• Toxicological Research
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• v.29 no.4
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• pp.221-227
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• 2013

Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid bodies (EBs). In earlier study, embryonic stem cell test (EST) was established for assessment of the embryotoxic potential of compounds. Using EBs indicating the onset of differentiation of mouse ES cells, many toxicologists have refined the developmental toxicity of a variety of compounds. However, due to some limitation of the EST method resulting from species-specific differences between humans and mouse, it is an incomplete approach. In this regard, we examined the effects of several developmental toxic chemicals on formation of EBs using human ES cells. Although human ES cells are fastidious in culture and differentiation, we concluded that the relevancy of our experimental method is more accurate than that of EST using mouse ES cells. These types of studies could extend our understanding of how human ES cells could be used for monitoring developmental toxicity and its relevance in relation to its differentiation progress. In addition, this concept will be used as a model system for screening for developmental toxicity of various chemicals. This article might update new information about the usage of embryonic stem cells in the context of their possible ability in the toxicological fields.

• Korean Journal of Animal Reproduction
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• v.21 no.3
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• pp.281-285
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• 1997

The study was conducted to investigate on in vitro developmental rates of bisected bovine embryos co-culture in 10% FCS＋TCM-199 media containing hormones, oviductal epithelial cells and cumulus cells 0 to 7 days after bisection. In vitro developmental rates was defined as development rates on in vitro culture or FDA-test. The results are summarized as follows : 1. In vitro developmental rates of bisected bovine embryos co-cultured in 10% FCS＋TCM-199 media containing PMSG＋hCG, PMSG＋$\beta$-estradiol, hCG＋$\beta$-estradiol, PMSG, hCG 0 to 3 days and 4 to 7 days were 16.7~30.0% and 11.1~25.0%, respectively. In vitro developmental rates of bisected embryos co-cultured in 10% FCS＋TCM-199 media containing hormones significantly higher than that of non co-culture. 2. In vitro developmental rates of bisected bovine embryos co-cultured 10% FCS＋TCM-199 media containing oviductal epithelial cells 0 to 3 days and 4 to 7 days were 25.0% and 22.2%, respectively.

• Child Health Nursing Research
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• v.10 no.3
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• pp.321-331
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• 2004

Purpose: To develop an Infant Developmental Assesment Scale appropriate for Korean infants that includes cultural context. Method: The total sample included 990 infants aged birth to 24months. The developmental tests were conducted at hospital well baby clinic, daycare centers, public health centers and homes located in city, urban and rural areas. Item analysis was done to examine content validity of the scale. Test responses were analyzed by SPSS to examine the inter-rater reliability, and construct validity. Result: Based on the naturalistic observation and analysis of other developmenta l instruments, 260 Korean infant developmental items were created. The mean score of the developmental quotient of 966 infants was 101.63±10.89. Correlation coefficient of inter-rater reliability was .99. In addition, 84.6％ of total items showed Kappa .70 and above. The development quotient was significantly different depending upon the residential area and father's occupation, therefore, construct validity using known group technique was supported. Conclusion: The developed instrument can be used to assess the development of handicapped infants, as well as normal infant's general abilities and to study individual differences within the normal range for Korean.

• Agribusiness and Information Management
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• v.4 no.1
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• pp.1-12
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• 2012

Cameroon, with her numerous resources, still depends on foreign aid while the rate of poverty remains high. Thus, even though historical evidence gives impetus to the impasse over role of developmental aid, from the top down approach through to development as a springboard raising states from the doldrums of poverty, it is still very difficult to draw a substantial relationship between developmental aid and poverty reduction. Against this backdrop of controversy, I find it apt to put Cameroon on a balance scale. Therefore, the purpose of this research is to critically assess the implications of developmental aid on poverty reduction and agro-rural development in Cameroon, using the RUMPI Area Development Project in the South West region of Cameroon as a case study. The study will situate and contextualize the top-down and bottom-up approaches to development within the basis of a Cameroonian perspective, using the Sachs-Easterly debate. The RUMPI Project was introduced with the objective of improving agriculture and empowering the rural woman; thereby fighting poverty within the South West region of Cameroon. Despite its criticism of the barriers to development created by corruption, political pressure and limited use of local and grass-root partnerships, the study, in assessing these failures also tries to outline vital ways in which the project can be improved upon.

• Journal of the East Asian Society of Dietary Life
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• v.19 no.6
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• pp.839-845
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• 2009

The objective of this study was to examine the eating habit characteristic and developmental outcomes of young children (ages 24 months through 42 months) as well as their mothers' nutritional attitudes and maternal levels of nutrition knowledge. The study also analyzed relationships among the children's eating habits and developmental outcomes and the mothers' nutritional attitudes and nutrition knowledge levels. The subjects included 164 young children who were enrolled in early childhood education and care settings in Seoul and Gyunggi province. The main results were as follows. There were significant correlations among the young children's eating habits and developmental outcomes, specifically between their attitudes towards meals and fine motor skills, communication, social-emotional aspects, and cognitive areas (p<0.01). In addition, there were significant correlations among the young children's eating habits, the mothers' nutritional attitudes and their nutrition knowledge levels (p<0.01).

• Journal of Family Resource Management and Policy Review
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• v.17 no.2
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• pp.75-91
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• 2013

This study is focused on the amount of time spent on child care by mothers with preschool children with developmental disabilities. It is designed to find out how much time mothers spend taking care of their children and to identify related factors. The subjects of this study are 162 mothers of children with developmental disabilities residing in Seoul. The findings are as follows: First, mothers with preschool children with developmental disabilities spent 6 hours and 50 minutes per day caring for their children during weekdays and 6 hours and 10 minutes on weekend days. This is double the amount of time spent by the average mother with preschool children. Second, mothers spent much more time caring for their disabled children than they do for their children without disabilities. Third, determinants of a mother's time for caring their disabled child during weekdays were mother's employment, the number of children, and gender of the disabled child. On weekend days, determinants of mother's care time were the number of children and husband's help for childrearing.

• Korean Journal of Social Welfare
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• v.47
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• pp.7-33
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• 2001

The purpose of this study was to the impact of organizational culture on the organizational effectiveness in hospitals were empirically analysed. Data were collected by 151 social workers including general hospitals with one social worker at least and single-department hospital with two social workers or more, were identified nationwide through the registry of Korean Association of Medical Social Workers and Korean Association of Hospitals. The results of this study were summarized as follows; First, most social workers report that characteristic of culture in their hospitals are group culture the first, hierarchial culture the second, rational culture the third, and developmental culture finally in order of social worker's recognition. Second, according to the types of organizational culture, there were significantly different levels of organizational effectiveness. Social worker's perceived group cultures in hospital showed higher job satisfaction, organizational commitment than other culture patterns. And also, social worker's perceived developmental cultures in hospital showed higher organizational commitment quality of social service than other culture patterns. Third, multiple regression analysis was conducted to find the relationship of organizational culture and organizational effectiveness. As a result, developmental culture showed a strong relationship with job satisfaction, organizational commitment and quality of social services Finally, as for the cultural affects on the organizational effectiveness depended on intensive attention to developmental culture in hospital Consolidating the attribute of developmental culture in hospital is also proposed to improve the organizational cultures.

• Toxicological Research
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• v.35 no.1
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• pp.65-74
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• 2019

Tetrahydrocurcumin (THC) is a major metabolite of curcumin, which is obtained from Curcuma longa. THC has various benefits and overcomes the bioavailability issue of curcumin. To establish it as a pharmacologically active molecule, its safety profile has to be determined. Thus, the present study aimed to determine the preclinical safety profile of THC in a 90-day subchronic and reproductive/developmental toxicity study in Wistar rats. THC at oral doses of 100, 200, and 400 mg/kg was administered daily for 90 days. Rats in the recovery group were kept for 14 days after treatment termination. The animals were observed for treatment-related morbidity, mortality, and changes in clinical signs, clinical pathology, and histopathology. In the reproductive/developmental toxicity study, THC at 100, 200, and 400 mg/kg was administered orally to rats and the reproductive/developmental parameters in adult male and female rats and pups were observed. THC at up to 400 mg/kg/day of did not have any significant effect on all parameters in male and female rats in both toxicity studies. Thus, 400 mg/kg/day can be considered as the no-observed-adverse-effect-level of THC in rats.

• International Journal of Advanced Culture Technology
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• v.10 no.2
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• pp.135-139
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• 2022

The purpose of this study is to explore the application structure of customized "lifelong education: (versus) higher education" for individuals with developmental disabilities in two types.As for the research method, expert consultation was composed secondary with literature analysis as the primary procedure.The contents of the study were presented by classifying the application structure of customized lifelong education versus higher education for individuals with developmental disabilities into two types. Accordingly, the first research content is a school type-centered structure, which can be understood as a type that focuses on higher education while linking aspects of lifelong education. And the second research content is a structure centered on the type of independent life of individuals with developmental disabilities, which can be understood as a type that focuses on lifelong education while linking with the aspects of higher education. As a result of the study, the aspect that the research contents considered above can be gradually realized through the currently established infrastructure at Daegu University in the current situation in Korea has been improved.

• Journal of Convergence for Information Technology
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• v.11 no.10
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• pp.277-292
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• 2021

This study explores the narrative presented by Clandinin and Connelly as a qualitative study through in-depth interviews with five field workers in art education with developmental disabilities in order to find out what kind of experiences the field workers with developmental disabilities have in the field and what the meaning of that experience is. was performed. According to the purpose of the study, personal narratives generated through individual educational experiences, cultural and social narratives to which they belong, and institutional narratives of educational institutions such as schools, welfare centers, and children's art education institutions were examined. This study is meaningful as basic data that contributes to the study of art education for the developmental disabled from childhood to adulthood, and it is suggested that the discussion be expanded through the direction of art education for the developmental disabled presented by field workers.