• Journal of mucopolysaccharidosis and rare diseases
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• v.3 no.1
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• pp.1-8
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• 2017

Mucopolysaccharidosis (MPS) type III, or Sanfilippo syndrome is a rare autosomal recessive lysosomal storage disorder. It is caused by a deficiency of one of four enzymes involved in the degradation of the glycosaminoglycan (GAG) heparan sulfate. The resultant cellular accumulation of heparan sulfate causes various clinical manifestations. MPS III is divided into four subtypes depending on the deficient enzyme: MPS IIIA, MPS IIIB, MPS IIIC and MPS IIID. All the subtypes show similar clinical features and are characterized by progressive degeneration of the central nervous system (CNS). Main purpose of the treatment for MPS III is to prevent neurologic deterioration. However, conventional enzyme replacement therapy has a limitation due to inability to cross the blood-brain barrier. Several experimental treatment options for MPS III are being developed.

• The Journal of Korea Robotics Society
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• v.7 no.2
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• pp.101-112
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• 2012

It is well-known that when singularities are located within the workspace of the parallel mechanism (PM), the usefulness of its workspace is significantly deteriorated. To handle this problem, we suggest an optimal design method which leads to more useful and larger workspace of the PM by taking its singularity locations into consideration in design process. Kinematic models of three selected planar PMs, a 5R type PM, a 3-RPR type planar PM, and a 3-RRR type planar PM, are derived via screw theory and their singularity analyses are conducted. Then workspace optimal designs for those three PMs are conducted to verify that the suggested design method leads more useful and larger workspace in which deterioration by singularity is minimal.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2014.05a
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• pp.174-175
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• 2014

A Rural house in Chungcheong area have been variety of matters, rapid deterioration of house and incomplete of maintenance control, that is represented lack of durability heating from lack of heat insulation property, health worsening form use of toxic substance and so on. For farmers who did not know where to repair and how to repair, they are urgently needed measures of standard and basis that is to realize a condition of rural house. Accordingly, this study drew major matters and priority for revitalization through analysis of type of rural house from research on the actual condition in order to develope of diagnostic criteria of rural house.

• The KSFM Journal of Fluid Machinery
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• v.4 no.3 s.12
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• pp.39-45
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• 2001

It is reported recently that the pump head deterioration near the best efficiency point, from single-phase flow to the choke due to air entrainment became less in a screw-type centrifugal pump than in a general centrifugal pump. Moreover, at a narrow tip clearance, the pump head became partially higher in two-phase flow than that in single-phase flow. However, the internal pressure fluctuations on this pump due to air entrainment have not been studied yet. For that reason, we have examined the influences of void fraction, flow coefficient and impeller tip clearance on pressure fluctuations in the casing. The void fraction became larger, the influence of tip clearance on pressure distribution became less.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.1
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• pp.214-218
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• 2016

Catenary maintains the tension of the catenary using automatic tensioning devices to meet performance require m ents exhibited by the house is generated in accordance with the new external temperature changes. Double spring type autom a tic tensioning device is permanent and does not require the usual maintenance, and a deterioration due to no recognizable ab normalities characteristic of the nature of the internal state has the disadvantage that can not be confirmed. The disassembled for automatic spring-tension capabilities ensure efficient operation and life expectancy of the adjustment device via a check by analyzing the changes in old age determine the remaining lifetime is expected to be available as a basis for maintenance in the future.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.4
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• pp.1491-1500
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• 1996

Unstable performance deterioration was found on the performance curve of a small propeller fan with a back plate. To investigate this phenomenon and the effects of the back-plate on the performance of the fan, performance tests and flow measurement using 3-hole pitot tube were carried out. Measurements showed that when the flow rate is small, the radial flow dominates, and when the flow rate is large, the axial flow dominates. Performance characteristic of the propeller fan changes from radial to axial type as the flow rate increases. Unstable performance changes are the result of type change of the flow through the fan.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1997.10a
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• pp.95-102
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• 1997

Jointless bridge is a new construction method applicable to bridge of short length. In the jointless bridge expansion of superstructure due to thermal effect was absorbed in the flexible pile-type abutment in stead of expansion joint in the conventional bridges. By removing expansion joint, it retards deterioration and extends life time of bridge. In this paper, jointless bridge of steel box girder type was studied through finite element analysis. Stress variations of superstructure and pile due to thermal effect was studied for the two span continuous integral bridge of 80m length and the results of analysis was presented.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.22 no.9
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• pp.786-791
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• 2009

Transformer failures are mostly due to partial discharges (PDs) caused by the deteriorated insulation. It is, therefore, important to monitor PD occurrence in insulation system and prevent their deterioration. The presented paper deals with a PD detection method by a capacitive probe, which easily apply to cast - resin dry - type transformers. The PD detection system consists of a capacitive probe and a low noise amplifier having the frequency bandwidth of 500 $Hz{\sim}30$ MHz. In the experimental set-up, sensitivity of the system is 7.16 mV/pC.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2000.10a
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• pp.273-280
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• 2000

Building structures which are in need of large open space make the damping effect of the structures decrease greatly. Assembly and office buildings with a lower natural frequency have a higher possibility of experiencing excessive vibration induced by human activities. These excessive vibration make the residents uncomfortable and the serviceability deterioration. The loads induced by human activities were classified into two types. First type is in place loads as like jumping, foot stamping and body bouncing. The other type is moving loads as like walking, running and dancing. A series of laboratories experiments had been conducted to study the dynamic loads induced by human activities, The earlier works were mainly concerned to parameters study of dynamic loads as like activity type, weight, sex, surface condition of structure and etc. In this paper, we have measured directly the walking loads by using the platform. And we have evaluated and analyzed load-time history of walking loads. One of the most important parameter is pacing rate (walking speed) in the walking loads. The difference between the maximum value and minimum value of walking loads depends on the walking speed.

• The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.7 no.4
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• pp.26-33
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• 1993

The acoustic emission automatic detection system is developed to observe tree deterioration phenomena. Applying an alternating voltage of 15(kVnns) toXLPE tree specimens, many pulses of small amplitude are detected when the bush type tree developes branch type and a few pulses of high amplitude prcxluced as branch type propagated to bush type tree. Therefore, it is known that pulses having small amplitude operates as a destructive factor. It is observed that the skewness of the amplitude and the number of average pulses as distribution tendency of three dimension are characteristic quantity of AE pulses. As the trajectory of skewness is farther from the origin on the S-plane, it is more likely to breakdown.