• Journal of the Korean Society of Manufacturing Process Engineers
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• v.2 no.2
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• pp.52-59
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• 2003

Cam mechanism is a machine part frequently used in machinery. Specially, conjugate cam mechanism is very suitable for the high speed working and the heavy power translation. Then a conjugate cam mechanism need high precision for the relations between cam profiles and follower rollers. So, its design and manufacturing are very difficult. Thus, this study is a branch of exclusive CAM systems for design and NC machining of conjugate earn mechanism based on a master plate earn profile in order to exchange an old plate cam mechanism to a new conjugate earn mechanism. For the design of the other cam profile by using a master cam profile, some calculation processes were used by vector summation methods, from master cam profile data to the center data of master follower, from the center data of master follower to the center data of the other follower considered in link mechanism, and offsetting in the center direction of base circle of the other cam from the center data of the other follower. Finally, a sample conjugate cam was selected and machined m order to prove the contents of this study.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.06a
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• pp.740-749
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• 1998

This paper proposes compression of image data using neural networks based on conjugate gradient method and dynamic tunneling system. The conjugate gradient method is applied for high speed optimization .The dynamic tunneling algorithms, which is the deterministic method with tunneling phenomenon, is applied for global optimization. Converging to the local minima by using the conjugate gradient method, the new initial point for escaping the local minima is estimated by dynamic tunneling system. The proposed method has been applied the image data compression of 12 ${\times}$12 pixels. The simulation results shows the proposed networks has better learning performance , in comparison with that using the conventional BP as learning algorithm.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.7 s.110
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• pp.638-647
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• 2006

Recently, the DFT-Spread OFDM has been studied for the PAPR reduction. However, the DFT-Spread OFDM produces more ICI and SCI problems than OFDM because phase offset mismatch of the DFT spreading code results from the random phase noise in the oscillator. In this paper, at first, phase noise influence on the DFT-Spread OFDM system is theoretically analyzed in terms of the BER performance. Then, the conventional ICI self-cancellation methods are discussed and two kinds of ICI self-cancellation methods are newly proposed. Lastly, a new DFT-Spread OFDM system which selectively adopts the ICI self-cancellation technique is proposed to resolve the interference problem and PAPR reduction simultaneously. Proposednew DFT-Spread OFDM system can minimize performance degradation caused by phase noise, and still maintain the low PAPR property. Among the studied methods, DFT-Spread OFDM with data-conjugate method or newly proposed symmetric data-conjugate method show the significant performance improvements, compared with the DFT-Spread OFDM without ICI self-cancellation schemes. The data-conjugate method is slightly better than symmetric data-conjugate method.

• The Journal of the Acoustical Society of Korea
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• v.20 no.3
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• pp.8-14
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• 2001

In this paper, we present a new cost function for subband block adaptive algorithm and block conjugate gradient algorithm for noise cancellation of acoustic signal. For the cost function, we process the subband signals with data blocks for each subbands and recombine it a whole data block. After these process, the cost function has a quadratic form in adaptive filter coefficients, it guarantees the convergence of the suggested block conjugate gradient algorithm. And the block conjugate gradient algorithm which minimizes the suggested cost function has better performance than the case of full-band block conjugate gradient algorithm, the computer simulation results of noise cancellation show the efficiency of the suggested algorithm.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.831-838
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• 2004

A fluid-solid conjugate solver has been newly developed and applied to an actual engine disk system. Most of the currently available conjugate solvers lack the special thermal modeling for turbomachinery disk system applications. In the present new code, these special models are implemented to expand the applicability of the conjugate method and to reduce the required computational resources. Most of the conjugate analysis work so far are limited to the axisymmetric framework. However, the actual disk system includes several non-axisymmetric components which inevitably affect the local heat transfer phenomena. Also the previous work devoted to this area usually concentrate their efforts on the steady-state thermal field, although the one in the transient condition is more critical to the engine components. This paper presents full 3D conjugate analysis of a single stage high pressure turbine rotor-stator disk system to assess the three-dimensional effects (Fig. 1). The analysis is carried out not only in the steady-state but also in the engine accelerating transient condition. The predicted temperatures shows good agreement with measured data.

• Biomolecules & Therapeutics
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• v.23 no.6
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• pp.493-509
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• 2015

Antibody-drug conjugates utilize the antibody as a delivery vehicle for highly potent cytotoxic molecules with specificity for tumor-associated antigens for cancer therapy. Critical parameters that govern successful antibody-drug conjugate development for clinical use include the selection of the tumor target antigen, the antibody against the target, the cytotoxic molecule, the linker bridging the cytotoxic molecule and the antibody, and the conjugation chemistry used for the attachment of the cytotoxic molecule to the antibody. Advancements in these core antibody-drug conjugate technology are reflected by recent approval of Adectris$^{(R)}$(anti-CD30-drug conjugate) and Kadcyla$^{(R)}$(anti-HER2 drug conjugate). The potential approval of an anti-CD22 conjugate and promising new clinical data for anti-CD19 and anti-CD33 conjugates are additional advancements. Enrichment of antibody-drug conjugates with newly developed potent cytotoxic molecules and linkers are also in the pipeline for various tumor targets. However, the complexity of antibody-drug conjugate components, conjugation methods, and off-target toxicities still pose challenges for the strategic design of antibody-drug conjugates to achieve their fullest therapeutic potential. This review will discuss the emergence of clinical antibody-drug conjugates, current trends in optimization strategies, and recent study results for antibody-drug conjugates that have incorporated the latest optimization strategies. Future challenges and perspectives toward making antibody-drug conjugates more amendable for broader disease indications are also discussed.

• The Journal of the Korea Contents Association
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• v.20 no.6
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• pp.1-8
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• 2020

The use of text data in big data analytics has been increased. So, much research on methods for text data analysis has been performed. In this paper, we study Bayesian learning based on conjugate prior for analyzing keyword data extracted from text big data. Bayesian statistics provides learning process for updating parameters when new data is added to existing data. This is an efficient process in big data environment, because a large amount of data is created and added over time in big data platform. In order to show the performance and applicability of proposed method, we carry out a case study by analyzing the keyword data from real patent document data.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.3 s.94
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• pp.319-326
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• 2005

In the multi-carrier OFDM communication system for the high data rate transmission, the ICI caused by phase noise of transceiver local oscillator may degrade the system performance seriously. In this paper, a new ICI self-cancellation scheme using data-conjugate method is proposed to reduce the ICI caused by phase noise effectively. Then, the CPE, ICI and CIR are derived by the phase noise linear approximation method. Besides, to analyze the efficiency of system performance improvement, the proposed method is compared with the original OFDM and the conventional ICI self-cancellation scheme using data-conversion method. As results, the performance degradation caused by ICI can be mitigated effectively in the OFDM system with ICI self-cancellation scheme, and more performance improvement can be achieved by the proposed ICI self-cancellation scheme using data-conjugate method than the conventional ICI self-cancellation scheme using data-conversion method when phase noise exists.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.26 no.4
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• pp.387-396
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• 2008

An integration between construction CAD data and GIS data needs geo-referencing processes of construction CAD data whose coordinate systems are their own native or even unknown. Generally, these processes are based on manually detected conjugate-vertices. In this study, we proposed an semi-automated conjugate -vertices detection method for building features between construction CAD data and a digital map using a vertex attributed string matching algorithm. A geo-referencing function for construction CAD data based on the similarity transform could be derived with those conjugate-vertices. Using our proposed method, we overlaid geo-referenced CAD data to a digital map of the College of Engineering, Seoul National University and evaluated our method.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.25 no.1
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• pp.107-119
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• 1999

3 Kinds of PEG-hEGF conjugate, PEG5-hEGF, PEG5-hEGF, PEG10-hEGF, were synthesized. Major fractions containing 2 chains of PEG were separated by preparative GPC. Molecular weight was estimated by GPC-MALLS, TOF-Mass and SDS-PAGE, and the data were well corresponding to calculated one. The cell proliferation effect of the conjugates was evaluated, Indicating that the conjugate bound to longer chain PEG exhibits lower activity. Selective modification of hEGF and activity preservation of PEG-hEGF conjugate are undergoing.