• Medical Lasers
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• 제8권2호
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• pp.50-58
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• 2019

Background and Objectives Low-level light therapy (LLLT) is an application of low-power light for various purposes such as promoting tissue repair, reducing inflammation, causing analgesia, etc. A previous study suggested the effect of light emitting diode (LED) light with the wavelength of 740 nm for promoting wound healing of corneal epithelial cells. This current study aimed to confirm the effect of LLLT for managing inflammation of a dry eye disease (DED) mouse model. Materials and Methods A total of 50C57BL/6 female mice were randomly grouped into 5 groups to compare the effect of LLLT:1) Control group, 2) Only LLLT group, 3) Dry eye group, 4) LLLT in dry eye group, and 5) Early treatment group. DED was induced with 4 daily injections of scopolamine hydrobromide and desiccation stress for 17 days, and LLLT at 740 nm was conducted once every 3 days. To analyze the effect of LLLT on the DED mouse model, tear volume, corneal surface irregularities, and fluorescence in stained cores were measured, and the level of inflammation was assessed with immunohistochemistry. Results The DED mouse model showed significant deterioration in the overall eye condition. After LLLT, the amount of tear volume was increased, and corneal surface irregularities were restored. Also, the number of neutrophils and the level of inflammatory cytokines significantly decreased as well. Conclusion This study showed that LLLT at 740 nm was effective in controlling the corneal conditions and the degree of inflammation in DED. Such findings may suggest therapeutic effects of LLLT at 740 nm on DED.

• 한국산학기술학회논문지
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• 제19권10호
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• pp.346-351
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• 2018

금속 3D 프린팅 기술은 레이저 빔의 초점에 금속분말을 주입하는 방식에 따라 대표적으로 PBF(Powder Bed Fusion)방식과 DED(Direct Energy Deposition)방식으로 나뉜다. DED 방식은 금속 분말 도포와 동시에 레이저를 조사하여 3차원 구조물을 제작하는 금속 3D 프린팅 기술이고, PBF 방식은 일정 높이로 3차원 그래픽을 슬라이싱 한 후 한 층씩 금속 분말을 적층하여 레이저를 이용해 3차원 구조물을 제조하는 방식이다. DED 방식을 사용하면 레이저 클래딩, 금속 용접 등에는 강점을 가지지만 3D 형상을 제작할 경우 밀도가 낮아지는 문제점이 발생한다. DED 방식에서의 구조체 밀도 문제를 해결하기 위해 PBF 방식을 도입하면 상대적으로 밀도가 높은 3차원 구조물을 제작하는데 용이하다. 본 논문에서는 갈바노 스캐너와 광섬유로 전송되는 Nd:YAG 레이저 빔을 이용한 약 $30{\mu}m$ 크기의 스테인리스 강 분말을 이용하는 PBF 방식의 3차원 프린터를 제작하고, 이를 이용하여 얇은 금속 구조물을 제작하였다. 또한 레이저의 조사 횟수, 출력, 초점 크기, 스캐닝 속도에 따른 선폭의 최적조건을 찾았으며, 그 결과 최적 조건은 레이저 조사 횟수 2회, 출력 30 W, 초점 크기 $28.7{\mu}m$, 스캐닝 속도 200 mm/s에서 최소 선폭은 약 $85.3{\mu}m$로 측정되었다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제12권4호
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• pp.418-425
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• 2012

In this paper, efficient implementation of error correction code (ECC) processing circuits based on single error correction and double error detection (SEC-DED) code with check bit pre-computation is proposed for memories. During the write operation of memory, check bit pre-computation eliminates the overall bits computation required to detect a double error, thereby reducing the complexity of the ECC processing circuits. In order to implement the ECC processing circuits using the check bit pre-computation more efficiently, the proper SEC-DED codes are proposed. The H-matrix of the proposed SEC-DED code is the same as that of the odd-weight-column code during the write operation and is designed by replacing 0's with 1's at the last row of the H-matrix of the odd-weight-column code during the read operation. When compared with a conventional implementation utilizing the odd-weight- column code, the implementation based on the proposed SEC-DED code with check bit pre-computation achieves reductions in the number of gates, latency, and power consumption of the ECC processing circuits by up to 9.3%, 18.4%, and 14.1% for 64 data bits in a word.

• BMB Reports
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• 제47권9호
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• pp.488-493
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• 2014

Adaptor protein FADD forms the death inducing signaling complex (DISC) by recruiting the initiating caspases-8 and -10 through homotypic death effector domain (DED) interactions. Cellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of death ligand-induced apoptosis downstream of death receptors, and FADD competes with procaspase-8/10 for recruitment for DISC. However, the mechanism of action of FADD and c-FLIP proteins remain poorly understood at the molecular level. In this study, we provide evidence indicating that the death effector domain (DED) of FADD interacts directly with the death effector domain of human c-FLIP. In addition, we use homology modeling to develop a molecular docking model of FADD and c-FLIP proteins. We also find that four structure-based mutants (E80A, L84A, K169A and Y171A) of c-FLIP DEDs disturb the interaction with FADD DED, and that these mutations lower the stability of the c-FLIP DED.

• 한국분말재료학회지
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• 제29권4호
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• pp.309-313
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• 2022

In this study, additive manufacturing of a functionally graded material (FGM) as an alternative to joining dissimilar metals is investigated using directed energy deposition (DED). FGM consists of five different layers, which are mixtures of austenitic stainless steel (type 316 L) and low-alloy steel (LAS, ferritic steel) at ratios of 100:0 (A layer), 75:25 (B layer), 50:50 (C layer), 25:75 (D layer), and 0:100 (E layer), respectively, in each deposition layer. The FGM samples are successfully fabricated without cracks or delamination using the DED method, and specimens are characterized using optical and scanning electron microscopy to monitor their microstructures. In layers C and D of the sample, the tensile strength is determined to be very high owing to the formation of ferrite and martensite structures. However, the elongation is high in layers A and B, which contain a large fraction of austenite.

• 대한전자공학회논문지SD
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• 제45권1호
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• pp.43-49
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• 2008

본 논문에서는 Ant Colony Optimization(ACO)을 이용하여 Single-Error Correcting & Double-Error Detecting(SEC-DED)을 제공하는 메모리 ECC 체커 회로의 소비전력을 절감하는 방안을 제시한다. H-매트릭스를 통해 구현되는 SEC-DED 코드인 Hsiao 코드의 대칭성과 H-매트릭스 구성상의 높은 자유도를 이용하여 회로의 면적, 딜레이에 영향을 주지 않고 최소의 비트 트랜지션이 일어나도록 H-매트릭스를 최적화한다. 실험을 통하여 H-매트릭스의 최적화를 위한 ACO 매핑과 파라메터의 설정을 알아보고 이의 구현 결과를 랜덤 매트릭스 구성을 통한 방식 및 기존의 GA알고리즘을 이용한 최적화 방식과 비교하여 소비 전력이 기존의 방식에 비해 절감될 수 있음을 보여준다.

• 한국분말재료학회지
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• 제31권2호
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• pp.152-162
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• 2024

The directed energy deposited (DED) alloys show higher hardness values than the welded alloys due to the finer microstructure following the high cooling rate. However, defects such as microcracks, pores, and the residual stress are remained within the DED alloy. These defects deteriorate the wear behavior so post-processing such as heat treatment and hot isostatic pressing (HIP) are applied to DED alloys to reduce the defects. HIP was chosen in this study because the high pressure and temperature uniformly reduced the defects. The HIP is processed at 1150℃ under 100 MPa for 4 hours. After HIP, microcracks are disappeared and porosity is reduced by 86.9%. Carbides are spherodized due to the interdiffusion of Cr and C between the dendrite and interdendrite region. After HIP, the nanohardness (GPa) of carbides increased from 11.1 to 12, and the Co matrix decreased from 8.8 to 7.9. Vickers hardness (HV) decreased by 18.9 % after HIP. The dislocation density (10^-2/m²) decreased from 7.34 to 0.34 and the residual stress (MPa) changed from tensile 79 to a compressive -246 by HIP. This study indicates that HIP is effective in reducing defects, and the HIP DED Stellite 6 exhibits a higher HV than welded Stellite 6.

• 제어로봇시스템학회논문지
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• 제6권2호
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• pp.228-233
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• 2000

It is common to apply the technology of FPGA (Fie이 Programmable Gate Array) which is one of the design methods for ASIC(Application Specific IC)to the active components used in the data processing at the digital system of satellite aircraft missile etc for compact lightness and integration of Printed Circuit Board (PCB) In carrying out the digital data processing the FPGAs are designed for the various functions of the Process Control Interrupt Control Clock Generation Error Detection and Correction (EDAC) as the individual module. In this paper an FPGA chip for Single Error Correction and Double Error Detection (SEC-DED) for EDAC is designed and simulated by using a VLSI design software LODECAP.

• Journal of Welding and Joining
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• 제34권4호
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• pp.1-8
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• 2016

Metal AM(Additive Manufacturing) has been steadily developed and that is classified into two method. PBF(Powder Bed Fusion) deposited in the bed by the laser or electron beam as a heat source of the powder material and DED(Directed Energy Deposition) deposited by varied heat source of powder and solid filler material. In the developed countries has been applying high productivity process of solid filler metal based DED method to the aerospace and defense sectors. The price of the powder material is quite expensive compared to the solid filler metal. A study on DED method that is based on a solid filler metal is increasing significantly although was low accuracy and degree of freedom.

• 대한전자공학회논문지SP
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• 제44권3호
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• pp.23-32
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• 2007

H.264 영상 부호화 표준은 인트라 예측에서 압축 효율을 향상시키기 위해 율-왜곡 최적화(RDO : Rate Distortion Optimization) 방법을 사용한다. 이러한 방법을 사용함으로써 현재 블록에 대한 최적의 부호화 모드의 선택이 가능해졌지만 복잡도와 연산은 이전대비 더욱 증가하였다. 본 논문은 우세한 에지 방향(DED : Dominant Edge Direction)의 예측을 통한 고속인트라 모드 결정 알고리즘을 제안한다. 이를 위해 이 알고리즘은 이산 코사인 변환(DCT : Discrete Cosine Transform) 계수를 근사화하여 이용한다. DED를 예측함으로써 $4{\times}4$ 휘도 블록의 경우 최적 모드 결정을 위한 율-왜곡 최적화 계산에 9개 모드 중 3개 모드가 선택된다. $16{\times}16$ 휘도 블록과 $8{\times}8$ 색상 블록의 경우 4개 모드 대신에 2개 모드가 최적 모드 결정을 위해 율-왜곡 최적화 계산을 수행한다. 이러한 방법을 이용한 실험 결과 인트라 전체 검색 방법대비 약 72%의 연산시간이 감소하는 결과를 보여준다.