• Korean Journal of Social Welfare
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• v.65 no.2
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• pp.179-201
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• 2013

Since the 1960s, Korean welfare regime has been characterized by developmental welfare regime, of which invisible welfare programs like relation-based welfare are one of core elements. Developmental welfare regime of Korea has been dismantled after 1990s by the internal and external pressures. Focusing on the declines of relation-based welfare, this study examines the dismantle of developmental welfare regime of Korea. Since the late-1990s, the roles of inter-family income transfer and public income transfer are significant changed in terms of each share of total household income and each contribution of poverty alleviation. In other words, the role of public welfare has been growing while that of relation-based welfare has been decreased in the last twenty years. For the sake of a successful welfare regime transition in Korea, redistributional function of public welfare is quite important, but the development of reciprocal social economy and open community are also needed. Because, at this time and in this place, traditional welfare state building strategy is not proper in many aspects. However, it is impossible to achieve the development of reciprocal open community by restoration of relation-based welfare which has been already declined. This study regards enlargement of social economy or third sector as a development of reciprocal open community, and insists that cooperatives are especially worthy of notice.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6261-6265
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• 2013

Background: Recent studies have suggested that expression of the RAS protein activator like-1 gene (RASAL1) is decreased in gastric carcinoma tissues and cell lines, indicated a role in tumorigenesis and development of gastric cancer. Reduced expression of RASAL1 could result in aberrant increase of activity of RAS signaling pathways in cancer cells. However, the exact mechanism which induces down-regulation of the RASAL1 gene remains unclear. This study aimed to determine the methylation status and regulation of RASAL1 in gastric cancer. Materials and Methods: Using the methylation-specific polymerase chain reaction (MSP), the methylation status of CpG islands in the RASAL1 promoter in gastric cancers and paired adjacent non-cancerous tissues from 40 patients was assessed and its clinicopathological significance was analyzed. The methylation status of RASAL1 in gastric cancer lines MKN-28, SGC-790l, BGC-823, as well as in normal gastric epithelial cell line GES-l was also determined after treatment with a DNA methyltransferase inhibitor, 5-aza-2'-doexycytidine (5-Aza-CdR). RAS activity (GAS-GTP) was assessed through a pull-down method, while protein levels of ERK1/2, a downstream molecule of RAS signaling pathways, were determined by Western blotting. Results: The frequencies of RASAL1 promoter methylation in gastric cancer and paired adjacent non-cancerous tissues were 70% (28/40) and 30% (12/40) respectively (P<0.05). There were significantly correlations between RASAL1 promoter methylation with tumor differentiation, tumor size, invasive depth and lymph node metastasis in patients with gastric cancer (all P<0.05), but no correlation was found for age or gender. Promoter hypermethylation of the RASAL1 gene was detected in MKN-28, SGC-790l and BGC-823 cancer cells, but not in the normal gastric epithelial cell line GES-1. Elevated expression of the RASAL1 protein, a decreased RAS-GTP and p-ERK1/2 protein were detected in three gastric cancer cell lines after treatment with 5-Aza-CdR. Conclusions: Aberrant hypermethylation of the RASAL1 gene promoter frequently occurs in gastric cancer tissues and cells. In addition, the demethylating agent 5-Aza-CdR can reverse the hypermethylation of RASAL1 gene and up-regulate the expression of RASAL1 significantly in gastric cancer cells in vivo. Our study suggests that RASAL1 promoter methylation may have a certain relationship with the reduced RASAL1 expression in gastric cancer.

• Development and Reproduction
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• v.20 no.4
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• pp.297-304
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• 2016

Lectins belong to the pattern-recognition receptors (PRRs) class and play important roles in the recognition and elimination of pathogens via the innate immune system. Recently, it was reported that lily-type lectin-1 is involved when a pathogen attacks in the early immune response of fish. However, this study is limited to information that the lectin is involved in the innate immune response against viral infection. In the present study, the lily-type lectin-2 and -3 of Oplegnathus fasciatus (OfLTL-2 and 3) have been presented to be included B-lectin domain and two D-mannose binding sites in the amino acid sequence that an important feature for the fundamental structure. To investigate the functional properties of OfLTLs, the tissue distribution in the healthy rock bream and temporal expression during early developmental stage analysis are performed using quantitative real-time PCR. OfLTL-2 and 3 are predominantly expressed in the liver and skin, but rarely expressed in other organ. Also, the transcripts of OfLTLs are not expressed during the early developmental stage but its transcripts are increased after immune-related organs which are fully formed. In the challenge experiment with RBIV (rock bream iridovirus), the expression of OfLTLs was increased much more strongly in the late response than the early, unlike previously known. These results suggest that OfLTLs are specifically expressed in the immune-related tissues when those organs are fully formed and it can be inferred that the more intensively involved in the second half to the virus infection.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.15 no.3
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• pp.147-154
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• 2015

Purpose: 3HB and AcAc are two ketone bodies that can be used as energy source in brain via succinyl-CoA:3-ketoacid CoA transferase (SCOT) and mitochondrial acetoacetyl-CoA thiolase (beta-ketothiolase, T2), called ketolysis. In case of malfunction of these enzymes, ketolysis cannot occur fluently causing various clinical manifestations. We want to know the numbers of patients and clinical manifestations of ketolytic defects in Korea. Material: For 67 patients of ketolytic defects out of 2794 patients that have done urine organic acid analysis, we analyzed clinical manifestations and age distribution. The study period was from January 2007 to September 2015. Method: To confirm persistency of ketonuria, repeated and loading organic acid analysis were done at least 1 week period interval. SPSS was used for statistical analysis. Result: Thirty patients in infantile period (2 M-2 Y), 31 patients in childhood period (2 Y-12 Y), 5 patients after adolescent period (>12 Y) and 1 in neonatal period were diagnosed during the study period. The most frequent chief complaint was seizure followed by seizure with developmental delay and developmental delay only. Conclusion: Ketolytic defects were not so rare in Korea. Major clinical manifestations are seizure and developmental delay or mental retardation.

• Korean Journal of Child Studies
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• v.2
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• pp.1-16
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• 1981

This study had two purposes. First, to examine the stages and developmental order of object permanence based on Piaget's theory. Second, to assess the effects of delay, attentiveness, and direction of gaze. Two experiments were conducted to examine the object permanence development in infants. The subjects for the 2 experiments were randomly drawn from a well-baby clinic. The subjects for Experiment 1 were 72 infants, 12 each in 6 age levels : 6, 9, 12, 15, 18, and 21 months old. Experiment 1 was designed to examine the stages and developmental order of object concept development, ana infants received 5 tasks as follows : (1) finding an object partially hidden under one box (2) finding an object completely hidden under one box (3) finding an object after successive visible displacements (4) finding an object after one invisible displacement (5) finding an object after successive invisible displacements. The subjects for Experiment 2 were 24 9-month-olds. Experiment 2 was designed to assess the effects of delay, attentiveness, and direction of gaze for Stage IV of object concept development. Subjects were equally assigned into one of two delay groups: 0-sec delay and 3-sec delay. Attentiveness was rated in terms of a three-point scale, and then divided into high and low attentive groups. Direction of gaze was judged into two directions. In two experiments, infants received three trials of task, and received a score of 0, 1, 2 for each trials. Data were analyzed by ANOVA, Tukey test, and t-test for task performance, and direction of gaze was analyzed by chi-square. The results obtained from two experiments were as follows : 1. In object permanence test, subjects obtained significantly higher scores with age, and 6, 9, 12, 18 months were classified into different developmental stages. 2. In object permanence development, subjects received significantly different scores with task and a developmental order of tasks was found. First of all, infants mastered finding an object partially hidden under one box, and then mastered finding an object completely hidden under one box. Contrary to Piagetian theory, in this study, the development of finding an object after successive visible displacements and finding an object after one invisible displacement were sometimes reversed. Finally, finding an object after successive invisible displacements was mastered, and the concept of object permanence was completed. 3. In Stage IV of object concept development, a 3-sec delay did not significantly affect the performance of tasks. The O-sec delay group didn't perform significantly better than the 3-sec delay group. 4. In Stage IV of object concept development, attentiveness of infants significantly affected the performance of task. So the highly attentive infants obtained better performance scores than the low attentive infants. 5. In Stage IV of object concept development, direction of gaze significantly affected the performance of task. That is, infants who gazed at the box which contained the object showed a higher rate of success than infants who gazed at the box which had already displaced the object.

• Journal of the korean academy of Pediatric Dentistry
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• v.41 no.3
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• pp.225-232
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• 2014

The purpose of this study was to compare skeletal maturity index and dental developmental stages based on skeletal malocclusion. A total of 192 patients (89 male and 103 female) between 6 to 14 years old were selected for this study and underwent cephalograms, panorama radiographs, and hand-wrist radiographs. Any syndromic cases were excluded. Selected clinical parameters were dichotomised for statistical analysis. Chi-square, logistic regression analysis, and independent t-tests were used for the statistical evaluation. Canine, first molar, and second molar calcification were significantly associated with skeletal maturity in the logistic regression model (p < 0.05). In addition, patients who had higher skeletal maturity index were 11.43 times more likely to be female than those who had lower skeletal maturity index (p < 0.001). The patients with skeletal class II malocclusion displayed significantly higher dental developmental stage in canines, first premolars, first molars, and second molars than the patients with class III malocclusion (p < 0.05). The dental developmental stage of the patients was significantly associated with skeletal maturity. In addition, there was a significant difference between class II and class III malocclusion with some types of tooth calcification.

• The Journal of Korean Academy of Sensory Integration
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• v.17 no.3
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• pp.14-25
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• 2019

Objective : This study aims to verify the content validity and inter-rater reliability of the Korean version of the Peabody Developmental Motor Scale 2 (PDMS-2) and to identify the concurrent validity by comparing it with the Korean version of the Bruininks-Oseretsky Test of Motor Proficiency-2 (BOT-2). Methods : PDMS-2 was translated by the researcher and an eighth-year clinical occupational therapist. The content consistency of the Korean version of the PDMS-2 was verified by three professors with experience using it. After the verification of the content consistency of the PDMS-2 by the five clinical occupational therapists and the additional revision, the Korean version of the PDMS-2 was completed. The researcher and another occupational therapist evaluated the Korean version of PDMS-2 in 50 children and measured the inter-rater reliability. Concurrent validity was measured by comparing the results of the Korean version of PDMS-2 and Korean version of BOT-2. Results : The content consistency test showed overall agreement of mean 3.45, and the content understanding test showed a high level of understanding of mean 3.69. The inter-rater reliability and concurrent validity of the Korean version of the PDMS-2 showed a statistically significant correlation. Conclusion : The Korean version of the PDMS-2 showed high content understanding, reliability, and validity. It can assist clinicians and researchers who work in fields related to child treatment or development.

• 재활복지
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• v.20 no.1
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• pp.43-64
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• 2016

This study is to reveal the effects affecting mother' coping resources on caring stress of mothers caring for adult children with developmental disabilities. The research data was collected from the service users recruited from two disability organizations and the disabled community welfare centers in South Korea. The survey was limited to mothers caring for adult children with developmental disabilities over the age of 18. The samples of the study consisted of 119 mothers. The data were analysed through SPSS statistical program. It was used for the analysis method of Frequency analysis, T-test, ANOVA and Step wise regression. Analysis results are as follows: the family support and friend support of social coping resources is affecting in caring stress of mothers. Also, the mothers who is working are more caring stress than unemployed mothers and the mothers who is between 50age and 54age are more caring stress than the mothers of under 49 age. Based on these results, I proposed the idea of several programs for social work practice for community welfare centers based on the results.

• 재활복지
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• v.20 no.4
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• pp.107-134
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• 2016

The primary purpose of this study is to develop a quality of life scale for adults with developmental disabilities and to test its validity and reliability. For this purpose, the authors generated a initial item pool composed of 62 items based on the conceptual model of Felce and Perry (1995). The initial items were evaluated by three reviewers, and then the items were revised based on their feedbacks. Utilizing a survey questionnaire including the scale items, data on 430 adults with developmental disabilities were collected in collaboration with 33 social welfare agencies and residential facilities for people with disabilities. Through descriptive analysis, correlation analysis, and relevant theories, the qualities of each item were examined, and then the best 20 items were selected. Cronbach's ${\alpha}$ for the final scale was .87. The results of confirmatory factor analysis showed that the 5-factor model fitted the data reasonably well, In addition, criterion validity of each subfactor of the scale was successfully established, employing t-test, one-way ANOVA, and correlation analysis. In discussion, implications and limitations of this study were examined.

• Journal of the korean academy of Pediatric Dentistry
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• v.49 no.1
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• pp.35-44
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• 2022

The aim of this study is to evaluate the development of the left mandibular third-molar development with modified Demirjian method and its relation to chronological age. A total of 1653 digital panoramic radiographs of healthy individuals aged between 7 and 23 years who visited Yonsei University Dental hospital were selected. The developmental status of the left mandibular third molars was assessed using dental maturity scoring proposed by Demirjian et al. The mean age of the first appearance of mineralization, complete crown formation, and complete root formation were around 9, 14, 21 years respectively. Statistically significant differences between males and females in the development stage of D and G were revealed that crown formation and root length completion were attained earlier in males than in females. There was significant positive relationship between age and third molar development in both sexes, and new formula was presented to estimate age of children and adolescents based on their developmental stages of third molars. In this study, the use of left mandibular third molar as a developmental marker is appropriate, and age estimation can be attained with dental maturity stage.