• 무역상무연구
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• 제67권
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• pp.97-118
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• 2015

This study reviews the judgements by the Korean Supreme Court on the time of delivery of goods, as it depends on which bonded place the goods are kept for the purpose of the customs clearance. Thereafter, this study analyzes the Ocean Carrier's liability, when the cargoes are mis-delivered without the presentation of bill of lading in relation to the specific bonded place such as an independent bonded warehouse or a self-use bonded warehouse. Furthermore, considering that voyage charter is a kind of marine transport, this study also reviews whether or not the Court's judgements, which has been developed in respect of the carriage of affreightment, could be applied to voyage charter in respect of the time of delivery goods and the Ocean Carrier's liability for mis-delivery. Lastly, in the case that the substantial importer takes the goods from the independent bonded warehouse without the presentation of bill of lading after the customs clearance, it is noted that the Court has made the Ocean Carrier liable for the mis-delivery through the application of theory of double deposit contract. The position of the Court would be understandable in terms of the protection for the bona-fide holder of bill of lading, but this study reviews the limitation of liability as the device for the protection of the Ocean Carrier, considering the situation where the Ocean Carrier is somewhat unreasonably sacrificed under the bonded system provided for the convenience of substantial importer.

• Macromolecular Research
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• 제15권3호
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• pp.195-201
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• 2007

Non-viral vectors, including lipid- or polymer-based systems, have attracted much attention to date as a gene delivery vehicle, due to safety issues with viral vectors. Chitosan, a naturally existing cationic polymer, has shown great potential as a gene delivery carrier, as it has low immunogenicity and toxicity, excellent transcellular transport ability, and is relatively easy to chemically modify. This review summarizes and discusses the general features of chitosan and its applications as a delivery carrier of DNA and RNA.

• 무역상무연구
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• 제12권
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• pp.377-401
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• 1999

This study is focused on the privity of the contract of carriage of goods by sea, so to speak, privity between B/L holder and carrier by transfer of bill of lading, privity by attornment to delivery order and conflict between bills of lading and charterparty terms. Under a CIF contract, possession of the bill of lading is equivalent to possession of the goods, and delivery of the bill of lading to the buyer or to a third party may be effective to pass the property in the goods to such person. The bill of lading is a document of title enabling the holder to obtain credit from banks before the arrival of the goods, for the transfer of the bill of lading can operate as a pledge of the goods themselves. In addition, it is by virtue of the bill of lading that the buyer or his assignee can obtain redress against the carrier for any breach of its terms and of the contract of carriage that it evidences. In other words the bill of lading creates a privity between its holder and the carrier as if the contract was made between them. The use of delivery orders in overseas sales is commen where bulk cargoes are split into more parcels than there are bills of lading, and this practice gives rise to considerable difficulties. For example, where the holder of a bill of lading transferred one of the delivery orders to the buyer who presented it to the carrier and paid the freight of the goods to which the order related, it was held that there was a contract between the buyer and the carrier under which the carrier could be made liable in repect of damage to the goods. The contract was on the same terms as that evidenced by, or contained in, the bill of lading, which was expressly incorporated by reference in the delivery order. If the transferee of the delivery order presents it and claims the goods, he may also be taken to have offered to enter into an implied contract incorporating some of the terms of the contract of carriage ; and he will, on the carrier's acceptance of that offer, not only acquire rights, but also incur liabilities under that contract. Where the terms of the charterparties conflict with those of the bills of lading, it is interpreted as below. First, goods may be shipped in a ship chartered by the shipper directly from the shipowner. In that case any bill of lading issued by the shipowner operates, as between shipowner and charterer, as a mere receipt. But if the bill of lading has been indorsed to a third party, between that third party and carrier, the bill of lading will normally be the contract of carriage. Secondly, goods may be shipped by a seller on a ship chartered by the buyer for taking delivery of the goods under the contract of sale. If the seller takes a bill of lading in his own name and to his own order, the terms of that bill of lading would govern the contractual relations between seller and carrier. Thirdly, a ship may be chartered by her owner to a charterer and then subchartered by the chaterer to a shipper, to whom a bill of lading may later be issued by the shipowner. In such a case, the bill of lading is regarded as evidencing a contract of carriage between the shipowner and cargo-owners.

• Biomaterials and Biomechanics in Bioengineering
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• 제2권1호
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• pp.1-13
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• 2015

Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.

• Journal of Pharmaceutical Investigation
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• 제13권4호
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• pp.153-172
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• 1983

The use of carrier systems for the delivery of drugs to areas in the body in need of pharmacological intervention is now the subject of intense research in many laboratories. Because of its obvious advantages (e.g. protection of drugs from hostile environments, facilitated target penetration and avoidance of side effects), drug delivery is expected to ease the pressure and expense of new drug development by making better use of drugs in existence. Generally, carrier-mediated delivery has been envisaged either as direct transport of drugs to a biological target by a carrier that will associate with it selectively, or as release of drugs from a carrier circulating in the blood or immobilized in tissues, at rates compatible with optimal action. One system that has attracted considerable attention is the use of liposomes as carriers of pharmacologically active agents. 154 references were reviewed with special emphasis on the targeting of drugs by use of liposomes in this respect. Recent advances in the other carrier systems and in methods for the preparation of liposomes were also reviewed briefly.

• KSBB Journal
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• 제31권4호
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• pp.300-311
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• 2016

Recently gene delivery has been designed newly using bioactive biomaterial and applied in the various field by many researchers. In this study, we proposed a new gene delivery system which has the capability of targeting effect in the specific tissue and remarkably enhanced transfection efficiency. We investigated $^1H-NMR$ spectroscopy, particle size analyzer and gel retardation to confirm the correct preparation of gene delivery. Also, we identified the hemo-compatibility of gene delivery by hemolysis assay, non-cytotoxicity by MTT test and transfection efficiency. The uptake mechanism of the gene carrier was confirmed using inhibitor agent such as sodium azide, indomethacin, quercetin, colchicine, and chloropromazine. As a results, it was identified that gene carrier prepared by in this study entered in the cell by the microtubule-dependent, energy-dependent and clathrin-mediated endocytosis pathway.

• 폴리머
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• 제36권2호
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• pp.149-154
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• 2012

생체적합성을 가진 키토산과 강력한 항산화제로 알려진 리포산을 합성하여 만든 양친매성 고분자를 이용하여 약물전달시스템으로서의 응용 가능성을 알아보았다. 수용액 상에서 자기조립의 성질을 가지는 양친매성 고분자는 나노입자를 형성하고 이 입자 안에 항암제로 널리 쓰이는 5-fluorouracil을 고체분산법을 이용하여 봉입하였다. 최적의 약물전달체를 얻기 위하여 키토산에 결합된 리포산의 비율을 조절하여 입자크기 및 약물봉입률을 비교하였다. DLS를 이용하여 측정한 나노입자는 약 250 nm 정도의 크기를 가졌고 그 봉입률은 10% 내외로 측정되었다. 42%의 리포산 치환율을 가지는 공중합체가 약물전달체로서 가장 우수한 성능을 보여주었다.

• 무역상무연구
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• 제74권
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• pp.55-79
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• 2017

The Rotterdam Rules introduces new issues that have been ignored by previous international transport conventions. Among them, provisions on delivery of goods have been a much debated topic as it deviate from well established principles. Rotterdam Rules provides several alternatives in order to resolve uncertainty regarding delivery practice. The carrier have to make a resonable effort to deliver the goods following the required procedure which is different from transport document issued. Where the goods are not deliverable, the carrier could discharge from its obligations to deliver the goods when he deliver the goods by delivery instruction of shipper. In addition, he can take actions reasonably required according to circumstances if it is impossible to deliver the goods. These alternatives are not ideal, but they seem to be partly helping to solve practical problems arising in the process of delivery. However the delivery regime under the Rotterdam Rules could cause confusion in the traditional delivery principle. On the other hand, it puts a new burden on the parties concerned. In conclusion, the parties concerned should consider practical implications in issuing and transferring transport document as well as requesting and instructing delivery of goods.

• Journal of Pharmaceutical Investigation
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• 제41권6호
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• pp.323-329
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• 2011

In order to develop new protein carrier replacing poly(DL-lactic acid-co-glycolic acid) (PLGA) microspheres, succinylated pullulan acetate (SPA) was investigated to fabricate a long term protein delivery carrier. SPA microspheres loaded with lysozyme (Lys) as a model protein drug were prepared by a water/oil/water (W/O/W) double emulsion method. An acidity test of SPA copolymers after hydrolysis was performed to estimate the change of protein stability during releasing proteins from the microspheres. There was no pH change of SPA copolymers, but pH of PLGA polymers after hydrolysis was significantly decreased to around pH 2, indicating that the long-term stability of proteins released from SPA microspheres can be guaranteed. Loading efficiency of proteins into SPA microspheres was three times higher than those into conventional PLGA microspheres, indication of inducing stronger charge interaction between proteins and succinyl groups in SPA microspheres. Although initial burst behaviors were monitored in Lys-loaded SPA microspheres due to relatively strong hydrophilic succinyl segments in SPA microspheres, initial burst issues would be circumvented if the ratio of charge density of succinyl moieties and hydrophobic acetate groups is harmonically controlled. Therefore, in this study, a new attempt of protein delivery system was made and functional SPA was successfully confirmed as a new protein carrier.

• 항공우주정책ㆍ법학회지
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• 제21권2호
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• pp.71-96
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• 2006

본고에서는 국제항공화물운송에 있어서 운송인의 화물의 인도의무와 불법인도에 대한 책임에 관하여 몬트리올 협약, lATA 화물운송약관 및 법원판례를 중심으로 고찰하고자 한다. 몬트리올 협약 제13조에 의하면, 수하인은 화물이 도착지에 도착하였을 때에 운송인에 대하여 채무액을 지급하고 운송의 조건에 따랐을 경우에는 자기에게 화물의 인도를 요구할 수 있는 권리를 가지게 된다. 한편 운송인은 별도의 약정이 없는 한 화물이 도착하자마자 수하인에게 통지를 하여줄 의무가 있다. 몬트리올 협약 제18조에 의하면, 운송인은 화물의 파괴, 분실 또는 훼손으로 인하여 입은 손실에 대하여 그 손해의 원인이 되었던 사실이 항공운송 중에 발생되었다는 것을 유일한 조건으로 하여 책임을 부담하게 된다. 여기서 항공운송이라 함은 그 화물이 운송인의 보관하에 있는 기간을 포함한다. lATA 화물운송약관 제11조에 의하면, 운송인은 화물의 운송 중에 파괴, 멸실, 손상 또는 지연의 경우 입은 손해에 대하여 오직 그렇게 입은 손해의 원인된 사고가 제1조에 정의된 운송 중에 발생한 경우에만 송하인, 수하인 또는 기타인에게 책임을 진다. 여기서 운송이라함은 무상이든 또는 보수를 위한 것이든 간에 항공 또는 기타 운송수단에 의한 화물의 운송을 의미한다. 우리 대법원 판례(2004. 7. 22 선고)에 의하면, 운송인으로서 운송주선인은 보세창고에 입고된 화물이 실수입자에게 불법 인도된 경우에 보세창고를 지정한 자는 운송주선인 이나 그의 운송대리점이 아니라 실수입자이며, 운송주선인은 보세창고업자에 대하여 사용자로서의 지위에 있다고 볼 수 없으므로 보세창고업자의 화물의 무단반출에 대하여 손해배상책임을 지지 아니한다고 판시하였다. 결론적으로 운송인 또는 운송주선인이 항공화물의 불법인도로 인한 손해배상책임을 부담하지 않기 위하여는 항상 회물의 동향이나 상태에 대하여 주의를 기울여 화물이 불법인도 되지 않도록 선량한 관리자로서의 주의를 다하여야 할 것이다. 한편 우리 정부는 이미 발효된 몬트리올 협약에 가입하여 국제항공화물운송인의 권리, 의무 및 책임에 관하여 몬트리올 협약이 적용되도록 하여야 할 것이다.