• Journal of Genetic Medicine
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• v.19 no.2
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• pp.115-119
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• 2022

The 46,XX testicular disorder of sex development (DSD) is a rare condition in which 46,XX individuals develop testicular differentiation and virilization. Translocation of the sex-determining region Y (SRY) onto the X chromosome is the main cause of 46,XX testicular DSD, whereas dysregulation between pro-testis and pro-ovarian genes can induce SRY-negative 46,XX testicular DSD. Nuclear receptor subfamily 5 group A member 1 (NR5A1), a nuclear receptor transcription factor, plays an essential role in gonadal development in XY and XX embryos. Herein, we report the first Korean case of SRY-negative 46,XX testicular DSD with a heterozygous NR5A1 p.Arg92Trp variant. The patient presented with a small penis, bifid scrotum, and bilateral undescended testes. Whole exome sequencing revealed a heterozygous missense variant (c.274C>T) of NR5A1. Our case highlights that NR5A1 gene variants need to be considered important causative factors of SRY-negative non-syndromic 46,XX testicular DSD.

• Archives of design research
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• v.19 no.5 s.67
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• pp.281-292
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• 2006

Modern cities' paradigm is rapidly changing to evolve into multi-functional spaces including living space, culture, welfare and environment. Therefore, upon these changing needs, the cultural images and the quality control became major issues in this area. This thesis will examine cultural contents development, a successful case-study, and the analysis of complex space development plan. Thereby each development case in cultural contents area will be extracted and it will seek to find out how they could make a complex cultural space. Moreover, the role and boundary of each Project Management case and Project Manager will be analyzed. The analysis showcases the importance of comprehensive and systematic management system. As a result, along with the recognition of the strong ground for Project Management and Project Manager, comprehensive planand the most effective management system for various complex cultural space development plans would be PM application which is expected to be new alternatives to improve complex space development quality.

• Clinical and Experimental Reproductive Medicine
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• v.14 no.1
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• pp.51-59
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• 1987

The present experiments have been bone to verify the effects of the warming rate and the degenerated blastomere(s) on further development of the frozen and thawed 4- and 8-cell mouse embryos. The embryos obtained from the mouse superovulated and mated were frozen in the solution of 15M DMSO in PBS containing 10% FCS at a slowly cooling rate($0.3^{\circ}C/min$). Two methods of warming slowly($8^{\circ}C/min$) and quickly ($450^{\circ}C/min$) were applied for thawing embryos. The thawed embryos were grouped according to the number of healthy blastomere(s) in the embryos. Some of the embryos were eliminated their degenerated blastomere(s) by means of a micromanipulation technique. The embryos were examined their developmental phases after 48 or 72 hrs incubation. The rates of blastocyst development from the frozen and thawed 4- and 8-cell embryos were 72.7% and 73.5%, respectively in case of thawing slowly, and were 78.9% and 80.0%, respectively in case of thawing quickly. The rate in case of thawing quickly was significantly higher than that in case of thawing slowly. The rates of blastocyst development from the frozen and thawed 4- and 8-cell embryos eliminated their degenerated blastomere(s) increased 5.9% and 24.4%, respectively compared with those of control groups not eliminated. The more number of degenerated blastomere(s) were eliminated from the embryos, the higher rate of blastocyst development was shown. It may be concluded from the results that the quickly thawing method is better for increasing survival rate than the slowly thawing one, and that the degenerated blastomere(s) in the frozen and thawed embryos affects as an interfering factor for further development of the embryos.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.17 no.4
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• pp.25-31
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• 2009

In development phase of the Aircraft Systems, the reliability prediction of electronic equipments are usually performed using MIL-HDBK-217. The reliability of fielded electronic systems, however, used to be underestimated with MIL-HDBK-217. To solve this problem, some alternatives are suggested and Telcordia SR-332 is among them. In this case study, the reliability of ESU which controls gas turbine engine is predicted using Telcordia SR-332 along with the development test data. The predicted reliabilities of ESU using Telcordia SR-332 and MIL-HDBK-217 are also compared. As a result this case study showed that the predicted reliability using Telcordia SR-332 was better close to field(operation) reliability than MIL-HDBK-217.

• Journal of Aerospace System Engineering
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• v.5 no.2
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• pp.8-11
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• 2011

The scope of this paper is to show a risk management plan including how to perform risk assessment and to make a mitigation plan aspects of the communication payload system development. According to system engineering management guide of DoD of USA and risk management plan of satellite communication system, risk assessment and mitigation plan of communication payload system were performed. In this paper, it is indicated the process of risk management and risk assessment procedures as well as mathematical model for risk assessment of DoD guide. It is shown how risk assessment and mitigation plan have implemented in communication payload system development through case study.

• Korean Journal of Schizophrenia Research
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• v.19 no.1
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• pp.10-16
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• 2016

Objectives : This article aims to describe the development of smartphone application for the case management of patients with schizophrenia. Methods : Gwangju Bukgu-Community Mental Health Center developed and launched a smartphone application (HYM) for cognitive-behavioral case management and symptom monitoring. The development of the application involved psychiatrists, nurses, social workers, psychologists, and software technicians from a software development company (Goosl Corp.). Results : The HYM application for clients includes six main modules including Thought record, Symptom record, Daily life record, Official notices, Communication, and Scales. The key module is the 'Thought Record' for self-directed cognitive-behavioral treatment (CBT). When the client writes and sends the self-CBT sheet to the case manager, the latter receives a notification and can provide feedback in real time. 'Communication' and 'Official notices' are useful for promoting communication between case managers and clients with schizophrenia. Ratings in 'Symptom record', 'Daily life record', and 'Scales' modules are stored in graphic or table form representing changes in them and shared with case managers. Conclusion : The interactive function of this application is the key characteristics that distinguishes it from other mobile self-treatment tools. This smartphone application may contribute to the development of a youth- and customer-friendly case management system for individuals with early psychosis.

• The Transactions of the Korea Information Processing Society
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• v.2 no.5
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• pp.721-732
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• 1995

The IPSE(Integrated Project Support Environment) tool can be seen as a result of an attempt to synthesize the key aspects of language-centered, specific methodology-based and toolkit oriented environments, which are current CASE tools into an organic whole. The IPSE approach based on a process model is regarded as an effective way to implement integrated CASE. The PM-CASE(Process Model based CASE) tool is currently a prototype which draw diagrams describing processes by using a new modeling technique. Attributes related with a task of withen the process model should be defined an saved the database. These attributed are used to retrieve the information of products, and to call the tool related which the task. In this paper, TSEE(Process centered Software Engineering Environment) tools are compared and analyzed. By describing the basic concept, architecture and design of PM-CASE tool, a method of building an process model-based CASE tool is proposed be support an effect software development and management.

• Journal of Korean Academy of Nursing Administration
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• v.19 no.5
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• pp.668-678
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• 2013

Purpose: This study was done to develop a realistic clinical case and investigate nurses' decision-making about nurses' ethical dilemmas with physicians in the fields of nursing practice. Methods: Case development and a hypothetical case study were used. Participants were 52 nurses. Data were collected in 2012 and 2013 using an open-ended questionnaire and interviews and analyzed using content analysis and descriptive statistics. Results: Various dilemma situations between nurses and physicians, such as violence, deathbed, medication prescription, and physicians' incapacity unfairness, were suggested. A clinical dilemma case about medication prescription was developed based on nurses' experiences. Nurses' responses to the developed case situation and responses were classified into five types. Various reasons were given for making the decisions and about 56% of the nurses decided to notify their supervisor without deleting nursing records. Conclusion: In this study, a realistic clinical dilemma case was developed, and nurses' ethical decision making was identified. These findings can be used in developing effective strategies for nurses to solve ethical dilemmas and to improve ethical decision-making abilities.

• Journal of Internet Computing and Services
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• v.4 no.6
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• pp.1-11
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• 2003

This paper is introduced about Design driven testing, for real time system, based on use case approaches, We focuses on a part of an extended use case approach for real time software development, which partitions design schema into layered design component architecture of functional components called "design component", We developed a use case action matrix to contain a collection of related scenarios each describing a specific variant of an executable sequence of use case action units, which reflected the behavioral properties of the real time system design, in this paper, we attempt to apply real time system with design driven testing with test plan metrics which is introduced which produces an ordering of this scenario set to enhance productivity and both promote and capitalize on test case reusability of existing scenarios.scenarios.

• The Journal of the Korea Contents Association
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• v.12 no.2
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• pp.284-291
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• 2012

This study is to present development plan for next study on applying the method of case study by applying scientific inference focusing on analysis and generalization of case study or study question about the tendency of thesis for case study of the field of crisis management released since 2004. As the result of analysis, the study on crisis management of Korea is almost individual technical case study and it is rarely to get proper study which can contribute theoretical formation for development of individual course of crisis management. Furthermore researchers are required to study in-depth about study plan that presents organization of study or logic of case selection and formality for data analysis.