• BMB Reports
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• v.44 no.10
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• pp.686-691
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• 2011

Granulocyte colony-stimulating factor (G-CSF) is a cytokine secreted by stromal cells and plays a role in the differentiation of bone marrow stem cells and proliferation of neutrophils. Therefore, G-CSF is widely used to reduce the risk of serious infection in immunocompromised patients; however, its use in such patients is limited because of its non-persistent biological activity. We created an N-linked glycosylated form of this cytokine, hG-CSF (Phe140Asn), to assess its biological activity in the promyelocyte cell line HL60. Enhanced biological effects were identified by analyzing the JAK2/STAT3/survivin pathway in HL60 cells. In addition, mutant hG-CSF (Phe140Asn) was observed to have enhanced chemoattractant effects and improved differentiation efficiency in HL60 cells. These results suggest that the addition of N-linked glycosylation was successful in improving the biological activity of hG-CSF. Furthermore, the mutated product appears to be a feasible therapy for patients with neutropenia.

• Journal of Korean Elementary Science Education
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• v.42 no.1
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• pp.149-160
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• 2023

A Korean-version science curiosity questionnaire (Science Curiosity in Learning Environments [SCILE(15)]) was developed after factor analysis of the Korean-version SCILE(30) questionnaire. Pre-service elementary school teachers were surveyed using the Korean-version SCILE(30), and a factor analysis based on their responses was performed. The factor analysis demonstrated that the Korean-version SCILE(15) consisted of three curiosity factors: a 'science practices' factor, a 'stretching' factor, and an 'embracing' factor. Confirmatory factor analysis of the factor structure revealed correlations between all the factors, thus confirming their commonality as a science curiosity factors. The Cronbach alpha for the reliability of all items in the Korean-version SCILE(15) and of items by factor was greater than 0.700. The Korean-version SCILE(15) was therefore evaluated to be reliable as a science curiosity questionnaire. Pre-service elementary teachers who participated in the survey for the development of the SCILE(15) were aware of the 'science practices', 'stretching', and 'embracing' science curiosity factors. Analysis in a general linear model of the degree of recognition accorded by pre-service elementary teachers to the three science curiosity factors demonstrated significant differences between the curiosity factors in terms of recognition. This cohort of pre-service elementary teachers showed the highest level of recognition of the 'stretching' curiosity factor and the lowest level of recognition of the 'embracing' curiosity factor.

• Research in Plant Disease
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• v.21 no.1
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• pp.24-26
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• 2015

In April 2014, seedlings of Fallopia multiflora showing wilt symptom were first found at a greenhouse in Punggi-eup, Yeongju-si, Korea. A Fusarium-like fungus was isolated from the wilted plant and it was identified as Fusarium oxysporum based on morphological characteristics and nucleotide sequence data of translation elongation factor 1-${\alpha}$. The fungus isolated from the diseased plant was revealed to be pathogenic to the host plant through pathogenicity tests, and the reisolation of the pathogen confirmed Koch's postulates. This is the first report of Fusarium wilt occurring on Fallopia multiflora in the world.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.205-211
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• 2002

The purpose of this paper is 1) to extract managerial factor into each cell which is classified by the characteristic grill of new products 2) to construct a management model of new product development for korean companies. For this purpose, the characteristic grill of new products is classified by which is market/technology sphere. Moreover the focus of this analysis is on examination of success/failure factors, which have an important effect upon new product success or failure. The variables for this study were selected from literature survey and pre-interview was implemented specially. The subject of study was project leaders of electronics industry where have taken the leading part in product development activities in Korean manufacturing industries. Enquete survey was conducted in each firm and project managers were asked to respond. Conclusion of this study based on many significant results gained by the various multi-variate analysis are summarized as follows. First, it can he noted that success/failure factors are different by each classified model and characteristic grill of a new product. Second, it has been identified that the important factors of success products were technical & management support and market ability, the important factor of failure product were lacking in ability of technical development and R&D management system construction. This paper presents some useful guidelines in strategic and managerial aspects for development of new products. Concurrently, the model of this study should be a great practical approach for application of actual affairs.

• Journal of Genetic Medicine
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• v.19 no.2
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• pp.115-119
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• 2022

The 46,XX testicular disorder of sex development (DSD) is a rare condition in which 46,XX individuals develop testicular differentiation and virilization. Translocation of the sex-determining region Y (SRY) onto the X chromosome is the main cause of 46,XX testicular DSD, whereas dysregulation between pro-testis and pro-ovarian genes can induce SRY-negative 46,XX testicular DSD. Nuclear receptor subfamily 5 group A member 1 (NR5A1), a nuclear receptor transcription factor, plays an essential role in gonadal development in XY and XX embryos. Herein, we report the first Korean case of SRY-negative 46,XX testicular DSD with a heterozygous NR5A1 p.Arg92Trp variant. The patient presented with a small penis, bifid scrotum, and bilateral undescended testes. Whole exome sequencing revealed a heterozygous missense variant (c.274C>T) of NR5A1. Our case highlights that NR5A1 gene variants need to be considered important causative factors of SRY-negative non-syndromic 46,XX testicular DSD.

• Journal of Korean Academy of Nursing Administration
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• v.11 no.2
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• pp.159-172
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• 2005

Purpose: The Purpose of this study was to development a verbal abuse scale for operating room nurses in Korea. Method: To achieve the purpose of the study, a questionnaire was developed to interview 30 nurses and distributed to 761 nurses who working at 28 general hospital in Korea from september 7 to November 25, 2004. Item analysis and factor analysis were carried out to validate violence predicting scale. Cronbach's Alpha coefficient was used to test reliability of the scale. The data were analyzed by using SPSS/WIN 11.5 program. Result: As a result of the item analysis and factor analysis, 17 items were selected from the total of 30 items, and four factors were labeled as 'self esteem abuse by nurses(7 items)', 'self esteem abuse by physicians(6 items)', 'sexual abuse by physicians(2 items)', 'colleague abuse by physicians(2 items)'. Four factors were explained by 60.8% out of the total variance. The first factor explained 35.456%, second factor explained 12.401% and third factor explained 6.637%. And fourth factor explained 6.304%. Reliability of the factors were tested by Cronbach's Alpha coefficient and result was 0.885. Conclusion: The scale was identified to be a tool with a high degree of reliability and validity. Therefore, this scale can be effectively utilized for assessment of verbal abuse for operating room nurses by nurses and physicians in Korea.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1613-1616
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• 2004

The cellular response to hypoxia is controlled to a large degree by the transcription factor Hypoxia-inducible factor-1(HIF-1). HIF-1 is a transcription factor that is activated by hypoxia and plays a critical role in the development of the cancer phenotype. HIF-1 regulates transcription of a number of genes crucial for tumor survival under hypoxic conditions, including vascular endothelial growth factor(VEGF), erythropoietin(Epo) and several glycolytic enzymes. Tumors in which hypoxia can not induce HIF-1 transcriptional activity remain small and fail to metastasize. In this study, we examined whether aqueous root extract of Ailanthus altissima (REA) downregulate HIF-1, VEGF and p53, and raise the possibility that depletion of these proteins and the anti proliferative activities of REA have any effects on inhibition of angiogenesis in MCF-7 cells. Pharmacologic targeting of specific signal transduction pathways related to oncogenic transformation is a promising approach in cancer treatment. Therefore, REA could be a candidate drug for further clinical development.

• Journal of The Korean Digital Architecture Interior Association
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• v.11 no.3
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• pp.79-88
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• 2011

In the context of sustainability which is understood as equilibrium among three elements; human, space and time, the imbalance within the Seoul metropolitan area hinders its own area or the nation from development. Claims for the balanced development in the area are set up on the premise that there is a locational order of priority among the zones named 'overpopulation suppression', 'growth management' and 'conservation'. Based on the systematic consideration of competitiveness this study adopts the premise as a research hypothesis. Factor scales derived from the factor analysis, a kind of multivariate dependence analysis play an important role in this research process since they are measured by interval-ratio level and can be used for dependent variables in the statistical analysis. The hypothesis test carried out by means of the analysis of variance(ANOVA) concludes that the hypothesis assuming no difference in the competitiveness is rejected but the alternative hypothesis of the locational order mentioned above should be adjusted. Eigenvalues derived from the factor analysis could be used as weights for aggregate factor scales and the scales show that the priority is in the order of growth management - overpopulation suppression - conservation zones. This finding has also a significant implication that the countermeasures to cope with the lowering of the competitiveness resulted from the continuous and absolute restraints should be provided. And strategic approaches which are composed of key factors for each zone are deducted from in-depth review. (1) overpopulation suppression zone; health-welfare, educational base, public service factors, focusing on health-welfare one, (2) growth management zone; public service factor and (3) conservation zone; health-welfare, educational base factors, also focusing on health-welfare one.

• Fashion & Textile Research Journal
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• v.18 no.5
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• pp.595-605
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• 2016

Importance of appearance as a means of self-expression and communication is increasing in modern society even for men. And appearance has become an significant factor affecting men's quality of life. The main objectives of this study were to develop an instrument measuring appearance related quality of life(ARQoL), and examine the body factors influencing ARQoL. The ARQoL instrument was developed from in-depth interviews, focus group interviews, and literature review, and were revised through two pre-tests. The final questionnaire was administered through on-line survey with 440 men. Quota sampling was used based on age and body size. The results indicated that high ARQoL group showed significantly higher satisfaction on body factors including face, weight, shape, body proportion, hair, and overall impression than low ARQoL group. There was no significant difference in terms of satisfaction on height between two groups. Factor analysis showed that ARQoL consists of four factors - physical, economic, psychological and social factors. Overall impression was the most important body factor affecting all four factors of ARQoL and has very strong influence especially on economic ARQoL. BMI was also a significant factor affecting physical, economic and social ARQoL except psychological factor of ARQoL. Face had significant influence only on economic and psychological aspects of ARQoL.

• Korean journal of food and cookery science
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• v.21 no.3 s.87
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• pp.371-379
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• 2005

This article studied the motivational factor of participation skill competition and their effectiveness. This study was restricted to cooks within those who had participated in a cooking contest to allow measurement of participation and satisfaction. This thesis investigated 116 cooks by questionnaires from April 6, 2005 to April 23, 2005, of which 106 responses were used for statistical processing to perform this study First, from the motive of participation, 13 variables were analyzed into 3 factors such as the factor of social recognition, the factor of speciality, and the factor of self-development and self-realization. The factor as a motive of participating in skill competition has a significant effect on effectiveness. A total of three factors were extracted from Recognition consisting of 10 variables. Each factor was labeled as awareness of the competition, revision of test questions, and selection of the judges of the competition. Second, three factors were derived from 12 variables in association with the effect of the contest, including factors of contribution to industry development, technical and technological effect, and psychological effect. In addition, it was revealed that the motive of participating in skill competition had an significant impact on recognition. Third, the results of regression analysis demonstrated that factors relating to recognition of skill competition and participation motives significantly influence on the effect of the contest. One limitation of this study is that the Population of the survey was limited to those who had Participated in the contest. Thus, the findings of this study may not be generalizable for other cases. It is clear that further research is needed to collect more in-dept data from other similar competitions in an effort to extend the application of the present results to other studies.