• 대한소아치과학회지
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• 제38권1호
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• pp.68-74
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• 2011

레트 증후군은 X-염색체 연관 신경발달 장애로 주로 여아에서 발병하며 특히 언어 표현, 손의 사용 발달의 퇴행 및 심각한 지적 장애를 동반한다. 구강내 증상은 경련, 구강 위생 불량, 보행 장애, 구강 습관과 관련이 있고, 특히 이갈이가 가장 흔한 증상이다. 본 증례에서 레트 증후군 환아는 치아우식증을 주소로 내원하여 전신마취 하에 치료를 받았으며, 손의 상동증(stereotypic hand movement), 이갈이, 손가락 빨기 등의 전형적인 증상을 보였다.

• 한국생활과학회지
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• 제21권6호
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• pp.1043-1058
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• 2012

The purpose of this study was to identify how attitudes toward menopause and family-related variables (living with a first child, satisfaction with children, and marital satisfaction) were associated with the perceived menopausal symptoms of middle-aged Korean females. Data for the study were based on a community sample of 628 women whose ages ranged from 45 to 60, who were currently married and had at least one child. The respondents reported lower levels of menopausal symptoms, medium levels of marital satisfaction and slightly higher levels of satisfaction with children. Feelings of tiredness, irritability, and nervousness without apparent reason, and aches in the lumbago and joints were common menopausal symptoms reported in this study. Regression analysis was conducted to investigate the effects of monthly income, educational level, employment status, attitudes toward menopause, living with a first child, satisfaction with children, and marital satisfaction on perceived menopausal symptoms. Attitudes toward menopause, living with a first child, satisfaction with children and marital satisfaction were significantly associated with perceived menopausal symptoms. In particular, marital satisfaction had the strongest effect on perceived menopausal symptoms. The results showed that in the face of the developmental challenges experienced during the menopausal transition, family-related variables served as positive reinforcement for married middle-aged women. This finding suggests that in order to improve the menopausal transition, family education programs need to be developed and offered to middle aged females who suffer from severe menopausal symptoms.

• Journal of Ginseng Research
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• 제44권5호
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• pp.747-755
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• 2020

Background: Ginsenosides accumulation responses to temperature are critical to quality formation in cold-dependent American ginseng. However, the studies on cold requirement mechanism relevant to ginsenosides have been limited in this species. Methods: Two experiments were carried out: one was a multivariate linear regression analysis between the ginsenosides accumulation and the environmental conditions of American ginseng from different sites of China and the other was a synchronous determination of ginsenosides accumulation, overall DNA methylation, and relative gene expression in different tissues during different developmental stages of American ginseng after experiencing different cold exposure duration treatments. Results: Results showed that the variation of the contents as well as the yields of total and individual ginsenosides Rg1, Re, and Rb1 in the roots were closely associated with environmental temperature conditions which implied that the cold environment plays a decisive role in the ginsenoside accumulation of American ginseng. Further results showed that there is a cyclically reversible dynamism between methylation and demethylation of DNA in the perennial American ginseng in response to temperature seasonality. And sufficient cold exposure duration in winter caused sufficient DNA demethylation in tender leaves in early spring and then accompanied the high expression of flowering gene PqFT in flowering stages and ginsenosides biosynthesis gene PqDDS in green berry stages successively, and finally, maximum ginsenosides accumulation occurred in the roots of American ginseng. Conclusion: We, therefore, hypothesized that cold-induced DNA methylation changes might regulate relative gene expression involving both plant development and plant secondary metabolites in such cold-dependent perennial plant species.

• 한국철도학회논문집
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• 제16권2호
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• pp.129-137
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• 2013

본 연구는 최근 도시개발에 있어 관심사로 대두되고 있는 대중교통지향형 개발(TOD)에 대한 바람직한 개발방향을 모색하고, 서울시 역세권을 환승특성 유형별로 구분하여 실증분석을 통해 이에 대한 분석결과를 제시하는데 목적을 두고 수행하였다. 대중교통 이용자 특성에 미치는 영향력은 환승특성 유형별로 차이가 있는 것으로 규명 되었다. 향후 수도권의 대중교통전략 수집 시 차별화된 영향요소를 기반으로 개선(안)을 도출하는 것이 필요하며, 향후 지속적인 대중교통 이용수요 증진을 위한 기초를 마련해야 한다고 판단된다. 또한 지하철역과 직접적인 연계를 하기 보다는 보조적인 수단으로 버스전용차로(BRT)를 적절하게 연계하여 현재 단일역세권을 거점화하는 것이 필요하다고 판단된다.

• Journal of Preventive Medicine and Public Health
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• 제34권4호
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• pp.363-371
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• 2001

Objectives : To assess the degree of quality improvement (QI) implementation and to identify its associated factors. Methods : A mailed questionnaire survey of the QI staffs at hospitals with 400 beds or more was conducted between September 15 and October 30, 2000. Of the 108 hospitals eligible for inclusion in our study, 79 participated, yielding a response rate of 73.1%. After excluding 12 hospitals that did not perform any QI activities, 117 responses from 67 hospitals were used in our analysis. The degree of QI implementation was measured using the Malcolm Baldrige National Quality Award Criteria (MBNQAC). Factors evaluated for association with the degree of QI implementation were cultural, technical, strategic, and structural factors of the hospitals. Results : The average 01 implementation score across the 7 dimensions of MBNQAC was 3.34 on a 5-point scale, with the highest score for the area of customer satisfaction (3.88) followed by information and analysis (3.59) and quality management (3.35). The results of regression analysis showed that hospitals with a ofter information system (p<0.05) and using scientific and systematic problem solving approach (p<0.01) tended to perform a higher degree of QI implementation. While statistically insignificant, positive associations were observed for the factors of group or developmental culture, the degree of employee empowerment, and the use of prospective strategy. Conclusions : It appears that the most important factors contributing to active implementation of QI in Korean hospitals were the use of scientific skills in decision making, and having a quality information system to produce precise and valid information.

• 대한유전성대사질환학회지
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• 제18권3호
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• pp.95-98
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• 2018

미토콘드리아 질환은 단일 장기에서부터 여러 장기에 걸쳐 침범할 수 있다는 임상 증상의 광범위한 이질성이 특징이다. 안검하수, 색소 망막 퇴화, 외안근 마미, 시신경 위축 등과 같은 다양한 안구 증상이 미토콘드리아 질환에서 함께 나타날 수 있지만, 진행성 양안 백내장은 미토콘드리아 질환의 안과적 증상에서 매우 드물다. 저자들은 미토콘드리아 호흡 연쇄 복합체 결핍 환자에서 흔치 않은 안구 발현 현상인 진행성 양안 백내장 침범 사례를 경험하였기에 보고하는 바이다.

• 교육심리연구
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• 제28권1호
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• pp.1-21
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• 2014

이 연구에서는 과제의 유용가치가 상황적 흥미와 재참여 의지에 미치는 영향이 자기효능감 수준에 따라 다르게 나타나는지 살펴보고자 유용가치를 단기 유용가치(proximal utility)와 장기 유용가치(distal utility)로 각각 구분하여 비교하였다. 연구 1에서는 대학생을 대상으로 연산 과제에 대한 유용가치의 시간적 근접성과 자기효능감의 상호작용이 흥미유발에 미치는 효과를 살펴본 결과, 자기효능감이 높을수록 장기적인 유용가치가 흥미 유발에 효과적인 것으로 나타났다. 연구 2에서는 대학생과 발달적으로 차이가 있으며 학습 환경에서 수학이 필수적인 요소인 고등학생을 대상으로 교실학습 상황에서 연구를 수행하였다. 연구 결과, 대학생과 마찬가지로 자기효능감이 높을수록 장기적인 유용가치가 흥미 유발에 효과적인 것으로 나타났다. 이상의 연구 결과들은 과제에 대한 상황적 흥미를 증진시키기 위해 유용가치를 제공하는 경우 시간적 근접성과 자기효능감을 함께 고려해야 한다는 점을 시사한다.

• 한국융합학회논문지
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• 제10권10호
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• pp.267-274
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• 2019

본 연구는 부모의 양육태도와 아동발달의 관계를 알아보고자 하였다. 이를 위해 서울 및 수도권에 위치한 아동발달센터 및 아동관련 복지기관에 방문한 부모와 아동을 대상으로 검사를 실시하였다. 검사지는 총 230부를 준비하여 검사하였으나 검사과정에서 무응답 등의 누락 및 자료의 일관성 등의 문제로 신뢰성이 떨어진다고 판단되는 검사지 47부를 제외한 총 183부를 분석에 활용하였다. 자료 분석은 SPSS 18.0 버전을 이용하여 분석하였다. 검사대상자의 일반적 특성은 기술통계분석을 실시하였으며, 부모의 양육태도와 아동발달의 관계는 회귀분석을 실시하였다. 이와 같은 절차를 통해 다음과 같은 결과를 얻었다. 부모의 양육태도 중 자조행동에 있어 성취압력, 과잉기대가 영향을 주는 변수로 나타났으며, 소근육 운동에서는 감독, 과잉기대가 영향을 주는 것으로 나타났다. 표현 언어, 언어 이해에서는 성취압력, 과잉기대가 주요 변수로 영향을 주었다. 전체발달에 있어 성취압력, 감독, 과잉기대가 영향을 주는 것으로 나타났다.

• 실내환경 및 냄새 학회지
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• 제17권4호
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• pp.315-321
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• 2018

Phthalate is an endocrine disruptor that interferes with homeostasis and developmental regulation. It is highly toxic to the environment and is associated with various diseases of the human body. Using biological samples from 140 adult subjects, to evaluate the influencing factors which are related to contaminant concentration levels, we used correlation analysis and multiple regression analysis. Lastly, in order to analyze the health effects related to exposure to phthalates, we conducted a risk assessment by estimating acceptable daily intake exposure according to the influential factors. When we compared the concentration level according to influential factors, in general, the subjects who had engaged in home remodeling work had higher urinary phthalate metabolite concentrations levels than the subjects who had not engaged in home remodeling work. We can confirm statistically significant differences in DBP metabolites. In addition, we can confirm the concentration appeared higher in the categories such as using air freshener, sofa and foods. Through conducting a risk assessment of DEHP, BBzP, DiBP, and DnBP by using data on phthalate metabolite concentration in urine, it was found that the average concentration of all metabolites did not exceed TDI.

• 대한통합의학회지
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• 제9권4호
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• pp.1-9
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• 2021

Purpose : The purpose of this study was to investigate functional disability for the elderly in rural Korea and to identify influencing factors of functional disability. Methods : The data were collected for 76 community-dwelling elderly in rural area and above 65 years. We assessed cognitive function, functional disability, depression using LACLS, WHODAS 2.0, SGDS-K. Data were analyzed using descriptive statistics for general characteristics of subjects, Spearman's correlation among LACLS, SGDS-K, WHODAS 2.0, age, educational levels. And multiple regression was used to find influencing factors of functional disability. Results : As a result of this study, we identified that WHODAS 2.0 total score was 50.59, summary score was 9.94 and functional disability of the elderly in rural area is in the 70^th percentile. The highest level of disability occurred in areas related to 'life activities (household)', 'participation in society' and the lowest level of disability occured in areas of 'self-care', 'getting along with people'. Functional disability was significantly correlated with age (r=.398), cognitive function (r=-.547), depression (r=-.563) but not educational levels (r=-.215). Finally, we confirmed that depression (𝛽=.371), cognitive function (𝛽=-.263), widowed status (𝛽=.303), age (𝛽=.272), non-participation of community program (𝛽=.165) was significantly influencing factors of functional disability and the explanatory power of these factors was 52.80 %. Conclusion : This study revealed important factors of functional disability. Therefore, we need to consider these factors when we developed program related to health for the elderly (aged > 65 years) in rural Korea. Further, we need to standardize WHODAS 2.0 in order to enhance its applicability in clinical practices.