• 제목/요약/키워드: Degree of growth

검색결과 1,760건 처리시간 0.026초

혈소판 농축혈장과 법랑기질 단백질이 임플란트 골 연상 골 재생에 미치는 영향에 관한 비교연구 (Comparative study on the Effects of Platelet-Rich Plasma and Enamel Matrix Protein on Supracrestal bone Regeneration of Dental Implant)

  • 은희종;임성빈;정진형;홍기석;이종헌
    • Journal of Periodontal and Implant Science
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    • 제35권1호
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    • pp.235-250
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    • 2005
  • The current interest in periodontal tissue regeneration has lead to research in bone graft, root surface treatments, guided-tissue regeneration, administration of growth factors, and the use of enamel matrix protein as possible means of regenerating lost periodontal tissue. Several studies have shown that a strong correlation between platelet-rich plasma and the stimulation of remodeling and remineralization of grafted bone exits, resulting in a possible increase of 15-30% in the density of bone trabeculae. The purpose of this study was to study the histopathological results and differences between the use of platelet-rich plasma and the use of enamel matrix $protein(Emdogain^?)$ about bone regeneration at the implant. Implant fixtures were inserted and graft materials placed into the left femur in the experimental group, while the only implant fixtures placed in the control group. In the first experimental group, platelet-rich plasma and xenograft were placed at the supracrestally placed implant site, and in the second experimental group, $Emdogain^{(R)}$ and xenograft placed at the supracrestally placed fixture site. The degree of bone regeneration adjacent to the implant fixture was observed and compared histopathologically at 2, 4, and 8 weeks after implant fixture insertion. The results of the experiment are as follows: 1. The rate of osseointegration to the fixture threads was found to be greater in the experimental group compared to in the control group. 2. The histopathological findings showed that the bone regeneration, the partial osseointegration existed at 4 weeks, and that osseointegration and bone density increaced in the experimental groups at 8 weeks. 3. The results showed that new bone formation and bone remodeling increased in the area near to the fixture in the first and second experimental groups at 8 weeks than at 4 weeks. The results showed that in the area distant from the fixture, new bone formation did not increase and bone remodeling decreased in the first experimental group at 4, 8 weeks, and that new bone formation increased in the second experimental group. 4. The histopathological findings showed that AZ deposition in the first experimental group was remarkable at 2, 8 weeks, and in the second experimental group at 2, 4, 8 weeks in the area distant from the fixture threads.

갯바위에서 분리한 미생물의 항균활성 분석 (Antibacterial Activity of Bacteria Isolated from Rocks on the Seashore)

  • 박인숙;오륜경;이민정;문지영;김영옥;남보혜;공희정;김우진;안철민;김동균
    • 한국수산과학회지
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    • 제48권6호
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    • pp.904-912
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    • 2015
  • There is a great deal of research interest regarding substitutes for antibiotics because of various obstacles to the efficacy and use of antibiotics. We isolated and analyzed diversity of microbiota which exhibited antibacterial activity against 23 pathogenic bacteria, to develop alternative agent of antibiotics. By investigating the microbiota from rocks on the seashore, we characterized and obtained various antibacterial material-producing bacteria. Thirty-one isolates belong to four genera and seven species, according to 16S rDNA sequence analysis, showed antibacterial activities against 23 pathogenic bacteria. The Identity of 16S rDNA sequences indicated three species of Bacillus, one species of Paenibacillus, one species of Pseudomonas and two species of Enterobacter. Two isolates were similar to Bacillus aerophilus, four isolates were similar to Bacillus pumilus, seven isolates were similar to Bacillus safensis, 15 isolates were similar to Paenibacillus polymyxa, respectively. In addition, one isolate was similar with Pseudomonas poae, one isolate was similar to Enterobacter asburiae, and one isolate was similar to Enterobacter ludwigii, respectively. Variations of antibacterial activity and level among the same species were indicated the diverse strains of isolates. Vibrio vulnificus showed the highest degree of growth inhibition by 29 isolates. Further studies regarding antibacterial materials and bacteria suggest that development of probiotic strains or alternative agents to antibiotics.

인공산성(人工酸性)비의 철수(撤水) 및 분무(噴霧)가 배추, 무, 콩에 미치는 영향(影響) (Response of Chinese Cabbage, Radish and Soybean Exposed to Sprinkle and Mist of Simulated Acid Rain)

  • 박선도;이석순;김복진
    • 한국환경농학회지
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    • 제15권3호
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    • pp.335-340
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    • 1996
  • 인공산성비가 배추, 무, 콩의 생육과 토양의 화학성에 미치는 영향을 구명코저 인공산성비(pH 2.7)와 자연비(pH 6.0)를 10mm씩 2일 간격으로 살수(撒水)와 분무(噴霧) 처리하였다. 배추와 무는 30회, 콩은 62회 처리하였으며, 가시적 피해증상과 피해율, 엽록소 함량, 수량 및 수량관련특성, 식물체 무기양분 함량, 시험 후 토양의 화학성 등을 분석한 결과는 다음과 같다. 1. 인공산성비에 의한 가시적 피해증상은 배추는 담갈색 혹은 적갈색 반점이 생기고, 잎은 윤기가 없었다. 무는 잎 가장자리가 다소 위축되고, 담갈색의 반점이 생기며, 잎에 윤기가 없었다. 콩은 담갈색과 적갈색의 반점이 생기면서 잎의 가장자리가 위축되었다. 2. 인공산성비에 의한 피해정도는 3작물 모두 인공산성비 처리횟수가 증가할수록, 살수(撒水)보다 분무(噴霧)에서 다소 더 컸다. 3. 엽록소 함량은 인공산성비에 의하여 감소되었으나 인공산성비의 살수와 분무간에는 차이가 없었다. 4. 인공산성비 처리는 3작물의 수량을 모두 감소시켰으나 인공산성비를 처리할 때 살수와 분무간에는 차이가 없었다. 5. 수확기 배추, 무, 콩의 식물체 칼리, 석회, 고토 함량은 감소하였으나 황 함량은 증가되었고, 인공산성비를 처리할 때 살수와 분무간에는 차이가 없었다. 6. 시험후 토양의 화학성은 인공산성비 처리로 토양 pH, 석회, 고토, 칼리 함량은 감소시켰으나 황 함량은 증가하였고, 유기물, 전질소, 인산 함량은 차이가 없었다. 인공산성비를 처리할 때 살수와 분무간 토양의 화학성은 차이가 없었다.

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Camptothecin 에 의한 ST1571 의 항암 활성 증강 (Synergistic antitumor activity of ST1571 and camptothecin in human cancer cells)

  • 김미주;이상민;배재호;정병선;강치덕;김선희
    • 생명과학회지
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    • 제17권6호통권86호
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    • pp.748-755
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    • 2007
  • 본 연구에서는 전이성 암세포와 항암제 다제내성 세포에 있어서 항암제 내성에 영향을 미치는 것으로 알려진 DNA-dependent protein kinase (DNA-PK) 가 Abl protein-tyrosine kinases저해제인 STl571 내성에도 연관되어 있는지에 대하여 조사하였다. 또한 STl571 과 topoisomerase I 저해제인 camptothecin (CPT) 의 단독 및 병용처리에 의한 항암 활성을 전이성 암세포와 항암제 다제내성 세포를 대상으로 조사하였다. 세포의 전이도와 내성정도에 따라 STl571 의 감수성이 다르게 나타났다. 이와 함께 ST1571의 처리후 농도에 따라 전이도가 낮은 KMl2, PC3 세포와 항암제 감수성인 CEM, MCF-7 세포에서는 DNA-PK 의 발현이 감소하는 반면, 전이도가 높은 KML4a, PC-MM2 세포와 다제내성 CEM/MDR 및 MCR/MDR 세포에서는 그 발현이 증가되어 있음을 알 수 있었다. 이는 DNA-PK 의 발현이 STl571 의 내성에 관여한다는 것을 시사한다. 이와 같은 결과에 근거하여 DNA-PK 의 발현을 감소시키는 CPT를 STl571 내성을 나타내는 암세포에 대하여 STl571 과 병용처리 하였다. 그 결과 DNA-PK의 발현이 감소되고 세포증식이 억제됨으로써 ST1571 의 감수성이 CPT에 의해 증가하는 것을 알 수 있었다. 따라서 본 연구에서는 DNA-PK가 STl571 의 내성을 극복하는데 있어서 새로운 표적이 될 수 있으며, STl571 의 치료내성 극복에 CPT 와의 병용처리가 유효함을 알 수 있었다.

1990년대 대구의 신도시화 과정과 도시정책 (The New Urbanization Process and Urban Policy of Daegu in the 1990s)

  • 김순천;최병두
    • 한국지역지리학회지
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    • 제9권4호
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    • pp.461-480
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    • 2003
  • 본 논문은 대구를 사례로 신도시화 과정을 경제, 정치, 사회문화, 환경 그리고 공간적 측면으로 나누어 고찰하였다. 경제적으로 대구의 산업구조는 제조업 중심에서 서비스산업으로 바뀌었으며, 산업의 특화정도는 조립금속과 정밀 광학분야의 비중이 높아지고 있으나 여전히 섬유산업위주의 단선적 산업구조의 틀을 벗어나지 못하고 있다. 정치적으로 지방자치제의 실시로 지역 간의 경쟁이 첨예해지는 상황에서, 대구 지방정부는 전반적으로 지역여건을 성장주의적 분위기로 이끌어가면서, 약화되는 지역 투자나 생산기능을 확충하기 위해 민 관 학의 연계체계를 구성하여 지역의 현안 문제를 해결하는 경향을 보이고 있다. 사회적으로 구도시 체제에서는 대규모 하드웨어 시설에 많은 투자를 하였으나 신도시 체제에서는 사회문화적 소프트웨어시설에 많은 투자를 하게 되었다. 문화적으로는 기존의 축제가 행정 편의적이고 가시적 축제였다면, 현재의 축제는 시민들과 함께 할 뿐만 아니라 지역경제 활성화에 도움을 주는 축제로 변하고 있다. 환경적으로 지방자치제가 본격적으로 시작되면서 산업기반시설과 혐오시설의 입지로 인해 지방자치단체간의 가치 및 이해관계를 둘러싼 갈등문제가 심각하게 표출하고 있다. 마지막으로 신도시화 과정에서 주거팽창과 공간구조의 불균형적 이용은 토지이용의 비효율성을 야기하고 있다. 이런 무계획적인 도시의 외연적 확산은 직주분리와 사람들의 이동의 필요성을 증대시켰으며 이는 에너지 과소비적 도시공간구조를 가져왔다.

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질산화균 활성화조를 이용한 하수처리 공정에서의 유기물 및 질소, 인 제거에 관한 연구 (A Study on Removal of Organism and Nitrogen, Phosphorus in Wastewater Treatment Process Using Nitrifier Activated Reactor)

  • 동영탁;서동환;배유진;박주석
    • 상하수도학회지
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    • 제21권6호
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    • pp.727-735
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    • 2007
  • The use of water by cities is increasing owing to industrialization, the concentration of population, and the enhancement of the standard of living. Accordingly, the amount of waste water is also increasing, and the degree of pollution of the water system is rising. In order to solve this problem, it is necessary to remove organisms and suspended particles as well as the products of eutrophication such as nitrates and phosphates. This study developed a high-end treatment engineering solution with maximum efficiency and lower costs by researching and developing a advanced treatment engineering solution with the use of Biosorption. As a result, the study conducted a test with a $50m^3/day$ Pilot Scale Plant by developing treatment engineering so that only the secondary treatment satisfies the standard of water quality and which provided optimal treatment efficiency along with convenient maintenance and management. The removal of organisms, which has to be pursued first for realizing nitrification during the test period, was made in such a way that there would be no oxidation by microorganisms in the reactor while preparing oxygen as an inhibitor for the growth of microorganism in the course of moving toward the primary settling pond. The study introduced microorganisms in the endogeneous respiration stage to perform adhesion, absorption, and filtering by bringing them into contact with the inflowing water with the use of a sludge returning from the secondary settling pond. Also a test was conducted to determine how effective the microorganisms are as an inner source of carbon. The HRT(Hydraulic Retention Time) in the nitrification tank (aerobic tank) could be reduced to two hours or below, and the stable treatment efficiency of the process using the organisms absorbed in the NAR reactor as a source of carbon could be proven. Also, given that the anaerobic condition of the pre-treatment tank becomes basic in the area of phosphate discharge, it was found that there was excellent efficiency for the removal of phosphate when the pre-treatment tank induced the discharge of phosphate and the polishing reactor induced the uptake of phosphate. The removal efficiency was shown to be about 94.4% for $BOD_5$. 90.7% for $COD_{Cr}$ 84.3% for $COD_{Mn}$, 96.0% for SS, 77.3% for TN, and 96.0% for TP.

Effects of 1,25-dihydroxyvitamin D3 on the differentiation of MC3T3-E1 osteoblast-like cells

  • Kim, Hyun-Soo;Zheng, Mingzhen;Kim, Do-Kyung;Lee, Won-Pyo;Yu, Sang-Joun;Kim, Byung-Ock
    • Journal of Periodontal and Implant Science
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    • 제48권1호
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    • pp.34-46
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    • 2018
  • Purpose: The purpose of this study was to evaluate the effects of 1,25-dihydroxyvitamin $D_3$ on the proliferation, differentiation, and matrix mineralization of MC3T3-E1 osteoblast-like cells in vitro. Methods: MC3T3-E1 osteoblastic cells and 1,25-dihydroxyvitamin $D_3$ were prepared. Cytotoxic effects and osteogenic differentiation were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) activity assay, ALP staining, alizarin red S staining, and reverse transcription-polymerase chain reaction (RT-PCR) for osteogenic differentiation markers such as ALP, collagen type I (Col-I), osteocalcin (OCN), vitamin D receptor (VDR), and glyceraldehyde 3-phosphate dehydrogenase. Results: The MTT assay showed that 1,25-dihydroxyvitamin $D_3$ did not inhibit cell growth and that the rate of cell proliferation was higher than in the positive control group at all concentrations. ALP activity was also higher than in the positive control group at low concentrations of 1,25-dihydroxyvitamin $D_3$ ($10^{-10}$, $10^{-12}$, and $10^{-14}M$). RT-PCR showed that the gene expression levels of ALP, Col-I, OCN, and vitamin D receptor (VDR) were higher at a low concentration of 1,25-dihydroxyvitamin $D_3$ ($10^{-12}M$). Alizarin red S staining after treatment with 1,25-dihydroxyvitamin $D_3$ ($10^{-12}M$) showed no significant differences in the overall degree of calcification. In contrast to the positive control group, formation of bone nodules was induced in the early stages of cell differentiation. Conclusions: We suggest that 1,25-dihydroxyvitamin $D_3$ positively affects cell differentiation and matrix mineralization. Therefore, it may function as a stimulating factor in osteoblastic bone formation and can be used as an additive in bone regeneration treatment.

도시의 쇠퇴가 지역주민의 삶의 만족감에 미치는 영향 - 도시 규모의 차이를 중심으로 - (A Study on the Impact of the Urban Decline on the Subjective Well-being of Residents)

  • 권오규;강은택;마강래
    • 지역연구
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    • 제35권2호
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    • pp.33-47
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    • 2019
  • 본 연구는 도시쇠퇴가 주민의 주관적 삶의 만족감에 미치는 영향을 실증하였다. 실증분석을 위하여 우리나라 도시들을 규모별로 분류하고, 각각의 도시규모별 쇠퇴정도에 따른 전반적 생활만족감, 가족의 수입만족감, 주거환경 만족감으로 구분하여 살펴보았다. 도시쇠퇴의 진행과 삶의 만족감 변화의 동태적 관계를 규명하기 위하여 한국노동패널(KLIPS) 자료를 사용하여 고정효과모형(Fixed effect model)을 사용하였다. 분석결과 도시쇠퇴가 주민의 삶의 만족감에 미치는 영향은 거주하는 도시의 규모에 따라, 부문별 삶의 만족감에 따라 각기 다르게 나타나고 있다. 대도시 주민의 경우 도시쇠퇴가 진행됨에 따라 주거환경 만족감은 감소하나, 과밀 해소로 인한 사회적비용의 감소로 전반적 생활만족감은 증가하였다. 이와 달리 소도시 주민의 경우에는 도시의 쇠퇴가 전반적 삶의 만족감, 가족의 수입만족감, 주거환경만족감을 모두 감소시키는 것으로 확인되었다.

Korean Customer Attitudes Towards SNS Shopping

  • Cho, Young-Sang;Heo, Jeong-Yoon;Youn, Myoung-Kil
    • 유통과학연구
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    • 제10권8호
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    • pp.7-14
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    • 2012
  • As a new format of retailing, social shopping on SNS has rapidly grown in recent. Although there is much literature associated with customer behaviours in the academic world, little attention has been paid to identifying the shopping patterns of SNS shoppers. This paper will, thus, identify how perceived value has an impact on the buying intention of SNS shoppers, after illustrating what kind of factor influences the formation process of perceived value in the Korean marketplace. Given that SNS shoppers are for the most part 20s as well as 30s, the authors handed out questionnaires to them. Furthermore, based on literature review results, the conceptualised research model was developed. Despite lack of literature, the authors developed five constructs like price reduction, quantity- and time-limited message, product ranges, information-sharing, and required number of shoppers. The researchers made a considerable effort to identify the relationship between research concepts and each variable, based on a few research analysis methods such as frequency analysis, the Varimax rotation technique used orthogonal rotation, Cronbach's Alpha, PCA (Principle Component Analysis), and the like. Amongst the 5 variables used to measure the degree of influences on the perceived value as a social shopping characteristic, it has been evident that price cut, required minimum shoppers, product variety, and information-sharing have a positive impact on the perceived value formation processes of SNS customers. Also, this research implies that SNS retailers can differentiate themselves from other retailers by differently using the above factors. From a practitioner's point of view, these factors should be strategically used to increase the social shopping opportunities of SNS users. It is, furthermore, evident that the perceived value formed by the above 4 factors have played an important role in the buying decision process of SNS customers. In a sense, whether customers are aware of higher price cut rates, information-sharing, required minimum shoppers, and product variety has a positive impact on making buying decisions. From a retailer's point of view, online shopping mall operators are able to use blog as well as twitter to improve the buying intention as a marketing tool of social network, because the business activities provided by social shopping retailers, like the rapid, accurate responses to customer requirements, the provision of a variety of information, and the communications between customers are closely related to buying intentions. There are a few research limitations to conduct this empirical research. It was not easy to review prior papers, due to its lack. In spite of the increasing number of SNS shoppers in Korea, little research attention has been paid to this kind of research topic by academicians, because buying products or services through SNS is in its infancy. With regard to research populations, it would be difficult to generalise the research findings in Korea, owing to unbalanced respondent distribution. Considering the above research limitations as well as the growth of social shopping, many authors should pay considerable attention to SNS-related issues in the future, and develop the more sophisticated criteria to measure the characteristics of SNS shoppers.

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고려인삼의 항암효과에 관한 연구 (A Study on the Antitumor Activity of Panax ginseng)

  • Hwang, Woo-lk
    • Journal of Ginseng Research
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    • 제17권1호
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    • pp.52-60
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    • 1993
  • Panax ginseng has been extensively used in the traditional oriental medicine as a restorative, tonic and Prophylactic agent. Recently, several reports regarding to anticancer effects of Panax ginseng has accumulated. These studies emphasized the fact that the anticancer activities might be due to a glycoside group called ginsenoside or pan.u saponin which has a water soluble characteristic. However, the authors and collaborates demonstrated that a highly lipid soluble component in extract of Panax ginseng roots contains a considerable cytotoxic activities against marine leukemic cells (L1210, P388) and human censer cells (HRT-18, HT-29, HCT48). This study was devised to observe the cytotoxic activities of Petroleum-ether extract of Panax giuseng roots (crude GBD and its Partially Purified fraction from silicic acid column chromatography (7 : 3 GX) against sarcoma-180 (5-180) and Walker carcinosar- coma 256 (Walker 256) in vivo, and murine leukemic Lymphocytes (L1210) and human rectal cancer cells (HRT-18) and human colon cancer cells (HT-29 and HCT48) in vitro. Each cell-line was cultured in medium containing serial concentration of the crude GX or 7 : 3 GX in vitro. A highly lipid soluble compound in the extract of Panax ginseng root was cytocidal to murine leukemic cells and human colon and rectal cancer cells in vitro. In the meantime, ginseng saponin derivatives did not have cytotoxic effects at its corresponding concentration. The growth rates of the cancer cells in medium containing ginseng extracts were inhibited gradually to a significant degree roughly in proportion to the increase of the extract concentration. The cytotoxic activity of 7 : 3 GX was about 3 times more potent than that of crude GX, one unit of cytotoxic activity against L1210 cells being equivalent to 2.54 Ug and 058 Ug for the crude GX and 7 : 3 GX, respectively. The Ri value of the active compound on silica- gel thin layer chromatography with petroleum-ether/ethyl ether/acetic acid mixture (90 : 10 : 1, v/v/v) as a developing so lvent was 053. While, the Panaxydol and Panaxynol as active compounds were purified from Petroleum-ether extract of Panax ginseng root by Drs. Ahn and Kim, and author found out that the one unit of cytotoxic activity of the Panaxydol and Panaxynol against L1210 cells being equivalent to 056 Ug and 0.3918 respectively. The survival times of mice inoculated with S-180 cells were extended about 1.5 to 2 times by the 7 : 3 GX treatment compared with their control group. The significantly decreased hemoglobin values of rats after inoculation with Walker 256 were recovered to normal range by oral administration of the crude Gt The synthetic levels of protein, DNA and RNA in human colon and rectal cancer cells were significantly diminished by treatment with the crude GX, which can explain a part of the origin of its anticancer activity.

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