• 제목/요약/키워드: DON

검색결과 7,650건 처리시간 0.034초

물포화 Silica gel chromatography에 의한 Deoxynivalenol 생산에 관한 연구 (A study on deoxynivalenol production by water-saturated silical gel chromatography)

  • 김종수;최민철
    • 대한수의학회지
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    • 제32권3호
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    • pp.413-419
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    • 1992
  • Deoxynivalenol producing isolates of Fusarium Graminearum R 6576 was grown on rice for 25 days at 19,25 and $28^{\circ}C$. Maximum production of deoxynivalenol(DON) by Fusarium graminearum R 6575 occurred at $28^{\circ}C$ and 20 days. Maximum concentration of 940 ppm DON were obtained after 20 days at an initial moisture content of 40%. A DON derivative, 15-acetyl-DON (15-ADON), was also found at concentrations of 150~300ppm after 5~10 days. Crude culture extracts were purified by water-saturated silica gel column chromatography which selectivity extracted DON when methylene chloride was as the mobile phase. Purity of crystallized DON was verified by thin layer and high performance liquid chromatography. Also this method was advantage method or production of DON and require little organic sorbent than the other methods.

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Mouse에서의 Deoxynivalenol이 면역글로브린에 미치는 영향 (Effect of Deoxynivalenol on Immunoglobulin in the Mouse)

  • 이국천;이주홍;손성기;주영국
    • 한국동물위생학회지
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    • 제15권2호
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    • pp.166-173
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    • 1992
  • Mice were fed semi-purified diets containing 0, 2, 10 and 25 ppm(mg/kg) deoxynivalenol over 8 weeks and were assessed for effects on bodyweight gain, serum immunolglobulin levels and surface immunoglobulin bearing lymphocyte ratio. 1. The rate of body-weight gain was significantly reduced (p<0.05) at the 10 and 25 ppm of DON, whereas the mice ingesting the diet containing 2 ppm DON was not. 2. IgA in serum immunolglobulin was significantly increased (P<0.05) at the 10 and 25 ppm of DON, but IgG, IgM were decreased, whereas exposure to 2 ppm DON was not change. 3. Concentration of IgA from Peyer's patch of mice fed DON exhibited increased at 10, 25 ppm. 4. Lymphocytes surface marker studies revealed that IgA, IgG and IgM were 2.2%, 0.4% and 1.5% respectively. These results suggest that dietary exposure to DON alters regulation of IgA production

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Reduction of Deoxynivalenol in Barley by Chemical Treatments and Malting

  • Pei, Shi-Chun;Lee, Won-Jong;Kim, Suk-Shin
    • Food Science and Biotechnology
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    • 제14권6호
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    • pp.823-827
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    • 2005
  • Fusarium mycotoxin deoxynivalenol (DON) contents and its critical quality parameters were analyzed using two-rowed, six-rowed, and hulless barleys. DON content in the two-rowed Korean barleys was lower than that in the six-rowed barleys. The average DON contents of six-rowed, two-rowed, and hulless barleys were 1.35 ppm, 0.36 ppm, and 0.49 ppm, respectively. The DON content was reduced by 6.2% by sieving, by 6.0% by washing with water and by 18.1-69.8% by treatment with aqueous chemical solutions. Of the reagents investigated, aqueous sodium bicarbonate gave the greatest reduction in the barley DON level. The DON content was reduced to 62.5% of initial level after 3 days of steeping and to 23.1% after 3 days of germination. DON was not detected after steeping barley for 24 hr in 0.1M $Na_2CO_3$ solution with 0.1 % activated carbon.

<거울 모르는 사람들>의 서사적 특성과 편집성 인격장애 (The epical character of and Paranoid Personality Disorder)

  • 강미정
    • 고전문학과교육
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    • 제15호
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    • pp.163-189
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    • 2008
  • This paper is to reveal the relation between the epic of and paranoid personality disorder. I assume that the fact of not recognizing one's own face should be pathological problem. People who suffer from paranoid personality disorder show mistrust and anxiety. I expect that people who don't recognize their own faces from can be related to paranoid personality disorder. The epic of from "An Outline of Korean Folklore Literature" is related to the epic of mistrust and anxiety. The wife from distrusts her husband. She is in fear of being abandoned. She has a doubt that her husband has an affair, so she might lose him. After searching the epic of , I found some peculiarity of people's behave. When you have doubts about your lover, so you are in anxiety, it's hard to think logically. You keep digging for clues expecting that you would prove the unknown truth. It becomes really impossible to make a sense out of you. You cannot be persuaded. These all symptoms are related to paranoid personality disorder. Not every version of from "An Outline of Korean Folklore Literature" is all about symptoms. There are some versions show the solution. Separation for a specified period, self-examination, and recovery of distrust can be the way of solving the problem. In the scene of literary therapy practice, the epic of can be used for the treatment of paranoid personality disorder.

비수리(Lespedeza cuneata G. Don) 지상부 메탄올 추출물의 항산화 활성 (Antioxidant Activity of Methanol Extract from Aerial Parts in Lespedeza cuneata G. Don)

  • 김용한;류수노
    • 한국작물학회지
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    • 제53권spc호
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    • pp.121-123
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    • 2008
  • In order to verify the efficacy of Lespedeza cuneata G. Don which have been used as a folk traditional herb medicine from ancient times, the test of antioxidant activity and the analysis of constituents were carried out. Methanol extracts from L. cuneata G. Don showed a radical scavenging activity corresponding to that of (+)-catechin as positive control at 250 ${\mu}g$/mL (ca 90% inhibition), and inhibited more than 30% of DPPH radical at low concentration of 10${\mu}g$/mL. In the present study, as a fundamental study for the specification of antioxidant components from L. cuneata G. Don, the analysis for constituents for L. cuneata with HPLC was preformed although there was no results to identify functional flavonoids such as quercetin.

DA-7911, rhenium-188 tin colloid, as a new therapeutic agent of rheumatoid arthritis

  • Jeong, Mi-Young;Lee, In-Ki;Miwon Son;Kim, Soon-Hae;Jeong, Jae-Min;Moohi Yoo;Kim, Won-Bae;Lee, Eun-Hong;Song, Yeong-Wook
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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    • pp.222-222
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    • 2002
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Vomitoxin의 면역 독성효과 (Immunotoxic effects of vomitoxin)

  • 김종수;김용환
    • 대한수의학회지
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    • 제32권1호
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    • pp.25-34
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    • 1992
  • The present study were carried out to investigate the effects of Vomitoxin(Deoxynivalenol, DON) induced dysregulation of IgA synthesis. The data presented here demonstrate that exposure to dietary DON increases serum IgA and concurrently decreases IgG and IgM. Peyer's path(PP) and splenocytes from mice fed dietary DON produced increased IgA in mitogen stimulated and macrophage(MØ) perform essential role for Ig synthesis and was affected by the presence of DON. The synthesis and secretion of IgM and IgG under the presence of DON do not require T cell helper activity, whereas those of IgA do require such activity. These results suggest that dietary DON alters the regulation of IgA production and may act as an immunostimulator.

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Derivations of Single Hypothetical Don't-Care Minterms Using the Quasi Quine-McCluskey Method

  • 김은기
    • 한국산업정보학회논문지
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    • 제18권1호
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    • pp.25-35
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    • 2013
  • Automatically deriving only individual don't-care minterms that can effectively reduce a Boolean logic expressions are being investigated. Don't-care conditions play an important role in optimizing logic design. The type of unknown don't-care minterms that can always reduce the number of product terms in Boolean expression are referred as single hypothetical don't-care (S-HDC) minterms. This paper describes the Quasi Quine-McCluskey method that systematically derives S-HDC minterms. For the most part, this method is similar to the original Quine-McCluskey method in deriving the prime implicants. However, the Quasi Quine-McCluskey method further derives S-HDC minterms by applying so-called a combinatorial comparison operation. Upon completion of the procedure, the designer can review generated S-HDC minterms to test its appropriateness for a particular application.

도시지역 노인들의 도구적 일상생활 수행능력(IADL)에 영향을 미치는 요인 (Factors Affecting to the Instrumental Ability of Daily Living(IADL) in the Urban Elderly)

  • 이인학;문성기;김근조;박재영
    • The Journal of Korean Physical Therapy
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    • 제14권3호
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    • pp.238-272
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    • 2002
  • This study was intended to find out the factors affecting to the IADL, allowing objective assessment of physical function status of increasing elderly populations. The subjects of 635 elderly persons aged over 65 years old who live in Taejon metropolitan city were interviewed during the two-month period from June to July of 2000. The IADL of Older American Resources and Services(OARS), developed in Duke medical college of USA, was interpreted for use. The study results were statistically processed using SPSSWIN(ver 10.0) and conferred the following results: 1. Among the seven items of IADL, the women showed higher rates of 'yes' in items about using the telephone, getting to the places out of walking distance, going shopping for groceries, taking their own medicine while outnumbered by the men only in the item about managing their own money, without significant differences between them in items about preparing their own meals and doing their own housework. 2. In terms of IADL scores, $82.0\%$ of subjects showed the normal range of scores and $18.0\%$ were under the normal range, meaning dysfunction IADL. Specifications of general characteristics revealed that more dysfunctional were the male subjects, the higher age groups who are more than 75 years old, the higher educated groups, the groups who live in nursing homes, the groups without a spouse. 3. Based on daily activities, lower scores of IADL were found in the subjects who don't go out, who don't have recreational activities, who don't attend elderly gatherings in their neighborhood, who don't hold social meetings. Specifications of psychological traits revealed that more dysfunctional were IADL in the subjects who don't feel satisfied with their lives of the past or the present, who have a deep feeling of isolation, and who don't have the will to live. 4. Among 7 items of health habits, only the subjects who don't regular exercise had lower scores of IADL than those who do. According to HPI, the lower HPI, the more dysfunctional. 5. Based on the factors associated with IADL, the odds ratio of the subjects who don't live together with their families were 1.53 times that of the ones who do, who are educated 3.22 times that of the ones who are not, who don't have spouses 2.09 times that of the ones who do, who don't go out 4.35 times that of the ones who frequently go out, who don't recreational activities for an interest 2.64 times that of the ones who do, who don't attend elderly gatherings in their neighborhood 1.47 times that of the ones who do, who don't hold social meetings 2.23 times that of the ones who do, who don't feel satisfied with their present living 1.43 times that of the ones who do, who have a feeling of isolation 1.53times that of the ones who don'1, who have the weak will to live 3.21 times that of the ones who have the strong one, and who don't regular exercise 2.45 times that of the ones who do. 6. Logistic regression analysis of the study results found that such factors are significantly related as the degree of education, with/without spouse, social meetings, the will to live, and regular exercise, and that higher rates of dysfunctional subjects were in the more educated group, in the group without spouse, in the group who don't frequently go out, who don't have social meetings, who have the weak will to live, and who don't exercise.

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Don′t Care 정보를 이용한 임베디드 소프트웨어의 최적화 (Embedded Software Minimization Using Don′t Cares)

  • 홍유표
    • 대한전자공학회논문지SD
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    • 제37권3호
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    • pp.48-54
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    • 2000
  • 이 논문은 임베디드 소프트웨어를 위한 소프트웨어 합성시 don't care 정보를 이용하여 합성된 소프트웨어의 성능을 향상시키기 위한 방법을 제시한다. 임베디드 시스템은 주로 실시간 처리가 요구되는 분야에 사용되기 때문에 매우 까다로운 실시간 및 코드 크기의 제한이 있기 때문에 그에 관한 최적화는 매우 중요하다. 우리는 BDD 기반의 유한상태기계 전달 함수의 표현으로부터 확장된 유한상태기계를 유도하는 소프트웨어 합성의 경우에 돈 케어정보를 추출하고, 그를 이용한 BBD를 최소화하여, 일차적으로는 코드크기를 줄이고 결과적으로는 코드가 실행되는 임베디드 시스템의 성능을 향상시키는 방법을 제안한다. 그러한 방법이 적용된 실험적 결과를 제시하고, don't care 기반의 BDD 최소화와 BDD 변수의 동적 재배열의 결합 등 관련 연구 방향을 제안한다.

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