• Proceedings of the Korea Concrete Institute Conference
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• 2010.05a
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• pp.79-80
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• 2010

Age-dependent laboratory tests for a curved composite box girder were carried out to investigate age-dependent effects of concrete on toraional behavior of a curved girder. Time-dependent incremental finite element method predicted the toraional behavior as well as flexural including axial behaviors of the test specimen.

• Molecules and Cells
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• v.40 no.11
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• pp.864-870
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• 2017

The uncoupling protein 4 (ucp-4) gene is involved in age-dependent neurodegeneration in C. elegans. Therefore, we aimed to investigate the mechanism underlying the association between mitochondrial uncoupling and neurodegeneration by examining the effects of uncoupling agents and ucp-4 overexpression in C. elegans. Treatment with either DNP or CCCP improved neuronal defects in wild type during aging. Uncoupling agents also restored neuronal phenotypes of ucp-4 mutants to those exhibited by wild type, while ucp-4 overexpression attenuated the severity of age-dependent neurodegeneration. Neuronal improvements were further associated with reductions in mitochondrial membrane potentials. However, these age-dependent neuroprotective effects were limited in mitophagy-deficient mutant, pink-1, background. These results suggest that membrane uncoupling can attenuate age-dependent neurodegeneration by stimulating mitophagy.

• Proceedings of the Safety Management and Science Conference
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• 2007.11a
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• pp.107-119
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• 2007

The purpose of this article is to examine the relationship between unsafe behavior, human factor and human error. For the object, several correlation analyses for those three elements were implemented. Several hypotheses for the relationship between them was suggested. The suggested hypotheses were verified by a comprehensive survey received from 132 safety manager of manufacturing industry. The conclusions were proven from the hypotheses verificaiton as belows; 1) The dependent relation items between unsafe behavior and human factor are dress protection tool, machine(equipment) and working rule have a dependent relation. 2) The dependent relation items between human factor and human error are uncommunication, control, slaps, fatigue, education, system, unmonitoring, failure. 3) The dependent relation items between human error and unsfafe behavior are decline and product/working method,failure and uncommunication have a dependent relation.

• International Journal of Concrete Structures and Materials
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• v.18 no.3E
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• pp.161-164
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• 2006

Cellulose fiber reinforced cement(CFRC) pipe has been gradually introduced in the pipe market as a replacement of previously popular asbestos cement pipes. Since CFRC pipe is still relatively unknown in the pipe market, there are great concerns for the design and application in practice related to the time-dependent behavior of CFRC under long-term sustained loading. This paper presents an experimental investigation of the time-dependent behavior of cellulose fiber reinforced cement(CFRC) pipe. A total of six CFRC pipes were tested under various loading levels, and their vertical deformation was recorded to understand the characteristics of the time-dependent behavior. Based on the test results, a factor of safety(FS) of 1.82 is proposed, and a regression factor(R) of 1.88 is estimated for the application of CFRC pipes in practice.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.1
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• pp.193-198
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• 2009

In this paper, we consider the design problem of delay-dependent robust $H{\infty}$ controller of discrete-time descriptor systems with parameter uncertainties and interval time-varying delays in state and control input by delay-dependent LMI (linear matrix inequality) technique. A new delay-dependent bounded real lemma for discrete-time descriptor systems with time-varying delays is derived. The condition for the existence of robust $H{\infty}$ controller and the robust $H{\infty}$ state feedback control law are proposed by LMI approach. A numerical example is demonstrated to show the validity of the design method.

• BMB Reports
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• v.50 no.4
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• pp.186-193
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• 2017

In mammals, cap-dependent translation of mRNAs is initiated by two distinct mechanisms: cap-binding complex (CBC; a heterodimer of CBP80 and 20)-dependent translation (CT) and eIF4E-dependent translation (ET). Both translation initiation mechanisms share common features in driving cap- dependent translation; nevertheless, they can be distinguished from each other based on their molecular features and biological roles. CT is largely associated with mRNA surveillance such as nonsense-mediated mRNA decay (NMD), whereas ET is predominantly involved in the bulk of protein synthesis. However, several recent studies have demonstrated that CT and ET have similar roles in protein synthesis and mRNA surveillance. In a subset of mRNAs, CT preferentially drives the cap-dependent translation, as ET does, and ET is responsible for mRNA surveillance, as CT does. In this review, we summarize and compare the molecular features of CT and ET with a focus on the emerging roles of CT in translation.

• Communications for Statistical Applications and Methods
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• v.8 no.1
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• pp.127-135
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• 2001

In this paper, we consider a simple method for testing the assumption of independent censoring on the basis of a Cox proportional hazards regression model with a time-dependent covariate. This method involves a two-stage sampling in which a random subset of censored observations is selected and followed-up until their true survival times are observed. Lee and Wolfe(1998) proposed an adjusted estimate of the survivor function for the dependent censoring under a proportional hazards alternative. This paper extends their result to obtain a bootstrap confidence interval for the adjusted survivor function under the dependent censoring. The proposed procedure is illustrated with an example of a clinical trial for lung cancer analysed in Lee and Wolfe(1998).

• Transactions of Materials Processing
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• v.18 no.6
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• pp.494-499
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• 2009

The time-dependent constitutive law was utilized based on viscoelastic-plasticity to predict the time-dependent spring-back behavior of aluminum alloy 6022-T4 sheets. Besides nonlinear viscoelasticity, non-quadratic anisotropic yield function, Yld2000-2d, was used to account for the anisotropic yield behavior, while the combined isotropic-kinematic hardening law was used to represent the Bauschinger effect and transient hardening. For verification purposes, finite element simulations were performed for the draw-bending and the results were compared with experimental results.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.22 no.3
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• pp.179-199
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• 2018

The paper explores a tri-trophic food chain model with density dependent mortality of intermediate predator. To analyze this aspect, we have worked out the local stability of different equilibrium points. We have also derived the conditions for global stability of interior equilibrium point and conditions for persistence of model system. To observe the global behaviour of the system, we performed extensive numerical simulations. Our simulation results reveal that chaotic dynamics is produced for increasing value of half-saturation constant. We have also observed trajectory motions around different equilibrium points. It is noticed that chaotic dynamics has been controlled by increasing value of density dependent mortality parameter. So, we conclude that the density dependent mortality parameter can be used to control chaotic dynamics. We also applied basic tools of nonlinear dynamics such as Poincare section and Lyapunov exponent to investigate chaotic behaviour of the system.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2009.05a
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• pp.330-333
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• 2009

The time-dependent constitutive law was developed based on viscoelastic-plasticity to describe the time-dependent spring-back behavior of aluminum alloy 6022-T4 sheets. Besides nonlinear viscoelasticity, non-quadratic anisotropic yield function, Yld2000-2d, was used to account for the anisotropic yield behavior, while the combined isotropic-kinematic hardening law was used to represent the Bauschinger effect and transient hardening. For verification purposes, finite element simulations were performed for the draw-bending and the results were compared with experimental results.