• Asia Pacific Journal of Business Review
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• 제1권2호
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• pp.1-16
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• 2017

The fundamental goal of the research was to verify if the Twin Deficits Hypothesis holds for the economy of Zambia using time series data from 1980-2014. The current account and budget deficit were employed as key variables. The exchange rate was also used as a transmission mechanism to see how it contributes in the nexus. Cointegration tests confirmed a long run association of the variables. After fitting the VECM model, Granger causality tests confirmed the existence of twin deficits for Zambia. The results supported uni-directional reverse causality. The exchange rate was shown to be more significant in the long run than in the short run. The implosion of the time series as shown by the predicted cointegration equation implies that unless drastic measures are taken to cure the deficits, using the current account as the major target variable, twin deficits will persist for some time. The major policy implication of this research is that given that Zambia is a primary commodity-dependent developing country subsisting largely on copper revenues to sustain the economy, there is a need to move away from "copper addiction," given the recent volatility of earnings of primary commodities (e.g. through diversification of the economy, import substitution, and other strategies).

• 동의생리병리학회지
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• 제19권1호
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• pp.130-138
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• 2005

This experiment was designed to investigate the effect of Phellodendron amurense(PLDA) on the Alzheimer's disease. The effects of PLDA extract on $IL-1{\beta}$, IL-6, amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$ and AChE activity of PC-12 cell lysate treated by $A{\beta}$ plus $rIL-1{\beta}$ and behavior of memory deficit mice induced by scopolamine and mice glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine were investigated, respectively. PLDA extract suppressed $IL-1{\beta}$, IL-6, APP, AChE, GFAP mRNA in PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$ ; AChE activity in cell lysate of PC-12 cell treated by $A{\beta}$ plus $rIL-1{\beta}$. PLDA extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. PLDA extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. According to the above results, it is suggested that PLDA extract might be usefully applied for prevention and treatment of Alzheimer's disease.

• 동의신경정신과학회지
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• 제17권2호
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• pp.75-89
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• 2006

Objective : This experiment was designed to investigate the effect of Rhododendron simsii Planch(RSP) on the Alzheimer's disease. Method : The effects of RSP on amyloid precursor proteins(APP), acetylcholinesterase (AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by amyloid ${\beta}$ protein$(A{\beta})$ and $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ mRNA of THP-1 cell treated by lipopolysaccharide(LPS), AChE activity of PC-12 cell lysate treated by $A{\beta}$ and behavior of the memory deficit mice induced by scopolamine, and glucose, AChE in serum of the memory deficit mice induced by scopolamine were investigated, respectively. Result : 1. RSP suppressed APP, AChE, GFAP mRNA in PC-12 celt treated by $A{\beta}$. 2. RSP suppressed $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ mRNA in THP-1 cell treated by LPS. 3. RSP suppressed AChE activity in cell lysate of PC-12 cell treated by $A{\beta}$. 4. RSP increased glucose and decreased AChE significantly in the serum of the memory deficit mice induced by scopolamine. 5. RSP group showed significantly inhibitory effect on the scopolamine-induced impairment of teaming and. memory in the experiment of Morris water maze. Conclusion : According to the above results, it is suggested that RSP might be usefully applied for prevention and treatment of Alzheimer's disease and memory deficit symptom.

• 동의생리병리학회지
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• 제20권1호
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• pp.43-51
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• 2006

This experiment was designed to investigate the effect of Amomum villosum(AMV) on the Alzheimer's disease. The effects of AMV extract on amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell line treated by amyloid $\beta$ protein($A{\beta}$) : IL-$1{\beta}$, IL-6, TNF-$\alpha$ mRNA of THP-1 cell line treated by lipopolysaccharide(LPS) : AChE activity of PC-12 cell lysate treated by $A{\beta}$ : serum glucose, uric acid, AChE activity of memory deficit rats induced by scopolamine : behavior of memory deficit mice induced by scopolamine were investigated, respectively. AMV extract suppressed APP, AChE, GFAP mRNA in PC-12 cell treated by $A{\beta}$ : IL-$1{\beta}$, IL-6, TNF-$\alpha$ mRNA in THP-1 cell treated by LPS , AChE activity in cell lysate of PC-12 cell treated by $A{\beta}$. AMV extract increased glucose, decreased uric acid and AChE significantly in the serum of the memory deficit rats induced by scopolamine. AMV extract group showed significantly inhibitory effect on the memory deficit of mice induced by scopolamine in the experiment of Morris water maze. According to the above results, it is suggested that AMV extract might be usefully applied for prevention and treatment of Alzheimer's disease.

• 한국수자원학회논문집
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• 제52권5호
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• pp.325-335
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• 2019

본 연구의 목적은 일반 상호보완이론(Generalized Complementary Relationship, GCR)을 활용하여 실제증발산량을 추정하고, 추정한 실제증발산량기반 가뭄지수로부터 공통경계미국(Conterminous U.S., CONUS)에 대한 1895~2016년 기간 동안의 가뭄을 해석하는 것이다. GCR 이론으로부터 추정한 $ET_a$는 North American Land Data Assimilation System (NLDAS-2) Noah 지면모형(Land surface models)으로 산정한 $ET_a$와 비교 검증하였다. 또한, GCR로부터 증발산 부족량(ET Deficit)을 산정하고 이를 표준정규화하여 공통경계미국에 대해 Standardized Evapotranspiration Deficit Index (SEDI)를 산정하였다. 이렇게 산정한 SEDI는 Standard Precipitation Index (SPI)와 비교하였다. 본 연구로부터 GCR 기반 $ET_a$는 NLDAS-2 Noah모형의 $ET_a$보다 다소 크게 추정하는 경향을 보였다. SEDI와 SPI의 상관성은 지속시간이 클수록 더 크게 나타났다. 강수와 토양수분의 자료를 사용하지 않는 GCR이론으로부터 비교적 정확한 $ET_a$을 추정할 수 있으며, 증발산 기반인 SEDI가 적절한 가뭄해석에 이용될 수 있을 것으로 판단된다.

• The Korean Journal of Pain
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• 제36권1호
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• pp.51-59
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• 2023

Background: This study investigated the effect of an excess and a deficit of spinal 5-hydroxytryptamine (5-HT) on the mechanical allodynia and neuroglia activation in a rodent pain model of carrageenan inflammation. Methods: Male Sprague-Dawley rats were implanted with an intrathecal (i.t.) catheter to administer the drug. To induce an excess or deficit of 5-HT in the spinal cord, animals were given either three i.t. 5-HT injections at 24-hour intervals or a single i.t. injection of 5,7-dihydroxytryptamine (5,7-DHT) before carrageenan inflammation. Mechanical allodynia was measured using the von Frey test for 0-4 hours (early phase) and 24-28 hours (late phase) after carrageenan injection. The changes in the activation of microglia and astrocyte were examined using immunofluorescence of the dorsal horn of the lumbar spinal cord. Results: Both an excess and a deficit of spinal 5-HT had no or a minimal effect on the intensity of mechanical allodynia during the early phase but prevented the attenuation of mechanical allodynia during the late phase, which was observed in animals not treated with i.t. 5-HT or 5,7-DHT. Animals with an excess or deficit of 5-HT showed stronger activation of microglia, but not astrocyte, during the early and late phases, than did normal animals. Conclusions: Imbalance in the descending 5-HT pathway in the spinal cord could aggravate the mechanical allodynia and enhance the activation of microglia, suggesting that the spinal 5-HT pathway plays an essential role in maintaining the nociceptive processing in balance between facilitation and inhibition in inflammatory pain caused by carrageenan inflammation.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1683-1693
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• 2007

Urban has been operating Korail and the local autonomous entity in Korea. Over 70 LRTs will be constructed in the future, but it is hard to manage them due to structural deficit from construction debt, so Public finance plays a very important role in order to overcome a deficit. Therefore, it is necessary to plan detailed analysis and planned system about the expenditure of the amount which is borrowed from country and local government and business income from railroad companies like government grants, PSO. This research wishes to grasp the problem and present model about reasonable and efficient financial program, analyzing about increasing import and expenses of Urban.

• 한국컴퓨터정보학회논문지
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• 제20권11호
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• pp.135-142
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• 2015

This paper applied a VAR model to analyze the effects of RMB exchange rate brought to processing trade, non-processing trade and FDI. Then we can get the results that the appreciation of RMB could not solve the problem of US trade deficit. It is more likely that the appreciation just can transfer the trade imbalance to other country with US, which could not radically solve the economic problems of US. Also this paper find that the data of service trade is surplus while the main goods deficit was occur in advanced technology product, especially in the information & communications trade And US has real advantage in these industries, so the situation will be changed if US decreased the barrier in these industries. In that way, the imbalance situation should be greatly reduced.

• East Asian Economic Review
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• 제24권4호
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• pp.417-440
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• 2020

The coronavirus pandemic of 2019-20 confronted fiscally dominant regimes around the world with the question of whether the large deficits caused by the health crisis should be monetized or financed by issuing debt. The unpleasant monetarist arithmetic of Sargent and Wallace (1981) states that in a fiscally dominant regime tighter money now can cause higher inflation in the future. In spite of the qualifier 'unpleasant,' this result is positive in nature, and, therefore, void of normative content. I analyze conditions under which it is optimal in a welfare sense for the central bank to delay inflation by issuing debt to finance part of the fiscal deficit. The analysis is conducted in the context of a model in which the aforementioned monetarist arithmetic holds, in the sense that if the government finds it optimal to delay inflation, it does so knowing that it would result in higher inflation in the future. The central result of the paper is that delaying inflation is optimal when the fiscal deficit is expected to decline over time.

• 한국수자원학회논문집
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• 제33권4호
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• pp.447-459
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• 2000

수자원 개발이 인문 사회적 여건으로 날로 어려워짐에 따라 공급위주의 물 관리 정책이 한계에 달하고 이어 수요관리개념에 따른 적용 가능한 수자원관리 기법의 개발이 필요해지고 있다. 무효방류량을 최소화하여 한정된 물 자원 배분을 합리적으로 이룰 수 있는 실제 적용 가능한 수요관리기법은 수자원의 효율적 이용과 유역물관리 시스템의 방법론적 완성을 위해 반드시 필요하다. 본 연구는 기존의 물수지분석 기법을 댐 연계운영 모형과 조합하여 MIP 기법에 의해 이수목적 다목적댐 최적연계운영모형을 개발하고 낙동강 수계를 대상으로 모형의 적용성에 대한 검증을 실시하였으며 낙동강 수계의 용수공급능력을 재평가하였다. 이 결과를 계획 당시 자료 및 다른 모형에 의한 운영결과와 비교한 바 개발된 모형은 훌륭히 물 부족량 공급방식으로 수계의 물 공급을 보장할 수 있고 기존 모형등에 의한 방식보다 물배분과 관리에 효율적으로 활용 될 수 있음이 평가되었다.