• Toxicological Research
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• 제20권4호
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• pp.375-380
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• 2004

The toxicity of CKD-602 was investigated at doses of 0, 3, 9, and 27 mg/kg in rats, by administering the same total dose over 24-hr continuous infusion or bolus injection. CKD-602 treatment caused gastrointestinal symptoms such as diarrhea, soft stool, and soiled perineal region. It also decreased body weight at doses of 9 and 27 mg/kg in a dose-dependant manner. At 3 mg/ kg, clinical signs and body weight decrease were more severe in the infusion group than in the bolus group. In the bolus group, mortalities were 0/8, 0/8, 1/8, and 3/8 at 0, 3, 9, and 27 mg/kg, respectively, whereas those were 0/8, 1/8, 8/8, and 8/8 in the infusion group. $LD_{50}$ values were 36.25 mg/kg for bolus and 3.50 mg/kg for infusion, respectively. This finding indicates that the toxic potency of CKD-602 by continuous infusion is about 10 times higher than by bolus injection. Our findings suggest that the toxic effects of CKD-602 are dependant upon the duration of intravenous administration.

• 한국농공학회지
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• 제38권3호
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• pp.70-81
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• 1996

Solutions of geotechnical engineering problems require predictions of deformation and stresses during various stages of loading. Powerful numerical methods are available to make such predictions even for complicated problems. To get accurate results, realistic stress-strain relationships of soils are dependent on a number of factors such as soil type, density, stress level and stress path. Attempts are continuously being made to develope analytical models for soils incorporating all such factors. Isotropic compression-expansion test and a series of drained conventional triaxial tests with several stress path for Baekma river sand were performed to investigate stress-strain and volume change characteristics of Lade's single work hardening model dependant on the stress path. In order to predicted of stress-strain and volumetric strain behavior were determined the values of parameters for the mode by the computer program based on the regression analysis. Predicted stress-strain behavior of triaxial compression tests and optional stress path tests for increasing confining pressure with parameters obtained conventional triaxial compression tests agreed with several test results but the prediction results for decreasing confining pressure reduced triaxial compression tests make a little difference with test results.

• Journal of Electrochemical Science and Technology
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• 제1권1호
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• pp.57-62
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• 2010

The lithium ion concentration dependant ionic conductivity and thermal properties of poly(ethylene glycol) methyl ether methacrylate (PEGMA)/acrylonitrile-based copolymer electrolytes with $LiClO_4$ have been studied by differential scanning calorimetry (DSC), linear sweep voltammetry (LSV) and AC complex impedance measurements. In systems with 11 wt% of acrylonitrile all liquid electrolytes were obtained regardless of lithium ion concentration. Complex impedance measurements with stainless steel electrodes give ambient ionic conductivities $8.1\times10^{-6}\sim1.4\times10^{-4}S cm^{-1}$. On the other hand, a hard and soft films at ambient temperature were obtained in copolymer electrolyte system consists of 15 wt% acrylonitrile with 6 : 1 and 3 : 1 of [EO] : [Li] ratio, respectively. DSC measurements indicate the crystalline melting temperature of poly(PEGMA) disappeared completely after addition of $LiClO_4$ in this system due to the complex formation between ethylene oxide (EO) unit and lithium salt. As a result, free standing film with room temperature ionic conductivity of $1.7\times10^{-4}S cm^{-1}$ and high electrochemical stability up to 5.5V was obtained by controlling of acrylonitrile and lithium salt concentration.

• Geomechanics and Engineering
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• 제2권4호
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• pp.229-252
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• 2010

In this paper, Soil-Structure Interaction (SSI) effect is investigated using a new and integrated approach. Faster solution of time dependant differential equation of motion is achieved using numerical representation of wavelet theory while dynamic Infinite Elements (IFE) concept is utilized to effectively model the unbounded soil domain. Combination of the wavelet theory with IFE concept lead to a robust, efficient and integrated technique for the solution of complex problems. A direct method for soil-structure interaction analysis in a two dimensional medium is also presented in time domain using the frequency dependent transformation matrix. This matrix which represents the far field region is constructed by assembling stiffness matrices of the frequency dependant infinite elements. It maps the problem into the time domain where the equations of motion are to be solved. Accuracy of results obtained in this study is compared to those obtained by other SSI analysis techniques. It is shown that the solution procedure discussed in this paper is reliable, efficient and less time consuming as compared to other existing concepts and procedures.

• 간호행정학회지
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• 제14권2호
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• pp.144-149
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• 2008

Purpose: The aim of this study was to testify correlations between critical thinking disposition and decision making styles. Methods: The subjects of this study were 193 freshman nursing students in the 1 nursing school located in Incheon area. The data were collected by self-reporting questionnaires. The data were analyzed using descriptive statistics and Pearson correlation coefficient analysis. Results: The score of critical thinking disposition was revealed 3.96 points. The highest was inquisitiveness, the lowest was systematicity. The most frequent decision making style was revealed a rational decision making. The next was dependant decision making, intuitional decision making as follows. The critical thinking disposition and rational decision making had a statistically significant positive correlation. However the critical thinking disposition and dependant decision making had a statistically significant negative correlation. Conclusion: With these findings, we are found that the more increasing critical thinking disposition, the more developing rational decision making. It will suggested that the program for increasing nursing student's critical thinking disposition focused on systematicity, analyticity and truth seeking in critical thinking sub categories.

• 복식문화연구
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• 제4권2호
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• pp.173-185
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• 1996

The purpose of this study was to identify the relationship of clothing involvement and clothing buying behavior of women. A questionnaire was developed to measure clothing involvement, clothing purchasing motives, clothing purchasing criteria, fashion information sources, store selection criteria, and demographic characteristics. The questionnaire was administered to 430 female adults in Taegu. The data were analyzed using percentage, frequency, factor analysis, and t-test. The results of the study were s follows: 1. Subjects were divided into low clothing involved and high clothing involved groups. 2. Three dimensions of clothing purchasing motives were derived by factor analysis such as Aesthetic dependant, Impulsive, and Practical motive. Clothing purchasing criteria were factor analysed as Aesthetic, Qualitative, External, and Economical criterion. Fashion information sources were factor analysed as Printed & audio-visual oriented media, Marketer intensive search, Store search, Observation & Interpersonal search, and Experience. Store selection criteria were factor analyzed as Merchandise & Store atmosphere, Store convenience, and Brand & fashion. 3. There were significant differences between high involved and low involved consumers in clothing purchasing behavior. The high involved consumers showed more importance than low involved consumers about purchasing criteria expecially in aesthetic dependant. The high involved consumers put more importance to aesthetic, qualitative, and external criterion as clothing purchasing criteria. The high involved information sources. The high involved consumers were more concerned about merchandise & store atmosphere, and brand & fashion than low involved consumers in store selection criteria.

• 대한약침학회지
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• 제3권1호
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• pp.1-19
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• 2000

To study anti-cancer effect and molecular biological mechanism of bee venom for aqua-acupuncture, the effects of bee venom on cell viability and apoptosis were analyzed using MTT assay, tryphan blue assay, $[^3H]$thymidine release assay, flow cytometric analysis, and activity of caspase-3 protease activity assay. To explore whether anti-cancer effects of bee venom are associated with the transcriptional control of gene expression, quantitative RT-PCR analysis of apoptosis-related genes was performed. The obtained results are summarized as follows: 1. The MTT assay demonstrated that cell viability was decreased by bee venom in a dose-dependant manner. 2. Significant induction of apoptosis was identified using tryphan blue assay, $[^3H]$thymidine release assay, and flow cytomet1 ric analysis of sub $G_1$ fraction. 3. In analysis of caspase-3 protease activity, the activity had increased significantly, in a dose-dependant manner. 4. Quantitative RT-PCR analysis of the apoptosis-related genes showed that Bcl-2 and Bcl-$X_L$ were down-regulated whereas Bax was up-regulated by bee venom treatment.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.420-420
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• 2013

We investigated oxygen plasma effect on defect states near the interface of AlGaN/GaN High Electron Mobility Transistor (HEMT) structure grown on a silicon substrate. After the plasma treatment, electrical properties were evaluated using a frequency dependant Capacitance-Voltage (C-V) and a temperature dependant C-V measurements, and a deep level transient spectroscopy (DLTS) method to study the change of defect densities. In the depth profile resulted from the temperature dependant C-V, a sudden decrease in the carrier concentration for two-dimensional electron gas (2DEG) nearby 250 K was observed. In C-V measurement, the interface states were improved in case of the oxygen-plasma treated samples, whereas the interface was degraded in case of the nitrogen-plasma treated sample. In the DLTS measurement, it was observed the two kinds of defects well known in AlGaN/GaN structure grown on sapphire substrate, which have the activation energies of 0.15 eV, 0.25 eV below the conduction band. We speculate that this defect state in AlGaN/GaN on the silicon substrate is caused from the decrease in 2DEG's carrier concentrations. We compared the various DLTS signals with filling pulse times to identify the characteristics of the newly found defect. In the filling pulse time range under the 80 us, the activation energies changed as the potential barrier model. On the other hand, in the filling pulse time range above the 80 us, the activation energies changed as the extended potential model. Therefore, we suggest that the found defect in the AlGaN/GaN/Si structure could be the extended defect related with AlGa/N/GaN interface states.

• Journal of Acupuncture Research
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• 제17권2호
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• pp.169-186
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• 2000

To study anti-cancer effect and molecular biological mechanism of bee venom for aqua-acupuncture, the effects of bee venom on cell viability, apoptosis, and cell cycle were analyzed using MTT assay, tryphan blue assay, [3H]thymidine release assay, flow cytometric analysis, activity of caspase-3 protease activity assay, and immunocytometric analysis of PCNA. To explore whether anti-cancer effects of bee venom are associated with the transcriptional control of gene expression, quantitative RT-PCR analysis of apoptosis- and cell cycle-related genes was performed. The obtained results are summarized as follows: 1. The MTT assay demonstrated that cell viability was decreased by bee venom in a dose-dependant manner. 2. Significant induction of apoptosis was identified using tryphan blue assay, [$^3H$]thymidine release assay, and flow cytometric analysis of sub $G_1$ fraction. 3. In analysis of caspase-3 protease activity, the activity had increased significantly, in a dose-dependant manner. 4. Quantitative RT-PCR analysis of the apoptosis-related genes showed that Bcl-2 and $Bcl-X_L$ were down-regulated whereas Bax was up-regulated by bee venom treatment. 5. In flow cytometric analysis of cell cycle and immunocytometric analysis of PCNA expression, cell numbers of $G_1$ phase was increased by a dose-dependant manner. 6. In quantitative RT-PCR analysis of the cell cycle-related genes, p21, p27, and p57 were increased, while Cyclin D1, CDK4, c-Myc, c-Fos, and Histone H3 were decreased. In contrast, there were no remarkable changes in expression levels of CDC2 and c-Jun.

• 대한한방내과학회지
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• 제22권2호
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• pp.199-205
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• 2001

Background and Purpose : Transcranial doppler ultrasonography(TCD) is a noninvasive and nonradioactive technique for evaluation of the hemodynamics in large cerebral vessels. Sahyangsohap-won(SS) has been considered to be effective for the treatment of various disease, especially cerebrovascular, cardiovascular, and psychosomatoform disorders. But, there is no study about the effect of SS on the cerebral hemodynamics in humans. The aim of this study was to assess the effect of SS on the changes in cerebral hemodynamics and the dose-dependant effect by using TCD. Subjects and Methods : 30 healthy subjects were randomly divided into three group: group 1 took no drug, group 2 took SS one pill, and group 3 took SS 2 pills. Changes in the mean blood flow velocity(MBFV) and pulsatility index(PI) in the middle cerebral artery were evaluated by means of TCD. We obtained hypercapnia with breath-holding and evaluated cerebrovascular reactivity with the breath-holding index(BHI). Systolic blood pressure(SBP), diastolic blood pressure(DBP), and heart rate(HR) were measured by means of ambulatory blood pressure monitoring. In group 2 and group 3, the evaluations were performed during the baseline and were repeated at 20, 40, and 60 minutes after SS administration. In group 1, the evaluation was performed at corresponding time intervals. Results : In mean values of MSFV, PI, SSP, DBP, and HR, no stastically significant differences were found between the 3 groups. However, BHI values were significantly lower in groups 2 and 3 than in group 1 at 40 minutes after SS administration(P<0.05, group 1 vs group 2, group 1 vs group 3 by post-hoc analysis: Scheffe's test) but in dose-dependant effect, there was no difference between group 2 and group 3. Conclusion : These results suggest that SS can decrease vascular resistance in cerebral small arteries or arterioles and enhance their distensibility. Further studies on larger numbers of subjects are needed to confirm these effects and the dose-dependant effects.