• 제목/요약/키워드: Decline Diagnosis

검색결과 88건 처리시간 0.027초

개의 췌장적출이 혈청 Trypsin-like Immunoreacitivity (TLI)에 미치는 영향 (Effects of Pancreatectomy on Serum Trypsin-like Immunoreactivity (TLI) in Dogs)

  • 곽우연;윤화영;오태호;윤영민;이창우;최희인
    • 한국임상수의학회지
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    • 제18권1호
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    • pp.7-13
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    • 2001
  • Depending on the degree of exocrine pancreatic insufficiency, there are inconsistent values in the serum trypsin-like immunoreactivity (TLI), hematology, and serology. To determine the correlation between those values and complete pancreatic insufficiency, 10 pancreatectomized dogs as the treated group and 10 sham operation dogs as control group were used. The entire treated group showed significant decrease in serum TLI level from 2.63$\pm$0.20 ng/ml (day 0) to 1.81$\pm$0.43 ng/ml at day 1 after the pancreatectomy (p<0.05) and the decline maintained till the end of the experiment. Blood glucose level gradually increased, but albumin level showed significant decrease (p<0.05) at day 1 and maintained the decline. Three clinical signs were observed such as depression, vomiting, and diarrhea. The entire treated group showed diarrhea throughout the experiment, but depression and vomiting were gradually diminished. The activity of serum alkaline phosphatase in the treated group increased till day 2 then decreased, on the other hand, control group showed continuous increase till day 4, and then decreased. Only experimental group showed the increased alanine aminotransferase activity at day 1. Serum lipase activity in the treated group jumped up at day 1 and then dropped down, which was even lower than the control. Regarding serum amlyase activity gradually decreased. According to these results, the assay of trypsin-like immunoreactivity showed the consistent result, so it suggests that TLI is an useful tool to determine the pancreatic exocrine function and possible diagnosis of exocrine pancreatic insufficiency compared to the simple assay of plasma amylase and lipase.

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Breast Cancer in Iraq, Incidence Trends from 2000-2009

  • AL-Hashimi, Muzahem Mohammed Yahya;Wang, Xiang Jun
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권1호
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    • pp.281-286
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    • 2014
  • Background: Breast cancer is the most frequent malignancy of women worldwide. In Iraq, breast cancer ranks first among cancers diagnosed in women but no studies have been conducted on incidence trends. The present study of breast cancer in the country during 2000-2009 was therefore performed. Materials and Metbods: The registered data for breast cancer cases were collected from the Iraqi Cancer Registry/Ministry of Health. The significance of incidence rate trends during 2000-2009 was tested using Poisson regression. Age-standardized rates (ASR), and age-specific rates per 100,000 population were calculated. ResultS" A total of 23,792 incident breast cancer cases were registered among females aged ${\geq}15$ years, represented 33.8% of all cancers in females registered during 2000-2009. It ranked first in all the years. The median age at diagnosis was 49 and the mean age was 52 years. The incidence rate of all female breast cancer in Iraq (all ages) increased from 26.6 per 100,000 in 2000 to 31.5 per 100,000 in 2009 (APC=1.14%, p<.0001). The incidence in age groups (40-49), (50-59) and (70+) increased in earlier years and has recently (2005-2009) become stable. The incidence in age group (60-69) did not decline since 2003, while the incidence rates in the age group (15-39) started to decline in 2004. Conclusions' With the Iraqi Cancer Registry data during the period 2000-2009, the incidence of all female breast cancer in Iraq (all ages) has risen. We found rapid increase in the age specific incidence rate among age group 60-69. However, breast cancer among Iraqi women still affects younger age groups than their counterparts in developed countries. Further epidemiological research is needed to examine possible causes and prevention measures.

소아(小兒) stress에 관한 문헌적(文獻的) 고찰(考察) (A study on stress in Children)

  • 김기봉;김장현
    • 대한한방소아과학회지
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    • 제16권1호
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    • pp.105-124
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    • 2002
  • With the progress of civilization, the disorders due to the stress, which derived from the social-structural complexity and diversity, are on an increasing trend in our times. Accordingly, the accurate diagnosis and appropriate treatment for them are required. Especially in the current years, children's disorders delivered by the emotional problems keep increasing. In this research, the researcher tried to figure out the cause of the children's stress and its treatment, studied the theories of the stress in the modem medicine and the sever emotions in oriental medicine, and came to the conclusion as follows: 1. The stress can be defined as the combination of the reaction to noxious stimuli and its defense mechanism of the body, In oriental medicine, it is considered as pathological notions which includes seven emotions as the internal factor, six evils as the external factor and other foods, expectoration, ecchymoma as the non-internal/external factors. 2. Children usually get stressed by various reasons in a growth process such as schooling, relationship with friends, the opposite sex of family, or change of surroundings, and these can cause the various disorders. 3. In the study of the children's stress symptoms, it is found that the silent reaction is uncommon. It usually appeared in both reactions: firs, physical reactions such as stomachache, vomiting, headache, neural frequent urination, bronchial asthma or excessive respiration and/or, second, behavioral reactions such as a decline of performance, alimentary disorder, e.g. anorexia nervosa or bulimia, sleep disorder, e.g. nightmare or panic in sleep, anthrophobia, refusal to a school attendance or hyperactiveness. Besides, the peculiar mental disorder such as paroxysm of anger, tic, autism, nocturnal enuresis, lack of attentiveness, impediment in linguistic development, learning difficulty, intellectual decline, etc. can be appeared, and the heavy stress during the babyhood can cause the regression of behavior or the immaturity of formation of character. 4. The appropriate treatments for the children's stress are Osteopathy, Manpulation, Aroma Therapy, Alexander Technique, Autonomic Never Control Treatment, Biofeedback, Chiropractic, Dance Therapy, Feldenkrasis Technique, Gravity Therapy, Homepathy, Aquatherapy, Hypnotherapy, Naturopathy and Meditation.

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쇠퇴지역 도출 및 공간특성 분석에 관한 연구 - 공간적 자기상관을 이용하여 - (Deriving the Declining Areas and Analysing Their Spatial Characteristics Using the Spatial Autocorrelation Measure)

  • 윤정미;서경천
    • 한국지리정보학회지
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    • 제13권3호
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    • pp.64-73
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    • 2010
  • 본 연구는 충청권을 대상으로 공간특성을 분석하고 쇠퇴지역을 도출하는데 목적이 있다. 쇠퇴지역 도출을 위해 쇠퇴지표를 선정하고 충청권의 시 공간적 지표자료를 가공하여 공간자료로 이용하였으며, 쇠퇴지역의 특성을 도출하기 위하여 공간적 자기상관을 적용하였다. 공간적 자기상관은 '공간'이라는 요인을 고려하여 공간특성을 도출할 수 있는 방법이다. 또한 쇠퇴지역의 특성 도출을 위해 경제학적 개념을 도입하여 정(+)의 값을 가지는 지역은 보완지역으로 부(-)의 값을 가지는 지역은 대체지역으로 구분하였다. 이를 통해 주변지역의 성장으로 인해 쇠퇴되는 지역과 주변지역의 성장으로 인해 함께 성장하는 지역 등의 특성을 도출하였다. 본 연구는 충청권 시 군의 쇠퇴지역 도출 및 특성을 분석함으로써 향후 재생계획 수립을 위한 의사결정을 지원하고자 한다.

우리나라 도시재생 계획체계에 대한 연구 : 도시재생전략계획을 대상으로 (A Study on South Korean Urban Regeneration Plan System : for strategic urban regeneration plans)

  • 조병호;류태창;김현
    • 디지털콘텐츠학회 논문지
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    • 제18권8호
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    • pp.1577-1584
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    • 2017
  • 최근 전국적으로 많은 지자체들이 '도시재생특별법' 개정과 '도시재생 선도지역', '도시재생 뉴딜정책'의 추진으로 도시재생 사업을 추진하고 있지만, 공모사업 중심의 도시재생사업은 '도시재생특별법'에 의한 도시재생 계획체계에 맞게 추진하기에는 한계가 있다. 이처럼 공모사업 중심의 획일적인 계획과 비 계획체계에 의한 도시재생사업 추진되고 있어 많은 전략계획과 활성화계획 등 계획수립 소요시간 증가와 이에 따른 사회적 비용증가 등 많은 문제점을 야기하였다. 이에 본 연구에서는 도시재생 계획체계 정립 및 유연화 등의 방법론을 모색하고자 함을 목적으로 도시재생 계획체계의 운영 실태를 분석하여 문제점을 분석하고 개선 방안을 제시하여 우리나라의 도시재생 계획체계 재정립 등의 방안을 연구하고자 한다.

안정 상태에서의 정량 뇌파를 이용한 기계학습 기반의 경도인지장애 환자의 감별 진단 모델 개발 및 검증 (Development and Validation of a Machine Learning-based Differential Diagnosis Model for Patients with Mild Cognitive Impairment using Resting-State Quantitative EEG)

  • 문기욱;임승의;김진욱;하상원;이기원
    • 대한의용생체공학회:의공학회지
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    • 제43권4호
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    • pp.185-192
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    • 2022
  • Early detection of mild cognitive impairment can help prevent the progression of dementia. The purpose of this study was to design and validate a machine learning model that automatically differential diagnosed patients with mild cognitive impairment and identified cognitive decline characteristics compared to a control group with normal cognition using resting-state quantitative electroencephalogram (qEEG) with eyes closed. In the first step, a rectified signal was obtained through a preprocessing process that receives a quantitative EEG signal as an input and removes noise through a filter and independent component analysis (ICA). Frequency analysis and non-linear features were extracted from the rectified signal, and the 3067 extracted features were used as input of a linear support vector machine (SVM), a representative algorithm among machine learning algorithms, and classified into mild cognitive impairment patients and normal cognitive adults. As a result of classification analysis of 58 normal cognitive group and 80 patients in mild cognitive impairment, the accuracy of SVM was 86.2%. In patients with mild cognitive impairment, alpha band power was decreased in the frontal lobe, and high beta band power was increased in the frontal lobe compared to the normal cognitive group. Also, the gamma band power of the occipital-parietal lobe was decreased in mild cognitive impairment. These results represented that quantitative EEG can be used as a meaningful biomarker to discriminate cognitive decline.

도시 쇠퇴지역 공간 특성을 반영한 적합 도시재생 사업유형 적용방안 연구 (A Study on the Application of Suitable Urban Regeneration Project Types Reflecting the Spatial Characteristics of Urban Declining Areas)

  • 조돈철;신동빈
    • 한국지리정보학회지
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    • 제24권4호
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    • pp.148-163
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    • 2021
  • 본 연구는 「도시재생 활성화 및 지원에 관한 특별법」에 따라 2017년부터 시작된 도시재생 뉴딜사업(이하 '뉴딜사업')의 종류가 다양해짐에 따라 데이터 기반의 정확한 쇠퇴진단과 사업유형 예측이 중요하다고 판단되어, 전국 읍면동을 대상으로 가장 적합한 뉴딜사업 유형을 판별할 수 있는 적용 모형 개발을 위한 연구를 수행하였다. 적용 모형 개발을 위한 데이터는 통계지리정보서비스(SGIS)와 도시재생정보체계의 '도시재생 종합정보 개방체계'를 통해 수집하고 데이터 전처리를 거쳐 분석 모델을 위한 데이터를 구축하였다. 적용 모형은 다항 회귀분석과 다항 로지스틱 회귀분석을 통해 4가지 모형을 도출하였다. 4가지 모형의 적용 가능성과 유효성 검증을 위해 서울특별시를 대상으로 각 모형별로 기존에 선정된 뉴딜사업지에 공간분포도를 비교 분석한 결과 DI-54 모형이 가장 높은 일치율을 확인할 수 있었다. 또한 DI-54 모형을 전국 954개 도시 쇠퇴지역에 적용해본 결과에서도 적합 도시재생 사업유형 판별에 활용 가능성을 확인할 수 있었다.

Sarcopenia: Nutrition and Related Diseases

  • Du, Yang;No, Jae Kyung
    • 한국조리학회지
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    • 제23권1호
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    • pp.66-78
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    • 2017
  • "Sarcopenia", sarcopenia is an old age syndrome, and used to describe the reduction of skeletal muscle. Initially, it was thought that sarcopenia was only a senile disease characterized by degeneration of muscle tissue. However, its cause is widely regarded as multifactorial, with neurological decline, hormonal changes, inflammatory pathway activation, declines in activity, chronic illness, fatty infiltration, and poor nutrition, all shown to be contributing factors. Skeletal muscle mass can be measured by a variety of methods, currently, the commonly used methods are dual-energy X-ray scanning (DXA), computer tomography (CT), magnetic resonance imaging (MRI), etc. Muscular skeletal disorders can also be assessed by measuring appendicular skeletal muscle (ASM), particularly muscle tissue content. At the same time, sarcopenia refers to skeletal muscle cell denervation, mitochondrial dysfunction, inflammation, hormone synthesis and secretion changes and a series of consequences caused by the above process and is a progressive loss of skeletal muscle syndrome, which can lead to the decrease of muscle strength, physical and functional disorders, and increase the risk of death. Sarcopenia is mainly associated with the aging process, but also related to other causes such as severe malnutrition, neurodegenerative diseases, and disuse and endocrine diseases associated with muscular dystrophy, and it is the comprehensive results of multi-factors, so it is difficult to define that sarcopenia is caused by a specific disease. With the aging problem of the population, the incidence of this disease is increasingly common, and seriously affects the quality of the life of the elderly. This paper reviews the etiology and pathogenesis of myopathy, screening methods and diagnosis, the influence of eating habits, etc, and hopes to provide reference for the diagnosis and treatment of this disease. At present, adequate nutrition and targeted exercise remain the gold standard for the therapy of sarcopenia.

피질하 혈관성치매의 진단, 치료 및 예방 : 1례 보고와 함께 (Diagnosis, Treatment and Prevention of Subcortical Vascular Dementia with a Case Report)

  • 최성훈;구세광;전우현;백경민;한창현;전원경;이영준
    • 대한예방한의학회지
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    • 제14권3호
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    • pp.63-75
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    • 2010
  • Vascular dementia(VaD) is currently considered to be the second most common type of dementia. VaD is not a single diagnostic entity, but a heterogeneous syndrome which encompasses several clinicopathological forms of dementia resulting from cerebrovascular diseases. A common form of VaD is subcortical VaD which is characterized by lacunar infarcts and deep white matter changes, leading to a progressive decline in memory and cognitive function. The neuropsychological and cognitive profiles of subcortical VaD have been reported relatively homogeneous. At present, subcortical vascular dementia is regarded as the most important subtype of VaD with getting the attention of vascular dementia. The aims of this study are to discuss the concept of subcortical VaD and its importance focusing on diagnosis, prevention and treatment with a case report.

제주도에서 CADASIL 연구의 중요성: 역학, 진단 및 임상양상에 대한 고찰 (Importance of CADASIL research in Jeju: a review and update on epidemiology, diagnosis, and clinical spectrum)

  • 최재철;이정석;김기태
    • Journal of Medicine and Life Science
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    • 제17권3호
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    • pp.65-73
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    • 2020
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a single-gene disease of the cerebral small blood vessels caused by mutations in the NOTCH3 gene on chromosome 19. Although CADASIL was known as a rare disease, recent research has suggested that the NOTCH variants could be found frequently even in the general population. The main clinical features included recurrent stroke, migraine, psychiatric symptoms, and progressive cognitive decline. On brain magnetic resonance imaging, patients with CADASIL showed multifocal white matter hyperintensity lesions, lacunar infarcts, microbleeds, and brain atrophy. Among them, lacunar infarcts and brain atrophy are important in predicting the clinical outcomes of patients with CADASIL. In the Jeju National University Hospital, we have diagnosed 213 CADASIL patients from 2004 to 2020. Most NOTCH3 mutations were located in exon 11 (94.4%), and p.Arg544Cys was the most common mutation. The mean age at diagnosis was 61.0±12.8 years. The most common presenting symptoms were ischemic stroke (24.4%), followed by cognitive impairment(15.0%), headache (8.9%), and dizziness(8.0%). Although the exact prevalence of CADASIL in Jeju is still unknown, the disease prevalence could be as high as 1% of the population considering the prevalence reported in Taiwan. Therefore, it is necessary to discover efficient biomarkers and genetic tests that can accurately screen and diagnose patients suspected of having CADASIL in this region. Ultimately, it is urgent to explore the exact pathogenesis of the disease to identify leading substances of treatment potential, and for this, multi-disciplinary research through active support from the Jeju provincial government as well as the national government is essential.