• The Korean Journal of Physiology and Pharmacology
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• 제5권1호
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• pp.33-40
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• 2001

The aim of present study was to define the cellular mechanisms underlying changes in delayed rectifier $K^+\;(K_{DR})$ channel function in isoproterenol-induced hypertrophy. It has been proposed that $K_{DR}$ channels play a role in regulation of vascular tone by limiting membrane depolarization in arterial smooth muscle cells. The alterations of the properties of coronary $K_{DR}$ channels have not been studied as a possible mechanism for impaired coronary reserve in cardiac hypertrophy. The present study was carried out to compare the properties of coronary $K_{DR}$ channels in normal and hypertrophied hearts. These channels were measured from rabbit coronary smooth muscle cells using a patch clamp technique. The main findings of the study are as follows: (1) the $K_{DR}$ current density was decreased without changes of the channel kinetics in isoproterenol-induced hypertrophy; (2) the sensitivity of coronary $K_{DR}$ channels to 4-AP was increased in isoproterenol-induced hypertrophy. From the above results, we suggest for the first time that the alteration of $K_{DR}$ channels may limit vasodilating responses to several stimuli and may be involved in impaired coronary reserve in isoproterenol-induced hypertrophy.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.861-865
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• 2014

Background: High risk HPV (HR-HPV) testing has been recommended as an effective tool along with cytology screening in identification of cervical intraepithelial lesions (CINs) and prevention of their progress towards invasive cervical cancer. The aim of this study was to assess the HR-HPV DNA status by Hybrid Capture 2 (HC2) assay in healthy asymptomatic women of North-East India. Materials and Methods: This study examined cervical cell samples of forty three (n=43) healthy women by HC2 assay. A High Risk HPV DNA kit (Qiagen) was used which can detect 13 high risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68. Results: The mean relative light units (RLU) for samples was in the range of 141-5, 94, 619. HR-HPV DNA was confirmed in 16% (7/43) of participant women samples. Among demographic and clinical parameters, menstrual irregularity (p=0.039) and infection history (p=0.028) has shown statistically significant differences between the HR-HPV-positive and negative groups. In the HR-HPV positive group, two women were confirmed for CINs after colposcopy and histopathologic examination. Conclusions: We suggest that there may be an association between irregular menstruation and infection history of the urogenital tract with HR-HPV DNA prevalence in North-East Indian asymptomatic women. HC2 assay can be a valuable tool for HR-HPV screening.

• Bulletin of the Korean Chemical Society
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• 제31권5호
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• pp.1301-1304
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• 2010

The Indium modified mesoporous zeolite AlMCM-41 were synthesized by hydrothermal method and characterized by powder X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS) techniques. The Knoevenagel condensation of aldehyde with malononitrile or ethyl cyanoacetate was carried out at reflux condition in ethanol by using heterogeneous In/AlMCM-41 catalyst. This method is fast, efficient, easy work-up and eco-friendly to afford the corresponding Knoevenagel adducts. The catalyst was recovered and reused for several cycles with consistent activity.

• 대한화학회지
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• 제56권1호
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• pp.58-61
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• 2012

The solvent extraction of platinum (IV) metal from hydrochloric acid media using 4-(4-ethoxybenzylideneamino)-5-methyl-4H-1,2,4-triazole-3-thiol (EBIMTT) in chloroform was studied as a function of several variables, such as reagent, acid and metal ion concentration, effect of various diluents, and diverse ions. The proposed method was further applied for the separation of platinum (IV) from binary mixtures, synthetic mixtures, alloys and commercially available samples.

• Bulletin of the Korean Chemical Society
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• 제30권5호
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• pp.1054-1056
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• 2009

We have demonstrated a one-pot three component coupling of an aldehydes, an amines, and triethyl phosphite using 1-benzyl-3-methyl imidazolium hydrogen sulphate [bnmim][][$HSO_{4}$] as an efficient catalyst. All the reactions proceed under solvent-free conditions at room temperature. This methodology afforded the corresponding $\alpha$-aminophosphonates in shorter reaction times with excellent yields.

• 대한화학회지
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• 제54권5호
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• pp.582-588
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• 2010

Thiosemicarbazides의 cyclocondensation을 이용한 1,3,4-thiadiazoles, 1,3,4-triazoles과 1,3,4-oxadiazole계의 benzofuran의 합성을 좋은 수율로 합성하였다.

• 대한화학회지
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• 제55권6호
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• pp.960-968
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• 2011

A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff's bases, followed by the cyclocondensation of Schiff's bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.

• 한국유체기계학회 논문집
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• 제15권3호
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• pp.32-38
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• 2012

This paper is aimed to propose the design database(DB) of the inline micro-turbine for 5kW class. CFD analysis is performed to investigate the effect of a turbine on each parameter. This study showed that RadhaKrishna's data is different from the 5kW class in the low-head and the micro-turbine. Therefore, new DB for the design of inline micro-turbine for 5kW class could be needed. This study configured new design DB for the design of inline micro-turbine for 5kW class. The DB of this study showed that the optimal hub ratio(Dp/DR), the optimal body ratio(Db/DR) and the optimal range of body length ratio(Lh/DR) is 50%, 1.1 and 2.3 to 2.9, respectively.

• 디지털융복합연구
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• 제12권10호
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• pp.345-351
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• 2014

본 연구의 목적은 평면 모형의 가로, 세로 비율과 가상 cobb의 각도를 측정하는 등의 화상의 왜곡에 대한 비교 연구를 통해 3 spot DR 척추 전장 촬영 방법의 정확한 정보를 제공하는 것이다. 팬텀은 $H(40cm){\times}V(116cm){\times}D(2.3cm)$ 크기로 납판이 삽입 된 격자형 아크릴로 만들었다. 제작 모형을 사용하여 각 장비에 각각 3회, OFD를 변경하여 총 9회 촬영하였고 납 격자의 가로, 세로 길이와 비율을 측정하였다. 또한 모형에서 임의의 지점을 지정하여 Cobb 각도를 측정하였다. 가로 세로 비율은 CR은 0.98~1.01, scan DR은 0.96~0.97, 3 spot DR은 0.99~1.01로 측정되었다. Cobb 각도는 각각 $52.5{\sim}53.3^{\circ}$, $52.1{\sim}54.3^{\circ}$, $52.8{\sim}53.2^{\circ}$로 측정되었다. 실험 결과에 의해 평면 모형을 이용한 본 연구에서 척추 전장 촬영을 위한 3 spot DR 촬영 방식의 영상은 왜곡이 없는 정확한 방법이다.

• 전자공학회논문지
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• 제50권12호
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• pp.22-29
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• 2013

광대역 주파수 범위에 대해서 무지향성 방사 패턴을 나타내는 실린더형 유전체 공진기와 1/4 파장 길이의 모노폴의 결합구조를 제안한다. 모노폴은 저주파 대역에서 동작하고 DR 은 고주파 대역에서 동작하며 모노폴이 DR 에 전계 결합에 의하여 급전기로서 작동한다. 실린더형 DR에서 광대역 동작을 위해서 아래쪽에 직사각 구조로 식각이 이루어진다. 안테나의 크기는 DR 의 내경, 외경 및 높이가 5.8 mm, 11.6 mm 및 6.0 mm 의 크기이며 10 dB 대역폭은 4.7-18.2 GHz 범위의 대역폭을 나타내었다.