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A New Chemical Constituent from the Hairy Root Cultures of Catharanthus roseus

  • Chung, Ill-Min;Park, Han-Young;Ali, Mohd;San, Ka Yiu;Peebles, Christie A. M.;Hong, Seung-Beom;Ahmad, Ateeque
    • Bulletin of the Korean Chemical Society
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    • v.28 no.2
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    • pp.229-234
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    • 2007
  • One new compound, 3,7,11,19,23,27-hexamethyl-15-hydroxymethylene-n-octacos-5,8,20-triene-10β,18α- diol-10β-D-glucopyranoside (1), along with the three known compounds, 3-epibetulinic acid (2), n-pentadecanyl octa-dec-19-en-oate (3) and β-sitosterol (4) were isolated from the methanolic extract of the cultured Catharanthus roseus hairy roots. The structures of the one new and three known compounds were elucidated using one- and two-dimensional NMR in combination with IR, EI/MS, FAB/MS. To the best of our knowledge, 3,7,11,19,23,27-hexamethyl-15-hydroxymethylene-n-octacos-5,8,20-triene-10β,18α-diol-10β-D-glucopyranoside, 3-epibetulinic acid and n-pentadecanyl octa-dec-19-en-oate were identified for the first time from the hairy roots of C. roseus.

전자선 직접묘사에 의한 Deep Submicron NMOSFET 제작 및 특성

  • Lee, Jin-Ho;Kim, Cheon-Soo;Lee, Heyung-Sub;Jeon, Young-Jin;Kim, Dae-Yong
    • ETRI Journal
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    • v.14 no.1
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    • pp.52-65
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    • 1992
  • 전자선 직접묘사 (E-beam direct writing lithography) 방법을 이용하여 $0.2\mum$$0.3\mum$ 의 게이트길이를 가지는 NMOS 트랜지스터를 제작하였다. 게이트만 전자선 직접묘사 방법으로 정의하고 나머지는 optical stepper를 이용하는 Mix & Match 방식을 사용하였다. 게이트산화막의 두께는 최소 6nm까지 성장시켰으며, 트랜지스터구조로서는 lightly-doped drain(LDD) 구조를 채택하였다. 짧은 채널효과 및 punch through를 줄이기 위한 방안으로 채널에 깊이 붕소이온을 주입하는 방법과 well을 고농도로 도핑하는 방법 및 소스와 드레인에 $p^-$halo를 이온주입하는 enhanced lightly-doped drain(ELDD) 방법을 적용하였으며, 제작후 성능을 각각 비교하였다. 제작된 $0.2\mum$의 게이트길이를 가지는 소자에서는 문턱전압과 subthreshold기울기는 각각 0.69V 및 88mV/dec. 이었으며, Vds=3.3V에서 측정한 포화 transconductance와 포화 드레인전류는 각각 200mS/mm, 0.6mA/$\mum$이었다. $0.3\mum$소자에서는 문턱전압과 subthreshold 기울기는 각각 0.72V 및 82mV/dec. 이었으며, Vds=3.3V에서 측정한 포화 transconductance는 184mS/mm이었다. 이러한 결과는 전원전압이 3.3V일 때 실제 ULSI에 적용가능함을 알 수 있다.

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Query Term Expansion and Reweighting using Term-Distribution Similarity (용어 분포 유사도를 이용한 질의 용어 확장 및 가중치 재산정)

  • Kim, Ju-Youn;Kim, Byeong-Man;Park, Hyuk-Ro
    • Journal of KIISE:Databases
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    • v.27 no.1
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    • pp.90-100
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    • 2000
  • We propose, in this paper, a new query expansion technique with term reweighting. All terms in the documents feedbacked from a user, excluding stopwords, are selected as candidate terms for query expansion and reweighted using the relevance degree which is calculated from the term-distribution similarity between a candidate term and each term in initial query. The term-distribution similarity of two terms is a measure on how similar their occurrence distributions in relevant documents are. The terms to be actually expanded are selected using the relevance degree and combined with initial query to construct an expanded query. We use KT-set 1.0 and KT-set 2.0 to evaluate performance and compare our method with two methods, one with no relevance feedback and the other with Dec-Hi method which is similar to our method. based on recall and precision.

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Survey on the Elementary School Lunch Program in Seoul Area (서울지역 국민학교 학교급식 실태에 관한 조사 연구)

  • 정은자
    • The Korean Journal of Food And Nutrition
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    • v.4 no.1
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    • pp.81-90
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    • 1991
  • This study was conducted a comprehensive survey of 39 elementary schools operating school lunch program in Seoul area. The purpose of this study was to investigate the realities of school lunch program. This method of the research was based on the interview survey with dietitian working at each school with prepared questionnaire. The survey was conducted for 16 days from Dec. 5 to Dec. 20., 1990. The results of this study were as follows ; (1) The average numbers of children supplied with food were 1,244 for each school. It was about 44.3Bb of the students enrolled in the school. The average feeding cost was 738 won per a child for a day. (2) Only one school was operating nutritional education as a regular educational program, and others were operating nutritional education off and on. (3) All nutrient intake except energy were higher than the RDA for school lunch program. (4) The ratio of animal food was 46.2%, and that of vegetable food was 53.8%. (5) The ratio of schools without sterilizer cabinet came to 56.4%, and that of schools without warmer was 97.4%. (6) The facilities for drainage, lighting, ventilation, anti-rat of a cookery were comparatively good.

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Studies on the Optimal Time for Therapy of Fasciola spp. Infected Cattle in Central Area of Korea (간질감염우에 대한 구충적기 검토( II ))

  • 손봉환;강구식;한태호
    • Korean Journal of Veterinary Service
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    • v.15 no.1
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    • pp.1-6
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    • 1992
  • A survey on the dosage optimal time for the bovine fascioliasis was carried out from Jan. 1987 to Dec. 1990. The results were summarized as follows ; 1. The mean infection rate was 27.7% (1,662 heads were infected out of 3,247 heads In 205 herds). A seasonal infection rate was winter (34.6%) >spring(32.5%) >summer(24.7%) > autumn(22.8%) 2. In the density of the fasciola spp. egg of infected bovine feces remarks 79.6% on the range below 10. 3. The density of fasciola spp. egg is not directly proportinal to the infection rate, and remarks on the range from 5 to 20. 4. In the herds dosed vermifuge the appearance of the fasciola spp. egg is as follows ; 1∼3 months show 3.8% and 4∼6 months 8.5% 5. The dosage optimal time for the bovine fasciliasis is as follows ; 1) According to the monthly infection rate the first dosage optimal time is Dec and Feb and the second-Jun and Aug. 2) In the herd dosed vermifuge the dosage optimal time is to dose twice by 60 days interval after 3∼4 months from previous dosage.

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Analysis of polychlorinated biphenyls in shellfish collected from a market

  • Lee, Ga-Jeong;Moon, Ji Yong;Lee, Eun-Hwa;Ha, Hye-Sook;Jeong, Gi Ho
    • Analytical Science and Technology
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    • v.18 no.6
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    • pp.529-534
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    • 2005
  • We collected seven species of shellfish; all originating from the southern coastal areas of Korea, from a market every three months from Dec. 2001 to Sept. 2002, and determined the total polychlorinated biphenyl(PCB) levels by the sum of 26 individual congener levels. A GC-ECD system was applied for identification and quantification of these PCB congeners. Mussel showed the highest level in Sept. 2002 at 34.5 ng/g dry weight(d.w.). All species except mussel showed the lowest total PCB level in Dec. 2001 and their levels in tissue ranged from 0.6 to 5.5 ng/g d.w. The total PCB levels ranged from 0.8 to 17.3 ng/g in Mar. 2002, 2.2 to 9.5 ng/g in June 2002, and 1.8 to 34.5 ng/g d.w. in Sept. 2002. The principal congener group was penta-CBs, which accounted for 32% of the total PCBs, followed by hexa-CBs at 23%, and tetra-CBs at 21%.

Quasi-nonvolatile Memory Characteristics of Silicon Nanosheet Feedback Field-effect Transistors (실리콘 나노시트 피드백 전계효과 트랜지스터의 준비휘발성 메모리 특성 연구)

  • Seungho Ryu;Hyojoo Heo;Kyoungah Cho;Sangsig Kim
    • Journal of IKEEE
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    • v.27 no.4
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    • pp.386-390
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    • 2023
  • In this study, we examined the quasi-nonvolatile memory characteristics of silicon nanosheet (SiNS) feedback field-effect transistors (FBFETs) fabricated using a complementary metal-oxide-semiconductor process. The SiNS channel layers fabricated by photoresist overexposure method had a width of approximately 180 nm and a height of 70 nm. The SiNS FBFETs operated in a positive feedback loop mechanism and exhibited an extremely low subthreshold swing of 1.1 mV/dec and a high ON/OFF current ratio of 2.4×107. Moreover, SiNS FBFETs represented long retention time of 50 seconds, indicating the quasi-nonvolatile memory characteristics.

Community Structure and Distribution Pattern of the Pleuronectiform Fishes in the Uljin Marine Ranching Area, Korea (울진바다목장에서 어획된 가자미목(Pleuronectiformes) 어류의 군집구조 및 공간분포)

  • Yoon, Byoung Sun;Park, Jeong-Ho;Sohn, Myong Ho;Yang, Jae Hyeong;Yoon, Sang Chul;Choi, Young Min
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.46 no.4
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    • pp.413-423
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    • 2013
  • To elucidate the variation of species composition, biomass and length distribution of flatfishes by the period and region in the Uljin marine ranching area, bottom trawl survey was investigated at the six stations from Feb. 2008 to Dec. 2010. During the survey period, a total 4 families 17 species in the Pleuronectiformes, average 69,158 $ind./km^2$ and 5,625 $kg/km^2$ were identified, in 2008 appeared in 14 species, average 25,798 $ind./km^2$ and 2,333 $kg/km^2$ and in 2009 appeared in 13 species, average 102,360 $ind./km^2$ and 5,634 $kg/km^2$ and in 2010 appeared in 14 species, average 75,704 $ind./km^2$ and 8,632 $kg/km^2$. The individual dominant species, occupying over 10% of total individuals, was Pleuronectes herzensteini (20,811 ind., 30.0%), Hippoglossoides pinetorum (18,666 ind., 26.9%) and Glyptocephalus stelleri (13,499 ind., 19.4%) also the biomass dominant species, occuping over 10% of total biomass, was P. herzensteini (2,207 kg, 39.3%), Pleuronectes yokohamae (857 kg, 15.3%), H. pinetorum (761 kg, 13.5%), Kareius bicoloratus (677 kg, 12.1%). From the cluster and MDS analysis based on Bray-Curtis similarity matrix of fourth root transformed data of species number and individuals in the Uljin marine ranching area from Feb. 2008 to Dec. 2010 was divided into two different groups of the flatfishes community in 2008 and from Jan. to Apr. in 2009 and 2010 (Group A) and the pleuronectiform community in from May to Dec. in 2009 and 2010 (Group B). From the cluster and MDS analysis using the similarity of demersal organisms community among six stations, the Uljin marine ranching area was divided into two different groups of Group 1 (St. 1 and St. 3) and Group 2 (St. 2, St. 4, St. 5 and St. 6).

Assessment of three European fuel performance codes against the SUPERFACT-1 fast reactor irradiation experiment

  • Luzzi, L.;Barani, T.;Boer, B.;Cognini, L.;Nevo, A. Del;Lainet, M.;Lemehov, S.;Magni, A.;Marelle, V.;Michel, B.;Pizzocri, D.;Schubert, A.;Uffelen, P. Van;Bertolus, M.
    • Nuclear Engineering and Technology
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    • v.53 no.10
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    • pp.3367-3378
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    • 2021
  • The design phase and safety assessment of Generation IV liquid metal-cooled fast reactors calls for the improvement of fuel pin performance codes, in particular the enhancement of their predictive capabilities towards uranium-plutonium mixed oxide fuels and stainless-steel cladding under irradiation in fast reactor environments. To this end, the current capabilities of fuel performance codes must be critically assessed against experimental data from available irradiation experiments. This work is devoted to the assessment of three European fuel performance codes, namely GERMINAL, MACROS and TRANSURANUS, against the irradiation of two fuel pins selected from the SUPERFACT-1 experimental campaign. The pins are characterized by a low enrichment (~ 2 wt.%) of minor actinides (neptunium and americium) in the fuel, and by plutonium content and cladding material in line with design choices envisaged for liquid metal-cooled Generation IV reactor fuels. The predictions of the codes are compared to several experimental measurements, allowing the identification of the current code capabilities in predicting fuel restructuring, cladding deformation, redistribution of actinides and volatile fission products. The integral assessment against experimental data is complemented by a code-to-code benchmark focused on the evolution of quantities of engineering interest over time. The benchmark analysis points out the differences in the code predictions of fuel central temperature, fuel-cladding gap width, cladding outer radius, pin internal pressure and fission gas release and suggests potential modelling development paths towards an improved description of the fuel pin behaviour in fast reactor irradiation conditions.

Growth inhibition of human pancreatic cancer cells by CR2945-targeted liposome

  • Yoon, Na-Young;Kim, Jin-Seok
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.416.3-417
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    • 2002
  • Among the promising cancer therapy is targeting of the drug to tumor cells via receptor specific ligands. CR2945, $\beta$-2-( [2-(8-azaspiro [4.5] dec-8-ylcarbony!)-4.6-dimethylphenyl]amino-2-oxoethyl] -(R)-1-naphthalenepropanoic acid. is known to have an inhibitory effect on a gastrin receptor of colorectal cancer cells. As the human pancreatic cancer cells (BxPC-3) express gastrin receptors. interruption of binding of gastrin with gastrin receptor of human pancreatic cancer cells by CR2945 inhibits the growth of human pancreatic cancer cells. (omitted)

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