• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5895-5900
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• 2013

Dictamnine (Dic) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells and dihydroartemisinin (DHA) also has potent anticancer activity on various tumour cell lines. This report explores the molecular mechanisms by which Dic treatment and combination treatment with DHA and Dic cause apoptosis in human lung adenocarcinoma A549 cells. Dic treatment induced concentration- and time-dependent cell death. FCM analysis showed that Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (${\Delta}{\Psi}m$) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis. Combination treatment with DHA and Dic dramatically increased the apoptotic cell death compared to Dic alone. Interestingly, pretreatment with z-DQMD-fmk significantly attenuated DHA and Dic co-induced apoptosis, implying that caspase-3 plays an important role in Dic and DHA co-induced cell apoptosis. Collectively, we found that Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA enhanced Dic induced A549 cell apoptosis via a caspase-dependent pathway.

• Journal of Internet Computing and Services
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• v.19 no.1
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• pp.105-111
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• 2018

This paper presents the analysis of image quality with FHD(Full HD) resolution camera equipped DIC(Digital Image Correlation) platform for the measurement of the architectural structure's relative displacement. DIC platform was designed based on i.MX6 of Freescale. Displacement measurement based on DIC method, the error is affected by image quality factors as pixel number, brightness, contrast, and SNR[dB](Signal to Noise Ratio). The effect were analyzed. The displacement of ROI(Region Of Interest) area within the image was measured by sub-pixel units based on DIC method. The non-contact telemetry property of DIC method, it can be used to long distance non-contact measurement. The various displacement results was measured and analyzed with the image quality factor adjustment according to the distance(25m, 35m, 50m).

• Structural Engineering and Mechanics
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• v.69 no.4
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• pp.467-477
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• 2019

Digital image correlation (DIC) is now a popular and extensively used full-field metrology technique. In general, DIC is performed by using a turnkey solution offered by various manufacturers of DIC. In this paper, a simple and economical set-up for DIC is proposed which uses easily accessible digital single-lens reflex (DSLR) camera rather than industrial couple-charged device (CCD) cameras. The paper gives a description of aspects of carrying a DIC experiment which includes experimental set-up, specimen preparation, image acquisition and analysis. The details provided here will be helpful to carry DIC experiments without specialized DIC testing rig. To validate the responses obtained from proposed DIC set-up, tension and fatigue tests on specimens made of IS 2062 Gr. E300 steel are determined. Tensile parameters for a flat specimen and stress intensity factor for an eccentrically-loaded single edge notch tension specimen are evaluated from results of DIC experiment. Results obtained from proposed DIC experiments are compared with those obtained from conventional methods and are found to be in close agreement. It is also noted that the high resolution of DSLR allows the use of proposed approach for fracture characterization which could not be carried out with a typical turnkey DIC solution employing a camera of 2MP resolution.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.8
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• pp.617-626
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• 2021

During supersonic flight of vehicles, the thermal behavior of structures under high-temperature environment is important for thermal-structural design. In this study, full-field thermal deformation and stress concentration of the notched structure was performed using global-local multi-digital image correlation (multi-DIC) systems. This techniques were developed and implemented by multi-DIC systems consists of 2D DIC system and 3D DIC system. The specimen was heated in a heating chamber to achieve the thermal expansion behavior. Then the images of structure's deformation and stress concentration at various temperature were recorded and analyzed by multi-DIC system. Afterward, full-field thermal deformation of the notched structure was determined with DIC technique and stress concentration at the notched structure was calculated by further processing. Finite element analysis of the notched structure is performed in ABAQUS^TM and the results of the experiments show good agreement with those obtained from simulation. The results achieved in this study show the efficiency of the muilti-DIC method in thermal deformation as well as stress concentration of notched structure.

• Journal of the Korean housing association
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• v.27 no.6
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• pp.95-104
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• 2016

The purpose of this research is to compare housing wealth effects of home-owning single income couples (SIC) and dual income couples (DIC) on their non-durable consumption and to assess the effects by location, age groups, housing structure type, debt-to-asset ratio and employment status. Using the Korean Labor and Income Panel Study (KLIPS) of 2014, this empirical study identified 1,198 SIC households and 1,044 DIC households, and employed multiple regression analysis. The main results reveal that the difference of financial portfolios between SIC and DIC households was little but housing wealth effects were stronger among SIC households than DIC counterpart. It's evident that housing wealth effects were conspicuous for SIC and DIC households who were headed by wage earners aged over 40s, and resided in apartment outside the Seoul Metropolitan Area. However, household debt became a determinant in contradicting housing wealth effects of SIC and DIC households. While the household financial dimension was in proportion to income, DIC households didn't gain much financial security due to increasing expenditure. Further, this research imply that liquidity constraints explicitly posed a more serious threat to SIC households whose dependence on housing asset is larger than their counterpart.

• Journal of the Korean Society of Safety
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• v.29 no.5
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• pp.15-21
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• 2014

The aim of this work is conduct the study on light weight and structural performance improvement of the composite wind power blade. GFRP (Glass Fiber Reinforced Plastic) pre-empted by CFRP(Carbon Fiber Reinforced Plastic), the major material of wind power blade, was identified the superiority of mechanical performance through the tensile and fatigue test. SENT(Single Edge Notched Tension) specimen fracture test was conducted on the specimen that laminated together 2 ply CFRP with 4 ply GFRP through DIC(Digital Image Correlation) analysis. The SENT specimen thickness and $a_0/W$ ratio is 1.45 mm and 0.2, respectively. The fracture test accomplished with displacement control with 0.1 mm/min at the room temperature. The experimental apparatus used for the fracture test consisted of a 50kN universal dynamic tester and CCD camera connected to a personal computer (PC), which was used to record images of the specimen surface. Following data acquisition, the images and load-displacements were transferred to the PC, on which the DIC software was implement. The experiment and DIC analysis results show that CFRP/GFRP laminated composite exhibits improvement of the strength, compared with that of the existing blade material. This study shows the result that the strength of CFRP rotor blade of wind turbine satisfies through the experimental and DIC method.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.391-397
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• 2017

Recently, digital image correlation (DIC) techniques have been used to measure dynamic deformation during tensile testing. The standard tensile test method measures the average displacement of the relevant specimen to calculate the true stress-strain curve. Therefore, the validity of the true stress curve is restricted to the stress incurred within the uniform stretching interval, i.e., the maximum stress corresponds to the starting point of the necking deformation. Alternatively, if DIC is used, the effective range of the strain and strain rate can be extended to the breaking point of the tensile specimen, because of the feasibility of measuring the local strain over the entire area of interest. Because of these advantages, many optical 3D measurement systems have been introduced and used in research and industry. However, the conventional 3D measurement systems are exceedingly expensive and time consuming. In addition, these systems have the disadvantage of a very large equipment size which makes their transport difficult. In this study, a 2D image correction method employing a 2D DIC measurement method in conjunction with a numerical analysis method is developed using a smartphone. The results of the proposed modified 2D DIC method yielded higher accuracy than that obtained via the 3D measurement equipment. In conclusion, it was demonstrated that the proposed 2D DIC and calibration methods yield accurate measurement results with low time costs.

• Corrosion Science and Technology
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• v.23 no.2
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• pp.113-120
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• 2024

An attempt was made to apply digital image correlation (DIC) strain analysis to in-situ scanning electron microscopy (SEM) observations of bending deformation to quantify local strain distribution inside a ZnMgAl-alloy coating in deformation. Interstitial-free steel sheets were hot-dipped in a Zn-3Mg-6Al (mass%) alloy melt at 400 ℃ for 2 s. The specimens were deformed using a miniature-sized 4-point bending test machine inside the SEM chamber. The observed in situ SEM images were used for DIC strain analysis. The hot-dip ZnMgAl-alloy coating exhibited a solidification microstructure composed of a three-phase eutectic of fine Al (fcc), Zn (hcp), and Zn2Mg phases surrounding the primary solidified Al phases. The relatively coarsened Zn₂Mg phases were locally observed inside the ZnMgAl-alloy coating. The DIC strain analysis revealed that the strain was localized in the primary solidified Al phases and fine eutectic microstructure around the Zn₂Mg phase. The results indicated high deformability of the multi-phase microstructure of the ZnMgAl-alloy coating.

• Computers and Concrete
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• v.17 no.6
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• pp.831-848
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• 2016

This study aims to characterize the multiple cracking behavior of HTPP-ECC (High tenacity polypropylene fiber reinforced engineered cementitious composites) by Digital Image Correlation (DIC) Method. Digital images have been captured from a dogbone shaped HTPP-ECC specimen exhibiting 3.1% tensile ductility under loading. Images analyzed by VIC-2D software and ${\varepsilon}_{xx}$ strain maps have been obtained. Crack widths were computed from the ${\varepsilon}_{xx}$ strain maps and crack width distributions were determined throughout the specimen. The strain values from real LVDTs were also compared with virtual LVDTs digitally attached on digital images. Results confirmed that it is possible to accurately monitor the initiation and propagation of any single crack or multiple cracks by DIC at the whole interval of testing. Although the analysis require some post-processing operations, DIC based crack analysis methodology can be used as a promising and versatile tool for quality control of HTPP-ECC and other strain hardening composites.

• Structural Engineering and Mechanics
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• v.45 no.4
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• pp.471-494
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• 2013

In this paper, identification of isotropic and orthotropic linear elastic material constitutive parameters has been demonstrated by a FEA-free energy-based inverse analysis method. An important feature of the proposed method is that it requires no finite element (FE) simulation of the tested material. Full-field displacements calculated using digital image correlation (DIC) are used to compute DIC stress fields enforcing the equilibrium condition and DIC strain fields using interpolation functions. Boundary tractions and displacements are implicitly recast into an objective function that measures the energy residual of external work and internal elastic strain energy. The energy conservation principle states that the residual should be zero, and so minimizing this objective function inversely identifies the constitutive parameters. Synthetic data from simulated testing of isotropic materials and orthotropic composite materials under 2D plane stress conditions are used for verification of the proposed method. When identifying the constitutive parameters, it is beneficial to apply loadings in multiple directions, and in ways that create non-uniform stress distributions. The sensitivity of the parameter identification method to noise in both the measured full-field DIC displacements and loadings has been investigated.