• Title/Summary/Keyword: Development factor

Search Result 10,324, Processing Time 0.043 seconds

Regulation of Preimplantation Development of Mouse Embryos by Insulin and Tumor Necrosis Factor alpha (생쥐 초기배아에서 Insulin과 Tumor Necrosis Factor $\alpha$에 의한 발생의 조절)

  • 계명찬;한현주;최진국
    • Development and Reproduction
    • /
    • v.5 no.2
    • /
    • pp.101-106
    • /
    • 2001
  • Present study was aimed to verify the role of insulin and TNF-$\alpha$ in development of preimplantation embryos. Mouse morula were cultured for 40 hr in the presence or absence of insulin(400 ng/ml) and TNF-$\alpha$ (50 ng/ml). The morphological development, cell number of blastomeres per blastocyst, and mitogen activated protein kinase(MAPK) activity were examined. The developmental rate and cell number per embryo were the highest in insulin treatment group and the lowest in TNF-$\alpha$ treatment group. There was no significant difference in developmental rate between control and insulin plus TNF-$\alpha$ group. Taken together, it suggested that TNF-$\alpha$ impaired embryonic development and that insulin rescued developmental impairment imposed by TNF-$\alpha$. In blastocysts, insulin treatment significantly increased MAPK activity. TNF-$\alpha$ decreased the MAPK activity in a concentration-dependent manner. In the TNF-$\alpha$(50 ng/ml) -primed embryos, activation of MAPK by insulin was attenuated. In conclusion, these results suggest that there was a cross talk between insulin and TNF-$\alpha$ by means of activation of MAPK in preimplantation embryos and that insulin might rescue damage of embryos exposed to TNF-$\alpha$.

  • PDF

Influence of Neuromuscular Electrical Stimulation on MEF2C and VEGF Expression of Neonatal Rat Skeletal Muscle During Suspension Unloading (신경근전기자극이 체중 부하를 제거한 신생 흰쥐 골격근 조직의 MEF2C 및 VEGF 발현에 미치는 영향)

  • Koo, Hyun-Mo;Lee, Sun-Min
    • Physical Therapy Korea
    • /
    • v.14 no.1
    • /
    • pp.28-36
    • /
    • 2007
  • The aim of this study was to identify the effect of suspension unloading (SU) and electrical stimulation upon the development of neonatal muscular system. For this study, the neonatal rats were randomly divided into three groups: a control group, an experimental group I, and an experimental group II. The SU for experimental group I and II was applied from postnatal day (PD) 5 to PD 30. The electrical stimulation for soleus muscle of experimental group IIwas applied from PD 16 to PD 30 using neuromuscular electrical stimulation (NMES), which gave isometric contraction with 10 pps for 30 minutes twice a day. In order to observe the effect of SU and ES, this study observed myocyte enhancer factor 2C (MEF2C) and vascular endothelial growth factor (VEGF) immunoreactivity in the soleus muscles at PD 15 and PD 30. In addition, the motor behavior test was performed through footprint analysis at PD 30. The following is the result. At PD 15, the soleus muscles of experimental group Iand II had significantly lower MEF2C, VEGF immunoreactivity than the control group. It proved that microgravity conditions restricted the development of the skeletal muscle cells at PD 15. At PD 30, soleus muscles of the control group and experimental group II had significantly higher MEF2C, VEGF, immunoreactivity than experimental group I. It proved that the NMES facilitated the development of the skeletal muscle cells. At PD 30, it showed that SU caused the decrease in stride length of parameter of gait analysis and an increase in toe-out angle, and that the NMES decreased these variations. These results suggest that weight bearing during neonatal developmental period is essential for muscular development. They also reveal that NMES can encourage the development of muscular systems by fully supplementing the effect of weight bearing, which is an essential factor in the neonatal developmental process.

  • PDF

Analysis of the Technology Adoption Impact Factors for Automated Construction Equipment (건설 자동화 장비 도입을 위한 기술도입 영향요인 분석)

  • Lee, Chijoo;Lee, Ghang;Sim, Jaekyang
    • Korean Journal of Construction Engineering and Management
    • /
    • v.14 no.2
    • /
    • pp.56-64
    • /
    • 2013
  • New construction technologies, especially automated equipment, are rarely deployed on a construction site where many accidents and claims occur. This study analyzed and derived impact factors for technology adoption to improve the chance of adopting automated construction equipment to the field. First, impact factors were classified into functional and non-functional factors. Then the functional factors were divided into usability and functionality factors, and the non-functional factors into cost, construction property, and organization factors. Next, the importance and realization possibility of each impact factor were analyzed through a survey with experts. Usability and functionality were analyzed to have the highest importance and realization possibility. Lastly, the differences between construction companies and equipment development companies in the importance and realization possibility of each factor were analyzed. Construction companies recognized previous relationship, operator's attitude, members' will, and construction quality more important than equipment development companies.. The equipment development companies should consider these differences between the view of construction companies and that of equipment development companies on the impact factors. The result of this study can be used as a basis for evaluating for automated construction equipment in the preliminary development phase.

The Behavior Variation of the Ion Viscosity and the Compressive Strength of the Seawater and Freshwater Flooded Chlorosulfonated Polyethylene After Accelerated Thermally Ageing (가속 열화 후 해수 담수 침지된 Chlorosulfonated Polyethylene의 이온 점도와 압축 강도의 특성 변화)

  • Hong, So Young;Kim, Min Ju;Jeong, Eun Mi;Kim, Jin Pyo;Shin, Yong Deok
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
    • /
    • v.32 no.6
    • /
    • pp.490-495
    • /
    • 2019
  • This study performs the thermal aging of chlorosulfonated polyethylene (CSPE) for 807.36 and 1,614.48 hours at $110^{\circ}C$, which is equivalent to 40 and 80 years of aging at $50^{\circ}C$ in nuclear power plants, respectively. Flat-type CSPEs were soaked in seawater for five days and then dried for five days at room temperature. Furthermore, the soaked CSPEs were cleaned for 5 days with fresh water and dried for 1,100 days at room temperature. Through this process, the log IV of the CSPEs decreases, whereas the dissipation factor of the CSPEs increases as thermally accelerated aged years increase at the measured frequency. Although the phase degree of the response voltage versus excitation voltage of the CSPEs increases, that of the response current versus excitation voltage decreases with the thermally accelerated aging. The thermal conductivity of the CSPEs increases slightly, but the thermal diffusivity does not vary with the thermally accelerated aged year increase. The displacement of the compressive strength of the CSPEs decreases gradually as the thermally accelerated aged years increase.

Analysis of the Participation Reasons and Deterrents on Welfare Facility Dietitians for the Elderly (노인복지시설 영양·급식관리자의 교육 참여동기 및 저해 요인 분석)

  • Kim, Su Jin;Lee, Min A;Cho, Wookyoun;Lee, Youngmee;Choi, Jiyoung;Park, Eunju
    • Korean Journal of Community Nutrition
    • /
    • v.24 no.2
    • /
    • pp.127-136
    • /
    • 2019
  • Objectives: This study analyzed the education participation reasons and deterrents of dietitians who work in welfare facilities for the elderly. Methods: The survey was completed by 144 dietitians working at welfare facilities for the elderly in Korea. The survey was conducted in October, 2018, both on-line and off-line, based on the demographic characteristics, work status on welfare facilities for the elderly, Participation Reasons Scale (PRS) and Deterrents to Participation Scale (DPS-G). The data were analyzed using frequency analysis, descriptive analysis, factor analysis, reliability analysis, regressive analysis using SPSS ver. 25.0. Results: The reason for participation were divided into three factors: 'Responsibility of professional and self-development ($5.76{\pm}1.04$)', 'Job stability and personal benefits ($4.98{\pm}1.28$)', and 'Interaction and development of professional competencies ($5.85{\pm}1.00$)'. 'Interaction and development of professional competencies' was the highest motivation factor. Also, the deterrents for participation were divided into four factors: 'Dispositional barrier ($2.70{\pm}1.29$)', 'Dissatisfaction of education usability ($3.39{\pm}1.38$)', 'Institutional barrier ($4.21{\pm}1.45$)', and 'Situational barrier ($2.36{\pm}1.30$)'. 'Institutional barrier' showed the highest deterrents factor. In addition, 'Responsibility of professional and self-development' and 'Interaction and development of professional competencies' were negative attributes for 'Dispositional barrier' (p<0.001). Conclusions: These results provide basic data to promote participation in education and contribute to the improvement of their job ability and education capacity of the food and nutrition management of welfare facilities for the elderly.

A Study on the Recognition and Development of Skin Care Subjects Using VR (VR 활용 피부미용 교과목 인식과 개발에 관한 연구)

  • Lee, Jung-Hee
    • Journal of the Korean Applied Science and Technology
    • /
    • v.38 no.6
    • /
    • pp.1485-1492
    • /
    • 2021
  • In this study, in order to secure an educational environment for the development of skin beauty subjects using VR based on the learners' awareness of VR, a total of 105 learners' perception of VR, VR experience elements, and the development of VR-using skin beauty subjects, questions about general characteristics were conducted using an online questionnaire. As a result of the survey through frequency analysis, factor analysis, and correlation analysis, the higher the awareness of VR, the higher the educational performance and immersion (p<.01). It was found that awareness and interest were high (p<.001). As for the correlation, the higher the VR-using skin care experience factor, the higher the perception of VR-using skin beauty course development. Therefore, it was confirmed that it is necessary to develop and educate skin beauty subjects using VR in line with learners' expectations and the 4th industrial revolution era. Therefore, in follow-up studies, it is considered that it is necessary to develop and operate VR-based skin beauty subjects.

Reproductive Ecology of the Freshwater Marsh Clam, Corbicula papyracea (Heude) in Bukhan River (북한강 엷은재첩, Corbicula papyracea (Heude) 의 번식생태)

  • Kim, Dae-Hee;Lee, Wan-Ok;Lee, Jun-Sang
    • The Korean Journal of Malacology
    • /
    • v.30 no.2
    • /
    • pp.107-116
    • /
    • 2014
  • Gonadal development and maturation mechanism were studied on the freshwater marsh clam Corbicula papyracea (Heude), which is the endangered species in Korea. The specimens were collected in the rearing ponds and waterway of NFRDI in Gapyeong-gun, Gyeonggi-do from January to December 2004, and then investigated by condition factor, relative growth, gonadal development phases and gonad histological characters based on 30-50 individuals every month. Comparing with the freshwater marsh clam, C. papyracea is small, light olive brown shell and violet interior. The hermaphrodite individuals of C. papyracea take an internal fertilization and fertilized eggs are stored in the foster-sack in the gills, then the hatched juveniles are released outside after an ovoviviparous process. The average water temperature of inhabit area was in range of $1.8-27.0^{\circ}C$ and usually took great effects on the gonad maturation of C. papyracea. The condition factor ranged from 0.14 to 0.21 throughout the year, which was the lowest during winter season (December-February), and gradually increased to the highest value of 0.21 in May. The ratio of meat weight to total weight was 25.9-38.7%, indicating the similar trend with condition factor. The highest values of condition factor and the ratio of meat weight appeared 1-2 months later than gonadosomatic index reached the peak value, it was probably because that the ovoviviparous eggs would spend a long period before hatching from the foster-sack in the gills. To synthesize the characters of meat weight, condition factor and gonad development by histological study, reproductive cycle of C. papyracea could be divided into five successive stages: multiplicative stage (December to February), growing stage (February to May), mature stage (June to August), spawning stage (August to November), recovery stage (November to December). The smallest shell length of matured C. papyracea was 12.6 mm, and individuals, larger than 16 mm, was formed the nursery in the gills.

Characteristics of Ocean Environment in the Dry and Wet Seasons in the South Sea of Korea (한국 남해의 갈수기와 풍수기에 따른 해양 환경 특성)

  • Choi, Yong-Kyu;Yang, Joon-Yong;Lee, Young-Sik;Yu, Jun;Kim, Dae-Kweon;Han, In-Seong;Go, Woo-Jin
    • Journal of Environmental Science International
    • /
    • v.16 no.4
    • /
    • pp.459-466
    • /
    • 2007
  • To analyze the water characteristics in the dry and wet seasons, the data for temperature, salinity, nutrients and $chl-{\alpha}$ were used, which were observed in the south coastal area of Korea during April to October 2000. At Yeosu in the south coast of Korea, the higher values of 35.0 psu in salinity were shown in March and April, the lower values of 23.0 psu in salinity were shown in August and September. The annual range of salinity was 12.0 psu. The total amount of precipitation in the wet season (July to October) was occupied 68% (about 846 mm) during 2000. The precipitation of the dry season (November to June) was occupied 32% (about 394 mm) in the year In the coastal area, the salinity variation is distinct in the period of July to October. Based on this result, we divided the season into two parts: the dry season during April to June and the wet season during July to October. Factor analysis was shown that temperature has strong negative relation and nutrients show positive relations in the dry season by the factor 1, which explains the total valiance of 50.6% at the surface water. In the wet season, salinity has negative relation and nutrients show positive relation by the factor 2, which explains the total variance of 33.5%. The bottom layer also showed similar to those of surface water in the results of factor analysis. These mean that nutrients become rich due to the freshwater inflow in the wet season. The low saline water is shown not only in the south coast but also in the overall region in the South Sea of Korea. It is suggested that the South Sea of Korea may call a ROFI (Region of Freshwater Influence) system in summer.

An Explanatory Data Analysis about the Relationship between Mortality Level and Four Indicators Relating to the Causes Mortality Decline (사망수준과 사망 원인관련 지표들 간의 관계에 대한 자료탐색 분석)

  • Lee Sung Yong
    • Korea journal of population studies
    • /
    • v.26 no.2
    • /
    • pp.33-62
    • /
    • 2003
  • The purpose of this study is to analyze the relative importance of three factor -socioeconomic development, public health development, egalitarian nature of socioeconomic development- affecting mortality declines. Infant mortality rate and life expectancy at birth are used as the mortality index, that is the dependent variables, while GNP is used as the indicator of socioeconomic development, primary school enrollment ratio of female as the indicator of egalitarian nature of socioeconomic development, population per hospital bed as the indicator of public health. The data of these variables are collected two time-periods -before 1970 and during 1970-1980- over 50 countries. The explanatory data analysis is used as the statistical technique. We can find whether the relationship between dependent variable and independent variables are linear or nonlinear, and which case is the influential case in our model. The main results of this study are followings. First, the association between infant mortality rates and four indices are not linear. The most important factor explaining the variation of infant mortality is GNP, while primary enrollment of female is the second and GINI is the third important factor. However, population per hospital bed does not have a significant effect on the infant mortality rates in this study. Second, life expectancy at birth is log-linearly related to GNP. Unlike infant mortality rates, the most important factor explaining the variation of life expectance at birth is women's education and the next important factor GNP, and then the third one GINI. But, still population per hospital bed is not significantly related to the variation of life expectance in this study.

Feasibility Assessment of Spectral Band Adjustment Factor of KOMPSAT-3 for Agriculture Remote Sensing (농업관측을 위한 KOMPSAT-3 위성의 Spectral Band Adjustment Factor 적용성 평가)

  • Ahn, Ho-yong;Kim, Kye-young;Lee, Kyung-do;Park, Chan-won;So, Kyu-ho;Na, Sang-il
    • Korean Journal of Remote Sensing
    • /
    • v.34 no.6_3
    • /
    • pp.1369-1382
    • /
    • 2018
  • As the number of multispectral satellites increases, it is expected that it will be possible to acquire and use images for periodically. However, there is a problem of data discrepancy due to different overpass time, period and spatial resolution. In particular, the difference in band bandwidths became different reflectance even for images taken at the same time and affect uncertainty in the analysis of vegetation activity such as vegetation index. The purpose of this study is to estimate the band adjustment factor according to the difference of bandwidth with other multispectral satellites for the application of KOMPSAT-3 satellite in agriculture field. The Spectral band adjustment factor (SBAF) were calculated using the hyperspectral satellite images acquired in the desert area. As a result of applying SBAF to the main crop area, the vegetation index showed a high agreement rate of relative percentage difference within 3% except for the Hapcheon area where the zenith angle was 25. For the estimation of SBAF, this study used only one set of images, which did not consider season and solar zenith angle of SBAF variation. Therefore, long-term analysis is necessary to solve SBAF uncertainty in the future.