• Journal of Advanced Navigation Technology
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• v.15 no.5
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• pp.833-838
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• 2011

X-ray device used in the diagnosis has made possible to have more effective and accurate diagnosis, powered by the development of various devices. Based on this, X-ray device has become the most basic and essential diagnostic equipment in clinical medicine. At present, in the image acquisition field using X-ray, the use of Digital radiography which is useful in the acquisition time reduction and transfer of images and is possible to have the dose reduction has expanded. With the structure using one detector, this DR device has disadvantages in that it needs structural changes unlike existing X-ray and the detector should be moved to the desired position depending on the shooting location. Therefore, in this study, using BLDC(Brushless direct current) motor and PID(Proportional integral differential) control method, the automatic control system of 3-axis which is upward and downward, left and right and rotation of detector where having the most movement in DR was designed and produced and its performance was evaluated.

• Progress in Medical Physics
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• v.14 no.4
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• pp.234-239
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• 2003

We examined the variation of percent depth dose (PDD) curves for 10 MV X-rays in the presence of magnetic fields. The EGS4 Monte Carlo code was applied and modified to take account of the effect of electron deflection under magnetic field was used. We defined and tested DI (dose improvement) and DR (dose reduction) to describe variation of PDD curves under various magnetic fields. For a magnetic field of 3 T applied at the depth region of 5-10 cm and field size of 10${\times}$10 $\textrm{cm}^2$, the DI is 1.56 (56% improvement) and DR is 0.68 (32% reduction). We explained the results from the Lorentz law and the concept of electron equilibrium. We suggested that the dose optimization in radiotherapy can be achieved from using the characteristics of dose distributions under magnetic fields.

• Atmosphere
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• v.26 no.3
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• pp.473-482
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• 2016

An accurate determination of turbulent fluxes over an urban area is a challenging task due to its morphological diversity and associated flow complexity. In this study, an eddy covariance (EC) method is applied over a highly heterogeneous urban area in a small city (Gongju), South Korea to investigate the quantitative influence of 'coordinate tilt' in determining the turbulent fluxes of sensible heat, latent heat, momentum, and carbon dioxide mass. Two widely-used coordinate transform methods are adopted and applied to eight directional sections centered on the site to analyze a 1-year period EC measurement obtained from the urban site: double rotation (DR) and planar fit (PF) transform. The results show that mean streamline planes determined by the PF method are distinguished from the sections, representing morphological heterogeneity of the site. The sectional pitch angles determined by the DR method also compare well with those in the PF method. Both the PF and DR methods show large variabilities in the determined streamline planes at each directional section, implying that flow patterns may form in a complicate way due to the surface heterogeneity. Resulting relative differences of the turbulent fluxes, defined by $(F_{DR}-F_{PF})/F_{DR}$, are found on average +13% in sensible heat flux, +21% in latent heat flux, +37% in momentum flux, and +26% in carbon dioxide mass flux, which are larger values than those reported previously for fairly homogeneous natural sites. The fractional differences depend significantly on wind direction, showing larger differences in northerly winds at the measurement site. It is also found that the relative fractional differences are negatively correlated with the mean wind speed at both stable/unstable atmospheric conditions. These results imply that EC turbulent fluxes determined over heterogeneous urban areas should be carefully interpreted with considering the uncertainty due to 'coordinate tilt' effect in their applications.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.5
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• pp.113-119
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• 2008

Conventional 1-1-1 cooperative protocol offers path-loss gain as advantage of multi-hop and spatial diversity which is equivalent to MIMO system. This protocol is enable to get higher reliability and reduction of power consumption than those of the single-hop or multi-hop. But the 1-1-1 cooperative protocol get only the diversity order 2 and limited path-loss reduction gain because this protocol has a single cooperative relay. We propose 1-2-1 cooperative protocol using two cooperative relays R1, R2. The 1-2-1 cooperative protocol can improve path-loss reduction and increase diversity order 3. Moreover, the cooperative relay R2 attains diversity order 2. The signaling method in transmission uses DF (Decode and Forward) or DR (Decode and Reencode) and 1-2-1 DF/DR cooperative protocol are applied to clustering based wireless sensor networks (WSNs). Simulations are performed to evaluate the performance of the protocols under Rayleigh fading channel plus AWGN (Additive White Gaussian Noise).

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.293-297
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• 2016

TRAIL, tumor necrosis factor (TNF)-related apoptosis-inducing ligand belongs to one of important cytokine superfamilIES, tumor necrosis factor ($TNF{\alpha}$). TRAIL-2 receptor agonists activate several cell signaling pathways in cells in different manners and could lead to apoptosis or necrosis. Agonistic egg yolk antibodies like IgY which have been developed in a selective manner could activate TRAIL death receptors such as TRAIL-2 (DR5) and thus apoptosis signaling. We here investigated induction of apoptosis in human breast cancer cells (MCF7 cell line) by an IgY produced against an 21 aminoacid epitope of the human TRAIL-2 receptor. As the first step a small peptide of 21 aminoacids choosen from the extracellular domain of DR5 protein was produced with a peptide synthesizer. After control assays and confirmation of the correct amino acid sequence, it was injected to hens immunized to achieve high affinity IgYs. At the next step, the produced IgYs were extracted and examined for specificity against DR5 protein by ELISA assay. Subsequently, the anticancer effect of such IgYs was determined by MTT assay in the MCF7 human breast cancer cell line. The produced peptides successfully immunized hens and the produced antibodies which accumulated in egg yolk specifically recognized the DR5 protein. IgYs exerted significant toxicity and killed MCF7 cells as shown by MTT assay.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.257-261
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• 2016

Cancer causes cells to avoid death while being the second cause of death in the world itself. Damaged cells in the absence of apoptosis will increasingly amplify their inefficient genome. Of the two main apoptosis inducing pathways in cells, the first has p53 protein as the main initiating factor in the cascade. According to research results this protein s mutated in 50% of cancers and sointerest has cooncentrated on the second pathway that features death receptors. Among these receptors TRAIL1/DR5 is especially expressed in cancer cells. So targeting such receptors can initiate the apoptotic cascade in cells. Interestingly by substitution of activating ligands with antibodies as agonists, we could efficiently turn on the apoptosis pathway. First of all, three small peptides from the DR5 protein extracellular domain were synthesized and injected with two different kind of adjuvants (Fround and liposomal encapsulation) separately into mice at 15 day intervals. As a result, liposomal peptides induced the immune system more efficient than Frounds adjuvant and at the end point the antibodies which were obtained from liposomal peptide injection induced much more effective death. Liposomal formol could be used as an adjuvant in immunization utilizing small peptides. They carry, protect and deliver peptides very efficiently. In addition, small peptides of a certain size from the extracellular domain of DR5 proteins not only can induce immune system but also produce antibodies playing a remarkable anti-cancer roles against breast cancer cells (MCF-7).

• The Korean Journal of Applied Statistics
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• v.33 no.3
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• pp.229-238
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• 2020

The very first statistics department in Korean universities was founded in 1962, meaning it has been 57 years since Korean academia has regarded statistics as a wholly independent field of study. Dr. Junbo Kim was the first faculty member hired by Korea University's statistics department. He made a seminal contribution to the development and publication of statistics textbooks in those early years, and in 1971, spearheaded the efforts to found the Korean Statistical Society, serving as its first president. Naturally, Dr. Kim's significant contributions have laid the cornerstones for the advancement of statistics as an independent field of study in Korea. In this paper, I will explore two main subjects: one is the early history of the Korean Statistical Society with a special emphasis on Dr. Kim's contributions, and the other is an analytical overview his publications. Specifically, I will focus on Modern Statistics: A Synthesis of Statistics and Estimates』(Kim, 1954), and 『Inferential Statistics: An Introduction to Sample Survey and Experimental Design』(Kim, 1956).

• Restorative Dentistry and Endodontics
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• v.39 no.3
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• pp.215-219
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• 2014

Whenever endodontic therapy is performed on mandibular posterior teeth, damage to the inferior alveolar nerve or any of its branches is possible. Acute periapical infection in mandibular posterior teeth may also sometimes disturb the normal functioning of the inferior alveolar nerve. The most common clinical manifestation of these insults is the paresthesia of the inferior alveolar nerve or mental nerve paresthesia. Paresthesia usually manifests as burning, prickling, tingling, numbness, itching or any deviation from normal sensation. Altered sensation and pain in the involved areas may interfere with speaking, eating, drinking, shaving, tooth brushing and other events of social interaction which will have a disturbing impact on the patient. Paresthesia can be short term, long term or even permanent. The duration of the paresthesia depends upon the extent of the nerve damage or persistence of the etiology. Permanent paresthesia is the result of nerve trunk laceration or actual total nerve damage. Paresthesia must be treated as soon as diagnosed to have better treatment outcomes. The present paper describes a case of mental nerve paresthesia arising after the start of the endodontic therapy in left mandibular first molar which was managed successfully by conservative treatment.

• The Journal of Korean Medicine
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• v.26 no.1 s.61
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• pp.37-45
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• 2005

In the present study, we examined the effect of crude methanolic extract (CME) from Euonymus alatus (Thunb.) Sieb on arachidonic acid (AA) cascade in SKBR3 human breast cancer cell line. CME had a potent inhibitory activity of prostaglandin E2 (PGE2) release induced by A23187, a $Ca^{2+}$ ionophore. The inhibition was concentration-dependent, with the 50 value of about 5 M. CME had no inhibitory effect on A23187-induced phosphorylation of p42/p44 extracellular signal regulated kinase/mitogen-activated protein kinase or on the liberation of [14C]-AA from the cells labeled with [14C]-AA. However, CME concentration-dependently inhibited the conversion of AA to $PGE_2$ in microsomal preparations, showing its possible inhibition of cyclooxygenase (COX). In enzyme assay in vitro, CME inhibited the activities of both constitutive COX (COX­I) and inducible COX (COX-2) in a concentration-dependent manner, with the 50 values of about 0.8 and 2M, respectively. Lineweaver-Burk plot analysis indicated that CME competitively inhibited the activities of both COX-l and -2. This study is a first demonstration that CME directly inhibits COX activity.

• Journal of Electrical Engineering and Technology
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• v.13 no.3
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• pp.1069-1078
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• 2018

Demand response (DR) programs give opportunity to consumers to manage their electricity bills. Besides, distribution system operator (DSO) is interested in using DR programs to obtain technical and economic benefits for distribution network. Since small consumers have difficulties to individually take part in the electricity market, an entity named demand response provider (DRP) has been recently defined to aggregate the DR of small consumers. However, implementing DR programs face challenges to fairly allocate benefits and payments between DRP and DSO. This paper presents a procedure for modeling the interaction between DRP and DSO based on a bilevel programming model. Both DSO and DRP behave from their own viewpoint with different objective functions. On the one hand, DRP bids the potential of DR programs, which are load shifting and load curtailment, to maximize its expected profit and on the other hand, DSO purchases electric power from either the electricity market or DRP to supply its consumers by minimizing its overall cost. In the proposed bilevel programming approach, the upper level problem represents the DRP decisions, while the lower level problem represents the DSO behavior. The obtained bilevel programming problem (BPP) is converted into a single level optimizing problem using its Karush-Kuhn-Tucker (KKT) optimality conditions. Furthermore, point estimate method (PEM) is employed to model the uncertainties of the power demands and the electricity market prices. The efficiency of the presented model is verified through the case studies and analysis of the obtained results.