• Proceedings of the Korean Geotechical Society Conference
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• 2003.03a
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• pp.681-688
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• 2003

Rock damage induced by blasting can not be avoided during tunnel construction and may affect tunnel stability. But the mutual interaction between tunnel blasting design and tunnel stability design is generally not considered. Therefore this study propose a methodology to take into considration the results of the blasting damage in tunnel stability design. Rock damage is evaluated by dynamic numerical analysis for the most common blasting pattern adopted in road tunnel. Damage zone is determined by using the continuum damage model which is expressed as a function of volumetric strain. And the damage effect is taken into account by the damaged rock stiffness and the damaged failure criteria in tunnel stability assessment. The extend of plastic zone and deformation increase compared to the case of not considering blast-induced rock damage.

• Journal of the Korean Society for Nondestructive Testing
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• v.23 no.6
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• pp.559-565
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• 2003

A spectral element model-based structural damage identification method (SDIM) was derived in the previous study by using the damage-induced changes in frequency response functions. However the previous SDIM often provides poor damage identification results because the nonlinear effect of damage magnitude was not taken into account. Thus, this paper improves the previous SDIM by taking into account the nonlinear effect of damage magnitude. Accordingly an iterative solution method is used in this study to solve the nonlinear matrix equation for local damages distribution. The present SDIM is evaluated through the numerically simulated damage identification tests.

• The Journal of Korean Medicine
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• v.23 no.4
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• pp.113-124
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• 2002

Objects: This research was conducted to investigate the protective effect of Bupleuri Radix against ischemic damage using PC12 cells and global ischemia in gerbils, Methods: To observe the protective effect of Bupleuri Radixon ischemic damage, viability and changes in activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase and production of malondialdehyde (MDA) were observed after treating PC12 cells with Bupleuri Radix during ischemic damage. Gerbils were divided into three groups: a normal group, a 5-minute two-vessel occlusion (2VO) group and a Bupleun Radix administered group after 2VO. The CCAs were occluded by microclip for 5 minutes, Bupleuri Radix was administered orally for 7 days after 2VO. Histological analysis was performed on the 7th day. For histological analysis, the brain tissue was stained with 1 % of cresyl violet solution. Results: 1. Bupleuri Radix has a protective effect against ischemia in the CA1 area of the gerbil's hippocampus 7 days after 5-minute occlusion. 2. In the hypoxia/reperfusion model using PC12 cells, the Bupleuri Radix has a protective effect against ischemia in the dose of 0.2{\;}\mu\textrm{g}/ml,2{\;}\mu\textrm{g}/ml{\;}and{\;} 20{\;}\mu\textrm{g}/ml$. 3. Bupleuri Radix increased the activities of glutathione peroxidase and catalase. 4. The increased activity of superoxidedismutase (SOD) by ischemic damage might have been induced as an act of self-protection. This study suggests that Bupleuri Radix has some neuroprotective effect against neuronal damage following cerebral ischemia in vivo with a widely used experimental model of cerebral ischemia in Mongolian gerbils. Bupleuri Radix also has protective effect on a hypoxia/reperfusion cell culture model using PC12 cells. Conclusions: Bupleuri Radix has protective effect against ischemic brain damage during the early stages of ischemia.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.50 no.5
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• pp.520-526
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• 2017

Carnosine was recently reported to protect against the DNA damage induced by oxidative stress. In this study, we investigated the protective effect of eel Anguilla japonica carnosine extracts prepared using different methods (heat treatment extracts, HTEs; ion exchange chromatography, IEC; ultrafiltration permeation, UFP) on leukocyte DNA damage using the comet assay. Human leukocytes were incubated with extracts of eel carnosine at concentrations (of 10, 50, $100{\mu}g/mL$), and then subjected to an oxidative stimulus [$200{\mu}M$ hydrogen peroxide ($H_2O_2$)]. Pretreatment of the cells for 30 min with carnosine significantly reduced the genotoxicity of $H_2O_2$ measured as DNA strand breaks. The protective effects of the three types of extract (HTE, IEC, and UFP) increased with concentration. At the highest concentration (100 g/mL). there were no statistical differences in oxidative damage between each extract treatment and PBS-treated negative controls. When leukocytes were incubated with carnosine for 30 min after exposure to $H_2O_2$. the protective ability of each extract changed. Therefore, eel carnosine inhibits the $H_2O_2$ induced damage to cellular DNA in human leukocytes, supporting the protective effect of this compound against oxidative damage.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.561-568
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• 2005

The factors affecting the long-term design strength of geogrid can be classified into factors on creep deformation, installation damage, temperature, chemical degradation and biological degradation. Especially, creep deformation and installation damage are considered as main factors to determine the long-term design strength of geogrid. Current practice in the design of reinforced soil is to calculate the long-term design strength of a reinforcement damaged during installation by multiplying the two partial safety factors, $RF_{ID} and RF_{CR}$. This method assumes that there is no synergy effect between installation damage and creep deformation of geogrids. Therefore, this paper describes the results of a series of experimental study, which are carried out to assess the combined effect of installation damage and creep deformation for the long-term design strength of geogrid reinforcement. The results of this study show that the tensile strength reduction factors, RF, considering combined effect between installation damage and creep deformation is less than that calculated by the current design method.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.54-54
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• 2023

Nypa fruticans Wurmb (N. fruticans) is a plant that belongs to Araceae and N. fruticans is mainly found in tropical mangrove systems. The parts (leaves, stems, and roots) of N. fruticans are traditionally used for asthma, sore throat, and liver disease. N. fruticans contains flavonoids and polyphenols, which are substances that have inhibitory effects on cancer and oxidant. In previous studies, some pharmaceutical effects of N. fruticans on melanogenesis and inflammation have been reported. The present study is conducted to investigate the effect of the ethyl acetate fraction of N. fruticans (ENF) on oxidative DNA damage and UVB-induced DNA damage. DNA damage response (DDR) pathway is important in research on cancer, apoptosis, and so on. DDR pathways are considered a crucial factor affecting the alleviation of cellular damage. ENF could reduce oxidative DNA damage derived from reactive oxygen species by the Fenton reaction. Also, ENF reduced the intensity of intracellular ROS in the live cell image by DCFDA assay. UVB is known to cause skin and cellular damage, then finally contribute to causing the formation of tumors. As for the strategies of reducing DNA damage by UVB, inhibition of p53, H2AX, and Chk2 can be important indexes to protect the human body from DNA damage. As a result of confirming the protective effect of ENF for UVB damage, MMPs significantly decreased, and the expression of apoptosis-related factors tended to decrease. In conclusion, ENF can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage and UVB-induced DNA damage. These results are considered to be closely related to the protective effect against radicals based on catechin, epicatechin, and isoquercitrin contained in ENF. Based on these results, it is thought that additional mechanism studies for inhibiting cell damage are needed.

• Earthquakes and Structures
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• v.9 no.4
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• pp.851-873
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• 2015

A methodology for estimation of statistical properties (viz. mean and standard deviation) of the expected seismic damage to reinforced concrete framed structures subject to corrosion of reinforcement, over a specified reference time (typically the service life of the structure) is proposed in this paper. The damage to the structure under the earthquake loading is characterised by the damage index, determined using the modified Park and Ang damage model. The reduction in area, yield strength and strain at ultimate of steel reinforcement, and the reduction in compressive strength of cover concrete due to corrosion are taken into account in the estimation of damage. The proposed methodology is illustrated through an example problem. From the results obtained, it is noted that there is an increase of about 70% in the mean value of expected seismic damage to the reinforced concrete frame considered over a reference time of 30 years when effect of corrosion is taken into consideration. This indicates that there is a need to consider the effect of corrosion of reinforcement on the estimation of expected seismic damage.

• Structural Engineering and Mechanics
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• v.59 no.1
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• pp.123-132
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• 2016

Many military and commercial aging aircrafts flying beyond their design life may experience severe crack and corrosion damage, and thus lead to catastrophic failures. In this paper, were used in a finite element model to evaluate the effect of corrosion on the adhesive damage in bonded composite repair of aircraft structures. The damage zone theory was implemented in the finite element code in order to achieve this objective. In addition, the effect of the corrosion, on the repair efficiency. Four different patch shapes were chosen to analyze the adhesive damage: rectangular, trapezoidal, circular and elliptical. The modified damage zone theory was implemented in the FE code to evaluate the adhesive damage. The obtained results show that the adhesive damage localized on the level of corrosion and in the sides of patch, and the rectangular patch offers high safety it reduces considerably the risk of the adhesive failure.

• The Korea Journal of Herbology
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• v.26 no.4
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• pp.95-99
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• 2011

Objective : In this study, we demonstrate the protective effect on oxidative DNA damage of leaf extracts from Abeliophylli distichi Folium via its antioxidant activity for the establishment of new value for the herbal medicine. Methods : Abeliophylli distichi Folium leaves were extracted with hot-water and ethylacetate (EtOAC). The 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical and hydroxyl scavenging assay and $Fe^{2+}$ chelating assay were performed for antioxidative effect and ${\varphi}$X-174 RF I DNA cleavage assay and intracellular DNA damage assay were used for inhibitory effect of intracellular DNA damage. Results : In DPPH, Hydroxyl radical scavenging activity and $Fe^{2+}$ chelating activity of EtOAC extracts were 94.72%, 62.88%, 41.13%, and hot-water extracts were 88.86%, 56.7%, 37.4% at 200 ${\mu}g/m{\ell}$, respectively. Also, those extracts showed protective effect of DNA damage against the oxidative stress. Conclusion : These results indicated that the leaf extracts of Abeliophylli distichi Folium can be used as a natural antioxidants, which effectively inhibits the oxidative DNA damage.

• Earthquakes and Structures
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• v.15 no.3
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• pp.307-317
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• 2018

The current study explores the soil-structure interaction (SSI) effect on the potential seismic damage of mid-rise non-seismically designed reinforced concrete frames retrofitted by Fibre Reinforced Polymer (FRP). An 8-storey reinforced concrete frame poorly-confined due to transverse reinforcement deficiency is selected and then retrofitted by FRP wraps to provide external confinement. The poorly-confined and FRP retrofitted frames with/without SSI are modelled using hysteretic nonlinear elements. Inelastic time history and damage analyses are performed for these frames subjected to different seismic intensities. The results show that the FRP confinement significantly reduces one or two damage levels for the poorly-confined frame. More importantly, the SSI effect is found to increase the potential seismic damage of the retrofitted frame, reducing the effectiveness of FRP retrofitting. This finding, which is contrary to the conventionally beneficial concept of SSI governing for decades in structural and earthquake engineering, is worth taking into account in designing and evaluating retrofitted structures.