• Journal of Korean Neurosurgical Society
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• 제64권1호
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• pp.125-135
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• 2021

Objective : This study aimed to validate the Korean version of the Repeatable Battery for the Assessment of Neuropsychological Status Update (K-RBANS). Methods : We performed a retrospective analysis of 283 psychiatric and neurosurgery patients. To investigate the convergent validity of the K-RBANS, correlation analyses were performed for other intelligence and neuropsychological test results. Confirmatory factor analysis was used to test a series of alternative plausible models of the K-RBANS. To analyze the various capabilities of the K-RBANS, we compared the area under the receiver operating characteristic (ROC) curves (AUC). Results : Significant correlations were observed, confirming the convergent validity of the K-RBANS among the Total Scale Index (TSI) and indices of the K-RBANS and indices of intelligence (r=0.47-0.81; p<0.001) and other neuropsychological tests at moderate and above significance (r=0.41-0.63; p<0.001). Additionally, the results testing the construct validity of the K-RBANS showed that the second-order factor structure model (model 2, similar to an original factor structure of RBANS), which includes a first-order factor comprising five index scores (immediate memory, visuospatial capacity, language, attention, delayed memory) and one higher-order factor (TSI), was statistically acceptable. The comparative fit index (CFI) (CFI, 0.949) values and the goodness of fit index (GFI) (GFI, 0.942) values higher than 0.90 indicated an excellent fit. The root mean squared error of approximation (RMSEA) (RMSEA, 0.082) was considered an acceptable fit. Additionally, the factor structure of model 2 was found to be better and more valid than the other model in χ2 values (Δχ2=7.69, p<0.05). In the ROC analysis, the AUCs of the TSI and five indices were 0.716-0.837, and the AUC of TSI (AUC, 0.837; 95% confidence interval, 0.760-0.896) was higher than the AUCs of the other indices. The sensitivity and specificity of TSI were 77.66% and 78.12%, respectively. Conclusion : The overall results of this study suggest that the K-RBANS may be used as a valid tool for the brief screening of neuropsychological patients in Korea.

• Journal of Korean Neurosurgical Society
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• 제65권2호
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• pp.315-324
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• 2022

Objective : The aim of this study was to verify the equivalence and effectiveness of the tablet-administered Korean Repeatable Battery for the Assessment of Neuropsychological Status (K-RBANS) for the prevention and early detection of dementia. Methods : Data from 88 psychiatry and neurology patient samples were examined to evaluate the equivalence between tablet and paper administrations of the K-RBANS using a non-randomly equivalent group design. We calculated the prediction scores of the tablet-administered K-RBANS based on demographics and covariate-test scores for focal tests using norm samples and tested format effects. In addition, we compared the receiver operating characteristic curves to confirm the effectiveness of the K-RBANS for preventing and detecting dementia. Results : In the analysis of raw scores, line orientation showed a significant difference (t=-2.94, p<0.001), and subtests showed small to large effect sizes (0.04-0.86) between paper- and tablet-administered K-RBANS. To investigate the format effect, we compared the predicted scaled scores of the tablet sample to the scaled scores of the norm sample. Consequently, a small effect size (d≤0.20) was observed in most of the subtests, except word list and story recall, which showed a medium effect size (d=0.21), while picture naming and subtests of delayed memory showed significant differences in the one-sample t-test. In addition, the area under the curve of the total scale index (TSI) (0.827; 95% confidence interval, 0.738-0.916) was higher than that of the five indices, ranging from 0.688 to 0.820. The sensitivity and specificity of TSI were 80% and 76%, respectively. Conclusion : The overall results of this study suggest that the tablet-administered K-RBANS showed significant equivalence to the norm sample, although some subtests showed format effects, and it may be used as a valid tool for the brief screening of patients with neuropsychological disorders in Korea.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권1호
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• pp.37-44
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• 2023

Objectives: Tic disorders are highly heritable; however, growing evidence suggests that environmental factors play a significant role in their pathogenesis. Studies on these factors have been inconsistent, with conflicting results. Therefore, this study aimed to examine the associations of pre- and perinatal exposure to Tourette syndrome (TS) or chronic tic disorders (CTD) in Korean school-aged children. Methods: This case-control study used data from a large prospective cohort study. The primary outcome was TS/CTD diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria and Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version. Demographic, pre-, and perinatal information was obtained from the maternal questionnaires. Data between the TS/CTD and control groups were compared using the chi-squared or Student's t-test, as appropriate. Two-step logistic regression analyses were used to test the association between TS/CTD and pre- and perinatal risk factors. Results: We included of 223 children (78 with TS/CTD and 145 controls). Significant differences in the demographic data between the two groups were observed. The male sex ratio, mean parental age, parental final education level, and family history of tics were included as confounders. In the final adjusted multivariable model, TS/CTD was significantly associated with antiemetic exposure during pregnancy (odds ratio [OR]=16.61, 95% confidence interval [CI] 1.49-185.22, p=0.02) and medically assisted reproduction (OR=7.89, 95% CI 2.28-27.28, p=0.01). Conclusion: Antiemetic exposure and medically assisted reproduction are significantly associated with the risk of TS/CTD. These results should be replicated in future prospective and gene-by-environment studies.

• 농업생명과학연구
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• 제50권4호
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• pp.59-71
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• 2016

논에서 이앙시기에 따른 화본과와 사초과 잡초의 발생 양상을 확인하고 벼에 대한 피해 정도를 알아보기 위해서 벼 이앙기를 4월 30일부터 6월 19일까지 10일 간격으로 달리하여 이앙 한 후 5월 20일부터 잡초발생과 벼의 생육을 확인하였다. 잡초들의 발생본수는 화본과와 사초과 잡초 모두 1차와 2차 이앙시기에 이앙한 시험구에서 발생본수가 많았으며, 크게 1, 2차 이앙구와 3, 4, 5, 6차 이앙시기 두 개의 그룹으로 나누어지는 결과를 보였다. 개체 당 건물중이 비교적 큰 피는 7월까지는 조기 이앙한 경우 건물중이 큰 값을 보였으나 8월 이후에는 만기 이앙한 시험구에서 건물중이 더 큰 값을 보였다. 반면 사초과 잡초는 지속적으로 빨리 이앙한 경우가 늦게 이앙한 경우보다 건물중이 높은 값을 보였다. 논의 써레질 시기가 빨라짐에 따라 조기에 잡초가 발생하고 높은 잡초생장률을 보이며 잡초의 경합력이 커져 벼의 생육과 수량이 줄어들었다. 잡초생장율을 기준으로 볼 때 화본과는 사초과 잡초에 비해 출수기 이후에 미치는 영향이 큰 것으로 확인되었다.

• Korean Journal of Radiology
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• 제22권3호
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• pp.366-375
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• 2021

Objective: To evaluate the radiological tumor response patterns and compare the response assessments based on immune-based therapeutics Response Evaluation Criteria in Solid Tumors (iRECIST) and RECIST 1.1 in metastatic clear-cell renal cell carcinoma (mccRCC) patients treated with programmed cell death-1 (PD-1) inhibitors. Materials and Methods: All mccRCC patients treated with PD-1 inhibitors at Henan Cancer Hospital, China, between January 2018 and April 2019, were retrospectively studied. A total of 30 mccRCC patients (20 males and 10 females; mean age, 55.6 years; age range, 37-79 years) were analyzed. The target lesions were quantified on consecutive CT scans during therapy using iRECIST and RECIST 1.1. The tumor growth rate was calculated before and after therapy initiation. The response patterns were analyzed, and the differences in tumor response assessments of the two criteria were compared. The intra- and inter-observer variabilities of iRECIST and RECIST 1.1 were also analyzed. Results: The objective response rate throughout therapy was 50% (95% confidence interval [CI]: 32.1-67.9) based on iRECIST and 30% (95% CI: 13.6-46.4) based on RECIST 1.1. The time-to-progression (TTP) based on iRECIST was longer than that based on RECIST 1.1 (median TTP: not reached vs. 170 days, p = 0.04). iRECIST and RECIST 1.1 were discordant in 8 cases, which were evaluated as immune-unconfirmed PD based on iRECIST and PD based on RECIST 1.1. Six patients (20%, 6/30) had pseudoprogression based on iRECIST, of which four demonstrated early pseudoprogression and two had delayed pseudoprogression. Significant differences in the tumor response assessments based on the two criteria were observed (p < 0.001). No patients demonstrated hyperprogression during the study period. Conclusion: Our study confirmed that the iRECIST criteria are more capable of capturing immune-related atypical responses during immunotherapy, whereas conventional RECIST 1.1 may underestimate the benefit of PD-1 inhibitors. Pseudoprogression is not rare in mccRCC patients during PD-1 inhibitor therapy, and it may last for more than the recommended maximum of 8 weeks, indicating a limitation of the current strategy for immune response monitoring.

• Korean Journal of Radiology
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• 제24권9호
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• pp.903-911
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• 2023

Objective: Regrowth after radiofrequency ablation (RFA) of symptomatic large thyroid nodules, initially treated as benign, sometimes turns out to be malignancies. This study aimed to assess the ultrasound (US) characteristics of thyroid nodules initially treated as benign with RFA and later diagnosed as cancers, predictive factors for cancers masquerading as benign, and methods to avoid RFA in these cancers. Materials and Methods: We reviewed the medical records of 134 consecutive patients with 148 nodules who underwent RFA between February 2008 and November 2016 for the debulking of symptomatic thyroid nodules diagnosed as benign using US-guided biopsy. We investigated the pre-RFA characteristics of the thyroid nodules, changes at follow-up after RFA, and the final surgical pathology. Results: Nodule regrowth after RFA was observed in 36 (24.3%) of the 148 benign nodules. Twenty-two of the 36 nodules were surgically removed, and malignancies were confirmed in seven (19.4% of 36). Of the 22 nodules removed surgically, pre-RFA median volume (range) was significantly larger for malignant nodules than for benign nodules: 22.4 (13.9-84.5) vs. 13.4 (7.3-16.8) mL (P = 0.04). There was no significant difference in the regrowth interval between benign and malignant nodules (P = 0.49). The median volume reduction rate (range) at 12 months was significantly lower for malignant nodules than for benign nodules (51.4% [0-57.8] vs. 83.8% [47.9-89.6]) (P = 0.01). The pre-RFA benignity of all seven malignant nodules was confirmed using two US-guided fine-needle aspirations (FNAs), except for one nodule, which was confirmed using US-guided core-needle biopsy (CNB). Regrown malignant nodules were diagnosed as suspicious follicular neoplasms by CNB. Histological examination of the malignant nodules revealed follicular thyroid carcinomas, except for one follicular variant, a papillary thyroid carcinoma. Conclusion: Symptomatic large benign thyroid nodules showing regrowth or suboptimal reduction after RFA may have malignant potential. The confirmation of these nodules is better with CNB than with FNA.

• 대한임상독성학회지
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• 제21권2호
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• pp.135-142
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• 2023

Purpose: In patients with glufosinate poisoning, severe neurological symptoms may be closely related to a poor prognosis, but their appearance may be delayed. Therefore, this study aimed to determine whether the Acute Physiology and Chronic Health Evaluation II (APACHE II) score could predict the neurological prognosis in patients with glufosinate poisoning who present to the emergency room with alert mental status. Methods: This study was conducted retrospectively through a chart review for patients over 18 years who presented to a single emergency medical center from January 2018 to December 2022 due to glufosinate poisoning. Patients were divided into groups with a good neurological prognosis (Cerebral Performance Category [CPC] Scale 1 or 2) and a poor prognosis (CPC Scale 3, 4, or 5) to identify whether any variables showed significant differences between the two groups. Results: There were 66 patients (67.3%) with good neurological prognoses and 32 (32.8%) with poor prognoses. In the multivariate logistic analysis, the APACHE II score, serum amylase, and co-ingestion of alcohol showed significant results, with odds ratios of 1.387 (95% confidence interval [CI], 1.027-1.844), 1.017 (95% CI, 1.002-1.032), and 0.196 (95% CI, 0.040-0.948), respectively. With an APACHE II score cutoff of 6.5, the AUC was 0.826 (95% CI, 0.746-0.912). The cutoff of serum amylase was 75.5 U/L, with an AUC was 0.761 (95% CI, 0.652-0.844), and the AUC of no co-ingestion with alcohol was 0.629 (95% CI, 0.527-0.722). Conclusion: The APACHE II score could be a useful indicator for predicting the neurological prognosis of patients with glufosinate poisoning who have alert mental status.

• Korean Journal of Radiology
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• 제25권8호
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• pp.756-766
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• 2024

Objective: To evaluate the efficacy and safety of thermal ablation in treating solitary low-risk T2N0M0 papillary thyroid cancer (PTC) and compare the outcomes of microwave ablation (MWA) and radiofrequency ablation (RFA). Materials and Methods: This retrospective, single center study involved 34 patients (age: 40.0 ± 13.9 years; 28 female) who had low-risk T2N0M0 PTC with a maximum diameter >2 cm and ≤4 cm and underwent MWA (n = 15) or RFA (n = 19) from November 2016 to April 2023. The primary outcomes were the cumulative rate of disease progression and delayed surgery rates. In contrast, the secondary outcomes included changes in tumor size, cumulative rate of complete tumor disappearance, and complication rates. Results: The median follow-up period was 18.0 months (interquartile range [IQR]: 9.0-40.0 months). At 12 months, the median volume reduction rate of the ablation zone was 74.2% (IQR: 53.7%-86.0%). Disease progression was noted in two patients within 1 year, including one patient with local tumor progression post-RFA and one with a new tumor post-MWA, resulting in a constant cumulative disease progression rate of 8.8% (95% confidence interval [CI]: 0%-19.8%) throughout the remaining follow-up period. Both patients were subsequently treated with additional ablation and did not require surgery. The cumulative rates of complete tumor disappearance at 1, 3, and 5 years were 4.0% (95% CI: 0%-11.4%), 26.8% (95% CI: 2.7%-44.9%), and 51.2% (95% CI: 0%-79.1%), respectively. No significant differences were observed in the disease progression (P = 0.829) or complete tumor disappearance (P = 0.633) rates between the MWA and RFA groups. Complications occurred in 14.7% (5/34) of patients presenting with transient hoarseness. RFA had a higher but not statistically significant complication rate than MWA did (21.1% [4/19] vs. 6.7% [1/15]; P = 0.355). Conclusion: Both MWA and RFA demonstrated promising short-term outcomes in terms of efficacy and safety in treating solitary low-risk T2N0M0 PTC, with no significant differences.

• 생물환경조절학회지
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• 제21권3호
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• pp.276-280
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• 2012

국내 아스파라거스 생산의 단경기인 12월 생산을 위한 가온시기를 구명코자 수행하였으며 '그린타워' 품종 16~19개월 된 근주를 사용하였다. 가온시기는 2004년 10월 25일부터 2005년 1월 20일 까지 15일 간격으로 7처리로 하였으며 수확시기, 수확량과 품질을 비교하였다. 맹아소요일은 가온시기가 늦어짐에 따라 길어져 12월 30일 가온구에서 52일 로 가장 길게 소요되었으며 이후 점차 짧아졌다. 10월 25일 가온시 11월 7일부터 수확이 가능하였으며, 11월 15일과 11월 30일에 가온할 경우 각각 12월 수확이 가능하였고, 12월 15일 이후 가온 할 경우 1월 상순 이후에 수확이 가능하였다. 주당 순수, 순중 및 총 수량은 휴면이 타파된 1월 10일 이후에 가온하는 처리에서 크게 증가되었다. 그러나 12월 수확을 위해서는 11월 15일에 가온 하는 것이 총수량 및 상품수량에서 각각 607kg/10a와 386kg/10a으로 10월 25일 가온하는 193kg/10a에 비하여 크게 증가되었다. 이상의 결과 제주에서 하우스 재배시 12월 생산을 위한 적정 가온시기는 수량과 품질면에서 11월 15일이 바람직할 것으로 판단되었다.

• 한국작물학회지
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• 제2권
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• pp.11-26
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• 1964

파종기의 이동이 수도의 출수기 및 기타 수량구성용소 등 제형질에 미치는 영향 및 품종간 변이를 알고저 50품종을 공시하여 3월 15일부터 7월 28일까지 15일간격을 두고 10회에 걸쳐 파종하고 20일묘와 40일묘를 이식하여 그 특성을 조사하여 제I보로 '파종기 및 묘대기간의 차이가 출수기에 미치는 영향 및 품종간의 변이'를 보고한바 있다. 본보는 제1보에 계속된 것으로 40일묘이앙구에 대한 벼의 간장, 수장, 수수, 수종 및 고간종 등 수량구성요소에 대하여 1년간의 실험성적을 조사분석하였다. 제I보에서 보고한 바와 같이 파종기가 지연됨에 따라 출수까지의 일수가 단축되었으며 대부분의 품종은 제VIII파종기까지는 거의 직선적 단축경향을 보였으며 일부의 품종은 제IX파종기까지 그러한 경향을 보였고 제X파종기에서는 거의 전부가 출수하지 못하였다. 따라서 파종기이동에 따르는 출수까지의 일수의 변화가 수량구성요소에 미치는 영향 및 품종간의변이에 관하여 본실험의 결과를 요약하면 다음과 같다. 1. 간장 : 간장은 파종기의 이동에 따라 출수까지의 일수가 단축되면 간장도 짧아지는 경향을 보였으며 각파종기에 있어서 품종적으로 보면 출수까지의 일수가 긴 것은 간장이 짧았다. 2. 수장 : 수장은 파종기의 이동에 따라 출수까지의 일수가 단축되면 수장도 단축되었으며 각파종기에 있어서 품종적으로 보면 출수까지의 일수가 긴 품종은 수장이 짧고 출수까지의 일수가 짧은 품종은 수장이 긴 경향을 보였으나 현저하지는 않았다. 3. 수수 : 1주수수는 품종 및 파종기를 통하여 출수까지의 일수가 길어 질수록 증가하였으며 단 제IX파종기에서 만은 출수까지의 일수가 길면 수수는 감소하였다. 4. 수중 : 1주수중은 품종 및 파종기를 통하여 출수까지의 일수가 길 수록 무거운 경향을 보였는데 제VII 및 제VIII파종기에서는 반대로 출수까지의 일수가 길면 1주수중은 가벼운 경향을 나타냈다. 5. 고종 : 1주고간중은 품종 및 파종기를 통하여 출수까지의 일수가 길어 질수록 무거운 경향을 보였다. 6. 신고비 : 신고비는 제1파종기로부터 점차 높아져서 제V파종기에 최고에 달하였고 각파종기에 있어 품종적으로 보면 제I∼제III파종기와 제VII∼제VIII파종기에 있어서는 출수까지의 일수가 길면 신고비는 낮고 그밖에 파종기 즉 보통재배인 제IV 및 제V, 제VI파종기에서는 출수까지의 일수가 길면 신고비가 높았다.