• Title/Summary/Keyword: Developmental Model

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Establishing the Managerial Boundary of the Baekdu-daegan(II) - In the Case of Semi-mountainous District - (백두대간 관리범위 설정에 관한 연구(II) - 준산악형 구간을 대상으로 -)

  • Kwon, Taeho;Choi, Song-Hyun;Yoo, Ki-Joon
    • Journal of the Korean Association of Geographic Information Studies
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    • v.7 no.1
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    • pp.62-74
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    • 2004
  • Baekdu-daegan is the greatest mountain chain as well as the major ecological axis of the Korean Peninsula. In recent year, however, this area is faced with the various kinds of developmental urge. To cope adequately with these problems, this study was executed to prepare synthetic and systematic management with conservation-oriented strategy for Baekdu-daegan and to suggest spatially definite zoning for the managerial area. This study is to take into consideration the traditional concepts of stream and watershed as well as the actual disturbance on Baekdu-daegan area. The study area is selected with semi-mountainous type, from Namdeokyusan to Sosagogae. To propose the process for reasonably establishing the managerial boundary adjacent to the Ridges, the analysis was carried out that ArcGIS was mainly used for its analysis with digital maps, Landsat TM image and ArcGIS Hydro Model. Landsat TM image was classified by 5 land use types such as cultivated land, urban area, barren area, water body and forest. Based on these analyses results, the managerial boundaries as alternatives from the Ridges were produced by watershed expansion process, and used for tracing the changes of areal ratio of various land use types to the relevant watersheds to search out the adequate managerial boundary. The results show that watershed expansion process could be effective tool for establishing the managerial boundary, and eighth expanded watershed toward Muju-Gun(west) and fifth expanded watershed toward Geochang-Gun(east) might be included for the adequate managerial boundary of the case site.

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Dietary Exposure to Transgenic Rice Expressing the Spider Silk Protein Fibroin Reduces Blood Glucose Levels in Diabetic Mice: The Potential Role of Insulin Receptor Substrate-1 Phosphorylation in Adipocytes

  • Park, Ji-Eun;Jeong, Yeon Jae;Park, Joon Beom;Kim, Hye Young;Yoo, Young Hyun;Lee, Kwang Sik;Yang, Won Tae;Kim, Doh Hoon;Kim, Jong-Min
    • Development and Reproduction
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    • v.23 no.3
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    • pp.223-229
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    • 2019
  • Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR). T2DM is correlated with obesity and most T2DM medications have been developed for enhancing insulin sensitivity. Silk protein fibroin (SPF) from spiders has been suggested as an attractive biomaterial for medical purposes. We generated transgenic rice (TR) expressing SPF and fed it to diabetic $BKS.Cg-m+/+Lepr^{db}$ mice to monitor the changes in blood glucose levels and adipose tissue proteins associated with energy metabolism and insulin signaling. In the present study, the adipocyte size in abdominal fat in TR-SPF-fed mice was remarkably smaller than that of the control. Whereas the adenosine monophosphate-activated protein kinase (AMPK)-activated protein kinase and insulin receptor substrate 1 (IRS1) protein levels were increased in abdominal adipose tissues after TR-SPF feeding, levels of six-transmembrane protein of prostate 2 (STAMP2) proteins decreased. Phosphorylation of AMPK at threonine 172 and IRS1 at serine 307 and tyrosine 632 were both increased in adipose tissues from TR-SPF-fed mice. Increased expression and phosphorylation of IRS1 at both serine 307 and tyrosine 632 in adipose tissues indicated that adipocytes obtained from abdominal fat in TR-SPF-fed mice were more susceptible to insulin signaling than that of the control. STAMP2 protein levels decreased in adipose tissues from TR-SPF-fed mice, indicating that STAMP2 proteins were reducing adipocytes that were undergoing lipolysis. Taken together, this study showed that TR-SPF was effective in reducing blood glucose levels in diabetic mice and that concurrent lipolysis in abdominal adipocytes was associated with alterations of AMPK, IRS1, and STAMP2. Increased IRS1 expression and its phosphorylation by TR-SFP were considered to be particularly important in the induction of lipolysis in adipocytes, as well as in reducing blood glucose levels in this animal model.

A Converged Study on the Longitudinal Relationship between Self-esteem and Community Spirit in Adolescents: Focusing on the Data of KCYPS (청소년의 자아존중감과 공동체의식에 관한 종단적 융합연구 -한국아동·청소년패널조사를 중심으로-)

  • Choi, Jung-Hyun
    • Journal of Convergence for Information Technology
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    • v.9 no.12
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    • pp.62-70
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    • 2019
  • The study used cross-lagged path modeling to examine the longitudinal associations between self-esteem and community spirit among adolescents. This is a longitudinal study designed to examine the developmental changes of adolescents' self-esteem and community spirit in Korea. This study used the data collected by the Korean Children and Youth Panel Survey (KCYPS) from 2014 through 2016. Participants were surveyed from the 5th grade to the 7th, which belonged to the 1st elementary school cohort panel of the KCYPS. To be used as the data of this study, children should have all information at 3-time points: the 5th grade; 6th grade; 7th grade. The collected data were analyzed with PSAW 18.0 and AMOS statistical program. The participants in this study were 903 males (51.6%) and 847 females (48.4%). The level of self-esteem was 3.29±.51, 3.19±.55, and 3.15±.57 point at 5th grade, 6th grade, and 7th grade each. The level of community spirit was 3.12±.52, 3.09±.59, 3.15±.55 point respectively. Community spirit from elementary school to middle school is consistently predicted by previous self-esteem. Likewise self-esteem has a significant predictive effect on subsequent community spirit.

Isolation and identification of goose skeletal muscle satellite cells and preliminary study on the function of C1q and tumor necrosis factor-related protein 3 gene

  • Wang, Han;He, Ke;Zeng, Xuehua;Zhou, Xiaolong;Yan, Feifei;Yang, Songbai;Zhao, Ayong
    • Animal Bioscience
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    • v.34 no.6
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    • pp.1078-1087
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    • 2021
  • Objective: Skeletal muscle satellite cells (SMSCs) are significant for the growth, regeneration, and maintenance of skeletal muscle after birth. However, currently, few studies have been performed on the isolation, culture and inducing differentiation of goose muscle satellite cells. Previous studies have shown that C1q and tumor necrosis factor-related protein 3 (CTRP3) participated in the process of muscle growth and development, but its role in the goose skeletal muscle development is not yet clear. This study aimed to isolate, culture, and identify the goose SMSCs in vitro. Additionally, to explore the function of CTRP3 in goose SMSCs. Methods: Goose SMSCs were isolated using 0.25% trypsin from leg muscle (LM) of 15 to 20 day fertilized goose eggs. Cell differentiation was induced by transferring the cells to differentiation medium with 2% horse serum and 1% penicillin streptomycin. Immunofluorescence staining of Desmin and Pax7 was used to identify goose SMSCs. Quantitative realtime polymerase chain reaction and western blot were applied to explore developmental expression profile of CTRP3 in LM and the regulation of CTRP3 on myosin heavy chains (MyHC), myogenin (MyoG) expression and Notch signaling pathway related genes expression. Results: The goose SMSCs were successfully isolated and cultured. The expression of Pax7 and Desmin were observed in the isolated cells. The expression of CTRP3 decreased significantly during leg muscle development. Overexpression of CTRP3 could enhance the expression of two myogenic differentiation marker genes, MyHC and MyoG. But knockdown of CTRP3 suppressed their expression. Furthermore, CTRP3 could repress the mRNA level of Notch signaling pathway-related genes, notch receptor 1, notch receptor 2 and hairy/enhancer-of-split related with YRPW motif 1, which previously showed a negative regulation in myoblast differentiation. Conclusion: These findings provide a useful cell model for the future research on goose muscle development and suggest that CTRP3 may play an essential role in skeletal muscle growth of goose.

Gestational Exposure to Pesticides Induces Oxidative Stress and Lipid Peroxidation in Offspring that Persist at Adult Age in an Animal Model

  • Ndonwi, Elvis Ngwa;Atogho-Tiedeu, Barbara;Lontchi-Yimagou, Eric;Shinkafi, Tijjani S.;Nanfa, Dieudonne;Balti, Eric V.;Indusmita, Routray;Mahmood, Amena;Katte, Jean-Claude;Mbanya, Armand;Matsha, Tandi;Mbanya, Jean Claude;Shakir, Ali;Sobngwi, Eugene
    • Toxicological Research
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    • v.35 no.3
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    • pp.241-248
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    • 2019
  • Pesticide exposure may induce biochemical alterations including oxidative stress and lipid peroxidation. However, in the context of developmental origin of health and disease, putative trans-generational effect of exposure to pesticides are insufficiently studied. We therefore aimed to evaluate the biochemical effect of gestational exposure to four pesticides on female Wistar rats and their offspring at adult age. We studied 30 female nulliparous Wistar rats divided into 5 equal groups. Group 1 served as the control group and received distilled water while group 2, 3, 4 and 5 received orally pesticide 1 (imidacloprid), pesticide 2 (chlorpyrifos), pesticide 3 (imidacloprid + lambda cyhalothrin) and pesticide 4 (oxamyl) respectively once daily throughout gestation at a dose equivalent to 1/10 lethal dose 50. The mothers were followed up until one month post gestation. The offspring were followed up from birth until adult age (12 weeks). In all animals at each time point we evaluated malondialdehyde (MDA), oxidative stress and liver function enzymes. There was similar variation of total body weight in all the groups during and after gestation. However, Female Wistar rats of the exposed groups had significant alterations in liver SOD (-30.8% to +64.1%), catalase (-38.8% to -85.7%) and GSH (-29.2% to -86.5%) and; kidney catalase (> 100%), GSH (> 100%). Moreover, MDA, alanine transaminase (ALT) and aspartate transaminase (AST) levels were significantly higher in pesticide exposed rats compared to the control group. Similar alterations in antioxidant enzymes, MDA and liver function enzymes were observed in offspring of treated rats evidenced at weaning and persisting until adult age. Exposure to pesticides causes oxidative stress and lipid peroxidation in exposed female Wistar rats and their offspring. The persistence in offspring at adult age suggests transgenerational adverse effects.

Development of Korean SPAR(Soil-Plant-Atmosphere-Research) System for Impact Assessment of Climate Changes and Environmental Stress (기후변화 및 환경스트레스 영향평가를 위한 한국형 SPAR(Soil-Plant-Atmosphere-Research) 시스템의 개발)

  • Sang, Wan-Gyu;Kim, Jun-Hwan;Shin, Pyong;Baek, Jae-Kyeong;Lee, Yun-Ho;Cho, Jung-Il;Seo, Myung-Chul
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.21 no.3
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    • pp.187-195
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    • 2019
  • The needs for precise diagnostics and farm management-decision aids have increased to reduce the risk of climate change and environmental stress. Crop simulation models have been widely used to search optimal solutions for effective cultural practices. However, limited knowledge on physiological responses to environmental variation would make it challenging to apply crop simulation models to a wide range of studies. Advanced research facilities would help investigation of plant response to the environment. In the present study, the sunlit controlled environment chambers, known as Korean SPAR (Soil-Plant-Atmosphere-Research) system, was developed by renovating existing SPAR system. The Korean SPAR system controls and monitors major environmental variables including atmospheric carbon dioxide concentration, temperature and soil moisture. Furthermore, plants are allowed to grow under natural sunlight. Key physiological and physical data such as canopy photosynthesis and respiration, canopy water and nutrient use over the whole growth period are also collected automatically. As a case study, it was shown that the Korean SPAR system would be useful for collection of data needed for understanding the growth and developmental processes of a crop, e.g., soybean. In addition, we have demonstrated that the canopy photosynthetic data of the Korean SPAR indicate the precise representation of physiological responses to environment variation. As a result, physical and physiological data obtained from the Korean SPAR are expected to be useful for development of an advanced crop simulation model minimizing errors and confounding factors that usually occur in field experiments.

Early Successional Change of Vegetation Composition After Clear Cutting in Pinus densiflora Stands in Southern Gangwon Province (강원도 남부지역에서 소나무림 벌채 후 초기 종조성 변화)

  • Cho, Yong Chan;Kim, Jun Soo;Lee, Chang Seok;Cho, Hyun Je;Lee, Ho Yeong;Bae, Kwan Ho
    • Journal of Korean Society of Forest Science
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    • v.100 no.2
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    • pp.240-245
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    • 2011
  • Vegetation changes were studied for 16 yr in clearcut logged Pinus densiflora forests in the southern Gangwon-do province in Korea by applying chronosequence approach. Ambient temperature and relative humidity, Detrended Correspondence Analysis (DCA), Multiple Responses Permutation Procedure (MRPP), Indicator Species Analysis (ISPAN) were used to examine successional trajectory and compositional changes. After clearcutting, canopy openness was increased abruptly at three folds (1yr 68.3% and R1 23.0%) and then decreased, but relative moisture was slightly decreased (6%) compare to control site. In the result of DCA, right after clear cutting, vegetation composition was developed heterogeneously compared to control sites, and then approached to control sites within 16 years. Based on MRPP, species composition of each developmental stages (1yr, 3yr, 10yr and 16yr) revealed signigicant differences to that of control vegetation (R1, R3, R10 and R16). Indicator species in 1yr and 3yr samples included various woody species rather than herbaceous species, but in 10yr and 16yr, herbaceous were more abundant. Earlier succession of pine forests likely can explain to Initial Floristic Composition (IFC) Model.

The Mediated Effects of Ego-Resilience and Countertransference Management Ability in the Relationship Between Counselor's Adult Attachment and Development Levels of Counselors (상담자의 성인애착과 상담자 발달수준의 관계에서 자아탄력성, 역전이 관리 능력의 매개효과)

  • Jeong, Jae-Sun;Hong, Hye-Young
    • The Journal of the Korea Contents Association
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    • v.21 no.12
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    • pp.632-644
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    • 2021
  • The purpose of this study was to examine the mediating effect of ego-resilience and countertransference management ability in the relationship between counselor's adult attachment and development levels of counselors. For this purpose, 389 counselors who conducted more than 5 times of verbal counseling per case were surveyed for 3 weeks using the online questionnaire function. Data were analyzed using SPSS 21 and AMOS 21, reliability analysis was conducted, and constructed structural equation model(SEM) and to verify validity, fitness, and mediating effects. The results of the analysis are as follows: First, counselor's attachment anxiety and attachment avoidance had indirect effects on the ability to manage countertransference through the medium of ego-resilience(p<.001). Second, counselor's attachment avoidance had an indirect effect on counselor's developmental level through countertransference management ability(p<.05). Third, it was confirmed that counselor's attachment anxiety and attachment avoidance had an effect on counselor's development level through double mediation of ego-resilience and countertransference management ability(p<.001). The significance and limitations of these results and suggestions for follow-up studies were discussed.

Is Does Failure Mindset Transmitted through Generations?: The Dual Mediating Effects of Mother's Happiness and Mother-Adolescent Open Communication (실패 마인드셋은 세대 간 전승되는가?: 어머니의 행복감과 개방적 의사소통의 이중매개효과)

  • Jung, Jiyu;Kim, Hansaem;Yang, Sujin
    • Korean Journal of Culture and Social Issue
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    • v.28 no.3
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    • pp.419-439
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    • 2022
  • The purpose of this study was to examine the relationship between failure mindset of the mother and adolescent, along with the mediating effects of mother's happiness and mother-adolescents (first and second-year middle school students in Seoul) open communication. For this study, self-reported data of 270 mother-adolescent dyads were analyzed using SPSS and Process macro Model 6. The results revealed that the mother's failure mindset directly predicted their adolescent's failure mindset. The mediating effect of the mother-adolescent open communication was significant, but the mediating effect of the mother's happiness was not significant. However, the mediation effect of the mother's failure mindset on the adolescent's failure mindset through mother's happiness and mother-adolescent open communication was significant. These results suggest that "failure-is-enhancing" mindset of mothers improve their positive affect and parenting skills, which contributes to developing adolescent's belief system about failure. Putting the results together, this study is significant in that it identified the intergenerational relationship of the failure mindset. Besides, the study results serve as a foundation for intervening on the adolescent's failure mindset by verifying the developmental mechanism of the failure mindset.

A Study on the Functions of Urban Health Centers under the Local Autonomy system (지방자치제에서의 도시보건소 기능강화 방안에 관한 연구)

  • 김진삼;박형종;김공현;김병성
    • Health Policy and Management
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    • v.4 no.1
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    • pp.1-24
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    • 1994
  • Recently, two main changes were observed in relation to activities of District Health Centers. One is the rapid increase in the quantity and variety of people's demands for health services due to improvement of income level and the other is an introduction of autonomy in local administration. Unitl recently, the District Health Services were mostly depended on the instructions and orders given by Central Governments, and it would be necessary to prepare for the future implementation of autonomous local administration. Especially, the urban health centers may need more attention than those in rural areas because of their complexity and it would be more difficult in choosing and implementing a most suitable health programs for urban communities. This study was made to find out a feasibl developmental model which could be applicable for the urban bealth centers in Kyeongnam- do area. The most studies relating to health centers activities in the past were made by saking questions to current health center workers, but this study has made an effort to find out the opinions of those who are representing the people in the community. For this study, therefore, the Members of Gity Parliament and Village Headmen from 10 cities is Kyeongnam- do were interviewed for the study and the results obtained were compared to those of health officers. It was found that both Parliament Members and Village Headmen were well aware of the need of health centers, however, they tend to put lower priority for health services in compare with other community activities, and pointed out poor quality of services and lack of public understanding as the problems to be overcome. As to the desirable body for policy decision and implementation of health programs, the Members of Local Parliament think the Local Parliament as ideal, where as Village Headmen prefer health experts, and health officenr prefer District Health Center respectively. The most urgent problems of the District health Centers are mentioned as lack of health manpower. As the results of his study, the followings are suggested for improvement of District Health Services; First : reinforcement of professional health workers, Second : establishment of Community Health Council, Third : strengthening of public health education and support, Fourth : flexibility in Local Autonomy and target system relating to health activities.

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