• Journal of dental hygiene science
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• v.9 no.3
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• pp.361-367
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• 2009

This study was conducted to know oral maxillofacial symptoms accroding to dental fear and dental use behavior. 334 persons Older than junior high school students in Daegu, South Korea who visited to dental clinic were targeted From March 1.2008 to March 15, 2008. Statistics tool was SPSS 12.0 for Windows. General characteristics and response degree according to oral maxillofacial symptoms was analyzed by frequency study. Fear and difference according to oral maxillofacial symptoms we re conducted by T-test and One-Way ANOVA. Correlation analysis was used to verify relation between fear and oral maxillofacial symptoms. Results are followings. 1. Women felt fear higher than men did. Persons who were older felt fear higher and these were statistically related. 2. Extraoral external was 62.9%, hightest on the symptoms response degree according to oral maxillofacial symptoms. Feeling back side of the head on the strain and neck was stiff on the items were high. 3. Oral maxillofacial symptoms were high in the case when they had regular inspection, experience of scaling, experience of anesthesia and visited to the clinic often. And. Two cases(having regular inspection and visiting to the clinic often) were statistically related. Conclusion: Each pan of oral maxillofacial symptoms in the high fear group according to oral maxillofacial symptoms and it was all statistically related. And, fear and each oral maxillofacial pains were positively related and it was statistically related.

• Journal of Genetic Medicine
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• v.16 no.2
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• pp.55-61
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• 2019

Purpose: Genetic defects in the nuclear-encoded mitochondrial aminoacyl-tRNA synthetases were first identified as causes of various disorders in 2007. Variants in IARS2, which encodes a mitochondrial isoleucyl-tRNA synthetase, were first reported in 2014. These variants are associated with diverse phenotypes ranging from CAGSSS (CAtaracts, Growth hormone deficiency, Sensory neuropathy, Sensorineural hearing loss, and Skeletal dysplasia) and Leigh syndrome to isolated nonsyndromic cataracts. Here, we describe the phenotypic and genetic spectrum of Korean patients with IARS2-related disorders. Materials and Methods: Using whole-exome sequencing followed by Sanger sequencing, we identified five patients with IARS2 mutations. Their medical records and brain magnetic resonance images were reviewed retrospectively. Results: All five patients presented with developmental delay or regression before 18 months of age. Three patients had bilateral cataracts, but none had hearing loss or sensory neuropathy. No evidence of skeletal dysplasia was noted, but two had short stature. One patient had cardiomyopathy and another exhibited renal tubulopathy and hypoparathyroidism. Their brain imaging findings were consistent with Leigh syndrome. Interestingly, we found the recurrent mutations p.R817H and p.V105Dfs*7 in IARS2. Conclusion: To our knowledge, this is the first report of Korean patients with IARS2-related disorders. Our findings broaden the phenotypic and genotypic spectrum of IARS2-related disorders in Korea and will help to increase clinical awareness of IARS2-related neurodegenerative diseases.

• Journal of dental hygiene science
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• v.17 no.1
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• pp.46-55
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• 2017

Many people in Korea suffer from a fear of dental treatments; however, only a few studies have focused on this population. This study assessed the effectiveness of cognitive behavioral therapy (CBT) and its interventions in reducing dental anxiety, especially when administered by trained dental staff. Using case studies, the authors analyzed the content of each session and examined the process of reducing dental anxiety. First, the authors observed that the results of both dental fear scale and subjective unit of disturbance decreased significantly with changes in cognitive distortions related to dental anxiety and that rapid improvements were noted after two therapy sessions. Second, the study reported that practicing relaxation (deep-breathing) and muscle relaxation techniques; using hand signals to indicate anxiety or discomfort; establishing an empathic relationship with the therapist; making an anxiety list; and graded insensitive and exposure along with rehearsal, were effective in coping with dental anxiety and in changing negative thoughts towards the dentist. Third, a simple cognitive behavioral intervention can be effective in reducing dental anxiety. In summary, a short-term, five-session psychological intervention with CBT produced a sustained decrease in the symptoms of dental anxiety, allowing the patients to receive the required procedures. The authors discussed the study limitations and the implication of their results on future research.

• The Korean Journal of Pesticide Science
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• v.10 no.2
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• pp.91-98
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• 2006

The objective of this study was to compare dioxin contents in spinach, soil and air and to evaluate the relation of dioxin concentrations in crop and its cultural environment. Sample weighing for the precise peak detection in dioxin analysis was also determined. The fragmentogram of HpCDFs, and especially OCDF, indicated different pattern from that of TeCDD/F, PeCDD/Fs and HxCDDs/Fs, which showed the same pattern. In case of field culture spinach (wet sample 2 kg) in Japan, peak of OCDF could be detected clearly, while market spinach (wet sample 1 kg) showed the only baseline detection. The result makes it possible to suppose the fact that production place of market spinach was not contaminated with OCDF, but atmospheric pattern of production place was similar to that of open field sample. So we could decide that the sample of agricultural crops were needed more than 2 kg in wet weight for the evaluation of precise peak The total tendency of dioxin concentration levels in field culture spinach may be affected by OCDD and HCDF distributed in soil. However, on the whole the major factor seems to be the atmospheric deposition.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.4
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• pp.1483-1491
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• 2010

The purpose of this study was to examine current status of the types of dental filling materials and preventive materials among Korean children in mixed dentition. Seven elementary schools were randomly selected from four metropolitan regions in South Korea. The total of 711 children aged 9-10 years old were examined with their parents’ informed consents. Oral examination was conducted by one trained dentist. The mean number of dfs was $7.9{\pm}8.0$ ($ds=1.3{\pm}2.5,\;fs=6.6{\pm}7.6$) and DMFS was $1.4{\pm}2.2$ ($DS=0.2{\pm}0.8,\;FS=1.1{\pm}2.1$). The average of filled surfaces using amalgam, composites, sealants, and others were $2.8{\pm}3.9,\;1.6{\pm}2.8,\;2.9{\pm}3.2$, and $4.5{\pm}7.0$, respectively. The use of dental filling material according to region, the amalgam was the highest in Daegu and the resin was the highest in Pusan. In permanent teeth, about 70% of total filling surfaces had sealant and about 20% was resin fillings, and the proportion of amalgam filling surfaces was less than 10%.

• Journal of KIISE:Computer Systems and Theory
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• v.36 no.4
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• pp.259-273
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• 2009

Most of large-scale distributed file systems decouple a metadata operation from read and write operations for a file. In the distributed file systems, a certain server named a metadata server (MDS) maintains metadata information in file system such as access information for a file, the position of a file in the repository, the namespace of the file system, and so on. But, the existing systems used restrictive metadata management schemes, because most of the distributed file systems designed to focus on the distributed management and the input/output performance of data rather than the metadata. Therefore, in the existing systems, the metadata throughput and expandability of the metadata server are limited. In this paper, we propose a new non-shared metadata management scheme in order to provide the high metadata throughput and scalability for a cluster of MDSs. First, we derive a dictionary partitioning scheme as a new metadata distribution technique. Then, we present a load balancing technique based on the distribution technique. It is shown through various experiments that our scheme outperforms existing metadata management schemes in terms of scalability and load balancing.

• Radiation Oncology Journal
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• v.29 no.3
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• pp.191-198
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• 2011

Purpose: Although the role of squamous cell carcinoma antigen (SCC-Ag) as a predictive and prognostic factor for uterine cervical cancer has been identified in previous studies, 1) the effective patient group of screening for recurrence with SCC-Ag, 2) the relationship between SCC-Ag and recurrence site, and 3) the relationship between the change of SCC-Ag and treatment outcome or recurrence have not been described. Materials and Methods: The study included 506 patients with histologically proven uterine cervical cancer between January 1994 and December 2010. We determining the serum SCC-Ag level before treatment and after treatment, and conducted a retrospective review of the patients' records. We evaluated the sensitivity and specificity of SCC-Ag for the detection of tumor recurrence by comparing biochemical recurrence with clinical recurrence. Results: The pretreatment SCC-Ag level and the proportion of patients over 1.5 ng/mL were higher in poor prognostic patient group. In the univariate and multivariate analysis, pretreatment SCC-Ag showed a statistically significant correlation with tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage, pathology. In patients with biochemical recurrence vs. those without, 5-year DFS and OS were 27.6 vs. 92.7% (p ${\leq}$ 0.001) and 53.7 vs. 92.5% (p ${\leq}$ 0.001), respectively. Conclusion: Our study reconfirmed the known function of pretreatment SCC-Ag, but could not confirm the function of biochemical response as a predictive factor for treatment and as a prognostic factor. There was no statistically significant relationship between SCC-Ag level and recurrence site. We confirmed the role of SCC-Ag as a follow-up tool for recurrence of disease and which patient groups SCC-Ag was more useful for.

• Radiation Oncology Journal
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• v.37 no.2
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• pp.91-100
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• 2019

Purpose: Internal mammary lymph node (IMN) involvement is associated with poor prognosis in breast cancer. This study investigated the treatment outcomes of initial clinically IMN-positive breast cancer patients who received adjuvant radiotherapy (RT), including IMN irradiation, following primary breast surgery. Materials and Methods: We retrospectively reviewed data of 95 breast cancer patients with clinically detected IMNs at diagnosis treated with surgery and RT between June 2009 and December 2015. Patients received adjuvant RT to the whole breast/chest wall and regional lymph node (axillary, internal mammary, and supraclavicular) areas. Twelve patients received an additional boost to the IMN area. Results: The median follow-up was 43.2 months (range, 4.5 to 100.5 months). Among 77 patients who received neoadjuvant chemotherapy, 52 (67.5%) showed IMN normalization and 19 (24.6%) showed a partial response to IMN. There were 3 and 24 cases of IMN failure and any recurrence, respectively. The 5-year IMN failure-free survival, disease-free survival (DFS), and overall survival (OS) were 96%, 70%, and 84%, respectively. IMN failure-free survival was significantly affected by resection margin status (97.7% if negative, 87.5% for close or positive margins; p = 0.009). All three patients with IMN failure had initial IMN size ≥1 cm and did not receive IMN boost irradiation. The median age of the three patients was 31 years, and all had hormone receptor-negative tumors. Conclusion: RT provides excellent IMN control without the support of IMN surgery. Intensity-modulated radiotherapy, including IMN boost for breast cancer patients, is a safe and effective technique for regional lymph node irradiation.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.287-292
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• 2013

Background: Low tyrosine-protein phosphatase nonreceptor type 12 (PTPN12) expression may be associated with breast cancer growth, proliferation, and metastasis. However, the prognostic value of PTPN12 in breast cancer has not been clearly identified. Patients and Methods: 51 triple-negative breast cancer (TNBC) patients and 83 non-TNBC patients with a histopathology diagnosis from October 2001 to September 2006 were included in this study. Immunohistochemical staining for PTPN12 on tissue microarrays was conducted. Results: High PTPN12 expression was seen in 39.2% of TNBC and 60.2 % of non-TNBC cases. Low PTPN12 expression was associated with lymph node status (p = 0.002) and distant metastatic relapse (p = 0.002) in TNBC patients. Similarly, low PTPN12 expression in non-TNBC patients was significantly correlated with lymph node status (p = 0.002), stage (p = 0.002) and distant metastatic relapse (p = 0.039). The high PTPN12 expression group was associated with longer DFS and OS compared with low PTPN12 expression group only in TNBC cases (p = 0.005, p = 0.015), according to univariate Cox regression analysis. Conclusion: These findings provide evidence that low expression of PTPN12 is associated with worse prognosis and may be used as a potential prognostic biomarker in TNBC patients.

• The Korean Journal of Emergency Medical Services
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• v.15 no.2
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• pp.85-99
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• 2011

Purpose: The purpose of this study is to examine the EMT student's attitude to the disabled and provide the basic materials of educational program to make them have right awareness and attitude of the disabled. Methods: The subjects of this study were 348 of 339 emergency medical students at three departments of emergency medical in G metropolitan city who gave consent to take part in the research and the data were collected for 10 days from Mar. 2 to 11, 2011. It used DFS (Disability Factor Scale) developed by Siller (1967) and revised and complemented by Lee Jong Nam (1997) after validity and reliability test. Data collected were analyzed with technical statistics, t-test and ANOVA using SPSS/ PC 12.0 Results: The results of this study are summarized as follows. 1. On the question that there are the disabled around the subjects, 74.7% of the respondents answered 'none', and on the question of having concerns on the disabled problems, 61.5% of the respondents answered 'they have no concerns on them'. In addition, on the question of effective methods for improving a negative awareness of the disabled, many of subjects responded the governmental support must be a priority. 2. The subjects' attitude to the disabled scored average 3.13 and they have positive attitude to the disabled. In six sub-areas of attitude to the disabled, tension in contact with the disabled scored 2.90, inferred emotional disorder 2.79, unconditional repulsion 2.78, refusal to friendly relation 2.74, limitation of other functions undamaged 2.66 and distorted identification 2.65. 3. Variable showing a significant difference in the results of analysis according to general characteristics of subjects was age and those who are over '21' showed more positive attitude to the disabled than those who are below '20'. 4. In the results of analysis according to the subjects' disability related characteristics, those who have the disabled in their friends or family and have concerns on the disabled problems have a positive attitude to the disabled. Promotion and education through mass communication for changing the awareness of the disabled into a positive attitude will be most effective. Conclusion: Consequently, positive attitude of EMT student's to the disabled can be fostered by continuous contact with the disabled and their participation in voluntary services in the dimension of individual or school will be important and also the various practical methods such as enlightenment movement and supply of right information through mass communication should be sought.