• Fisheries and Aquatic Sciences
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• 제12권1호
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• pp.35-43
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• 2009

Sturgeons and paddlefishes are frequently referred to as 'living fossils' among the actionpterygian lineage. They are increasingly facing threats to their existence because of various anthropogenic pressures. In this study, we present the complete mitogenome sequence of the Russian sturgeon Acipenser gueldenstaedtii (Acipenseriformes; Acipenseridae). The mitogenome showed highly homogeneous molecular features compared to previously known vertebrate mitogenomes. Phylogenetic tree inferred from concatenated protein-coding and tRNA genes unambiguously revealed the monophyly of A. gueldenstaedtii, Acipenser stellatus, and Huso huso. Genetic information of the endangered A. gueldenstaedtii will provide baseline data needed to develop molecular markers for stock identification and assessment of population diversity and also to develop future conservation strategies.

• 대한가정학회지
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• 제31권1호
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• pp.25-33
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• 1993

Sex preference and pregnancy motivation are analyzed using the data of 117 pregnant women in Chonju City. The results indicate that women prefer son, regardless of various sociodemographic variables such as pregnancy experience, number of children, women's education, occupation, income, religion, experience, number of children, women's education, occupation, income, religion, and men's education and occupation. Sex preference is statistically significant by women's marital status and age, and children's sex composition. The analysis on 19 pregnancy motivation items shows that pregnancy motivation differs by women's occupation, marital status, number of children, education and their partner's education. Factor analysis on pregnancy motivation items reveals six dimensions for all pregnancy: economic ability, value of child-care, psychological stability, family lineage, old economic dependency are statistically significant dimensions for son preference compared with daughter preference.

• Molecules and Cells
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• 제43권2호
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• pp.107-113
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• 2020

The Runt-related transcription factors (RUNX) transcription factors have been known for their critical roles in numerous developmental processes and diseases such as autoimmune disorders and cancer. Especially, RUNX proteins are best known for their roles in hematopoiesis, particularly during the development of T cells. As scientists discover more types of new immune cells, the functional diversity of RUNX proteins also has been increased over time. Furthermore, recent research has revealed complicated transcriptional networks involving RUNX proteins by the current technical advances. Databases established by next generation sequencing data analysis has identified ever increasing numbers of potential targets for RUNX proteins and other transcription factors. Here, we summarize diverse functions of RUNX proteins mainly on lymphoid lineage cells by incorporating recent discoveries.

• The Korean Journal of Physiology and Pharmacology
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• 제25권3호
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• pp.197-206
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• 2021

Carnosol is a phenolic diterpene phytochemical found in rosemary and sage with reported anti-microbial, anti-oxidant, anti-inflammatory, and anti-carcinogenic activities. This study aimed to investigate the effect of carnosol on the lineage commitment of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) into osteoblasts and adipocytes. Interestingly, carnosol stimulated the early commitment of mBMSCs into osteoblasts in dose-dependent manner as demonstrated by increased levels of alkaline phosphatase activity and Alizarin red staining for matrix mineralization. On the other hand, carnosol significantly suppressed adipogenesis of mBMSCs and downregulated both early and late markers of adipogenesis. Carnosol showed to induce osteogenesis in a mechanism mediated by activating BMP signaling pathway and subsequently upregulating the expression of BMPs downstream osteogenic target genes. In this context, treatment of mBMSCs with LDN-193189, BMPR1 selective inhibitor showed to abolish the stimulatory effect of carnosol on BMP2-induced osteogenesis. In conclusion, our data identified carnosol as a novel osteoanabolic phytochemical that can promote the differentiation of mBMSCs into osteoblasts versus adipocytes by activating BMP-signaling.

• BMB Reports
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• 제52권5호
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• pp.324-329
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• 2019

Recent progress in cellular reprogramming technology and lineage-specific cell differentiation has provided great opportunities for translational research. Because virus-based gene delivery is not a practical reprogramming protocol, protein-based reprogramming has been receiving attention as a safe way to generate reprogrammed cells. However, the poor efficiency of the cellular uptake of reprogramming proteins is still a major obstacle. Here, we reported key factors which improve the cellular uptake of these proteins. Purified red fluorescent proteins fused with 9xLysine (dsRED-9K) as a cell penetrating peptide were efficiently delivered into the diverse primary cells. Protein delivery was improved by the addition of amodiaquine. Furthermore, purified dsRED-9K was able to penetrate all cell lineages derived from mouse embryonic stem cells efficiently. Our data may provide important insights into the design of protein-based reprogramming or differentiation protocols.

• Spatial Information Research
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• 제8권1호
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• pp.31-50
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• 2000

국가 GIS 구축사업의 일환으로 지형도를 비롯한 여러 가지 주제들이 수치지도로 구축되어왔다. 이렇게 구축된 수치지도는 사용하고자 하는 목적에 맞게 올바르게 구축되어 그 정확도를 신뢰할 수 있을 경우에만 효율적으로 사용될 수 있다. 본 연구의 목적은 양질의 수치지도를 구축하는데 필요한 합리적인 검수방안을 제시하는데 있다. 이를 위해 국내·외에서 요구되는 수치지도의 품질요소와 검수현황을 살펴보았고, 수치지도에서 발생하는 오류유형을 분석했다. 이러한 오류유형을 바탕으로 데이터생성연혁, 데이트포맷, 위치정확성, 속성정확성, 기하구조의 적합성, 논리적 일관성, 경계인접, 완전성, 도곽선 범위의 9가지 기존을 마련한 뒤 작업계획, 오류유형 정의, 납품내역검수, 육안중첩검수, 현지조사검수, 전산정밀검수, 자동검수, 검수결과판정, 검수결과해석으로 이어지는 9단계의 체계적인 다단계 검수절차를 제안하였다.

• Molecules and Cells
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• 제44권3호
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• pp.127-135
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• 2021

Since the introduction of RNA sequencing (RNA-seq) as a high-throughput mRNA expression analysis tool, this procedure has been increasingly implemented to identify cell-level transcriptome changes in a myriad of model systems. However, early methods processed cell samples in bulk, and therefore the unique transcriptomic patterns of individual cells would be lost due to data averaging. Nonetheless, the recent and continuous development of new single-cell RNA sequencing (scRNA-seq) toolkits has enabled researchers to compare transcriptomes at a single-cell resolution, thus facilitating the analysis of individual cellular features and a deeper understanding of cellular functions. Nonetheless, the rapid evolution of high throughput single-cell "omics" tools has created the need for effective hypothesis verification strategies. Particularly, this issue could be addressed by coupling cell engineering techniques with single-cell sequencing. This approach has been successfully employed to gain further insights into disease pathogenesis and the dynamics of differentiation trajectories. Therefore, this review will discuss the current status of cell engineering toolkits and their contributions to single-cell and genome-wide data collection and analyses.

• 대한가정학회지
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• 제8권1호
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• pp.62-86
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• 1970

A study on the upper garment of Korean women, JUORI The upper garment of Korean women. JUGORI, is an inherited mode from the ancient clothing style in the various aspects based on the particulars of Korean clothes. The ancient style of clothes is originated from KWAMDUI belonging to inhabitants of Northern Territory of Korea. And it is quite different from Chinese clothes in lineage. However, this unicque mode of clothes has been much influnced by the Chinese culture and also by the climate of Korea. And it is quite different from Chinese clothes in lineage. However, this unicque mode of clothes has been much influnced by the Chinese culture and also by the climate of Korean penynsula. The changes of the pattern of JUGORI, in a word, is a sign of shortening tendency of size. This tendency of JUGORI is remarkably seen in the shortening of length and other parts are decreased in size. The JUGORI in the ancient age was fallen below the weist of woman, which is similar to Robe, and was worn with band. However, the length of the JUGORI has been gradually shortened, and therefore, GORUM took place of the band. The shortening tendency of JUGORI is seemed to be shown its sign in the initial time of its origin, because there are some evidences that the women in Sylla Dynasty, and this tendency has been much expedited during the period of Koryu Dynasty with influences of Monggorian culture (Won Lynasty of China) The oldest sample for data of JUGORI in nowaday is one the remains of Yi Dynasty, and this sample for data provides all the particulars of the modern pattern of JUGORI. The tendency of JUGORI had been continued even in Yi Dynasty, and at the end of the Dynasty, the clothes was shortened that the women felt inconvenient wearing it in the status of the shortened JUGORI which was even hardly cover the initial time of epoch of modernization induced from the Western civilization, and after 1920s and 1930s JUGORI become a larger tendency. This is a sing of revival of practical use and rationalization of JUGORI become a shortening tendency again, and the size is similar with that of early age of Yi Dynasty. Instead of these similarities, the particulars of modern JUGORI is weighing on much emphasis on curve beauty and expression of experior beauty. The reason is that, together with westernization of clothes, JUGORI became a special pattern of clothes as a traditional Korean women wears. The very thing explaining this pattern of JUGORI is the "ARIRANG DRESS". And there are some fashion using button instead of GORUM and half sleeve JUGORI for summer use which is regarded as a part of improved aspect of life in Korea. in Korea.

• 한국콘텐츠학회논문지
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• 제16권2호
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• pp.374-386
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• 2016

프로버넌스 데이터는 데이터의 근원 정보나 변경 이력을 표현하는 메타데이터이다. 프로버넌스 정보는 변경 이력 정보가 쌓이면서 원본데이터와 비교하여 수십 배에 달하는 양을 차지한다. 따라서 대용량의 프로버넌스 데이터를 효율적으로 압축하기 위한 기법이 요구된다. 본 논문에서는 RDF 그래프 패턴을 고려한 프로버넌스 압축 기법을 제안한다. 제안하는 기법은 표준 PROV 모델을 기반으로 프로버넌스를 표현하고 텍스트 인코딩을 통해 프로버넌스 데이터를 숫자로 인코딩한다. 그래프 패턴을 이용하여 RDF 데이터와 프로버넌스 데이터를 압축한다. 제안하는 기법은 기존 프로버넌스 압축 기법과는 달리 시맨틱 웹상의 RDF 문서를 고려하여 프로버넌스 데이터를 압축한다. 압축률, 처리시간에 대한 성능 평가를 통해 제안하는 기법의 우수성을 증명한다.

• 헤리티지:역사와 과학
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• 제52권2호
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• pp.196-219
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• 2019

"삼국유사(三國遺事)"에 의하면 황룡사 구층목탑은 백제의 장인 아비지(阿非知)에 의해 선덕여왕 13년(645)에 건립된 것으로 전한다. 이후 고려 고종 25년(1238) 몽고군의 침략으로 사찰이 완전히 불타버리기 전까지 약 700년 동안 당시대인의 정신문화 속에서 최고의 자리를 차지하는 상징이자 호국불교의 구심체로서 존재하였다. 그동안 많은 연구자들이 문헌기록과 발굴조사 자료를 근거로 황룡사 창건 목탑에 대한 구조와 전체적인 형태에 대한 다양한 복원안을 제시해왔다. 하지만 그들이 제시한 황룡사 목탑의 모습은 기본적으로 현재 남아 있는 목탑지의 외형적인 형태와 단순한 목구조를 가정한 사각구층의 형태였다. 이는 관련 자료의 부족과 제한된 지식으로 인해 황룡사 창건 목탑의 기술적 계보에 대한 충분한 인식이 부족한 시기에 이루어진 것이어서 새로운 자료의 발견과 고대 대형 불탑의 구조 체계에 대한 인식 정도에 따라 충분히 수정될 수 있을 것으로 생각한다. 본고에서는 2005년부터 진행된 <황룡사 복원 연구>를 통해 정리된 목탑지에 대한 재분석 자료를 근거로 동아시아 고대 불탑의 구조 체계에 대한 폭넓은 이해 속에서 황룡사 창건 목탑의 계보와 구조에 대한 새로운 인식이 필요함을 제안해보고자 한다. 황룡사 창건 목탑은 통일신라와 고려시대에 걸쳐 적어도 두 번의 큰 중창을 겪는 동안 기단의 규모와 평면 형식 등이 변화된 것으로 추정되며, 이에 따라 상부 구조에도 큰 변화가 있었을 것으로 파악된다. 발굴조사 결과 드러난 유구에서 삼국시대에 만들어진 것으로 전하는 구층목탑과 관련된 흔적은 현재 판축으로 조성된 기단토와 심초석 정도이며, 그외 초석과 기단 석재 등 대부분은 9세기 이후의 것일 가능성이 높다. 따라서 황룡사 창건 목탑의 실질적인 구조는 당시 동아시아 대형 불탑의 변화과정 속에서 이해하여야 하며, 기술적 계보는 북조의 영향을 받은 백제의 대형 불탑에서 찾아야 할 것이다. 나아가 남산 탑곡 마애조상군에 표현된 9층 마애탑의 모습과 황룡사지 강당지에서 출토된 금동제 불탑 난간편 분석을 통하여 파악된 고고자료를 근거로 황룡사 창건 목탑의 이미지를 추정해본다면 외형상으로뿐만 아니라 구조적으로도 지금까지 우리가 인식하고 있던 순수한 목구조를 한 사각구층탑과는 다른 형태로 파악되는데, 아마도 실심체를 갖춘 이원 구조의 팔각구층탑일 것으로 파악된다.