mellitus adults. Methods The subjects were 2 groups; exercise group(n=11, $age=57.36{\pm}8.74$), non-exercise group(n=10, $age=59.20{\pm}5.81$). Walking exercise five or more times a week, and more than 10,000 steps per day with writing the walking diary ordered to the exercise group. For date analysis, mean and standard deviation scores were calculated, and independent t-test was performed. Result After 45 days of walking exercise, weight (p <.01), abdominal obesity rate (p <.05), body fat mass (p <.05) showed significant difference between the groups. but diabetes indicators and vascular compliance tend to decreased in the exercise group, there was no significant difference between the groups. Conclusions Walking exercise is effective in improving body composition.

• 한국식품영양과학회지
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• 제29권5호
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• pp.875-880
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• 2000

Reactive oxygen species are produced under diabetic conditions and possibly cause various forms of tissue damage in patients with diabetes mellitus. The aim of this study was to examine the effects of high glucose on the alloxan-induced beta cell injury. The insulinoma (RINm5F) cells were clutured either with high glucose (22.2 mM) or normoglucose (5.6 mM) in RPMI 1460 media for 3 days. The SOD activities were determined by spectrophotometric assay and nitroblue tetrazolium (NBT) stain. The effects of high glucose on the cytotoxicity of alloxan were also investigated in RINm5F cells and the cells viability were determined by 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) methods. Results showed that the CuZn-SOD activity was decreased but Mn-SOD activity was increased significantly in RINm5F cells cultured with high glucose (22.2 mM) media. The cytotoxicity of alloxan was increased by high glucose compared with normoglucose in RINm5F cells. Diethyl-dithiocarbarmate (DDC), as inhibitor of CuZn-SOC, also potentiate the alloxan-induced cytotoxocity in RINm5F cells. These results suggest that, in RINm5F cells, short term culture with high glucose media decreases Cu-Zn-SOD activity and the decreased activity of CuZn-SOD many one of the causative factors of beta-cell injury induced by high glucose.

• 센서학회지
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• 제28권5호
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• pp.305-310
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• 2019

The purpose of this study is to classify the concentration of HbA1c (glycosylated hemoglobin), which is an indicator in the management of accurate blood glucose level in diabetic patients, using a non-invasive optical property measurement method. To measure the optical properties of HbA1c, the optical source uses LEDs and laser diodes of 400 nm in the visible region and 1450 nm in the nearinfrared region using thermopile to detect the Raman scattering intensity. An HbA1c control solution was used. As a result, the optical properties of 5% (normal) and 9% (abnormal) HbA1c control solutions showed specificity in which the output values were reversed at 850 nm and 950 nm, respectively. This property was applied to distinguish between normal and abnormal values in diabetes. In addition, considering tissue penetration depths for non-invasive measurements, two wavelengths were determined to be effective in distinguishing the concentrations of HbA1c control solutions at 5%, 7%, and 9%.

• Archives of Plastic Surgery
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• 제49권4호
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• pp.543-548
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• 2022

Microvascular reconstruction frequently requires anastomosis outside of the zone of injury for successful reconstruction. Multiple options exist for pedicle lengthening including vein grafts, arteriovenous loops, and arteriovenous bundle interposition grafts. The authors performed a systematic review of arteriovenous bundle interposition grafts to elucidate indications and outcomes of arteriovenous grafts in microvascular reconstruction. A systematic review of the literature was performed using targeted keywords. Data extraction was performed by two independent authors, and descriptive statistics were used to analyze pooled data. Forty-four patients underwent pedicle lengthening with an arteriovenous graft from the descending branch of the lateral circumflex femoral artery. Most common indications for flap reconstruction were malignancy (n = 12), trauma (n = 7), and diabetic ulceration (n = 4). The most commonly used free flap was the anterolateral thigh flap (n = 18). There were five complications, with one resulting in flap loss. Arteriovenous bundle interposition grafts are a viable option for pedicle lengthening when free flap distant anastomosis is required. The descending branch of the lateral circumflex femoral artery may be used for a variety of defects and can be used in conjunction with fasciocutaneous, osteocutaneous, muscle, and chimeric free flaps.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2021년도 제63차 동계학술대회논문집 29권1호
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• pp.107-109
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• 2021

본 연구는 당뇨병 환자의 자기조절에 대한 주관적 유형과 특성을 분석하고자 시도되었으며, 당뇨병 환자의 주관성을 연구하는데 효과적인 Q방법론을 적용하였다. 대상자는 제2형 당뇨병을 진단받은 사람으로서 경구약이나 인슐린 주사로 치료받고 있으나 현재는 입원한 싱태가 아닌 사람 38명으로 구성하였으며, Q표본 40개의 진술문을 가장 부정(-4)에서 가장 긍정(+4) 범위의 9점 척도 상에 분류하도록 하였다. Q분류된 자료는 QUANL PC program을 이용하여 주요인분석(principal component factor analysis)과 배리맥스 회전(varimax rotation)을 통해 Q 요인분석이 행해졌다. 분석결과 당뇨병환자 자기조절에 대학여 제 1유형은 근거기반 순응형, 제2유형은 위기의식 자립거부형, 제3유형은 정보기반 관계지향형, 제4유형은 자기신뢰 실천형, 제5유형은 주관적 결핍 기반 반응 행동형으로 5가지 유형의 관점을 보여주었다. 따라서 당뇨병 환자 효율적 관리방법을 위해 당뇨병 환자의 질병 관리의 부정적 행위 성향을 이해하고, 당뇨지식 교육, 당뇨관리 정보 및 긍정적 심리를 통한 자기조절 프로그램을 개발 할 필요가 있다.