• Journal of the Korean Chemical Society
• /
• v.35 no.5
• /
• pp.461-468
• /
• 1991

The cationic polymerizations of substituted oxiranes which have pendant energetic groups such as azido, and nitrato, are investigated theoretically using the semiempirical MNDO, and $AM_1$ methods. The nucleophilicity and basicity of substituted oxiranes can be explained by the negative charge on oxygen atom of oxiranes. The reactivity of propagation in the polymerization of oxiranes can be represented by the positive charge on carbon atom and the low LUMO energy of active species of oxiranes. Ring opening of the complexed cyclic oxonium ion to the open chain carbenium ion is expected computational stability of the oxonium and carbenium ion by 30∼40 kcal/mol favoring the carbenium ion. The relative equilibrium concentration of cyclic oxonium and open carbenium ions will be a major determinant of mechanism. The chain growth $SN_1$, mechanism will be at least as fast as that for $SN_2$ mechanism.

• Journal of Internet Computing and Services
• /
• v.9 no.2
• /
• pp.69-81
• /
• 2008

It has become more difficult to correspond a cyber attack quickly as patterns of attack become various and complex. However, current security mechanism just have passive defense functionalities. In this paper, we propose new network security mechanism to respond various cyber attacks rapidly and to chase and isolate the attackers through cooperation between security zones. The proposed mechanism makes it possible to deal effectively with cyber attacks such as IP spoofing, by using active packet technology including a mobile code on active network. Also, it is designed to hove more active correspondent than that of existing mechanisms. We implemented these mechanisms in Linux routers and experimented on a testbed to verify realization possibility of attacker response framework using mobile code. The experimentation results are analyzed.

• Strategy21
• /
• s.30
• /
• pp.143-176
• /
• 2012

We are witnessing the growing maritime tension on the East Asian sea these days. Each naval powers in the region are competing each other to acquire more advanced naval capabilities. Based upon the rapid economic development, China is actively beefing up its naval capabilities and expand its boundary of naval activities all over the East Asian region. Chinese Navy already unveiled its expansive naval strategy replacing the traditional concept of 'Near-Sea Defense' with the new concept of 'Far-Sea Defense' strategy. In response to potential rival's naval build up, the U.S. is redeploying its naval forces focusing on the Asia-Pacific region. The U.S. enhances its joint naval exercises with the countries in the region, such as Japan, India, Australia and so on. In addition, Washington is devising new naval strategy under the concept of 'Air-Sea Battle' to deter Peking's so-called 'Anti-Access/ Area Denial(A2AD)' strategy. As a close ally of the U.S., Japan also disclosed its clear intention to strengthen the Maritime Self Defense Force(MSDF)'s capabilities by introducing the new concept of 'Dynamic Defense Force' in 2011. Under the new concept, JMSDF is pursuing the additional acquisition of submarines, quasi-aircraft carriers, Aegis-equipped destroyers, etc. Under the new president's strong leadership, Russia is also invigorating the naval build-up. Especially, Russia is fortifying the Pacific Fleet's naval assets by deploying new-type of naval ships such as the Mistral which was imported from France. In the midst of competitive naval build-up among the major naval powers in the region, we are observing the growing maritime conflicts on the East China Sea as well as South China Sea. Those naval conflicts can pose severe threats to our national interests. Maritime conflicts on the East or South China Sea can imperil our sea lanes which will be indispensible for national economic development. Neighboring countries' maritime conflicts also will cast an uncertainty on the path to mobilize international cooperation to resolve the North Korean issues. We should contribute to ease the maritime tension in the region by various ways. First, we should actively galvanize the bilateral maritime dialogue among the major naval powers in the region. Second, we also should take the lead to form a multilateral maritime cooperation mechanism in the region. Above all, we should set the aim to be a peaceful maritime power who can contribute to a building of stable maritime order in the region with a considerable naval power.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.48 no.1
• /
• pp.35-42
• /
• 2020

Electromechanical Actuator(EMA) for flight vehicles generally serves to control the fin deflection angle or the thrust vector angle. This paper deals with design and development of EMA for both aerodynamic control and thrust vector control. In this paper, a novel compact EMA is proposed that can simultaneously control both the tail fin and the jet vane with one actuator and detach the jet vane after vertical launch and rapid turn of the flight vehicle so as to increase efficiency during flying to target. To do this, we designed the EMA using a push-push link mechanism and derived a mathematical model. The mathematical model is validated by comparing simulation result and experimental data. The performance and reliability of the proposed EMA have been verified through performance test, environmental test and ground test. The proposed EMA is expected to be useful as an EMA for flight vehicles because of its simple and compact structure, as well as its performance and reliability.

• Journal of Life Science
• /
• v.30 no.1
• /
• pp.88-95
• /
• 2020

Using a random arbitrarily primed polymerase chain reaction, messenger RNA expression levels were assessed after exposure to 10% (v/v) toluene for 8 hr in solvent-tolerant Pseudomonas sp. BCNU 106. Among the 100 up-expressed products, 50 complementary DNA fragments were confirmed to express repeatedly; these were cloned and then sequenced. Blast analysis revealed that toluene stimulated an adaptive increase in the gene expression level in association with transcriptions such as LysR family of transcriptional regulators and RNA polymerase factor sigma-32. The expression of catalase and Mn2+/Fe2+ transporter genes functionally associated with inorganic ion transport and metabolism increased, and the increased expression of type IV pilus assembly PilZ and multi-sensor signal transduction histidine kinase genes, functionally categorized into signal transduction and mechanisms, was also demonstrated under toluene stress. The gene expression level of beta-hexosaminidase in association with carbohydrate transport and metabolism increased, and those of DNA polymerase III subunit epsilon, DNA-3-methyladenine glycosylase II, DEAD/DEAH box helicase domain-containing protein, and ABC transporter also increased after exposure to toluene in DNA replication, recombination, and repair, and even in defense mechanism. In particular, the RNAs corresponding to the ABC transporter, Mn2+/Fe2+ transporter, and the β-hexosaminidase gene were confirmed to be markedly induced in the presence of 10% toluene. Thus, defense mechanism, cellular ion homeostasis, and biofilm formation were shown as essential for toluene tolerance in Pseudomonas sp. BCNU 106.

• Nutritional Sciences
• /
• v.8 no.1
• /
• pp.23-27
• /
• 2005

The major garlic component, Allicin [diallylthiosulfinate, or (R, S)-diallyldissulfid-S-oxide] is known for its medicinal effects, such as antihypertensive activity, microbicidal activity, and antitumor activity. Allicin and diallyldisulfide, which is a converted form of allicin, inhibited the cholesterol level in hepatocytes, in vivo and in vitro. The metabolism of allicin reportedly occurs in the microsomes of hepatocytes, predominantly with the contribution of cytochrome P-450. However, little is known about how allicin affects the genes involved in the activity of hepatocytes in vivo. In the present study, we used the short-term intravenous injection of allicin to examine the in vivo genetic profile of hepatocytes. Allicin up-regulate ten genes in the hepatocytes. For example, the interferon regulator 1 (IRF-I), the wingless-related MMTV (mouse mammary tumor virus) integration site 4 (wnt-4), and the fatty acid binding protein 1. However, allicin down-regulated three genes: namely, glutathione S-transferase mu6, a-2-HS glycoprotein, and the corticosteroid binding globulin of hepatocytes. The up-regulated wnt-4, IRF-1, and mannose binding lectin genes can enhance the growth factors, cytokines, transcription activators and repressors that are involved in the immune defense mechanism. These primary data, which were generated with the aid of the Atlas Plastic Mouse 5 K Microarray, help to explain the mechanism which enables allicin to act as a therapeutic agent, to enhance immunity, and to prevent cancer. The data suggest that these benefits of allicin are partly caused by the up-regulated or down-regulated gene profiles of hepatocytes. To evaluate the genetic profile in more detail, we need to use a more extensive mouse genome array.

• International Journal of High-Rise Buildings
• /
• v.4 no.1
• /
• pp.65-73
• /
• 2015

Detailed finite element (FE) analyses of a full-scale four-story steel frame structure, subjected to consecutive 60% and 100% excitations from the JR Takatori records during the 1995 Hyogoken-Nanbu earthquake, are conducted using E-Simulator. The four-story frame was tested at the largest shake-table facility in the world, E-Defense, in 2007. E-Simulator is a parallel FE analysis software package developed to accurately simulate structural behavior up to collapse by using a fine mesh of solid elements. To reduce computational time in consecutive dynamic time history analyses, static analysis with gravity force is introduced to terminate the vibration of the structure during the analysis of 60% excitation. An overall sway mechanism when subjected to 60% excitation and a story mechanism resulting from local buckling of the first-story columns when subjected to 100% excitation are simulated by using E-Simulator. The story drift response to the consecutive 60% and 100% excitations is slightly smaller than that for the single 100% excitation.

• Journal of Environmental Science International
• /
• v.13 no.8
• /
• pp.711-719
• /
• 2004

The effect of nickel (Ni) on growth and some tolerance strategies with regard to heavy metal tolerance mechanism was investigated in radish (Raphanus sativus) seedlings. The protective effect of histidine on nickel stress conditions was also monitored. The seedling growth decreased with an increase in metal concentrations. The inhibitory effect was more pronounced in the root elongation than in the shoot elongation. Increasing Ni supply showed a progressive increase of Ni concentrations in the roots and shoots. Ni content was higher in the shoots than in the roots. In the presence of nickel, radish exhibited an antioxidative defense mechanism, as evidenced by the elevated malondialdehyde(MDA), showing that nickel is an efficient inducer of lipid peroxidation. Exposure of radish to elevated concentrations of nickel was accompanied by an increase in the proline content. Supplemental histidine in the presence of Ni ameliorated metal-induced growth inhibition and lipid peroxidation. Combinations of Ni and histidine resulted in a significant decline in proline content compared with Ni stress alone, indicating that histidine may provide protection against the adverse effect of Ni stress. From the results it is suggested that histidine is an efficient chelator by complexing metal ion within the plant and may playa role in nickel tolerance implicated in metal detoxification.

• BMB Reports
• /
• v.31 no.4
• /
• pp.328-332
• /
• 1998

The 8-hydroxyisocoumarin, named Centipedin, which has a significant antibiotic activity, was separated and solubilized with organic solvents, such as diethyl ether from centipede Scolopendra subspinipes multilans L. Koch. The Centipedin was purified by silicic acid column and high S cation exchange chromatography followed by reverse-phase HPLC. It was confirmed that Centipedin has a potent antibiotic effectiveness against Gram-negative Klebsiella pneumoniae ATCC 8308. The results showed that Centipedin blocks both DNA replication and RNA transcription during the growth of this pathogen in vivo. The biosynthesis of antibiotic 8-hydroxyisocoumarin was studied in vivo by feeding $[^{14}C]-labelled$ compound as a precursor to live centipede, in which $[^{14}C]acetate$ was the most efficiently incorporated into the Centipedin within 30 h after injection. Also, in vitro study on the biosynthesis of Centipedin showed that efficient incorporation of $[^{14}C]acetate$ occurred at pH range 5.0-7.0 for 10 h incubation and decreased significantly after then. It is suggested that 8-hydroxyisocoumarin is one of the defense compounds acting on bacterial infection in Scolopendra subspinipes.

• Proceedings of the Korea Information Assurance Society Conference
• /
• 2004.05a
• /
• pp.233-239
• /
• 2004

In this paper, we describe a defense mechanism to cope with stepping stones attacks in high-speed networks. (Stepping stones Attacker launches attacks not from their own computer but from intermediary hosts that they previously compromised.) We aim at tracing origin hacker system, which attack target system via stepping stones. There are two kind of traceback technology ; IP packet traceback, or connection traceback. We are concerned with connection traceback in this paper. We propose a new host-based traceback. The purpose of this paper is that distinguish between origin hacker system and stepping stones by using process structure of OS(Operating System).