• Biomolecules & Therapeutics
• /
• v.3 no.2
• /
• pp.97-103
• /
• 1995

The purpose of this study was to determine pharmacokinetic parameters of BR-28702-2, a new antineoplastic agent which is the conjugate of nucleotide and phospholipid, and to compare them with those of ara-C. Male rats were cannulated in the left femoral vein and received a single i.v. bolus dose of either BR-28702-2 or ara-C. BR-28702-2 was also administered i.p. and plasma samples were analyzed by reversedphase HPLC. The t$_{1}$2($\beta$)/ of ara-C(1.22 hr.) was significantly smaller than that of BR-28702-2(4.420 hr.). The absolute bioavailability of BR-28702-2 after i.p. injection was 1.125%. This lower bioavailability, together with previous reports that marked antineoplastic activity was observed when given i.p., indicates that BR-28702-2 would act as a depot system to release active moieties. Further works, therefore, need to be done to characterize active metabolites.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.33 no.3
• /
• pp.30-39
• /
• 2010

This paper considers a problem of optimizing torch paths to cut stock plates nested with open contours. For each contour, one of the two ending points is to be selected as a starting point of cutting with the other being the exit point. A torch path is composed of a single depot and a series of starting and ending points of contours to be cut. The torch path optimization problem is shown to be formulated as an extended version of the standard travelling salesman problem. To solve the problem, a hybrid genetic algorithm with the local search of torch paths is proposed. The genetic algorithm is tested for hypothetical problems whose optimal solutions are known in advance due to the special structure of them. The computational results show that the algorithm generates very near optimal solutions for most cases of the test problems, which verifies the validity of the algorithms.

• Proceedings of the Korean Information Science Society Conference
• /
• 2012.06b
• /
• pp.80-82
• /
• 2012

전쟁수행 패러다임이 변화하면서 NCW 환경에서 발생하는 네트워크 파워를 측정하려는 많은 연구들이 수행되고 있다. 그러나 기존의 연구는 현실의 전장환경내 구축되어 있는 C2 체계의 네트워크 구조와 각 시스템간의 상호운용성 요소를 평가에 반영하지 못하고 있다. 따라서 본 연구에서는 최근 다양한 분야에서 활용되고 있는 소셜 네트워크 분석 기법을 적용하여 다수의 지휘통제체계에 의해 구축되는 네트워크 구조를 평가할 수 있는 알고리즘을 제안한다. 제안한 알고리즘을 통해 진화하는 군 C2 체계의 네트워크 구조를 대상으로 평가 결과를 분석해보았으며, 연결성에 근거한 네트워크 구조에 상호운용성 가치를 반영함으로써 보다 실질적인 네트워크 파워를 제시함에 그 목적이 있다.

• Journal of the Korea Safety Management & Science
• /
• v.12 no.4
• /
• pp.175-181
• /
• 2010

The government have plans to improve the railway transport capacity and transport hub for the sustainable national transport and logistics system. Specially, there are much efforts to improve transportation capacity such as high speed transportation of rail freight, enlargement of BT train, development of double stack train, etc. between railway transport hubs. If the transport capacity between railway logistics hubs is increased as planned, we must increase the handling capacity of railway hub terminals. But there are limits to enlarge the terminal infrastructure because of investment scale, location circumstances and urban development plans. To ensure the capacity, with the minimum required enlargement of infrastructure, it is necessary to extremely increase the efficiency of terminal operations. For improving the efficiency, we have to introduce the efficient terminal operation systems based on u-IT and operation optimize technologies. In this paper, we analyse the issues and problems of railway terminals(including ICD) and suggest the concept of intelligent railway terminal and the construction components of technology.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.13 no.6
• /
• pp.127-133
• /
• 2014

This paper reviews a finite element model of a wire rope isolator (WRI) via an experimental comparison test. A local operation panel (LOP) mounted on a WRI is modeled using a finite element method. Mode analyses and harmonic analyses are conducted while varying of the thickness of the rope for the WRI. A feasible WRI can be selected considering the reduction of the vibration and the total weight of the LOP system.

• Proceedings of the KSR Conference
• /
• 2005.11a
• /
• pp.170-175
• /
• 2005

In this study, experimental and theoretical methods were applied to understand brake squeal noise VVVF rolling stock on tracks. Trailer cars needed to payed a particular attention, because they were the major source of brake noise. VVVF rolling stocks for lines no 1 of the subway system in Seoul were used for experimental analyses. In order to study brake squeal noise, a dynamometer test at the S&T Brake, Co., which was a manufacturer of brake pads had performed. For measuring vibration and noise, vibration tests of brake parts (brake lining, brake lining head, back plates, etc.) at the SNUT were executed. Also, vibration tests of disc assembly and lining block at the heavy maintenance shop of the Gunja depot were performed. The modal analyses by using an ANSYS which was one of the CAE commercial program were simulated to know the relationship to the mechanism of brake noise. On the based of the tests and the simulations it was found that specific frequencies of the brake parts affected squeal noise, and improvements for reducing squeal noise were proposed.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.37 no.1
• /
• pp.133-140
• /
• 2014

An efficient heuristic for two-vehicle-one-depot problems is developed in this research. Vehicle moving speeds are various along hour based time intervals due to traffic jams of rush hours. Two different heuristics are examined. One is that the delivery area assignment is made using Sweep algorithm for two vehicles by splitting the whole area in half to equally divide all delivery points. The other is using common area by leaving unassigned area between the assigned for two vehicles. The common area is reassigned by two stages to balance the completion time of two vehicle's delivery. The heuristic with common area performed better than the other due to various vehicle moving speeds and traffic jams.

• Proceedings of the KIEE Conference
• /
• 2005.07b
• /
• pp.1637-1639
• /
• 2005

The measurement of magnetic field is performed about DC and AC magnetic field in test track of depot. The test point is cap, on the converter/inverter box, on the traction motor, on the APSE and on the line filter, the height of measurement is bottom and 50 cm height. In case of AC magnetic field, the selected specific frequency is measured on the converter/inverter box. The AC magnetic field is checked and analysis through RS-232C and notebook PC. The DC magnetic field is measured by using the Hall Probe, test result is saved and analysis by PXI system. On the line filter, the maximum value is 1.4 mT in case of DC magnetic field and 0.044 mT in case of AC magnetic field at 50 Hz.

• Journal of the Korea Society of Computer and Information
• /
• v.24 no.1
• /
• pp.167-178
• /
• 2019

In this paper, we study the multi-objectives vehicle and drone routing problem with time windows, MOVDRPTW for short, which is defined in an urban delivery network. We consider the dual modal delivery system consisting of drones and vehicles. Drones are used as a complement to the vehicle and operate in a point to point manner between the depot and the customer. Customers make various requests. They prefer to receive delivery services within the predetermined time range and some customers require fast delivery. The purpose of this paper is to investigate the effectiveness of the delivery strategy of using drones and vehicles together with a multi-objective measures. As experiment datasets, we use the instances generated based on actual courier delivery data. We propose a hybrid multi-objective evolutionary algorithm for solving MOVDRPTW. Our results confirm that the vehicle-drone mixed strategy has 30% cost advantage over vehicle only strategy.

• Proceedings of the KIEE Conference
• /
• 2007.10c
• /
• pp.220-222
• /
• 2007

With the wide spread of direct current (DC) electric railroads in Korea, the stray currents or leakage currents from negative return rails become a pending problem to the safety of nearby underground infrastructures. The most widely used mitigation method for this interference is the stray current drainage method, which connects the underground metallic structures to the rails with diodes (polarized drainage) or thyristor (forced drainage). Although this method inherently possesses some drawbacks, its cost effectiveness and efficiency to protect the interfered structures has been the main reason for the wide adoption. In this paper, we show the field test results for the application of stray current drainage system to a city gas pipeline paralleling a depot area of a metropolitan rapid transit system. The process for optimal positioning is briefly illustrated. The effectiveness of constant voltage, constant current, and constant potential drainage schemes was also described.